Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.9e-06 0.00016 21.1 1.1 2 21 27 46 26 47 0.96

2 6 3.4e-05 0.0019 17.7 1.0 1 23 55 78 55 78 0.96

3 6 0.00029 0.016 14.8 2.5 1 21 107 127 107 128 0.97

4 6 1.3e-05 0.0007 19.1 0.2 1 23 136 159 136 159 0.96

5 6 1.3e-05 0.00074 19.0 1.8 1 21 205 225 205 226 0.95

6 6 2.7e-05 0.0015 18.0 2.6 1 23 234 257 234 257 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.9e-06	0.00016	21.1	1.1	2	21	27	46	26	47	0.96
2	6	3.4e-05	0.0019	17.7	1.0	1	23	55	78	55	78	0.96
3	6	0.00029	0.016	14.8	2.5	1	21	107	127	107	128	0.97
4	6	1.3e-05	0.0007	19.1	0.2	1	23	136	159	136	159	0.96
5	6	1.3e-05	0.00074	19.0	1.8	1	21	205	225	205	226	0.95
6	6	2.7e-05	0.0015	18.0	2.6	1	23	234	257	234	257	0.97

Coding Sequence: ATGGGATTCAGGAGGAGCCACGTGTTCAGGAGCCACGTGACACGGACTTGTTACACAGGATCGCCGAAGACGCCGATGAAATGCCCACAGTGCGGACGAACGTACAAGATGAAGCGTAATTTGACGACACATATGAAATTCGAGTGCGGCGGTCAGAGACACTTCGCGTGCCACATGTGCCCGGCCAGCTACACGCAGAATATCGGGCTGCGTCGACACTTGTTGAAACGGCACAATGTCTATTTGCCGCCAAAGTTCTCCGTACCGAAACAGCCGGCGAGACGGTCCAGGTACGGATGCTACACGAACATGGACGGGTTCACCTGCTACCAGTGCGGCCGAACGTATCAGATGAGGCACAATCTGGTGAAACATTTGCGATTCGAGTGCGGCGGACAAAAACACTTTGTGTGCACCGTGTGCCCGGCGAGATACACGCAAAACGGGAAGCTCAGGCAGCATATGCTGAACGCTCACAACATCTTCGTTCCGCCGCGAAAAACGTGGATGAGAACCGCTTACAgtCTCTACGAGAGCTATCCGTTTGACGCTCCGTCCGCCATGAAGACCATGTTGCCGAGTATCAGTCGCTACGTCCCCGAAGACCGTGAGTTCCAGTGCTCGAACTGCGGACGAAGATACTCGCTCAAGCACAATCTGATCAGGCACGAGCGTTACGAGTGCGGCGGTCAACGAAGATTCACCTGTGCTTTCTGCTCGAAGAAGTACACGCAGAATGGCACCCTACAGAAACACCTTCTCCGGTTCCATAACATCGTCCAGTATCCGAGACGGAAATTCAAACGACAGCCGAAATCCCGTAATCGTTTAGCGAACTTCGAGAATTAA
Protein Sequence: MGFRRSHVFRSHVTRTCYTGSPKTPMKCPQCGRTYKMKRNLTTHMKFECGGQRHFACHMCPASYTQNIGLRRHLLKRHNVYLPPKFSVPKQPARRSRYGCYTNMDGFTCYQCGRTYQMRHNLVKHLRFECGGQKHFVCTVCPARYTQNGKLRQHMLNAHNIFVPPRKTWMRTAYSLYESYPFDAPSAMKTMLPSISRYVPEDREFQCSNCGRRYSLKHNLIRHERYECGGQRRFTCAFCSKKYTQNGTLQKHLLRFHNIVQYPRRKFKRQPKSRNRLANFEN

Sequence clustering based on sequence similarity using MMseqs2