Dyak001994.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila yakuba
Gene Symbol
run
Assembly
GCA_016746365.1
Location
NC:20207979-20239019[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.7 5.8e+03 -2.8 0.7 40 77 38 75 9 84 0.66
2 2 1.4e-71 4.7e-68 227.1 0.1 4 129 119 244 116 244 0.98

Sequence Information

Coding Sequence
ATGCACATTTCTGCTGAGGTCAGTTCGACCACCTCAAATCAaatacagcagcagcagcagcagcaccagcagcaacaccagcagcagcagcagcaacagcaacagcagcaacagttgttgcagcagcagcaacaacagacaGCAACAACGACCACAACGAAGCGGCGGAATGCTGAGTCTTctgccagcaacaacaataacaacactagcacaaccaacaacaacaataacaacaacaacaacaacagcaccacaaacaacaacaacaacaataataataatgttaaaACAAAGCCCGTGGACACGAGTCCCTACTTGACCCCCGAGAATCTCATCGAGCGCACCGTCGACGTCCTGCTAGCCGAACATCCTGGCGAGCTGGTCAAGACGGGGTCTCCACATGTGGTCTGCACCACTTTGCCCACGCACTGGCGATCGAACAAGACTCTACCGATCGCCTTCAAGGTTTTGGCGCTGGGCGAGGTCATGGACGGCACTATAGTGACCATTAGAGCCGGAAACGATGAGAACTTCTGCGGCGAACTGAGAAACTGTACGGCCGTGATGAAAAATCAGGTGGCCAAGTTCAATGATCTGCGCTTCGTGGGCAGAAGCGGAAGGGGCAAGAGCTTCACACTGACGATTGTCATCTCGACGAACCCCATACAGATAGCCACCTACACCAAGGCCATCAAGGTGACCGTGGATGGGCCAAGGGAACCCAGATCGAAGGTGCGACACCAGGGATTCCATCCGTTCGCCTTTGGGCCACAACGTTTCGGACCGGATCCACTTATGGCCGGATTGCCCTTCAAGTTGCCAGGATTCGCACACCATCTCGTGGGGATGCACAGCCACCTGCATGCGCCCGATTGGCGCGCCCACATGGCCTTGGGCGGTCGCCCCGCCGCCTTTACCGCCGCCCCCTTTTTCGGTCACCATGCGGCCGCTTTTCCCACCGCCAGTGGCCTGCGTGGATTGAGTGGCGAcaaccagcagcaccagcagcagcagcagcagctggccaCCGTGGGGGCGGCACACAGCACCACCAGTCCGGAGGGATCGccgaccaccaccaccacgagCGGTACCCAGCTGAGCGCCTTTGTTCAGCCGCCAATGACGTCATCGCCGCCGCCGGTCACCAGCTTGCAGCacgacaataacaacaataacagcaacaacaacaacagcagcagccacataGACGCGGGCTTCGAAAGCGACAGCATTTCGGTGACAGGATCGCCGCGAAAGAGCCTCGCCTCCCCCCTCACCcacgacgaggaggaggcggaAGCAGAAGCGGaagcggatgcggatgcggaggCTGAGGAGGCGGAGGTGGGCGGTTTGAGTCTGAATGGCGGCGGCATTCAGGGCACGCTGCACAGCGAAAGTTCGCCCGGCTCGGGCGGCGCCTTCACCGCTCTCATTCAACGTAGTGGCAAAAATCCCACAGAATTATTTGGCGGCTTTGCCGGTGGTGCAGGTGGTAACCACTTTGCCCACAGCGGTCACAGTTTCAATCCCGCGCTGGCCGCCCAACTTTTCCTGCAAAGTCCGCTTTTGCCGCAATCCAGTCAGTGGCTGTATACGCAGCTATATGGCAGCTACAGTGATCTCCCCTGGCTGAGGAACGCGGCGGCCGCGGCGGCCGCCAATATAAATCCCGGTCAGGAGAATGCCGGTGTACCGCCGCTGGGCAGCAATCCGGATCACGATGGCGTTAACCTGATCAAGCGCTGTGTCACACTGATAACCCACAATCCGCCGGACGCGGAAAACGCCAATCCAAACGCCTCGCCGCCGGTCAGCTCCACCAGGCGATCGCCCTCGCCCGTGGAAACCATCGACTTGGACGACGTGAGCACCACATCGCGCTCGGCCAGCGGCTCCAGTGGCCTGGGCCTGGGCGGCGGAGTGGGCGGAATGGGTGGAGTGGGCGGTGCAGTGGGACCCATCAGGACGCGCACACCCAAACCGTCGGCGGATGTCTGGCGCCCCTACTAG
Protein Sequence
MHISAEVSSTTSNQIQQQQQQHQQQHQQQQQQQQQQQQLLQQQQQQTATTTTTKRRNAESSASNNNNNTSTTNNNNNNNNNNSTTNNNNNNNNNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPAAFTAAPFFGHHAAAFPTASGLRGLSGDNQQHQQQQQQLATVGAAHSTTSPEGSPTTTTTSGTQLSAFVQPPMTSSPPPVTSLQHDNNNNNSNNNNSSSHIDAGFESDSISVTGSPRKSLASPLTHDEEEAEAEAEADADAEAEEAEVGGLSLNGGGIQGTLHSESSPGSGGAFTALIQRSGKNPTELFGGFAGGAGGNHFAHSGHSFNPALAAQLFLQSPLLPQSSQWLYTQLYGSYSDLPWLRNAAAAAAANINPGQENAGVPPLGSNPDHDGVNLIKRCVTLITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTSRSASGSSGLGLGGGVGGMGGVGGAVGPIRTRTPKPSADVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00591483; iTF_00536542; iTF_00507394; iTF_00494163; iTF_00527086; iTF_00594324; iTF_00504463; iTF_00604613; iTF_00607591; iTF_00592170; iTF_00539438; iTF_00486351; iTF_00596433; iTF_00602361; iTF_00581308; iTF_00505181; iTF_00578303; iTF_00547840;
90% Identity
iTF_00596433;
80% Identity
-