Basic Information

Insect: Drosophila willistoni
Gene Symbol: MET32
Assembly: GCA_018902025.1
Location: CM032166.1:13590557-13595187[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 25 0.0011 0.087 13.5 1.1 1 23 214 236 214 236 0.97

2 25 0.00058 0.047 14.3 1.3 1 23 242 264 242 264 0.98

3 25 0.0011 0.089 13.4 0.2 2 23 296 317 295 317 0.95

4 25 0.0038 0.31 11.7 1.9 1 22 391 412 391 414 0.90

5 25 7 5.7e+02 1.4 0.7 2 21 424 443 423 444 0.90

6 25 0.6 49 4.8 0.3 3 23 485 505 484 505 0.96

7 25 0.02 1.7 9.4 3.2 1 23 585 608 585 608 0.95

8 25 0.76 62 4.5 1.3 1 21 617 637 617 638 0.87

9 25 0.35 28 5.6 3.9 1 23 647 670 647 670 0.97

10 25 4.3e-05 0.0035 17.8 0.4 2 23 693 714 692 714 0.97

11 25 1.7e-05 0.0014 19.1 5.5 1 23 722 744 722 744 0.99

12 25 0.0052 0.43 11.3 3.0 1 23 891 913 891 914 0.95

13 25 0.018 1.5 9.6 0.8 2 21 923 942 923 943 0.94

14 25 0.69 57 4.6 5.5 1 23 952 975 952 975 0.94

15 25 9e-06 0.00073 20.0 4.3 2 23 990 1011 989 1011 0.97

16 25 0.00013 0.011 16.3 0.9 1 23 1017 1039 1017 1039 0.98

17 25 0.0024 0.19 12.4 0.4 2 21 1066 1085 1065 1086 0.94

18 25 0.0081 0.66 10.7 4.8 1 23 1132 1155 1132 1155 0.96

19 25 0.052 4.2 8.1 0.7 1 23 1192 1215 1192 1215 0.92

20 25 6.7e-05 0.0055 17.2 1.8 1 23 1251 1274 1251 1274 0.98

21 25 5.3e-06 0.00043 20.7 0.2 2 23 1315 1336 1314 1336 0.95

22 25 0.00074 0.061 14.0 3.0 1 23 1342 1364 1342 1364 0.99

23 25 2.1e-06 0.00017 22.0 2.0 1 23 1370 1392 1370 1392 0.97

24 25 1.8e-07 1.5e-05 25.3 2.4 1 23 1398 1420 1398 1420 0.99

25 25 0.00049 0.04 14.5 0.2 1 22 1426 1447 1426 1450 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	25	0.0011	0.087	13.5	1.1	1	23	214	236	214	236	0.97
2	25	0.00058	0.047	14.3	1.3	1	23	242	264	242	264	0.98
3	25	0.0011	0.089	13.4	0.2	2	23	296	317	295	317	0.95
4	25	0.0038	0.31	11.7	1.9	1	22	391	412	391	414	0.90
5	25	7	5.7e+02	1.4	0.7	2	21	424	443	423	444	0.90
6	25	0.6	49	4.8	0.3	3	23	485	505	484	505	0.96
7	25	0.02	1.7	9.4	3.2	1	23	585	608	585	608	0.95
8	25	0.76	62	4.5	1.3	1	21	617	637	617	638	0.87
9	25	0.35	28	5.6	3.9	1	23	647	670	647	670	0.97
10	25	4.3e-05	0.0035	17.8	0.4	2	23	693	714	692	714	0.97
11	25	1.7e-05	0.0014	19.1	5.5	1	23	722	744	722	744	0.99
12	25	0.0052	0.43	11.3	3.0	1	23	891	913	891	914	0.95
13	25	0.018	1.5	9.6	0.8	2	21	923	942	923	943	0.94
14	25	0.69	57	4.6	5.5	1	23	952	975	952	975	0.94
15	25	9e-06	0.00073	20.0	4.3	2	23	990	1011	989	1011	0.97
16	25	0.00013	0.011	16.3	0.9	1	23	1017	1039	1017	1039	0.98
17	25	0.0024	0.19	12.4	0.4	2	21	1066	1085	1065	1086	0.94
18	25	0.0081	0.66	10.7	4.8	1	23	1132	1155	1132	1155	0.96
19	25	0.052	4.2	8.1	0.7	1	23	1192	1215	1192	1215	0.92
20	25	6.7e-05	0.0055	17.2	1.8	1	23	1251	1274	1251	1274	0.98
21	25	5.3e-06	0.00043	20.7	0.2	2	23	1315	1336	1314	1336	0.95
22	25	0.00074	0.061	14.0	3.0	1	23	1342	1364	1342	1364	0.99
23	25	2.1e-06	0.00017	22.0	2.0	1	23	1370	1392	1370	1392	0.97
24	25	1.8e-07	1.5e-05	25.3	2.4	1	23	1398	1420	1398	1420	0.99
25	25	0.00049	0.04	14.5	0.2	1	22	1426	1447	1426	1450	0.91

Sequence Information

Coding Sequence: ATGTTGCCCTCGGATATTTGCCGAACCTGTGCCACACAGAATAATAATTTATTACCGCTTGCCTCCTGCTCGGAAAAGCTACAGGAATTAACCCAAATTCCGCTATTGGAGCTGATCGGCGATGAAAATTTGCCCCAACATTTGTGTGGCGATTGCTTGGCCAAATTGGAGAATGCCTACGCCTTCGTGGAGCAAGCACGCAAGGTGAACAGGGATCTGCTAATGAAGTTGAGGCAGTGCCTTCTCGAGGAGACACCCATTGACATACCCATACCCAATGCAATGCAACAACAAATCAAAATGGAAATGGACGATGAGGATGGTGACCAGCAAGAGTTAGACGAAGAAGAGACTGCAGCCACAAGATTGGAACTCAAATGGCATGCGGACAGTGATGCCGAAAGTGAAGCAGAGGAGGAGGAAGCCGCTGATGGCAATGAAGATGAATACAAGCCATATCAGCCAAGGCGGAGCCTACGCAAGATTAAGCAGCAATCCGATAGCGAACAGGAATATCAAGAGCGCGATGAGAAAATTAACTTAAATCTTGAGAAAAATGATCCGGAGCCGCCTCCTAAGCGTCGTCGTGGTCGCCCACCTCGTCTGGCCAAAACTCTGGCTCTCAATTCCGACGGTCGTCACGTATGTGCTGAGTGTGGTAAAACGTTCTCCTGGTATAGGGATATGCAGCGTCATGCTCGCAGTCACTTCGAAGAAGCCGCCTTTAACTGTCCGCAATGTGGCAAGGGATTCCTACGCAAGGATAAATACATGTCCCACCTTAAATCCCATGAGAAACGGCAGGCAAAACGGGAAAATGTGGAATTATCTAAAGAATGGATATTCGCCGAGCGTTTATATAATTCGGAGCAACTAAGGCTTATCGAATGCAAATTGTGTGGTGTGCAATTTGAACGATTGAAAGACTTAAGATCGCATTTAGAGCTTCATTCGTCTAAAGAAACCCTTGGTCAACTGCAATTGGATCAAGAAGTAGTGAAAGAACACTTTGCGGATGAAAATATTGATCTAGAAAAGGTCAAGGATCTGATAACTAATGATATAAGTGAGGGGCATTTGGAAAAGTTCTGTGCTGTTGTCAATTCGAATGGATATGAGTTAAGTTTGAGTGATTCCGATGAAGATTTGCCTCCCGATATCGAACCCAAATACCACTGTGTCTTATGTAATGTGCCCTTTAAGCGCAAACATTTGCTCATCCGACACACAGTGGAAGAGCATTCCAAAGGGCATAATCAGCCACAATTACGCTGTAATCTCTGCCAGATCGGTTTCGTCTGTCTAAATTTATATGAACAACATCAACGTTCGCAGTGTTATGGTAAATTTAAGAGATATGGCTGCCGAAAATGTCCTGGAAAGTTTATGTGGTTAGAGAATTTGGATAAACATGAATGTGTCCAAAGCCGGGAGGAGGACAAACAAATTCTATGCTGCCTTTGCGATGCACAGTTGCCCAGTTTAGTTCAGTTGAGAGCCCACTTGCTTAGTCATCGAGATGGCTTGACGGGAATTGATCCTCTATATCAGGCAACATTCTTCCGTTGCTATTATCCAAAAGGTTTGGCCTGTAGCCAGTCCGAACTTAGCTCCCGTATAGTTGGCGACTTCGATGCTCAAGATTATGGTCGGTATTATAATGCTAGCCTTAGTTCTGGACAGGAATTAGATTTCTATGACTCCGATTCGGATGAAAGTGATGCACCTGGAGAATCTCAAGAAAAACCTCTTCACTCATGTACTTTGTGCGGCGAATCAATGAAACGTTTAACAAATCTTATTGAACATCAACAGAATTGTCATCAAGACGAAACCGAATCGTTTTCTTATTCTTGCAAGGATTGTTCAGAAAAGTTCGTGTGCGATGCTCTTTTGCTGCAGCATCGACGTCGCTCATGTGGCAAATTGCATGCCAAATTCCATTGCCAGCTGTGTCAAATGCATTTCGTTTGGCAAACCAACTATGAGCAACATTTGCGTGTAAATCATCCATCCGAGAAGGATTTGGATCAAATTATTAAACGGAAGCCTGTAGCTGCCCCTTCTGCCAGACTGCAGTGCAATGAATGTGATAAGGTGTTTATTTGGCCAAAGGACCTTAATCGCCACAAGCGCATGCATCAGCCCAGGACAGCATCTCAGTATGAATGCACACACTGTGAACGTAAATTTCATCGCAAAGATGGCCTTAAGTCCCACATGCGAGTGCACAGCGAAGAGATGCAACAGCTGGAGAAAATTGATAACGATGAGCACGATGAGAAACCACAAGCAAGCCAGATTTTAAGCGAACTAAGTCGGCCACATGGCTGCAAGCGAATTCAATGCATGATCTGCCATTCGCAGCACTCAAAAATAGCCGATCTGCGATGTCATCTAATGTCTCATCAGTTTGTTATCAGCTTGCCGCCCGAGAGGGAGAAGGATATTGTTGGCGTTTCCAAATCATTATATCCCGAATTGAGTGTGGCCCTGTCCCGAGATAATCTAATATCCCGTATTATGAATGATATTGGTAAGGGTGTGGAACTAGAGAGATTCATATCCGTTACGAATGAATCGGGCTTTGAACTCAGTTTGGATAGCAGCGAAACGGACTCGGACACCGATGAAGAGGATGCGAAAACAGATAGGCAAAAAATTAATCGCTATACTTGCTCCATTTGTCAAGTGGAAGTGAAGAGAAAGCATCAGTTATATGCCCATCAATTGGATCACCATCCTTGTGCAGAGGCCGCCGCAAATGTGTGCTCGCATTGTCAAGCGAGATTTGTGAGTGAGCAACTTCTCGAACATCATCTGAAGTCGCAGTGCCGAAATAACCATAAACGGCATCAATGTCGAAAGTGTACATGGCGCTTCCGTTGGCGGGAGAATCTCAAGCTCCATAACAATGTATGCCATCAAGCAGATGATTCTTTGTTGGGCCCAGACGGTGGAGAATTGCGTTGCAAGGAATGTCATCGAACCTTTAAAATGCAAAAGGATTTAACTCGTCACATGCTAATGCACTCGGATACAAGTATTTATCGTTGTCGTTGGTGTGCCCGTCGTTTCTACCGTCAGGCCAATCTTCTACAGCATATTGAACGACATGGCATCAGTGCCGATCAATTGCCTTATGCCGAATCTCTTCTTAATTCATATAATCATCCGCATGGTCAGAAAATCATTCAATGTAAAGTGTGTAACATAAACTTTAACTCAATCTCTGGGCTGCGGCATCACTTGAAGTCCTCTCCCAATGAGTCGCATCATGAACTTAGTTCAATGCAAAATTACTCGATTACCAATCATTTGGGCTATGAACTGAATTTGGACGACTCGGAGACAGATGACGAGGAAATCAAATCTGGAGGCAGTAATGAAATCTATACTTGCAGCATGTGCCACCTGCGTTGTGCAAGGAAATACGAACTCTATCAACATCAACAGGCCATGCATAGGTTAGAACGTATCCCCGATGGCTGCGATCAGTGCATTTTCAAGAGCGTATCTTCTGACATCATCGAGCATCATAAGCGCAATCAATGCGAGAATCAGGAGAAAACCTTCAAGTGCAGTAAATGTGGCTTTAAATTCATGTGGGAATCGAATATGTTAATCCACATGGATCTGCAACATCAGAAAACCGAAGAGGAAGAACAAGCCCAGGAGCAACAAATTGTGGAGCCAGCAACGGATTCAGTTATTAATTCATCATCAAATTCCAAACAAATGCAACAAATCTTCCAATGTGCTCTTTGCCCCAGGAAATACAATCGCAAAGATCGTCTCACGGCGCATATGAAAAAGTTTCACAATCCAAGTGGACCCAGCACCACATCAGGGGCTGGTCAGTCATCTACTACGTCAAAGAAATCTACTGCGGCAGCATCTTCATCAACTTTGGCTTCTGCCGCCAAGCAACCGAAACTATTTCTCTGTGCCTTCTGTGGCAAGGCAGTGAGTTCCTCGTCCAATCTTATCATTCACATGCGACGACACACTGGAGAAAAACCCTTCAAATGCGATTTCTGTGAAATGGCTTTTCCACGTTCCTCGGATCTGCAGTGTCATCGGCGAACACACACGGGCGAGCGTCCACATGTGTGTACAGTGTGCCAGAAAGGTTTCGCCAGATCCTATAAATTGCAGCAGCATATGCGCATCCACAATGGGGAACGACCCTACAAGTGCACCTATTGCGAGAAGAGTTTCACGCAATCCAACGATTTGACACTACATATACGTCGGCACACCGGCGAGCGGCCCTATCAGTGTGGCATTTGTGGTGAAAGATTCATTCAGGGTACTGCCCTTAAGAATCATCGTCAACAGCAGGGGCATCATGAACCAGGCGCTCCGGGTGGCCTGCCCGGAGAGGCGCCCATAAGGCGCACAGTTCTTCAGCAATTTTCAGGCGAATGA
Protein Sequence: MLPSDICRTCATQNNNLLPLASCSEKLQELTQIPLLELIGDENLPQHLCGDCLAKLENAYAFVEQARKVNRDLLMKLRQCLLEETPIDIPIPNAMQQQIKMEMDDEDGDQQELDEEETAATRLELKWHADSDAESEAEEEEAADGNEDEYKPYQPRRSLRKIKQQSDSEQEYQERDEKINLNLEKNDPEPPPKRRRGRPPRLAKTLALNSDGRHVCAECGKTFSWYRDMQRHARSHFEEAAFNCPQCGKGFLRKDKYMSHLKSHEKRQAKRENVELSKEWIFAERLYNSEQLRLIECKLCGVQFERLKDLRSHLELHSSKETLGQLQLDQEVVKEHFADENIDLEKVKDLITNDISEGHLEKFCAVVNSNGYELSLSDSDEDLPPDIEPKYHCVLCNVPFKRKHLLIRHTVEEHSKGHNQPQLRCNLCQIGFVCLNLYEQHQRSQCYGKFKRYGCRKCPGKFMWLENLDKHECVQSREEDKQILCCLCDAQLPSLVQLRAHLLSHRDGLTGIDPLYQATFFRCYYPKGLACSQSELSSRIVGDFDAQDYGRYYNASLSSGQELDFYDSDSDESDAPGESQEKPLHSCTLCGESMKRLTNLIEHQQNCHQDETESFSYSCKDCSEKFVCDALLLQHRRRSCGKLHAKFHCQLCQMHFVWQTNYEQHLRVNHPSEKDLDQIIKRKPVAAPSARLQCNECDKVFIWPKDLNRHKRMHQPRTASQYECTHCERKFHRKDGLKSHMRVHSEEMQQLEKIDNDEHDEKPQASQILSELSRPHGCKRIQCMICHSQHSKIADLRCHLMSHQFVISLPPEREKDIVGVSKSLYPELSVALSRDNLISRIMNDIGKGVELERFISVTNESGFELSLDSSETDSDTDEEDAKTDRQKINRYTCSICQVEVKRKHQLYAHQLDHHPCAEAAANVCSHCQARFVSEQLLEHHLKSQCRNNHKRHQCRKCTWRFRWRENLKLHNNVCHQADDSLLGPDGGELRCKECHRTFKMQKDLTRHMLMHSDTSIYRCRWCARRFYRQANLLQHIERHGISADQLPYAESLLNSYNHPHGQKIIQCKVCNINFNSISGLRHHLKSSPNESHHELSSMQNYSITNHLGYELNLDDSETDDEEIKSGGSNEIYTCSMCHLRCARKYELYQHQQAMHRLERIPDGCDQCIFKSVSSDIIEHHKRNQCENQEKTFKCSKCGFKFMWESNMLIHMDLQHQKTEEEEQAQEQQIVEPATDSVINSSSNSKQMQQIFQCALCPRKYNRKDRLTAHMKKFHNPSGPSTTSGAGQSSTTSKKSTAAASSSTLASAAKQPKLFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDFCEMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGICGERFIQGTALKNHRQQQGHHEPGAPGGLPGEAPIRRTVLQQFSGE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00612227;
90% Identity: iTF_00612227;
80% Identity: -