Basic Information

Insect: Drosophila varians
Gene Symbol: -
Assembly: GCA_018150405.1
Location: JAECWK010000125.1:16434043-16444933[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 1.5 1.4e+02 3.0 2.3 3 23 283 305 281 305 0.90

2 15 4.3 4e+02 1.6 1.1 3 21 447 465 446 469 0.90

3 15 0.054 5.1 7.6 0.5 2 21 491 510 490 513 0.89

4 15 0.26 25 5.4 1.2 1 23 530 553 530 554 0.94

5 15 0.21 20 5.7 0.3 1 21 558 578 558 582 0.90

6 15 0.0019 0.18 12.1 0.1 2 23 629 651 628 651 0.95

7 15 0.022 2.1 8.7 0.1 1 21 656 676 656 677 0.94

8 15 0.52 49 4.4 3.4 1 23 697 719 697 719 0.93

9 15 0.00014 0.013 15.7 4.2 2 23 732 752 731 752 0.97

10 15 0.00027 0.025 14.8 0.8 1 23 758 781 758 781 0.91

11 15 0.00052 0.049 13.9 0.5 1 23 805 827 805 827 0.97

12 15 2 1.9e+02 2.6 0.7 1 23 835 859 835 859 0.94

13 15 0.28 27 5.3 2.5 1 23 864 889 864 889 0.95

14 15 0.078 7.4 7.0 2.4 1 23 899 921 899 921 0.97

15 15 0.00056 0.053 13.8 3.1 1 20 927 946 927 948 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	1.5	1.4e+02	3.0	2.3	3	23	283	305	281	305	0.90
2	15	4.3	4e+02	1.6	1.1	3	21	447	465	446	469	0.90
3	15	0.054	5.1	7.6	0.5	2	21	491	510	490	513	0.89
4	15	0.26	25	5.4	1.2	1	23	530	553	530	554	0.94
5	15	0.21	20	5.7	0.3	1	21	558	578	558	582	0.90
6	15	0.0019	0.18	12.1	0.1	2	23	629	651	628	651	0.95
7	15	0.022	2.1	8.7	0.1	1	21	656	676	656	677	0.94
8	15	0.52	49	4.4	3.4	1	23	697	719	697	719	0.93
9	15	0.00014	0.013	15.7	4.2	2	23	732	752	731	752	0.97
10	15	0.00027	0.025	14.8	0.8	1	23	758	781	758	781	0.91
11	15	0.00052	0.049	13.9	0.5	1	23	805	827	805	827	0.97
12	15	2	1.9e+02	2.6	0.7	1	23	835	859	835	859	0.94
13	15	0.28	27	5.3	2.5	1	23	864	889	864	889	0.95
14	15	0.078	7.4	7.0	2.4	1	23	899	921	899	921	0.97
15	15	0.00056	0.053	13.8	3.1	1	20	927	946	927	948	0.95

Sequence Information

Coding Sequence: ATGAATCCGGAAGACTTGGACGACACCCACTTGTGCATAAAATGCAATGCCACTATTTTGGGATTGGGAAAGTACATTGAACACCGAAAACAAAACTGTTTGAATTCGGAAAAGAGGACAGTGACTACCACGACGGGTGGACCTGCCACAACATCGACTACCACTCAAGTCTCTCCAAATAGCAGCAATCTGGATCACAGCTACGATGGCTTCCACTTCACCGAACCGGAAGCCCCCAGCAGTTATTTGCGAAAGACCGCAGCCAGTCATGGCGGAAAAACCTCCAAGTCCTTGACCGAAGCCTATGATCTGACCTATGAACTTGGAGCTGATCTGTTCTTTTCATCGTTGCAGCTTCAGAGTGTTTCCACGGGCGGGAAGACAGGGTCAGTGGCACGGCCAGAGAGGCCGAAAGAGGATTCCTGGCCAGCACCAGGCAGAGATCCTTTGCTAAAGGCGGTAAGAGAGCACGATTTTAAGCCCCTCAACTTCCACCACGACTCCCCGGAAGCCAGCGAGGAGGAGGATGACGAGGACGACGCGGATGACTATGAACCGGAGCCAGAACCCGAGGAAGATGAGGAGGAGTACGATGTGAGGCGTCACTCACCGCCAACCGTGCCCGCCACTCACACAGGTGGCAAGTGGAAGCCGGAGCACCGCCCGCAGCTCCGCCATCCGCACATCGAACGCATCTCGCCCAGCTGGGATGAGCCCCCCGAGGAGACGTACACCCATCCCCCGGAGGATCACACAAAGGGAAAGTGGGTGCCCGGCAGCAAGCAGCTGGAGTACCGCGAGAACATTGATCTCACCAAGCTGGAGCAGCCGGGGGCCAGTTACTGGTGCAACATCTGCTGCAGGCGCTTGAAGAGTCGCCAGAACTACGAGCAGCATCTGCAAAGTGGCTACCACGTGAAGAGGGCGGAGGCCGAGTGCCAGCTGGAGCAGGCCACCCTGGGCAGAGAGCTCAGCCTGAGCAAGGAGTTCGCCGTGGAGGTCAAAGACAAGGAAAAGGATCTCCCAAAGCCGCCAAAGAGACCCAGGCGAGCCAACTTCCTGCGCTGCGATCTGTGTCGCCACACAATGGCCCGCCACTTGATGGGCAAGCACTTGATCTCCCACTACCACTACCGCCGCTTGCAGCAGCAACGGAACCAACTGAGGAGGCAGGCATCTCTGCAGGACGTCCTCAGCCACATGGGCAGCATTGTGAGGCAGTCTCCCTTCCAGTGCCTGCCCTGCAAGTTCTATGCTAACACGGAGGAGGCTTTCCTCGACCACTGGCAGTCGAAGGAACACTCAGATCACACCCAGAAGCTGGGTGGCTCCTTTTGGTGCGGCTACTGCCAGTTCGAGTGCGGCACCAACGATGAGATGTGGATGCACCTGCTTCATGCCTCCCACAAGGAGGTGCTCCTGGCCCTCAATCGCTCCGTTCCCATTTGCATTGCCCAGAGAAGACACATCCAGTGCTCCAGTTGCGGACTCAGTTTCCTGTACAACTTCCAGCTGCGCCGGCACTTTGCAGACGAACATCCTGGCCAGGCAGCCACTGGAAGCGCGGCGGATAACTATCAATGTCGCTTTCGGTGCGGCTTGTGTGGCATGCCACAAAAATCTCGCTTGGCCCTGCAGCGCCACGAAAAGCTCAAGCACCACGTGGCCAGGTATTACTGTGCCATTTGTCACCTGGACTTCGGAACGCCGCTGGAGGCACGACGCCATCGGAGTCTGCTGGAACACAAGCTGAAGTCGAGGCCGAAGTTGGCCTTGACCAAAGGGTACCCAGACAAGGAAATTGAAAGCATGCTAATGGTTGTCCTGGATGAGCCTTTGGATCGAAATGCCAATCCCCCGAAGAAAGCTAAAGTAGTCAGGAAGAAGTGCGCCAACTGCGAGGAGATCTTCAGTTCCCCTCAAGAATTGGCCCAGCATCGAGCTAAGGTGCATCCCGCGGACAACCATGTTTGTCTCAGCTGTGGCTTAAGTTTCGGATCCGCTCAAGCCTTGGGCAGGCACACCCGGAGCTGTAAGCCCCTGGCCAGCACATCCTCCTCCGCACCTGGAAATCCCAAGTCCGCCAGCTTCTCTTGTGATCAGTGCTCGTACCGGACCCAGTTCAAGTCTGATCTTATTTACCATCGGTTCTTCCACACTCGCACTGGGAGTATTGGCAAAAATGAGCTCCTGCAATGTCCTTTGTGCCCCAAACACTTCAGGAAGCATTCGCTCCGAGCCCATCTTAGGAATCACACGGACGAGAAGATCTTTGAGTGTCTTGAGTGCCGCCTCAAATTTGCCAGAAGACACAATCTAAAGAATCACGTTGCCGCAGTTCATGGGAAAAAGGAAGATCAGGAGGCGCCCAAAATGGACAAGAAAAAGGGAGTCCCGAAGAACAAGGCCACATTTCAGTGTGGAACCTGTGGAAAAATCCTAGCCAAAAAATACACCCTAAAGCTGCATGAGCTGAGTCACAAGGGGAAGTTGAAGAAGCATTTTAAGTGCCATTTCGAGGGCTGCTCCTATGCTGGATTGACCCAGGAGGGTCTCAAAACCCACCTGGTCTCCCACTCCCAAGGTAGTCACAAGTGTGACCGCGAAAATTGTGTCTATGTTGGAAAAAGTGAACTGCATTTAAAGAGACACCTTAAGTCGGCCCATGCCGCGGAGAATGGTGGCGAGGAGTGGTACTCGTGCGATCAGTGCGAGTTCAGGGCCCGCATCAAGGGCCACCTTCGCCGGCACTCGCTGCGGCACACGGGCCAGAAGCCCCACCAGTGCCCCCACTGCGACTTCCAGTGCAGCACCATAGACAATTTGCGCAAACACATCGTCAAGACTGGCAAGCATCCCGGCAAGTTCATCTACGAGTGCGGGAAGTGTAAGGATCAGGGATCCAAAGAAATATATAAATCCAACAGCCACAAGGACTACCAGAAGCATTTAAGTATACACAAAGTAGACTAA
Protein Sequence: MNPEDLDDTHLCIKCNATILGLGKYIEHRKQNCLNSEKRTVTTTTGGPATTSTTTQVSPNSSNLDHSYDGFHFTEPEAPSSYLRKTAASHGGKTSKSLTEAYDLTYELGADLFFSSLQLQSVSTGGKTGSVARPERPKEDSWPAPGRDPLLKAVREHDFKPLNFHHDSPEASEEEDDEDDADDYEPEPEPEEDEEEYDVRRHSPPTVPATHTGGKWKPEHRPQLRHPHIERISPSWDEPPEETYTHPPEDHTKGKWVPGSKQLEYRENIDLTKLEQPGASYWCNICCRRLKSRQNYEQHLQSGYHVKRAEAECQLEQATLGRELSLSKEFAVEVKDKEKDLPKPPKRPRRANFLRCDLCRHTMARHLMGKHLISHYHYRRLQQQRNQLRRQASLQDVLSHMGSIVRQSPFQCLPCKFYANTEEAFLDHWQSKEHSDHTQKLGGSFWCGYCQFECGTNDEMWMHLLHASHKEVLLALNRSVPICIAQRRHIQCSSCGLSFLYNFQLRRHFADEHPGQAATGSAADNYQCRFRCGLCGMPQKSRLALQRHEKLKHHVARYYCAICHLDFGTPLEARRHRSLLEHKLKSRPKLALTKGYPDKEIESMLMVVLDEPLDRNANPPKKAKVVRKKCANCEEIFSSPQELAQHRAKVHPADNHVCLSCGLSFGSAQALGRHTRSCKPLASTSSSAPGNPKSASFSCDQCSYRTQFKSDLIYHRFFHTRTGSIGKNELLQCPLCPKHFRKHSLRAHLRNHTDEKIFECLECRLKFARRHNLKNHVAAVHGKKEDQEAPKMDKKKGVPKNKATFQCGTCGKILAKKYTLKLHELSHKGKLKKHFKCHFEGCSYAGLTQEGLKTHLVSHSQGSHKCDRENCVYVGKSELHLKRHLKSAHAAENGGEEWYSCDQCEFRARIKGHLRRHSLRHTGQKPHQCPHCDFQCSTIDNLRKHIVKTGKHPGKFIYECGKCKDQGSKEIYKSNSHKDYQKHLSIHKVD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00550565;
90% Identity: -
80% Identity: -