Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 4.6e-07 3.6e-05 24.0 0.4 1 23 67 89 67 89 0.98

2 6 7.4e-06 0.00057 20.2 1.1 1 23 95 118 95 118 0.97

3 6 3.7e-05 0.0028 18.1 3.1 1 23 124 147 124 147 0.98

4 6 3.5e-06 0.00027 21.3 1.4 2 23 154 175 153 175 0.97

5 6 0.0035 0.27 11.8 2.6 1 23 181 203 181 203 0.93

6 6 0.0011 0.088 13.3 1.5 1 21 209 229 209 233 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	4.6e-07	3.6e-05	24.0	0.4	1	23	67	89	67	89	0.98
2	6	7.4e-06	0.00057	20.2	1.1	1	23	95	118	95	118	0.97
3	6	3.7e-05	0.0028	18.1	3.1	1	23	124	147	124	147	0.98
4	6	3.5e-06	0.00027	21.3	1.4	2	23	154	175	153	175	0.97
5	6	0.0035	0.27	11.8	2.6	1	23	181	203	181	203	0.93
6	6	0.0011	0.088	13.3	1.5	1	21	209	229	209	233	0.92

Coding Sequence: ATGCCTAAGAATCCACACGAGCAGGATCACGATTATTACATAGAGGACTTCGATCCAGCTGATTTGGTGGAGGAAGTATATGACTATGAATATGAAATAATACAGGACATTGCGACGGTGGAAACCAAGACAGAGGCAGAAACAGAGCCAAAGGCAACTGTTGCTGCTAAACGCCGACTGGCAAAAAAACCGCCTCCATATATCTGTCAAGAATGTAACAAATCGTTTTCGGTAAATAGCCGCCTGGTCGAACATATGCGCGTCCACACGGGTGAGCGACCTTTTCAATGTCCTCAATGTCCAGCCCGATTCGCCCAACGTTCCAATTGGAGCACGCACATACGTCACACACATAACAAGGAGGCTCCTTATAAGTGTTCCGAATGCAATCGTTGTTATGTCCGACGTCGCCTGCTCGATCAGCATGTGAAGACAGTTCATAGGCATTTGCGTGATCTGCGTTGCCAAGTGTGTGAGGCCACCTTTAGTCATCCTGTTAACTACAAGAAGCACATGCTCACGCATACCGGAGAGAAGGCCTATTCCTGTGAAGTTTGTAACAAGCAGTTTTGTCGTGCGGAGAATCGGGATATACATCGTTTCCTTCATAGCAACAGCAAGCCCTATGTCTGCACTGTATGCCATGCGGGATACATGAGGAAGCAGCACCTGATGCAACACATCCAGGCCACACAGCACGAGAATGACACAATCGTGAGACAAAAGCCATTCTGTTCTGTCATGAAGCAACACAAAAATGAGATGGTTGAAATGATAGAAGAAGAAGAAGTGGATGACGTCGAGTATATTTCAGACTTGGAGCAGCAGCAAAACGAGAAAATTGAAATGGCAGATGAAGAAGAGGAGGACGTCGAGTACATTATAGAATTTGAGCCGGAGAAAGACGAGGAAACTGAAATGACAGAAAAAGACGAAAACGTCGAGTACATTCTACACTTGGAGAATCAGCAGAAAAACGTGAAAACTGAAATGGCAGGAATAGAAGAAAACGTCGAGTATATTTCAAACTTTGACTAA
Protein Sequence: MPKNPHEQDHDYYIEDFDPADLVEEVYDYEYEIIQDIATVETKTEAETEPKATVAAKRRLAKKPPPYICQECNKSFSVNSRLVEHMRVHTGERPFQCPQCPARFAQRSNWSTHIRHTHNKEAPYKCSECNRCYVRRRLLDQHVKTVHRHLRDLRCQVCEATFSHPVNYKKHMLTHTGEKAYSCEVCNKQFCRAENRDIHRFLHSNSKPYVCTVCHAGYMRKQHLMQHIQATQHENDTIVRQKPFCSVMKQHKNEMVEMIEEEEVDDVEYISDLEQQQNEKIEMADEEEEDVEYIIEFEPEKDEETEMTEKDENVEYILHLENQQKNVKTEMAGIEENVEYISNFD

Sequence clustering based on sequence similarity using MMseqs2