Dtro008611.1
Basic Information
- Insect
- Drosophila tropicalis
- Gene Symbol
- topi
- Assembly
- GCA_018151085.1
- Location
- JAECWH010000848.1:12147120-12149713[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 3.2e-05 0.0025 18.2 1.1 2 23 248 269 248 269 0.97 2 9 0.05 3.9 8.2 0.2 2 23 296 317 295 317 0.95 3 9 0.093 7.2 7.3 0.0 2 23 377 398 376 398 0.95 4 9 0.00084 0.065 13.8 1.3 1 22 445 466 445 469 0.91 5 9 4.7e-07 3.6e-05 24.0 1.9 1 23 527 549 527 549 0.95 6 9 0.00048 0.037 14.5 1.1 1 23 555 580 555 580 0.96 7 9 0.41 31 5.3 1.7 1 23 586 608 586 608 0.88 8 9 3.5e-08 2.7e-06 27.5 0.4 1 23 614 636 614 636 0.99 9 9 0.0016 0.12 12.9 2.0 1 23 642 665 642 665 0.96
Sequence Information
- Coding Sequence
- ATGAGTGACTTAGATTTGTGGAACTTACAGACGGATAATGCTTCCGGTGAATATACAGTGGCTGAAATCGAGGTGGAAGATGGGGAGGACTTCATTGCTGAGGGACTGCAGCTGGGTGCTACTGTACTGGCCTCCAACGAGGGTGATGGCACCGTGGGACAGGTTTTTGGCAACGATGAATTATCCAAATTATTTGCATCAGCGCCAAAGGCCAATGTTGAAATACCAACAGAGGTGGTGGTGCAGCGTACTCTGGCGGACCCGGCTCTCAAGCAGATTTTACAGGAGGCTGATGGCACAGCTGGATTTGATCCGGAGGCTGAACAGTTGAAAATTCGAGATTTTTTGGCTGGCGTTAACAAAGGCAAGATGACCATGGAAGAGAGCGTTTTTCAGGCCCCTCGTGCCGGAACATCATCTAGTGCAACAACAAGTCGCACTATCAAATGCAGCAAGTGCAATTTGGTTTGTGATGTACATTCCATTAGTAAGCATACAAGTGAATGCGAAGGCGATGGCAATACTAAGGAGACTGTTGCTGGAAAACAGGACAAGGAAGCCACCTTGGTGTCCAAAGTGGAGCCGTCGGAATCGGCACCGCCTTTAAGTAAATCGGCCAGTGAACGCGTCTTACAGGAGAATCAGATACGATTGCGTCGCTACATCAAGGATGAGCTGAAATGCGATCTGACTACTGGAGCAGTGAACTCGCGCACGAAAAAAGCAACAAAAGGACCCAACGAGTGCACCATGTGCGAGCGTAAGTTTGTCCACGCATCTGGCCTGGTACGTCACATGGAGAAGCACGCTCTCGATCTGATTCCCAATAACAACATTCAACCACATGTGGTTACACCACCAGCTCCTGGATTGCATGTGGTTCTCAAGTGTAATTCCTGTGGACGAATCTTTTTTAATGTCAAGTCTGCCACAGATCATGTCCTGATTCACTTTCCACCGCAGCCGCAGTTAAGTGAACCCAAAGCCACAATTAAAGATAGCTTTGACATGGGTCAGTTCTTGTTAGAAGGGGATCAACTACTCGCCACGTTGTCTCAAGACATTTGTAACGTTAAGTCGCCTTTAGATTCGAAAATGTTCGAGACTCTGATTGTGGGCAGCGTGTTGCAGTGTGAATTCTGCGAATACATATTTGCAGGCATTTCGGAACTGCTCCTGCATTCAGCCACCCATTACCCTGAAAGGCGGTTTGAGTGCACGGCATGCGACTTGACCATGAACACGGCCAAGGAGGCTAGTGTACACTTTCAGACCGACTGTGTTTTCATGCGTGAAGGACTTAAGCAGCTAAATGTCACATTGAAACGTTATTTCGTGTGCAATGTATGCGAACTTAAGTTCTCTAGTGCAGAACTACTGCAGGAGCATCGATGCAGCTCCTATCATTACTTTCCTCGCCTCAGCGAACATAGCCAACGTCTGCTTTTGCCATGTGAGTTCTGTGAGGTTAATTTCGAATCCGCCCATGAGATATTTCCGCACAATGAGGAGAAACATTTGAACAAGAAAAAACGAGAAAAGGAGGCCCGCAACACTGGACCCGGTCGAGTACGTCAATATTTGTGTGATATATGCGGCAAGTCATACACCCAGTCCAGTCATCTCTGGCAGCACTTGCGTTTCCATCAGGGCGTTAAGCCCTTTGTTTGCCAGGAGGAGAACTGTGGCAGGAAATTTACCATTCGTCCGGATCTTAATGATCACATTCGCAAGTGCCACACTGGAGAGCGGCCATATCATTGTTTGGTATGTGGCAAGCGTTTCCTAACGGGATCCGTGTTCTATCAGCATCGTCTGATCCATCGTGGGGAGCGTCGGTATGAGTGCGATGAGTGCGGCAAGCGATTCTATCGTGCGGATGCCTTGAAGAACCATCAACGTATTCATACGGGTGAGAAACCATATAGTTGTCTATTCTGCACCAAGACCTTCCGCCAGCGCGGCGATCGCGATAAACATATTCGTGCACGTCACTCTCATTTGGATGCCAATTCACGACTCATGATGCAAATGCAGAAATTTCAACTGGAGGCCAAGGCCAAGAAAAATGGAAATAAAAAGAGTAATGAACCTGGGCCAACTGAGGACAACGGTGTTCTTGATGCCAAAGATATTACAGCAAAGCCAGAGCAGCAGGATGTGGAGACTTCTGGGACTGTCATAGAGGAGCATCTTGAGACTCCAAATGAAGAGACCATCAACGTTTTAATGGATGATAATGAAGTCGTCGTGGCTGAAGATGTTGTCTATCAGGAGTCGATACAGGAGGATATAACCAATACCAATGACGACATTATCATGAGCATTTTTGATCCTATTCCAGAGCCAAGTCAATCTTCGATTTTGGAAAGCATTCCCTTGCTGCACAGTCACGATAATGCCAAAGTAGTGGTAGTCAGAAATAATCCCTCACTGCCGATGTTTTCCGATGCTTATATGTAA
- Protein Sequence
- MSDLDLWNLQTDNASGEYTVAEIEVEDGEDFIAEGLQLGATVLASNEGDGTVGQVFGNDELSKLFASAPKANVEIPTEVVVQRTLADPALKQILQEADGTAGFDPEAEQLKIRDFLAGVNKGKMTMEESVFQAPRAGTSSSATTSRTIKCSKCNLVCDVHSISKHTSECEGDGNTKETVAGKQDKEATLVSKVEPSESAPPLSKSASERVLQENQIRLRRYIKDELKCDLTTGAVNSRTKKATKGPNECTMCERKFVHASGLVRHMEKHALDLIPNNNIQPHVVTPPAPGLHVVLKCNSCGRIFFNVKSATDHVLIHFPPQPQLSEPKATIKDSFDMGQFLLEGDQLLATLSQDICNVKSPLDSKMFETLIVGSVLQCEFCEYIFAGISELLLHSATHYPERRFECTACDLTMNTAKEASVHFQTDCVFMREGLKQLNVTLKRYFVCNVCELKFSSAELLQEHRCSSYHYFPRLSEHSQRLLLPCEFCEVNFESAHEIFPHNEEKHLNKKKREKEARNTGPGRVRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLEAKAKKNGNKKSNEPGPTEDNGVLDAKDITAKPEQQDVETSGTVIEEHLETPNEETINVLMDDNEVVVAEDVVYQESIQEDITNTNDDIIMSIFDPIPEPSQSSILESIPLLHSHDNAKVVVVRNNPSLPMFSDAYM
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00618653;
- 90% Identity
- -
- 80% Identity
- -