Basic Information

Gene Symbol
-
Assembly
GCA_014170255.2
Location
CM024334.1:3748751-3752045[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0067 0.52 10.9 0.3 2 23 40 61 39 61 0.96
2 13 0.012 0.92 10.1 2.5 1 23 67 90 67 90 0.93
3 13 0.0091 0.7 10.4 1.4 1 19 104 122 104 125 0.93
4 13 2.2 1.7e+02 2.9 2.4 2 22 141 161 140 161 0.93
5 13 0.3 23 5.7 2.0 2 23 413 435 412 435 0.94
6 13 0.025 1.9 9.1 0.6 1 23 460 482 460 482 0.97
7 13 0.0049 0.38 11.3 1.6 1 23 490 514 490 514 0.95
8 13 0.11 8.3 7.1 2.4 2 23 519 541 518 541 0.95
9 13 0.00027 0.021 15.2 0.2 2 21 554 573 553 574 0.93
10 13 0.0071 0.55 10.8 0.4 3 23 584 604 582 604 0.97
11 13 8.3e-07 6.4e-05 23.2 2.8 1 23 610 633 610 633 0.98
12 13 3.3e-05 0.0025 18.1 1.4 1 23 639 661 639 661 0.98
13 13 0.00031 0.024 15.1 2.9 1 23 667 689 667 689 0.95

Sequence Information

Coding Sequence
ATGGGTAGGTGTATGTACCTCAGATTCGATGGCCCCAGCAGCAGCAGCAGTGCGGCGGCGGCTGCTGCAGCCACCAAGTTGCTGGTGGAGATCACCACCGACGGAATACCCAAGCTCCACTGCCCGGTGTGCAACAAGGCGCTGGTCTCATTGGCCGGCTACGTGAAGCATGTCAAGAAGCACCAGCCGCCGGGCGGCTTCGAGTGCCGCAGCTGCGACGCTCGATTCTGCCACGAGGAGGAGTTGACTCAACACGCCAAGGATGAACATGGAGCCACCGGCGCAGCTGCTGGCCAAGAACGCAAGCCCTTCGTTTGCGAGAAGTGCGGGGCGGAGTACAAGTACCAGGAGGCATATCGACGCCACTGCAGGACCAAGTGTGGCGAGGAGAAGCCGCCGAAGGAGGAGACCCGACCCGTGGAGTGTAGTTCCTGCTACACCCGCTTCTCCTGCTTCGCCAGTCTGACCAAGCACCGGCGCAGTCGTCCCGAGACCTGCGGCCAGCCTGAGTACGATGTGCCTGGCGAGTCGGAGGTAAAGGGGAAGCGGAAAGCATACCGCAAGAAGGGCAGGAAGAGGGACTCCGATGATGAGACAACCTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCCTGGCCAGCCGGCTGAAGACGAAGCTCAAGCAGGAGAGCCAGTTCTCGGACTCGGGCGACGAGTGTCCCGACTTCGAGCCGAACAACAGTGAAGACGAGGCGGATTCCTCCGGATTTAAGCTGCCACCGCCGGCCATGGTCAAGGTGGAGGCCTTTGACGAGGAGGACTTTGAGTACCAGGACGCCAGCATGTATGTGAAGACGGAGAGCACGGATATCTTCAGCAACGAGAAGGATAAGCTACTGGATGTGCTGCTCAACGAGGGCGATGGCCTCAAACCCTTCGAGAGCTTGAAGGTGGAGCAGGGCGCCGGGATACTAGATGAGATTGCGGCCGTGCCGCTGGTGGAGGTGGCCGAGGAGGATGTCCTATCCCTAAGGGGTCCACGCAAGGAGGAGATTGTAAAGCGAAAGCGGGGCAGGCCGCCTAAGGAGAAGATACCAGTAATTAAGCGAAAGTATCGCAAACGAAACGCACCACGGTCGCCCTCGCCTGAGGATTCATCCGGAACCCCGAAGCGCGTGGCCAAGATCAGCAAGAAGGAGCTGAAGGAGCGCCTCAAGATGATCAACAAGATGGAAAAGTCCTGGAAGTGTCCGCATTGCGTGAAGATCTACCACATTCGCAAGCCCTACGAGAAGCATTTGCGTGACGACCACAAACTCAACGAGCAGGAGATGAAGGAAATATTCAAGGACGTGGACGTCCACGCCAAGCTAGACGAAGAGGTATTCAAGTGCAACATCTGCAGCAAGATCTATCTGGTCGAGAAGCGCCTGGTCACCCACATGAAGGTGCACGGCGAGGACGGCAAACTGACCTTCAAGTGTCCGTGCTACTGCAACCTGTTCTTCGCCACCAAGGAACAGGCCACGGAGCATGCCCGGGCCCAGCACAAGGAGCTGCTCTACTGCGAGAAGTGCGACAAGTACATGACCGGCCACGACAGCCTCAAGAACCACGAGCGCAATTTCCACTCGAAGAAGGAGCCGCGCAGCCAGCAGCGCAACCTCATCTGCGACAAGTGCGGCAAGAAGTTCACCGGACGCACCTCACTCTCCGACCATGTGCGCTCTGACTGCGGCCGCCTTCCACTCTACGGCTGCACCGTTTGCGGCAAACATTTGTCCACAGCTGGAATTCTCAAGACGCACATGCTCCTGCACAAAGCAGACACTCCCTACCAGTGCGACAAGTGCGGCAAGACGTTCAAGGTGAAGGCCCAGTACAAGTCGCATCTAAAGACGCGGCACACCGACTACAAGCCGTACAAGTGTCACCTCTGTCCCAAGGAGTATCCGTACAGGGAGAGCTTGCTTACCCACATGACCGTGCACACGGGCATCAAGCGTTTCTTGTGCAACAATTGCGGCAAGCGCTTCACCTGCATCTCCAACCTGCAGGCCCATCGCAAGGTGCATGCCGACACCTGCGGCCAGTTGCCGTTGAATGCCAAGGCCACCCAGTACATGGGCGTGCAGCGCGGCAAGCTGTTGATGGGCGCCAAGCCCGAGGCGGGCATGGAGTATGAGGAGACCAAGACACTGATCGCACAGGACGTTATCGACCGGGACATGCCCATGGCCCAGGAGCTGAACTTCCCATCCGACGGCTCGGCACCGCTGGCCACCGTGCCGTTGAACTACGCCTCCTCGCACCTGGTGCCCCACATCGTGCTCCAGACCATGCAGGCCGAGGCCCGGCGATTGGAGTAA
Protein Sequence
MGRCMYLRFDGPSSSSSAAAAAAATKLLVEITTDGIPKLHCPVCNKALVSLAGYVKHVKKHQPPGGFECRSCDARFCHEEELTQHAKDEHGATGAAAGQERKPFVCEKCGAEYKYQEAYRRHCRTKCGEEKPPKEETRPVECSSCYTRFSCFASLTKHRRSRPETCGQPEYDVPGESEVKGKRKAYRKKGRKRDSDDETTSXXXXXXXXXXXXXXLASRLKTKLKQESQFSDSGDECPDFEPNNSEDEADSSGFKLPPPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEKDKLLDVLLNEGDGLKPFESLKVEQGAGILDEIAAVPLVEVAEEDVLSLRGPRKEEIVKRKRGRPPKEKIPVIKRKYRKRNAPRSPSPEDSSGTPKRVAKISKKELKERLKMINKMEKSWKCPHCVKIYHIRKPYEKHLRDDHKLNEQEMKEIFKDVDVHAKLDEEVFKCNICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLYCEKCDKYMTGHDSLKNHERNFHSKKEPRSQQRNLICDKCGKKFTGRTSLSDHVRSDCGRLPLYGCTVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQYKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVHADTCGQLPLNAKATQYMGVQRGKLLMGAKPEAGMEYEETKTLIAQDVIDRDMPMAQELNFPSDGSAPLATVPLNYASSHLVPHIVLQTMQAEARRLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00615081;
90% Identity
iTF_00606536;
80% Identity
-