Basic Information

Gene Symbol
-
Assembly
GCA_014170255.2
Location
CM024333.1:10817185-10819241[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.41 32 5.2 0.2 3 23 283 304 282 304 0.90
2 10 1.9e-05 0.0014 18.9 0.3 6 23 313 330 313 330 0.99
3 10 1.4e-05 0.0011 19.3 0.3 1 23 336 359 336 359 0.98
4 10 0.0003 0.023 15.1 0.4 1 23 371 393 371 393 0.97
5 10 0.013 1 9.9 5.5 1 23 400 423 400 423 0.97
6 10 1.1e-05 0.00085 19.6 1.8 1 23 429 451 429 451 0.96
7 10 0.055 4.2 8.0 0.5 2 23 460 481 459 481 0.97
8 10 8.6e-05 0.0066 16.8 1.0 2 23 487 509 486 509 0.95
9 10 9.5e-07 7.3e-05 23.0 0.7 2 23 516 537 515 537 0.96
10 10 0.00017 0.013 15.9 4.4 1 23 543 566 543 566 0.96

Sequence Information

Coding Sequence
ATGATCTGTCGCCTGTGCCTGCGCTGCCTCAGCCCCGGCAGCGCCGTCTTCCTGTTCGAGACGGACGAGACGCTGGCGGAGACGCGGCTGGTCAAGATGATAGCCAAGTTTCTGCAGCTGGAGATCCTGCCCGACGACAGCATCTCGACCAGCGTGTGCACCGACTGCTGCGAGCACTTGGAGGACTTCAATGGCTTCTGGCAGCTGGTAGAGCAGAAGCAGTGCTCCCTGAAGAAGGAATTCCTCAATGTGGACGTCGACTGCGTGGCCATGAAGTGGACAGGCGGCGTGGACGTGGACGTGAACATTGACGAGCTGCCGCTGGCGGCAACGGACATGGACGAGAAGCCACTGGACATGCACAACCTGAGCCTGCTGGGCAGCGTGCTGGATGTGAATGTGGACAGTGTGGAGGTGGCTTCCCAGGCGCCGGTCTCGGTGTCCGTCAAGGAGCAGCTGCAAGATGACTCCGAGGAGGACGAGAAGCCCTACCTGGAGGCCCTGCCCGCGAGTGATAGCGAGCCGGACGCGCCCGAGGCCCTGCCAGTAGAAGACTCCTCGGACGATGAGCCGTTGGTCCGACTCCAGACCAAGCCTAAGCCGCCGCCCAAGCGCAAGCGCACGAACAAGGATCGTGAGAGCGGGATTTCGCTGGACCAGGAGCTCAAGGAGCTGCTCGACGACGGCAGCAAGCGGCGGCGCAGAAAGGCGCCCAGCGAGGGAGTAGCCACCGAGGTGCAGGAGACCGAGCTGCAGGCCGTCCTCGAACGCAAGCCCAAGGGCTGCTCGCGCGCCCAGCTGGCCAAGCGGTACGAGGAGGCCATTGCCAGCTACATGAGCGCCAGCTGTGACCTGTGCGACTTCAGTGCTCAATACCTGTCCGAGCTGAAGACCCACTTCCTGGAGGTGCACCAGCGCGAGTATTACATCAAGTGTTGCGGCAAGGTCTTCACGCGCGCCTCCAAACTAATGGATCACATCCGCAAGCACGTCAACCCCAAGCTCTTCACCTGCTCCATCTGCCAGAAGTCGCTCAATTCGCAGGACTACCTGGCCACCCACATCGAGACCGTGCACAACAAGGTCGCCCAGATCGGCAAGGTGCTCAAGTTTCCCTGCCCAAAGTGCGAGCGCACCTTCAGCAGCGAGCGCCGGATGGCCAACCACTTGGCCAAGCACGACACGGACCAGCTGGAGCACACCTGCGAGATCTGCTGCAAGAGCTTCGCCAACGTCCACCGGCTGCGACGACACATCCAATCCATCCACGAGGACCTGCACCGCCACGTCTGCGACATCTGCGGCAAGAAGTTCAAATTCAAGCCCTCCTTCGAGCGGCACCTGCTGGAGCACCAGGGCGTCGTGGCGCCTGCGGTGCAGTGTCCGGTGTGCGGGGTGTGGCTGAAGAACGAGCATAGCCTGCGACTGCATCGCTTCACGCACGACAGCACGGACACGGTGTGTCCGCAGTGCGGCAAGACCTGCACCTCACGCACCGCCCTGCGCGGCCACGTCAAGTACGCCCACAAGCTGACCACCAACCTGCAGTGCACATACTGCGAGAAGAGTTTCAAGCAGCAGCGCAACCTGGACGAGCACATGGCCATCCACACGGGCCTGCTGCTGTACAACTGCCCGCACTGCCCCAAGGAATGCCGATCCCGCTCCAACATGTACGTCCACATCAAGCAGCGCCACGCGGACGAGTGGCTGCGCGCGAAGATGGCGCGCTCGCACAATCCCCAGTTCAAGCCGGGATCTAGCGAGGGTCAGACCTGA
Protein Sequence
MICRLCLRCLSPGSAVFLFETDETLAETRLVKMIAKFLQLEILPDDSISTSVCTDCCEHLEDFNGFWQLVEQKQCSLKKEFLNVDVDCVAMKWTGGVDVDVNIDELPLAATDMDEKPLDMHNLSLLGSVLDVNVDSVEVASQAPVSVSVKEQLQDDSEEDEKPYLEALPASDSEPDAPEALPVEDSSDDEPLVRLQTKPKPPPKRKRTNKDRESGISLDQELKELLDDGSKRRRRKAPSEGVATEVQETELQAVLERKPKGCSRAQLAKRYEEAIASYMSASCDLCDFSAQYLSELKTHFLEVHQREYYIKCCGKVFTRASKLMDHIRKHVNPKLFTCSICQKSLNSQDYLATHIETVHNKVAQIGKVLKFPCPKCERTFSSERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHIQSIHEDLHRHVCDICGKKFKFKPSFERHLLEHQGVVAPAVQCPVCGVWLKNEHSLRLHRFTHDSTDTVCPQCGKTCTSRTALRGHVKYAHKLTTNLQCTYCEKSFKQQRNLDEHMAIHTGLLLYNCPHCPKECRSRSNMYVHIKQRHADEWLRAKMARSHNPQFKPGSSEGQT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00492388;
90% Identity
iTF_00617789;
80% Identity
-