Dtri002387.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila triauraria
Gene Symbol
lz
Assembly
GCA_014170255.2
Location
CM024333.1:19568764-19593601[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.9e-70 2.6e-66 221.0 0.0 8 129 253 374 247 374 0.98

Sequence Information

Coding Sequence
ATGCATTTGCCGCTCCTGGTGGCAGCCAGACAGGACAGACAGACGCCTCCAGCGGACCACAGCCATACGGGCGGAGGCGAGGGCGGAGGAACCCTAGCGGAATCCGCAGCAACCGGAGCCACTGTGGCGCCCGTCAGCATCGCCGCCGGTCCCGGCCGCCTCGCTCGCAGCTTGAACGGCTTGGGCGGCACCAGCGTCGGCGGCGTCGGCGGCGGAGGCGTAGGCGGAGGAGTCGGAGTCGGCGTCGGTGGCCACCACCACCATCACCTGCACCATCACTACGCCCCCTACGCCCCCTCGCCGTACCATCCCGTGCAGCCGTACAGCGGCGCCTATCCGCCGGCTGCCTCGCATCCGCCGGCAATGGTCACCTCGTCGTCCGCCTCGCCAACGGGCAACGGCTGGAGCAGCACCACCGGCGACTTCAAGGGCACCGTTGCGGTCACAGCCGTGGGAGCGGGCGCAGCGGCCGGTGGAGCCACCACGGCCACAGCCGGCGCCGGAGGCACTGCCCCCGAGATCCTGGCCGTGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCGGGCGAACTAGTGCGCACGAGCAATCCTTACTTCCTGTGCTCCGCCCTGCCCTCCCATTGGCGCTCCAATAAGACGCTGCCGCTGGCCTTCAAGGTCGTCGCCCTGGCGGAGGTGGGCGATGGCACCTATGTCACCATCCGGGCTGGGAACGATGAGAACTGCTGTGCCGAGCTGAGGAACTGCACGGCCCAGATGAAGAACGATGTGGCCAAGTTCAATGATCTGCGATTTGTGGGACGCAGTGGAAGAGGGAAGAGCTTTACGCTGACCATAACGGTGGCAACGAGTCCGCCACAGGTGGCAACCTATGCCAAAGCCATCAAGGTGACCGTCGATGGACCAAGGGAACCCCGGTCCAAGACAAGTCCCACTGGCGGTCCCCACTACCGCGCCTTGGGCCTTGGCCAGCGGCCCTACATCGATGGCTTTCCGAAGGCGCTCCACGAGCTGGAGACGCTGCGTCGCTCTAAAGTGGCGGCTGCCACAACGGCCGCCGCGGCTGCGGCAACGTCGGCCACAGCGGCTACTGCTGTTGCGGCTGCCGCAGCAGCGGTGGCGGTCACACCCACGGGCGGAGGTGGAGGAGGAGTCGGATCCGGAGCTGGTCTGGTGCAGCAATTGAGCAGCAATTACTCATCGCCGAATAGTACAATTAACTCGGACTGCCAGGTCTACAAGCCGAATGCGCCGCACATTCAAGAAACCGATCTAATGGGCGCCGGCGAGTGGACGGGATCCTCGAGTTCGGCGGCGGCCTACTACCACAGCCACGCCCACCACCATCCACACGCCCACCATCCGCACCATGCCCACGCCCACGCCCACCTGCAGCATCAGATGGCCTTGCCGCCGCCGCCCCCGCCGCCAGCGGCCGCTCCCGTTTCGGTGGGCGGCAATGGAGCCACCATGGGCGTGGGCGTGGGCGTGGGCATGGCGATGAATCACTACGGCGGCGGCTACGACTCGGCCAACTCCCTGGAGGCCGGCAACTATGCCGCTCACCTGCCCGCCGTGCTGCCCGAGATGCATGGCCATGGCTTCGCCACCGATCCCTACCAGACGGCGGGCTATGGCACTGGCAGCGTGGGCGTGGCCGGGGGAGGCAGTGCCTCCAAGTCGGAGCTGGACTATGGCGGAGGCTACAACCAGGCGTGGTCGAACGGATACCAGAACTACCAGTACGGCAGCTGCTCGGCCACGGCGCAGTATGGTCCTCAGGCGGCGGTGGCGCCTCCTCCGCCGCCGCCACCGCCGCCCGTGGTGCTGTACCCGCAGCTCTACTCCACGGTCAACCAGAACCAGATCCACCTCCATCTGCACAGCAGCGAGAAGCTGGAGCAGTACCTGGGCTCGGCCACCGGAGGCGAGCAGCTGACCATCAGCTCGCTGACCGGCAGCAGCCGGTCCAGCATCGAGATTGGCGGGAATCAGGGGGATCAGTACCAGCAGCAGCAGCAGCAGCACCTAACCCATCCCCACTCCCACAGCCATGGCCAGCATGGCCAGGTGGTGGAGTCCTCCAACGATGTCGGTGGCGTTGTGGTGGAGGCCTCGCGGCAGGAGGAGGACGTGGGCGATCTCACGCAGGTGTGGCGACCCTATTGA
Protein Sequence
MHLPLLVAARQDRQTPPADHSHTGGGEGGGTLAESAATGATVAPVSIAAGPGRLARSLNGLGGTSVGGVGGGGVGGGVGVGVGGHHHHHLHHHYAPYAPSPYHPVQPYSGAYPPAASHPPAMVTSSSASPTGNGWSSTTGDFKGTVAVTAVGAGAAAGGATTATAGAGGTAPEILAVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALAEVGDGTYVTIRAGNDENCCAELRNCTAQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPTGGPHYRALGLGQRPYIDGFPKALHELETLRRSKVAAATTAAAAAATSATAATAVAAAAAAVAVTPTGGGGGGVGSGAGLVQQLSSNYSSPNSTINSDCQVYKPNAPHIQETDLMGAGEWTGSSSSAAAYYHSHAHHHPHAHHPHHAHAHAHLQHQMALPPPPPPPAAAPVSVGGNGATMGVGVGVGMAMNHYGGGYDSANSLEAGNYAAHLPAVLPEMHGHGFATDPYQTAGYGTGSVGVAGGGSASKSELDYGGGYNQAWSNGYQNYQYGSCSATAQYGPQAAVAPPPPPPPPPVVLYPQLYSTVNQNQIHLHLHSSEKLEQYLGSATGGEQLTISSLTGSSRSSIEIGGNQGDQYQQQQQQHLTHPHSHSHGQHGQVVESSNDVGGVVVEASRQEEDVGDLTQVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00482760; iTF_00489861; iTF_00477798; iTF_00525670; iTF_00540870; iTF_00524199; iTF_00488493; iTF_00484910; iTF_00612591; iTF_00606097; iTF_00489156; iTF_00590030; iTF_00527087; iTF_00594325; iTF_00561526; iTF_00491291; iTF_00593629;
90% Identity
-
80% Identity
-