Basic Information

Insect: Drosophila tanythrix
Gene Symbol: topi
Assembly: GCA_035043275.1
Location: JAWNNC010000522.1:16167698-16170368[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 2e-05 0.0014 19.1 2.3 1 23 223 245 223 245 0.97

2 10 0.36 25 5.7 0.1 2 10 271 279 270 288 0.92

3 10 0.0013 0.093 13.4 0.1 2 23 349 370 348 370 0.96

4 10 2.1 1.5e+02 3.3 0.0 1 22 376 397 376 397 0.92

5 10 0.0049 0.34 11.6 0.9 1 21 417 437 417 441 0.90

6 10 5.1e-07 3.6e-05 24.1 1.9 1 23 505 527 505 527 0.95

7 10 4.2e-05 0.003 18.1 0.4 1 23 533 558 533 558 0.97

8 10 0.44 31 5.4 1.7 1 23 564 586 564 586 0.88

9 10 3.8e-08 2.6e-06 27.7 0.4 1 23 592 614 592 614 0.99

10 10 0.0035 0.25 12.0 1.9 1 23 620 643 620 643 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	2e-05	0.0014	19.1	2.3	1	23	223	245	223	245	0.97
2	10	0.36	25	5.7	0.1	2	10	271	279	270	288	0.92
3	10	0.0013	0.093	13.4	0.1	2	23	349	370	348	370	0.96
4	10	2.1	1.5e+02	3.3	0.0	1	22	376	397	376	397	0.92
5	10	0.0049	0.34	11.6	0.9	1	21	417	437	417	441	0.90
6	10	5.1e-07	3.6e-05	24.1	1.9	1	23	505	527	505	527	0.95
7	10	4.2e-05	0.003	18.1	0.4	1	23	533	558	533	558	0.97
8	10	0.44	31	5.4	1.7	1	23	564	586	564	586	0.88
9	10	3.8e-08	2.6e-06	27.7	0.4	1	23	592	614	592	614	0.99
10	10	0.0035	0.25	12.0	1.9	1	23	620	643	620	643	0.95

Sequence Information

Coding Sequence: ATGGATCCAGAATCCGAGTTTTACGATGGTGATGAATTCATGATAACCGAACTCGAGTTCGGTGATGATTTGATGGTGGACAGCAATGGATTGCAGCCAGGATCCACTCTACTGGTGTCCAATGAAATCGATGATTTTCTCGTTGATGAGGATTTGGGTCAGTTCTTTGAGATGCATGGCGGCATTCAGATACCCAACGAGGAGGTAGTGGAACGTACGTTGACAGATCCGGCGATAATGGGAATCATTGATGAAGCCAACGGACAGATGGATTTTGATCCGGAAGCAGAGGAACTCAAATTACGGGAGTTCTTATCGGGCGTTAACAATAGCATCGAGGTGAACGCGTTGCCCGGTATGGTTATCCAAGAGAATAAAAGTACTGCCATCCGTTTCATCCTGTGCTCCAATTGCAAAGGAATCTTCGATACGCCGGCATTCCAAAATCACAGCTGTGAATACGATGCGAACCAGAAAAAAATCGTAGCTCAGCAATTACCACTACAGCCGGAGAAGGAATCTTTGCCACCCAGGATAACGACCAGCGAGCGCATCATCGTTGAGAACCAGGTGCGCATGCGTCGCTATATGAAGGATGAGCTCAAGTATGATATGGAGGCTGGTTACGACAGTTCCAAGGTCAAGGAGTCGACTGTCAAGGGCACCCACGAGTGCAATATCTGTGAGCGCAAGTTTGTCCACTCCTCCGGCTTGGCGCGTCACTTGGAGAAGCATACTCTGGACCTAATCCCCGGACTGGCAACGCTGCAACAGAATCACACATCGAGACTTGGCGTTCTTATCGTCCTCAAATGCAAACATTGTGGACGCATTTTCCTCAACGTCAAACTTGCGCTAGAGCACGCCCTTGCGTATCACTCGATCAGCGAAGTGGTCAAATCAAGAAATGCGaataaagtgaaatttaaGCAGCAGCTCAAATTGCTACTGAAGCAACCGCAATCGATAACCGAAAAGCTAAAGAAGATATCACTGAAGCAGCAGGAGGAAATATTCAAAAACCAAGTGGTGACCAATGTCCTCCAGTGCGAATTTTGTGACTACATCTTTACCGATATTGCCCTGCTGTTGCGCCACTCGGCCACCCATTGGCCGGAGAGTCGGTTCGAGTGCACCGCCTGTGATTTGGCTCTGACCACCGCCAAAGATGCCAGTGTTCACTACCAGACCGAATGCGTCTATATGCGCGAGGAACTCAAGCAACTGCCATCTGCGCTGAAtcgtgtatttgtgtgcaatGTGTGCCAGCTGAGCTTTGCCAATGTGGAGCTGCTCCAGGAGCATCGCTATAGTTGCCTTCACTTCTTTCCGCGGCTCAGCGAGACCGGCACACGGCTGATGCTACCATGTGAATTCTGTGGCACCAATTTTCAGTGTGCCAAAGGGATTCAGGCCCACTACGAGGAGAAGCATCTCAATCGCAAGAAGCGGGAGAAAGAGCAGCTGCGCAACATCAGCATTGCATCATCATCCAAGGTCCGACTGCGTCAATATCTATGCGACATCTGTGGCAAATCCTACACACAGTCCAGCCATTTGTGGCAACATCTACGCTTTCATCAGGGTGTCAAGCCATTTGTTTGCCCGGAAGCGGACTGCGGTCGCAAATTCACGATACGTCCGGATCTCAATGATCACATACGAAAGTGTCATACTGGAGAACGGCCGTATCATTGTCTGGTTTGTGGCAAGCGTTTTCTCACTGGCTCGGTCTTTTACCAGCATCGACTCATCCATCGTGGCGAGCGGCGATACGAGTGTGAGGAGTGCGGCAAGCGTTTCTATCGCGCAGACGCATTGAAAAACCATCAGCGCATCCATACGGGCGAGAAGCCCTACGACTGTCAATTCTGCACGAAAACGTTCCGGCAACGCGGCGATCGGGATAAGCATGTGCGAGCGCGTCACTCCCACTTGGATGAGAATGGTCGTATGATGATGCGAATGCAGAAGTTTGAACTGGAGAAGGCGGCTGCGTTGAAAGCCAAGCAAATCCATGATTTGGGAAGTGAATATATTTTGGAGTCGGAGGATGCGTTGTCTGTTCTTTCGGAAGCATCTCCGTCAGAACAAGTGCAACATTTCGattataataatgaatatcccgaagaaactgaaattgtgtcaatgccaattaaaaatgaGGAGCCGAATTTAATGTCGTATTTGGATTTTGAGGGAGTAGAAGCAGTCGAGGCGCCACCtttcaatttggaaaataatggAAATGTCAAGGTTGTCGTGGTTGAAAATAATTCTTTGcagcaattttatttctaa
Protein Sequence: MDPESEFYDGDEFMITELEFGDDLMVDSNGLQPGSTLLVSNEIDDFLVDEDLGQFFEMHGGIQIPNEEVVERTLTDPAIMGIIDEANGQMDFDPEAEELKLREFLSGVNNSIEVNALPGMVIQENKSTAIRFILCSNCKGIFDTPAFQNHSCEYDANQKKIVAQQLPLQPEKESLPPRITTSERIIVENQVRMRRYMKDELKYDMEAGYDSSKVKESTVKGTHECNICERKFVHSSGLARHLEKHTLDLIPGLATLQQNHTSRLGVLIVLKCKHCGRIFLNVKLALEHALAYHSISEVVKSRNANKVKFKQQLKLLLKQPQSITEKLKKISLKQQEEIFKNQVVTNVLQCEFCDYIFTDIALLLRHSATHWPESRFECTACDLALTTAKDASVHYQTECVYMREELKQLPSALNRVFVCNVCQLSFANVELLQEHRYSCLHFFPRLSETGTRLMLPCEFCGTNFQCAKGIQAHYEEKHLNRKKREKEQLRNISIASSSKVRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEADCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYDCQFCTKTFRQRGDRDKHVRARHSHLDENGRMMMRMQKFELEKAAALKAKQIHDLGSEYILESEDALSVLSEASPSEQVQHFDYNNEYPEETEIVSMPIKNEEPNLMSYLDFEGVEAVEAPPFNLENNGNVKVVVVENNSLQQFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00557382;
90% Identity: iTF_00495301; iTF_00620040;
80% Identity: -