Basic Information

Insect: Drosophila tanythrix
Gene Symbol: Hnf4
Assembly: GCA_035043275.1
Location: JAWNNC010000514.1:2318821-2322496[+]

Transcription Factor Domain

TF Family: RXR-like
Domain: zf-C4|RXR-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7.9 2e+04 -4.7 3.6 140 155 159 174 140 186 0.50

2 2 9.2e-66 2.3e-62 210.5 0.1 1 197 321 516 321 521 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7.9	2e+04	-4.7	3.6	140	155	159	174	140	186	0.50
2	2	9.2e-66	2.3e-62	210.5	0.1	1	197	321	516	321	521	0.97

Sequence Information

Coding Sequence: ATGGTGCGCAAGTCCACTAGAGTTAAAATTCCTACTTGTCGTGCCATTGGCAGCGTTCTTTTGCGTGCTGCTGCCAGCAaaggcgctgctgctgctgttgcatctgctgctgctgttggtgagAGTGTTAACGATggggagcaggaggaggatgCAATGGTCAGGCGACGGCGACAACGGGACAGCATTGCACGCAGTTCACTCTCAAGTGATgatgAATCCGCTGAGAGCCCAACAATGCAGGCAGAGGCGCTGCCGGTGGGTTATCCTGCTGGTTCACCCATTGACCATGCCCTGAGCCCCAATGGCGTTGGCCTCGgcctcagcaacagcagcaaccagagCAGCGAGAATTTTACGATctgcaatggcaacagcaatgccagcaacaacaataataccaacaacaacaacaatttgtactCACCAAACATCAACAACCTTGCCAGCGGTGGCAGTAataaccaacaacagcagcagcatcagcagcaacaacaacaacaacaacagcagcagcagcagcaacaactgcagcaacaacaacaacaatcgcccACAGTTTGCGCAATTTGTGGAGATCGGGCGACGGGCAAACATTATGGCGCCTCCAGCTGTGATGGCTGCAAGGGATTTTTCAGGCGCAGCGTACGCAAAAATCATCAATATACCTGCCGATTCTCGCGCAACTGCGTGGTTGACAAGGACAAGCGGAATCAATGTCGCTACTGTCGGCTGCGCAAATGCTTCAAGGCGGGCATGAAGAAGGAGGCGGTGCAGAATGAACGTGATCGGATCAGCTGCCGTCGCACCTCCAACGATGATCCCGATCCCGGCAATGGCCTGTCTGTGGTGTCCCTCGTCAAGGCTGAGAACGAATCGAGACAGTCGAAGGCCGGGGCCGCCATGGAGCCCAACGTCCACGAGGATCTCTCCACAAAACAGTTTGCCAGTATCAACGATGTCTGCGAGTCAATGAAACAGCAGTTGCTCACCCTAGTCGAATGGGCCAAACAAATACCAGCCTTCAATGAACTCCAGCTGGACGATCAGGTCGCCCTGCTGCGCGCCCATGCGGGTGAGCATCTGCTCCTGGGCCTCTCACGTCGATCCATGCAACTGAAGGATGTGCTGCTGCTTAGCAATAATTGTGTCATCACCAGGCATTGTCCAGATCCACACGTCTCGCCCAATTTGGATATATCACGTATTGGAGCGCGCATCATTGATGAGTTGGTGGTCGTTATGAAGGATGTTGGCATTGATGAGACCGAATTCGCTTGCATCAAGGCGCTGGTCTTCTTTGATCCCAATGCCAAGGGTCTCAATGAGCCGCATCGCATCAAATCCTTGCGCCATCAGATACTCAACAATCTGGAGGATTACATTTCGGATCGGCAGTATGAGTCGCGTGGCCGATTTGGCGAgattttgctcattttgccGGTGCTGCAGTCAATCACATGGCAGATGATCGAACAGATACAGTTTGCTAAAATCTTTGGCGTGGCGCACATCGATTCGCTGCTGCAGGAGATGCTCCTGGGTGGTGAACTCGCGGACAATTCACTGCCCTTGTCGCCACCCAATCAGTCCAACGATTATCAGAGTCCCACACATGCTGTAAATCTGGACGGCGGCAGCCAGGCGAGCACCACAATGGATACGCTGGCGACGGTGACCAGCGGCAGCCATGGCCTAGATCTTGATGTGCAGCACATACAGGCGCTCATCGAGGCCAACAATACGGAGGACACTTTCCGTGAATATGCGGCCAACAATGCAGCAGCGGCTGTCATGCCAACGTCCGCAGTTACGCCACCCTTGAGCACAGCTGCCTGTAGTCCAAAATCGCAGGAGAGCGTCGCCTACTTGGATGCAAGCCAACGCCAATATAATGTCCAGCATAAGAGTCAGATAGTGCACACTCACAATCAAAACCAACGCGTGCATCCCTACCAAAGAGTGCCAACGTCGCCGGTCGATGCCGGACTCGTAATACGCAATCCGGCGGATATCACTCTCAATGAATACAACCGCAGCGAGGGCAACAGCGCCGACGAGCTGCTGCGACGCACCCCCTCAAAATACGTGCTCCCGAACTGCTAG
Protein Sequence: MVRKSTRVKIPTCRAIGSVLLRAAASKGAAAAVASAAAVGESVNDGEQEEDAMVRRRRQRDSIARSSLSSDDESAESPTMQAEALPVGYPAGSPIDHALSPNGVGLGLSNSSNQSSENFTICNGNSNASNNNNTNNNNNLYSPNINNLASGGSNNQQQQQHQQQQQQQQQQQQQQQLQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFSRNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVVSLVKAENESRQSKAGAAMEPNVHEDLSTKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMQLKDVLLLSNNCVITRHCPDPHVSPNLDISRIGARIIDELVVVMKDVGIDETEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNSLPLSPPNQSNDYQSPTHAVNLDGGSQASTTMDTLATVTSGSHGLDLDVQHIQALIEANNTEDTFREYAANNAAAAVMPTSAVTPPLSTAACSPKSQESVAYLDASQRQYNVQHKSQIVHTHNQNQRVHPYQRVPTSPVDAGLVIRNPADITLNEYNRSEGNSADELLRRTPSKYVLPNC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00560303;
90% Identity: iTF_00558716;
80% Identity: iTF_00607112;