Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00086 0.075 13.8 1.9 1 23 141 163 141 163 0.97

2 6 0.00026 0.022 15.5 0.7 1 23 170 193 170 193 0.94

3 6 0.00014 0.012 16.3 0.0 3 23 200 220 199 220 0.97

4 6 9.2e-06 0.0008 20.0 1.8 1 23 226 249 226 249 0.96

5 6 0.00015 0.013 16.2 0.3 1 20 254 275 254 278 0.90

6 6 0.00021 0.018 15.7 1.1 1 23 283 306 283 306 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00086	0.075	13.8	1.9	1	23	141	163	141	163	0.97
2	6	0.00026	0.022	15.5	0.7	1	23	170	193	170	193	0.94
3	6	0.00014	0.012	16.3	0.0	3	23	200	220	199	220	0.97
4	6	9.2e-06	0.0008	20.0	1.8	1	23	226	249	226	249	0.96
5	6	0.00015	0.013	16.2	0.3	1	20	254	275	254	278	0.90
6	6	0.00021	0.018	15.7	1.1	1	23	283	306	283	306	0.97

Coding Sequence: ATGCTGGACATGACCGTCATCTATGACCAAGAGAAAGACTTAAGCTATTACGACTGCTACGAGATCTGCACTAAGGAGGATCTGCGCCAGAAGCCCAGTCAGGAGCCTAAGGGCTTGTGCAACCGTTGTGCCGTGGAGCTGAGGTGGGCCTATGACTTCCACAAGAAGGTGGCGGTCGCCAATCAGCAGTTGCGCGAGATTTTCGAGTCCGCAAAGGCCAATGAAGGCTTGGCAGAACAAGAGCTAGAAATAGAACCAGATCTCGATGAGgcggatgaggaggaggctATGATGAGTGCTGAGTActtgctggaggagctggagcaacTGGACTCACAGGAGGAGCCACAGCCTGACCAGGCAGCCGCCAGCTTTGTCAGCATGGAGGAAATGGCACCCCGCAAGCGTCACAAGGGAAAATTCAATTGCGATTTCTGCCAAAAAACGTTCCAGAATTATTCCAGCAGGGCCAAGCACCAGGCGATTCACCTGACCAACAGGCCATATTTCCAGTGCGACCAGTGCAACAAGTCCTACCTCACCAAGCCGTCCCTCAAGGTCCACATGGACGCCAAGCACAGGCAGTCCGGCGTGGCCTGCGACATCTGCGGCAAGGTCTTTGCTATAGCCAAAGCCCTGGAGATCCACAAAAGATTTCACACCAAGGACTTTCCCTTTGCCTGTGATCTCTGCGAACGCAGATTCGCCCAGCGCTCGCACCTGACCCTCCATCAGCAGATAAAGCACTCTGGATGCCGATTCATCTGCGAGTTCCCCGACTGCCAGAAGTCCTTTACCTCGTCTGCGGCACTGAGGAATCACGAGTGGACGCATACGGCCATGCCATTCGAGTGTGCCTACTGCCAGCAGAGTTTTCCTGCTCGTACTAAACTACGAGTACATCTGAAACGGAAGCACTGCAAGCTAGTGGatgtggaggagctggaggggATGCGCAAGTTTCACATGACGCGCTCCAAGTTGGTCCTGGCAAGGATTGAGGACAAGCAGGAAGAGACAAGTGGACAAAGTACTAGTAATGAGGCTTCcagtaattttaaatcaaactaa
Protein Sequence: MLDMTVIYDQEKDLSYYDCYEICTKEDLRQKPSQEPKGLCNRCAVELRWAYDFHKKVAVANQQLREIFESAKANEGLAEQELEIEPDLDEADEEEAMMSAEYLLEELEQLDSQEEPQPDQAAASFVSMEEMAPRKRHKGKFNCDFCQKTFQNYSSRAKHQAIHLTNRPYFQCDQCNKSYLTKPSLKVHMDAKHRQSGVACDICGKVFAIAKALEIHKRFHTKDFPFACDLCERRFAQRSHLTLHQQIKHSGCRFICEFPDCQKSFTSSAALRNHEWTHTAMPFECAYCQQSFPARTKLRVHLKRKHCKLVDVEELEGMRKFHMTRSKLVLARIEDKQEETSGQSTSNEASSNFKSN

Sequence clustering based on sequence similarity using MMseqs2