Basic Information

Gene Symbol
ZNF584
Assembly
GCA_018152695.1
Location
JAECXN010000001.1:26058832-26059928[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.0015 0.095 13.0 0.3 1 20 60 79 60 82 0.92
2 7 8.3e-06 0.00051 20.1 0.1 2 23 96 117 95 117 0.96
3 7 0.017 1 9.7 0.8 1 16 123 138 123 146 0.83
4 7 0.013 0.8 10.1 0.9 1 23 152 177 152 177 0.95
5 7 7.1e-06 0.00044 20.4 0.6 1 23 183 205 183 205 0.97
6 7 0.011 0.67 10.3 0.1 1 23 211 233 211 233 0.95
7 7 0.0012 0.075 13.3 0.2 1 21 239 259 239 263 0.91

Sequence Information

Coding Sequence
ATGGAGCGAAACAAAATGGAACAAGGATTCAAGAACGACGATATCGAAGAGGAGGAGAATGCAGACATGCTATTCAGACCGCAAATCTATGATGAGGAATTGGCCCTGGAGCGGGAAGAACAAGAGCTCGAGGAATGGAATCTGAAGAACCAAAACTTACTAGGCGGAACCGCGTTCTTCATCTGCAGACACTGTCCGGAGGTATTCTTTAGCAAGATGGAACTAGCCGCCCATCGCCCTGTTCACCGGCTCAAAAGTGGACGGAGGAAATCCACCTTGGAGTTAACCTGCGAGGACTGTGGAAAGGTCTTTCAAAAGCGCAACGCCCTCGTGGATCACATGAATGCCCACCAAAGCCAGCGAAACTATCCGTGTCCTGAGTGTCCGGCTCGCTTTGTGCAACGCAGCAACAGGGATTGCCATGTAAAAAATATTCACAGGAAAGAGTACCTGCACTCCTGCCCGAATCCCGGCTGCGAAAGACGTTTCGAGCAGAAGCGGGAACGGGATCAGCACGTGAAAACAGTCCACCGGAAGGAGAAGGACTTTGTTTGCGCTGAGTGCAATGCCAGTTTTAGCCATCCCGTAAATTACCGAAAACACTTGGCTTCCCACAGCTCAGAGAAGAAGTACGATTGTCCAATTTGTCGAAAGCTCTTTGGACGCGCCGAAAACAGGGATATTCATCTCTTTGTCCATAGTATTTGTAAGGCCTATGTTTGCTCCGTTTGCGGAGCAGACTACATGCGTCGCACTCAGTTGATTCGCCATAGTAAAGAGCGTGGTCATTTGAACGACCCGATTGTTCGACAAAAGCCTCAGTTCAGTCCGGGCCTTGCCCAGAGACCCATTGGGATCAGCGGTCAGGTCCAGAAAGCTGCCCATCTGGAGGATGTGGAGTGGTCGCCGGAAGAGGATGCGAAGTTTCAATGCCCAGATGAGGAGGCTAGCCCTGGGTCCATTAGGAAGGTCCATAATGGTAGAACTGATCAAGGTTAG
Protein Sequence
MERNKMEQGFKNDDIEEEENADMLFRPQIYDEELALEREEQELEEWNLKNQNLLGGTAFFICRHCPEVFFSKMELAAHRPVHRLKSGRRKSTLELTCEDCGKVFQKRNALVDHMNAHQSQRNYPCPECPARFVQRSNRDCHVKNIHRKEYLHSCPNPGCERRFEQKRERDQHVKTVHRKEKDFVCAECNASFSHPVNYRKHLASHSSEKKYDCPICRKLFGRAENRDIHLFVHSICKAYVCSVCGADYMRRTQLIRHSKERGHLNDPIVRQKPQFSPGLAQRPIGISGQVQKAAHLEDVEWSPEEDAKFQCPDEEASPGSIRKVHNGRTDQG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

80% Identity
-