Basic Information

Gene Symbol
-
Assembly
GCA_014743375.2
Location
NC:14779433-14785394[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0045 0.26 11.6 0.1 1 23 195 218 195 218 0.97
2 12 0.00049 0.028 14.6 4.0 1 23 223 246 223 246 0.94
3 12 3e-05 0.0018 18.4 1.9 1 23 251 273 251 273 0.98
4 12 6.5 3.8e+02 1.6 5.0 1 23 279 303 279 303 0.94
5 12 0.00063 0.036 14.2 3.9 3 23 314 335 313 335 0.95
6 12 0.0037 0.22 11.8 0.2 1 23 341 364 341 364 0.96
7 12 0.0032 0.18 12.0 0.2 2 23 375 397 374 397 0.94
8 12 0.00037 0.021 15.0 0.3 1 23 425 447 425 447 0.97
9 12 6.5e-06 0.00037 20.5 2.1 1 23 454 476 454 476 0.96
10 12 0.00023 0.013 15.6 0.1 2 23 483 504 483 504 0.97
11 12 0.00049 0.028 14.6 0.8 1 23 511 533 511 533 0.99
12 12 0.00014 0.0078 16.3 3.7 1 23 539 562 539 562 0.98

Sequence Information

Coding Sequence
ATGGAAACGTGTCGCACCTGTGCGATTTCCATGTTTGTGTGCGACTTCGAGAatggcagcaacaacagccacTTCCTGGACCTCCATCATCCCGAGATGGTCCAAATCCGCCAGCAGTTCGTCAACTGGAATCTGAAGATCTCTCCCAATGATGGGCTGCCCCAAAAGATCTGCAGCGACTGCTTCACCAAGTTCTGCTCGATAAACGCATTCCGAGTGGCCTGCCAGGAGGCGCAGTTGAAGTTGTCCAATATCTACGACAAGATCGATGCCAGCAGCCTGGAGGAGGAGCACCAAGGCGAATTggaccaggcggaggagcaTCGGGGAACAGAAACAGCCAAACCAACAACGACGGTTTCAGACGAAACACAACCAAACACTGCCAGTGAAACCATAGAGATTTTTGTGGATGCCGTAGACATCGACGAGGAGGCCGAGGAGCATCCAACCGGGGAGTCTGCTCCTCCGGAACTGACCATTAGATACACCTGCAAGTTCTGCCTGCGGCCGCAGGAGAGCTATCAGCTGCAGCAGCTTCTGCTGGAGCACATCAACACCAGCCACGATCCGGAGCAGCCGTACAATTGTCCGGAGTGCGAGGCCCGCTTCCAGGATGCCGCCTCTAGGACCGTGCACCTGAAGAGCAGCCACGTGGAGAAGCAACATGCGTGCGGGGTGTGCGGCAAGAAGTACGGCGATCGGCACAATCTGCGCCACCACGTGGAGAAGTATCACTCGGAGACGGACTTCGAGTGTGCGCTGTGCGAGAAGCGATTCTACACGCGCAAGAGCCTCAACTACCACATGAAGTGGCACAATCCGGACCGCCAGTTCAAGTGTCGCCACGGCGGCTGCGAGCGACTCTTCATCAGCCAGCGACACCTCATGTGCCACGAGGCCACCCACTCGGGCACCAGCGCCAGGAAGAGCGAGCACTGCGGCTTCTGTGGAAAGACTTTTATACACCTGAAGACCCTTCGCTGGCACATTTATAGACAGCACGGCGGAGAGAAGCCGTACAAGTGTGCCAACTGCACGGAGGTTTTCGCATCCTACGCGGAGAAGCGAATCCACATGCTAGAGCGGCACAGGGAGAATCTAACTGCCATCGAGCGGAGCGAGTGCATGTTGTGCCGCCAGCCCTTTACCAGCGAACAGGATCTGATCCAGCACATGTCCCTGGAGCATCTGCAGCGTCCAGGGGCTCCGGTGATTGCCAACAACAAGCGGGTGCTGCAGCAGAAGCGGGAACGACAGTACTCCGGACTCTTCCAGTGTGGCAGCTGTACCCAGCGGTTCAACATGAAGTCGGCGCTGGAGCGGCACGCTGCCGTACACTCGGAAAAAGACCGACCCCATGCCTGTCCACAGTGCTCCAAGAGGTTCAAGCGCGCCCAGGACATGAAGTGGCACATCAAGACCCATGAAAAGGAGAAGCCCAATGTGTGCGATGTGTGTGGGAAGGCTTTCGCCCTTAAGTATGTGCTTACCCAGCACCGGTTGAGTCATGAGGTCTTGGAGAAAAACTTCAAGTGCAACGTTTGCGGTCGAGCCTATCTGTTTGAGAAGTCATTGCGGCTGCATCAGCGGGTTCATACTGGCAAAACCTACTATAAATGCGATCTCTGTCAAGAGAGATTCGTGACGCACATTAAGCTCAAAACTCACATGCAAAAGACACACGCCGCCACTCAGCCGCACTCTGCGGACCACCCTCTGGATGATCTGATCAACATTGTGATTTCCTAA
Protein Sequence
METCRTCAISMFVCDFENGSNNSHFLDLHHPEMVQIRQQFVNWNLKISPNDGLPQKICSDCFTKFCSINAFRVACQEAQLKLSNIYDKIDASSLEEEHQGELDQAEEHRGTETAKPTTTVSDETQPNTASETIEIFVDAVDIDEEAEEHPTGESAPPELTIRYTCKFCLRPQESYQLQQLLLEHINTSHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHGGCERLFISQRHLMCHEATHSGTSARKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFTSEQDLIQHMSLEHLQRPGAPVIANNKRVLQQKRERQYSGLFQCGSCTQRFNMKSALERHAAVHSEKDRPHACPQCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRVHTGKTYYKCDLCQERFVTHIKLKTHMQKTHAATQPHSADHPLDDLINIVIS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00491676;
90% Identity
iTF_00486747;
80% Identity
-