Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.2e-06 8.9e-05 23.0 0.7 2 22 174 194 173 194 0.95

2 6 0.012 0.84 10.5 0.1 2 23 204 225 204 225 0.97

3 6 7e-06 0.00051 20.6 2.4 2 23 232 253 231 253 0.96

4 6 6.5e-05 0.0047 17.6 0.7 1 23 259 281 259 281 0.98

5 6 0.00024 0.017 15.8 6.3 2 23 289 310 288 310 0.96

6 6 6.2e-08 4.5e-06 27.0 0.4 1 23 317 339 317 339 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.2e-06	8.9e-05	23.0	0.7	2	22	174	194	173	194	0.95
2	6	0.012	0.84	10.5	0.1	2	23	204	225	204	225	0.97
3	6	7e-06	0.00051	20.6	2.4	2	23	232	253	231	253	0.96
4	6	6.5e-05	0.0047	17.6	0.7	1	23	259	281	259	281	0.98
5	6	0.00024	0.017	15.8	6.3	2	23	289	310	288	310	0.96
6	6	6.2e-08	4.5e-06	27.0	0.4	1	23	317	339	317	339	0.98

Coding Sequence: ATGAGCACAGCACGACCCTTCTGTTTCGTGTGTGGCAAAATGAAGACTGTTGGCGTCTTTCAGCTCATCGAAGgATGCATAGTACCTGGCACCTTCAAGCCCATTAAAGATATATTAAAACACTTTGAAAAGATAATTAATCAGCGTTTGGAATTAACGCCAACCTCGGCCGCCTGCAGGGACTGCTTGGAATATTTATTCAACTACGACCGGCTTGTTAGAAATCTAAGTCAAGTCCAACGTCAAATTGCCGACTCATTGCTAAGTTGCCGCAAGCGGAAGCCAGGAAGTTTGCCGACAAAGAAGGCTGTCATAAAACCGAAAACGCAGGATGTGAGATCAAGAATTAAAGAAGATGATTTTGTACAGTCATCACCACAGAAAGCAGCTGTTAAGGAGGAGTCGACTGAAGAGGAGTTTTTACCAATGAACGAAGATCAGGATCAGCAAGAGGACTTTCAATTTAGCGATGGCGAGGACAGCATGGAATCGTCGGAGGAGGAACAATATCTAGAAATTCCTTGTCATATATGTGgcgaaatgttttcaaatcaAGATTGCCTGGAAAAGCATATTAAAACGGATAATTGTCAAAAGAACGAAAATGCCACCTGCAATATATGCGGCATTAAAGTCAAAGACGAGGAAGTTCTCGATTTGCACATGAACCTGCACGAGGGAAAGACTGAGCTGGAATGCCGATACTGTCCGAAAAAGTTTTCACACAAACGAAACGTTTTGCGGCACATGGAAGTGCATTGGGACAAAAAGAAATATCAGTGCGAAAAATGTGGTGAGCGTTTCTCGCTTTCCTGGCTAATGTATAACCATCTAATGCGACACGATGCCGAAGAGCATGCGCTTATCTGCGAGGTCTGTCATCAgcaattcaaaacaaaacgcaCCTACAAGCATCATCTGCGAACCCACCAAACGGATCGACCGCGTTACCCATGCCCAGATTGTGAGAAATCCTTTGTGGACAAATACACGTTAAAGGTGCACAAGCGTGTGCATTTACCTGTTGAAGCCGCACAGGAATAA
Protein Sequence: MSTARPFCFVCGKMKTVGVFQLIEGCIVPGTFKPIKDILKHFEKIINQRLELTPTSAACRDCLEYLFNYDRLVRNLSQVQRQIADSLLSCRKRKPGSLPTKKAVIKPKTQDVRSRIKEDDFVQSSPQKAAVKEESTEEEFLPMNEDQDQQEDFQFSDGEDSMESSEEEQYLEIPCHICGEMFSNQDCLEKHIKTDNCQKNENATCNICGIKVKDEEVLDLHMNLHEGKTELECRYCPKKFSHKRNVLRHMEVHWDKKKYQCEKCGERFSLSWLMYNHLMRHDAEEHALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHLPVEAAQE

Sequence clustering based on sequence similarity using MMseqs2