Basic Information

Insect: Drosophila subobscura
Gene Symbol: zfh1
Assembly: GCA_008121235.1
Location: NC:24397258-24424663[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0025 0.15 12.2 1.9 2 23 76 98 75 98 0.95

2 9 0.0018 0.11 12.6 0.1 1 23 314 336 314 336 0.96

3 9 9.8e-05 0.0058 16.6 1.7 2 23 351 372 350 372 0.97

4 9 4.8e-06 0.00028 20.7 6.3 1 23 381 403 381 403 0.99

5 9 0.00028 0.017 15.1 1.2 3 21 411 429 409 430 0.94

6 9 0.008 0.48 10.6 1.8 2 21 674 693 673 694 0.92

7 9 1.3e-05 0.00076 19.4 0.5 1 23 1063 1085 1063 1085 0.94

8 9 4.7e-05 0.0028 17.6 7.4 1 23 1091 1113 1091 1113 0.98

9 9 0.0024 0.14 12.2 4.3 1 21 1119 1139 1119 1140 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0025	0.15	12.2	1.9	2	23	76	98	75	98	0.95
2	9	0.0018	0.11	12.6	0.1	1	23	314	336	314	336	0.96
3	9	9.8e-05	0.0058	16.6	1.7	2	23	351	372	350	372	0.97
4	9	4.8e-06	0.00028	20.7	6.3	1	23	381	403	381	403	0.99
5	9	0.00028	0.017	15.1	1.2	3	21	411	429	409	430	0.94
6	9	0.008	0.48	10.6	1.8	2	21	674	693	673	694	0.92
7	9	1.3e-05	0.00076	19.4	0.5	1	23	1063	1085	1063	1085	0.94
8	9	4.7e-05	0.0028	17.6	7.4	1	23	1091	1113	1091	1113	0.98
9	9	0.0024	0.14	12.2	4.3	1	21	1119	1139	1119	1140	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTACACGTTTTGGCCAAGAGGATAACAGCATCATACAGCAGAGCATGCCATCGTCCACAGCCTTCACAATGCAGTTTCCCTCTTTGGCTTCCAGtctgcaccaccaccaggcACCGCACAGCAAGCCCAGCAATGGCTCCGGCGTtggcagccaggagcagcacgCACAGCCAGGTGTTTCCGTTGATGATTTCCTGGTCAAGTGCACGCAGTGCCACAAACGCTTCACCGAGTTTCAGTCCCTCAGCGAGCACATTGCCAGCGAGCATCCGCACGACAAGCTGAACTTCGAGGCGAGTCGCGGCTCCAGCGGCGCTGTGCAGCCGGAGAGCGATGCCGAGGATGAGCAGAGCAATCTGAGTGGCAGCCGCTATGCCAAGTCCCctgccaacaccaacaacacccaTGCCAAcccaagcaacaacaacaacagcgatcTGGCCaagaaccacaacaacaacaacaacagcagcaacagcagtaagCTCTCACCCATGTGCTCGCCCGGATCGGGGGGTCCCGCCGCAGATCTCTTTGCCCACCTCTCCCACGGAGCACCGCCTCAGCTGCCTCCCCACCTGCACGCTCAGTTCATGGCTGCCGCCGCTTTGGCCATGCAATCGGCACGCTCCGTCAGCTCCTCCGCCAGTTCGCCCAACAGtcaccatcaccagcagcagtcgcaccaccaccagcagcagcaacagcaccaccagcagcagcatcagcacctcctccagcaacagcaacagtcgcagcagcagcagcagcagatggccatgcagcagctgctgccgccacagcTACCggggagcaacagcagcgtggGCAGCAATTCCGCCTACGATCTGGATCTGAGTGCCCCACGATCCACCTCCAGTCCGGGCTCCACCACGGGCGACCTGAGCGGCGCCTACCCCTGCATGCAATGCACCGCCGCCTTCAGCAGTcgcgagcagctggagcagcacgAGCTGCTCCACTCGCCCACCGGGGGCCAGCCCACGGCACAAAATGTCTCTCAGACTTGCCGAATCTGCCACAAAGCCTTCGCGAATGTCTACCGCCTGCAACGGCACATGATCAGCCACGATGAGTCGGCGCTGCTACGCAAATTCAAGTGCAAGGAGTGCGACAAGGCGTTCAAATTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGTGACAACTGTGGCAAGCGCTTCTCGCACTCCGGCAGCTTTTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTGAAGCTGAACAACAATCGGGCGCTGCTCAAGCGCCTGGAGAAGAGTCCTGGCTCCGGGCCACGGCGCTCGCCCACGGACCTGCAGGGCCCCAAAAATGGTGCCGGAAAGATGTCCGATCAGCAGTCCCTGCCTCCGCTGCCCAATCCCATGATCTACTTTGCCGGCGAGGCGCAAGCGCAGGCAGCTGCCGCGAATGGAGCTCCTCCACCGTTCTACCCCAACTACATGAATGCTGCCCTGCTGGCCTTCCCCAATCCCTTCATGGCAGCGGCCCTGGACCCCCGCGTCCACCCCTACAGCATACAGCGGCTCCTGGAGCTGACGGCTGccggacaacagcagcaacaacaacagcagcagcgcgaggaacgcgaggagcaggagcagcacgaAGAGCCTGCGACGCCGGAGGAGCCCAAGCTGGTCATGGACATTGATGAGGCTGAGGCCAAGGAGCGATTGGTGCCACAGGCGAGCCCACAAACAATGCCAGAGGAGATTGAACCGGTTGTTGCCATGGCCACGACTCCCATCAAGCAGGAGCCCAGCCGAGAGCCCACCCCACTCCCGGAGAGTGCCCCGCAGTCGCCCAAGTCCttcaagcaggagcaggaggagcctcGTTCCCTGGAGGAGGATCAGCCCATGGAATCGGCTCAACCTGAAGCAACTGCCTCTTCACCCAGGAACACACCCGTGGAGCTGCGATGCAGCCGCTGCGACAAGCAGTTCAACCACCACACAGAGCTGGTGCAGCACGAGAAGGTTCTCTGCGGCCTGAtcaaggaggagctggagcagcactaccaccagcagcagcaacagcagcagcaccaacagctacagcaacaccaacagcagcagcatgaacaactccagcagcagcagcaggcatccTTTGGGCTGCCCTCTGCCAGcgaggatgacgacgaggaggaggagcgcgagaacgacaacgacacgGAGCAGCGTCCAGACAGCAACGAACGCAAGGTGCGCGTCCGCACGGCCATtaacgaggagcagcagcagcagctgaagcagcactACGCCCTCAATGCGCGGCCGAGTCGCGACGAGTTCCGAATGATTGCCGCCCGCCTCCAGCTGGATCCACGCGTGGTCCAAGTTTGGTTCCAGAACAATCGCTCACGCGAGCGGAAGATGCAGAGCTATGCGAGTGTCCACACGGCAGCCCCAGCCGCCAATGAAGTGCCCACCACTCCCGTTTCCAGCCGTCCCACAACCGAGGATCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCCTGACGCCCAAGAGCGACCACTCCGCCGTGTACGgattgccacagcaacaggcTGCCGGACAGCCAGCACCTGCCGACTTCCAGGAGGCCATCAACCTGAGCCGCAAGTTCTCCAGTTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCCTCTTCGGGCGCCTCACTGCAGCAAtcctctgcagctgcagccgccgcagcggcagcgctcTGGCCCTTCGGCGGACCGCCTCCATCGCCGCCCAGCCAGCACGAGGCCACGCCCGCCCAGCACTGCTCGACGCCGCGGGGCGGCCAGGCCTTTCCTGGACTCCAGTACATGCTGCCAATGCAGCGACTGCCCATGGAGGCGCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTCCGTGGCACCAGCCTCAGCCCGGGCGGCTCCGAGAAGCGCTCCTGGCGCGACGATGACTCCCGCATCTCCCACGAGGACGACTTTGGCAACGGTCTGATGCCGCCCAAGCCGCGCCGTGGCAAGGCCGAAACCCACGGGCATGCCGGGGATCCGGATCTGCCATTCGTCTGCGACCAGTGCGATAAGGCGTTTGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCATCACCTGACGGAGCACAAGCGTCTGCATAGCGGGGAGAAGCCCTTTCAGTGCTCCAAGTGCCTGAAGCGCTTCTCGCATTCGGGAAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCATACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKPSNGSGVGSQEQHAQPGVSVDDFLVKCTQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPANTNNTHANPSNNNNSDLAKNHNNNNNSSNSSKLSPMCSPGSGGPAADLFAHLSHGAPPQLPPHLHAQFMAAAALAMQSARSVSSSASSPNSHHHQQQSHHHQQQQQHHQQQHQHLLQQQQQSQQQQQQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSGPRRSPTDLQGPKNGAGKMSDQQSLPPLPNPMIYFAGEAQAQAAAANGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQQQQQQREEREEQEQHEEPATPEEPKLVMDIDEAEAKERLVPQASPQTMPEEIEPVVAMATTPIKQEPSREPTPLPESAPQSPKSFKQEQEEPRSLEEDQPMESAQPEATASSPRNTPVELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHQQLQQHQQQQHEQLQQQQQASFGLPSASEDDDEEEERENDNDTEQRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYASVHTAAPAANEVPTTPVSSRPTTEDQPLDLSVKRDSLTPKSDHSAVYGLPQQQAAGQPAPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQHEATPAQHCSTPRGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKPRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00600958;