Dsub008249.1
Basic Information
- Insect
- Drosophila subobscura
- Gene Symbol
- -
- Assembly
- GCA_008121235.1
- Location
- NC:4519853-4521843[-]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 8.9e-13 5.8e-09 35.9 0.1 1 97 131 227 131 229 0.89
Sequence Information
- Coding Sequence
- ATGACTGGTGATTATCAATCAACTCTACACGTCAATGAGGTCGATGGACAGAAAGATACTTCAGACGCAGAAGGAGCCGATATCGACGACTGGCAGAAGATATTTCGTAACGCGCCCCCGACCACCGCCATTGGGACCGCTGAAGGTGGCTACAtcgagcaggagctgcaggcatTTATGAACACACTCAATGTTGAAGATGATGCGGACGATGTCCAGGAGGTGCCCATACAGATTGAAACGATCGCTGTGGATGACGAAATAGACATTGGACTCGACAATACTAGAAAAAGGTTGTcgcaaaagaagcaaaagcaagcagcaggcacgCTGCAGAAGAAGCCAAAAGTGAAGAAACGGATTTTACGGAAGCGACTCGCTGAATATTCCTTTGTTGAGACCCTTTATCTGGCCGCCAACAGTAACAGCATTGACTTCCTGCGTTGGTCGAAGAAGGAAAAACATCTAATTGTGCCATATGTGGCGCTTCAGGAGCATTTGATCAGCTCTCGCCCCATGTTCCGTTGTCGCAGTGTCCTCCAGTTCGCGGCAGAGCTCTCGAGATATGGCTTTGAGCGTGTGTTTGACTTCGATTTCAAGGATGCGGCCAAGGCCACTATAGTCTTGGTCTTTCAGCACCCCAACTTTGTAATGGGTGCGCCGCACAAGATCCGTAAGATAAGCTACGTGAACATGCAAGAGGAACAAGAGAATGCACAGACTTCCGCAGCAGGACACCAGCAAAGGGACAATGATATCTGCACCACCTTTCACTCGTACATGTCGCCCCTGCAGGTGGCACGCTGCCGCCTCCACACGGAGCTGAGCTACCATTCCGATATGGCTCTGCTCCACGAATACGCCAATGAGTCCAACAAGCCGGTGGCCAAACGAGCCGGGCGTCCCGCACCCATCCTGGAAACGACCGTGGAGCAACAGCTTGCGGGCAGAACGGACAAGTTTGTGAATCCTTACGAGTCGGTGACCAAGATACTCACGAAGCAGGTGCCCTCGTATGCCGGCTACTATGGCAACGTGCCGCACCCGATGCTGGAGGACTTCTTCCAGGAGTACATGCCCCGCTATGGCATCAAGATAAGCGGCTACAAGCAGATCGTGATTGACGGCCACAACAACTCGAGTGACTTCAATCAGAATATACCAATTGGCAACGAAGACTCGGACGATGAGAACGATGATCCGGACAAGAGGGATGCCTTTGATCTGGAGGAGGTTATGCACCAGTTGTGCGACGAAGATGCCATCGCCAGCGAGGACGATGATGAGCTAGTTGAAGACTCTGTCGCAGTGGAGCTAGTGCTGAATGAAGACGACGGCACCTACACGTATATCAAAAAAGCTAAAGAAGAACAAAAGCCGCTGCCGAAGTTGGTTCTACCACAGAAAACGACAAAGAAACGTCAGCAGGATGATGatcaaaaaaagggaaagcaacCACTGCCCAAGAAGTCAAAGAAATGCCTGGTACAAGCTGAGATCGAGGACGACACAACcaatacagatacagatacagaaacgGGGCAGCCATCAGTGCAGCAGAATTTGAAGCCTTCTCTTCAGAATGCTATCGAGGAGGATGAGCTCTTGGATTTCGCTGGCGATGATGACGATAAGGAGTACATCGATCGGAAGGTGCTGCGCCGCACAGCCACGCTGTCGGCTTCCAAACGACGCAGCTACGAGTTGCGGAAAGTCAAGCGTGGCtccaagaaaaaataa
- Protein Sequence
- MTGDYQSTLHVNEVDGQKDTSDAEGADIDDWQKIFRNAPPTTAIGTAEGGYIEQELQAFMNTLNVEDDADDVQEVPIQIETIAVDDEIDIGLDNTRKRLSQKKQKQAAGTLQKKPKVKKRILRKRLAEYSFVETLYLAANSNSIDFLRWSKKEKHLIVPYVALQEHLISSRPMFRCRSVLQFAAELSRYGFERVFDFDFKDAAKATIVLVFQHPNFVMGAPHKIRKISYVNMQEEQENAQTSAAGHQQRDNDICTTFHSYMSPLQVARCRLHTELSYHSDMALLHEYANESNKPVAKRAGRPAPILETTVEQQLAGRTDKFVNPYESVTKILTKQVPSYAGYYGNVPHPMLEDFFQEYMPRYGIKISGYKQIVIDGHNNSSDFNQNIPIGNEDSDDENDDPDKRDAFDLEEVMHQLCDEDAIASEDDDELVEDSVAVELVLNEDDGTYTYIKKAKEEQKPLPKLVLPQKTTKKRQQDDDQKKGKQPLPKKSKKCLVQAEIEDDTTNTDTDTETGQPSVQQNLKPSLQNAIEEDELLDFAGDDDDKEYIDRKVLRRTATLSASKRRSYELRKVKRGSKKK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00514809;
- 90% Identity
- -
- 80% Identity
- -