Dstu005470.1
Basic Information
- Insect
- Drosophila sturtevanti
- Gene Symbol
- sd
- Assembly
- GCA_018150375.1
- Location
- JAECWJ010000378.1:1755459-1784293[-]
Transcription Factor Domain
- TF Family
- TEA
- Domain
- TEA domain
- PFAM
- PF01285
- TF Group
- Helix-turn-helix
- Description
- The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.1e-10 8.6e-06 25.9 0.0 2 34 90 124 89 126 0.87 2 2 3.9e-18 6.7e-14 51.9 0.8 34 66 171 203 150 205 0.84
Sequence Information
- Coding Sequence
- ATGAAAAATATTACAAGCTCAAGCACTTGCAGCACTGGCCTGCTGCAATTGCAGAATAATCTTAGCAGCAGCGAATTGGACGTTGTTGGCAAACCAGAGACGACGGCAGTTGGACCCGGCACCATACCATCTCCGTGGACACCAGTGAATGCCGGTCCTCCGGGTCCTCTGGGATCGGCAGACACAAATGGCAGCATGGTGGATAGTAAAAATTTGGATGTCGGTGATATGAGCGATGATGAAAAAGATTTATCATCTGCCGATGCCGAGGGTGTCTGGAGTCCAGATATCGAACAAAGCTTTCAAGAGGCCCTATCAATATATCCACCATGTGGACGCAGAAAAATCATCTTATCCGATGAGGGTAAAATGTATGCCATAGCCGTGTCCATGCCCATGTCCATACCCATGTCCGTGTCCGTGTCCGTGTCCGTATCCGTGTCCTGTACTATTATGTTGTTCCGTGCGTTCTCTGTGTTTTGTATATATGAACGTAGTCAATTTCTTATCCAAGAGGGCCGAAATGAGCTAATTGCACGCTATATTAAACTGCGTACGGGCAAGACGAGAACCCGTAAACAAGTCAGTTCCCACATCCAAGTGCTAGCCCGACGGAAACTGCGTGAAATTCAAGCAAAAATTAAAGTCCAATTTTGGCAACCGGGCCTACAGCCGAGCACCTCACAAGACATAAAGCCGTTCCCTCAGCCACCATATCCAGCTGGTAAACCATCGACAGCGGTATCTGGTGATATTGAAGCTGGTCTACCGGCCGCACAATTGCCATGGGAGGGTAGGGCGATTGCAACGCAAAAATTCCGTTTGCTAGAATTTACGGCATTCATGGAAATCCAAAGAGATGATATGTATAACCGTCACCTATTTGTACAATTGGGCGGCAAGCCATCCTTCTCCGATCCACTTTTAGAGACAGTTGATATACGACAGATATTCGATAAATTTCCGGAAAAATCCGGCGGTCTCAAAGATCTCTATGAAAAAGGTCCGCAAAATGCATTTTATTTGGTTAAATGTTGGGCGGATCTGAATACAGATATAACGACTGGCAGCGAAACGGGGGATTTCTATGGTGTAACAAGCCAATATGAAAGCAATGAGAATATCGAACTTGTCTGCTCGACAATCGTTTGCTCCTTTGGCAAACAGGTGGTGGAGAAGGTGGAAAGTGAATATTCTCGTTTAGAGAACAATCGCTATGTGTATCGCATACAGCGTTCACCGATGTGCGAATATATGATTAATTTCATACAAAAGCTGAAGAATTTACCTGAACGCTATATGATGAACAGTGTACTCGAGAACTTTACAATACTGCAATATTCAAATGCTGAAAGTTCTGCTCTAAATCTAAGCGGTGGTCGTGAAGATGGAACACCAGATGATGTTGATACTTCTGTCCAGGAGTTCCGCATGTTAAGACATGTCAATGTGGCGGCTGCCATGGCTGTGGTGGTCAATGCCGCTGCCACAGTTGGCACTGAAACCACTGAGGCTAGGGATACATAA
- Protein Sequence
- MKNITSSSTCSTGLLQLQNNLSSSELDVVGKPETTAVGPGTIPSPWTPVNAGPPGPLGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYAIAVSMPMSIPMSVSVSVSVSVSCTIMLFRAFSVFCIYERSQFLIQEGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQFWQPGLQPSTSQDIKPFPQPPYPAGKPSTAVSGDIEAGLPAAQLPWEGRAIATQKFRLLEFTAFMEIQRDDMYNRHLFVQLGGKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTDITTGSETGDFYGVTSQYESNENIELVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQYSNAESSALNLSGGREDGTPDDVDTSVQEFRMLRHVNVAAAMAVVVNAAATVGTETTEARDT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00594505;
- 90% Identity
- -
- 80% Identity
- -