Basic Information

Insect: Drosophila sordidula
Gene Symbol: zfh1
Assembly: GCA_035047465.1
Location: JAWNPQ010000163.1:4795250-4796419[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00022 0.014 15.7 0.2 1 21 195 215 195 216 0.97

2 6 8.8e-06 0.00057 20.1 0.8 2 23 230 251 230 251 0.98

3 6 0.00092 0.059 13.8 2.1 1 23 257 279 257 279 0.98

4 6 3.7 2.4e+02 2.4 1.0 1 11 306 316 306 318 0.92

5 6 0.091 5.9 7.5 0.2 1 21 328 348 328 349 0.93

6 6 0.0012 0.081 13.3 0.5 1 20 356 375 356 375 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00022	0.014	15.7	0.2	1	21	195	215	195	216	0.97
2	6	8.8e-06	0.00057	20.1	0.8	2	23	230	251	230	251	0.98
3	6	0.00092	0.059	13.8	2.1	1	23	257	279	257	279	0.98
4	6	3.7	2.4e+02	2.4	1.0	1	11	306	316	306	318	0.92
5	6	0.091	5.9	7.5	0.2	1	21	328	348	328	349	0.93
6	6	0.0012	0.081	13.3	0.5	1	20	356	375	356	375	0.96

Sequence Information

Coding Sequence: ATGAATTCGAAACGCATGAAATACACAACGCTGTCGAGTCCAACGGACGCGCCGTCCAAGGAGGAAATTGTGCCCGTTATCATACAGCACGATGGGGAGGATGTGGACGGCAGCGGGGAGTCGACACAATATACGTACGCGTACACCACCAACGAGGACGACGACACCGAAACGGCCGTGGTGACGCTCAACGATCGCGACCACGAGGCGCTGGCCAATGCCCAGGAGGTGATCATCGATGAGGACGGGCATGCGGTTACGCTGCAGCAGTTGGTCGAGAACAGCACCGTTGAGGAGGTGGAGACCATTGAGCAGGGCGATGGCACACACACCATCCTTCACATTGTGCCCAACATGGGTGGTGAGGACGAGGAAGATGATgaggaggatgaggatgaggacaACGACAATgtcgacgacaacgacgaggAGGCTATCGAACATGATGAGGACGAGATTGTTGGCGTCGAGCACGAGGAGGGCGAGGAGCCAGACGACGAAGATGACGAGATGGGTTCCATCGTATTTGAGGGCACCATCGATCACAGTCCCGAATCGGACTCGCAGTCGCGCAACAAAACCTTCTACTGTCCCAATTGCGGCAACTGCTACAGCGCCGCCGGCTCACTGAAGCTGCACATGCGCGCCTGCCTGCGACAGCGCAACGAGGTCTCCGCCGAGGATCGCAAGTGCAAGGTGTGCAGCAAGGTGTTCAATTCGGTTGCCTACCTCAAGGAGCACATGATGCGTCACACCGGCGAACAGCCGTTCCGCTGCACGCGCTGCTATCGCAAGTTCGTCGATGAGGCCAAATACAACACGCACATGGACTCGCACAAGCACCAGGACAAGCTGGAGGCCGAGGCCGAAGCGCTGGCCGCCCAACACGGCGGCAAGAAGGTGGTCGTCAAGGAGTTCACCTGCTCGTTCTGCTCGCAGAACTTTACCGTCGTCTTCGATGTTGGGCAGGTGAAACGGCGTTACGCCTGCGATACGTGCCGCGACAAATACTCCAATGCGGAGGCGCTGCGCCAGCACAAACAACAGGTGGAGGAGAAGCGCGAGTTTAGCTGCGAACGCTGCGGCCGCAAGTTCGTCTTCGAGGGCTTCCTGCAGCGCCATCTGCCAACCTGCGATGGCAGCATCAAGCGTCGCCGTGACATGAAGTAG
Protein Sequence: MNSKRMKYTTLSSPTDAPSKEEIVPVIIQHDGEDVDGSGESTQYTYAYTTNEDDDTETAVVTLNDRDHEALANAQEVIIDEDGHAVTLQQLVENSTVEEVETIEQGDGTHTILHIVPNMGGEDEEDDEEDEDEDNDNVDDNDEEAIEHDEDEIVGVEHEEGEEPDDEDDEMGSIVFEGTIDHSPESDSQSRNKTFYCPNCGNCYSAAGSLKLHMRACLRQRNEVSAEDRKCKVCSKVFNSVAYLKEHMMRHTGEQPFRCTRCYRKFVDEAKYNTHMDSHKHQDKLEAEAEALAAQHGGKKVVVKEFTCSFCSQNFTVVFDVGQVKRRYACDTCRDKYSNAEALRQHKQQVEEKREFSCERCGRKFVFEGFLQRHLPTCDGSIKRRRDMK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01549855;
90% Identity: iTF_00510850;
80% Identity: -