Basic Information

Insect: Drosophila sordidula
Gene Symbol: lz_1
Assembly: GCA_035047465.1
Location: JAWNPQ010000163.1:9771974-9792218[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.1 3.7e+03 -2.6 0.6 49 84 141 174 137 180 0.65

2 3 1.7e-70 5.7e-67 223.1 0.0 5 129 185 309 181 309 0.98

3 3 2.7 9.2e+03 -3.9 0.0 27 60 334 368 331 375 0.66

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.1	3.7e+03	-2.6	0.6	49	84	141	174	137	180	0.65
2	3	1.7e-70	5.7e-67	223.1	0.0	5	129	185	309	181	309	0.98
3	3	2.7	9.2e+03	-3.9	0.0	27	60	334	368	331	375	0.66

Sequence Information

Coding Sequence: ATGCATTTGCATCTAACCAGCGAAGCGGccgcgacagcagcaacagcaacagctacagcatCGACGCCGGCAAGCGTAgtgagcagcggcaacagcactTTCTACACGGGCTCGACGGCGACAGGCGAAGGAGTCGTCTCAGCTGTGACACCCGCCAGCGACGCCGGCCGTCTGGGgcgcagcatcagcagcagcggcagcggcagcggcagcggcaacgccaacggcggcggcagcaatcGCAGCATGGTCACATCGTCGGCCTCGCCAACGGGAACGGGCTGGTCAGCGCCGGCCGATTACAAGAACGCTACAACAGCTGTCACGGCTGCCGCagtggcggcggctgcggtCATGTGCGAGGTGCTCCCTTCGAGCAGCGCCAGTGTGGGCAGCAGCTCGCCGACAGGTGGCGCCAGCAACGGTACTGCCAATAGTGGGcacagtggcagcaacaagaacaatagcagcagcaacaacaacaacagcagcaataacaataatgcaGTGCATCAGGATCTGTTGTGGATGGAGCGATTTGTGCTGGAGAGACAGCAGGAGTATCCAGGAGAATTGGTGCGTACAAGCAATCCGTACTTTTTGTGCTCCGCCCTCCCCTCGCACTGGCGGTCGAATAAAACCCTGCCGCTGGCCTTCAAAGTTGTCGCCCTGGCGGACGTCGGCGATGGCACCTATGTGACCATCCGAGCGGGAAATGATGAGAACTGCTGCGCCGAGCTGCGAAACTATACCGCCCAAATGAAGAACGGTGTGGCCAAGTTTAACGATCTGCGCTTCGTGGGACGTAGTGGTCGAGGAAAGAGCTTCACGCTAACAATTACCGTTGCGACAAGCCCGCCACAAGTGGCCACCTATGCCAAAGCCATCAAAGTGACCGTCGACGGTCCAAGGGAGCCGCGCTCAAAGACGAGCCCTTCCGGCGGACCACAATATCGAGCTCTGGGCCTGGGCCAGCGACCATTCATCGATGGTTTCCCGAAAACTTTCCACGAGCTGGAAACGCTGCGTCGCTCCGCGAAGGTTGCGGCAGCCACGacggcagcggccgccgctgcggtATCGGTTGCATCGGCAGGCAACACGCTAACCACAAACGCTAGTATTGCCCAGCAATTGGGTAGCAATTACTCATCGTCGAATAGTACAATAAATTCGGATTGCCAGGGCTACAAGCCCAATGCGCCGCAAATTCAAGAGACCGATCTGATAGGCGCAGCTGAATGGACGGGCTCGGCTAGCTCCGGCGCCAACGTCGCCTACCCGGTGggcgtgggtgtgggtgtgggcgtgggtgTTCCCTATCATGCGCACCACAGTCACAcccactcgcactcgcactcgcatgGCCACGCGACGCACCACCACCACGCGCACCACCTACAGCACCAAGTGGCGctcccgccgccgccgccaccgccagcCGCAGCGCCGGTCCCGGTGCCGGTAGCGAACGCATCGGCCATGAATCACTACAGCAGCGCCATGGGTGGCTATGATACGACGACGCTCGACGCGGGCAACTATCATATATCGACGGTTCTGCCCGACATGCACGGCTTTTCGGCCGATCCGTATCAAACGGCCGCCGCAAGCGGCTACTGCGGCGCCAGCTCCAAGTCCGACCTGGAATCGTTGAACGCCAGCTATGGAGCCGCCTACAACAATGCGGCGGCGTGGTCGAATGGCTACAATAACTACCAGTATGGTAGCTGTTCGGCGACGGCAGCACAGTATGGCGGAGCTGGTGGCCATGGAACGGCGCCACCACCTCCAGTGGTACTGTATCCACAGCTCTATTCGACCGTTAACCAGAACCAGATACATCTGCATCTTCATAGCAGCGAAAAGCTGGAACAGTACCTGGCCACAGATCAGCAGTTGACAATCAGCTCACTTGGCGGTAATCGTTCCAGCATTGAGATTGGATTAGGAAcgggcggcggcaacggcaacggtgTCGGCGGCGGTGTCAGCGGCGGCGTCGCCCTGGgtgagcaggagcagcagacGGCAGTGGCCATTGCCGAGCAGGCCGCAGAGGGTGCTGCTCAGAACTATCACTTGCATCAccatcaccaccaccacgaggcgcagcggcagctggaggcacagcagcagcagcagcagcagcagcagctgcagagcgACGTCAGCAACGAGGCGGCACGGGAGGAGGACGTTGGCGATATGACGCAGGTCTGGCGACCCTATTGA
Protein Sequence: MHLHLTSEAAATAATATATASTPASVVSSGNSTFYTGSTATGEGVVSAVTPASDAGRLGRSISSSGSGSGSGNANGGGSNRSMVTSSASPTGTGWSAPADYKNATTAVTAAAVAAAAVMCEVLPSSSASVGSSSPTGGASNGTANSGHSGSNKNNSSSNNNNSSNNNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPSGGPQYRALGLGQRPFIDGFPKTFHELETLRRSAKVAAATTAAAAAAVSVASAGNTLTTNASIAQQLGSNYSSSNSTINSDCQGYKPNAPQIQETDLIGAAEWTGSASSGANVAYPVGVGVGVGVGVPYHAHHSHTHSHSHSHGHATHHHHAHHLQHQVALPPPPPPPAAAPVPVPVANASAMNHYSSAMGGYDTTTLDAGNYHISTVLPDMHGFSADPYQTAAASGYCGASSKSDLESLNASYGAAYNNAAAWSNGYNNYQYGSCSATAAQYGGAGGHGTAPPPPVVLYPQLYSTVNQNQIHLHLHSSEKLEQYLATDQQLTISSLGGNRSSIEIGLGTGGGNGNGVGGGVSGGVALGEQEQQTAVAIAEQAAEGAAQNYHLHHHHHHHEAQRQLEAQQQQQQQQQLQSDVSNEAAREEDVGDMTQVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00538009;
90% Identity: iTF_00541552;
80% Identity: -