Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:17151281-17169425[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00068 0.042 14.0 0.6 2 23 241 263 240 263 0.94

2 9 0.011 0.67 10.2 4.6 2 23 377 399 377 399 0.91

3 9 0.0053 0.33 11.1 2.3 3 23 474 495 472 495 0.94

4 9 0.012 0.72 10.1 0.4 2 23 729 751 728 751 0.96

5 9 0.0011 0.069 13.3 0.5 2 23 801 823 800 823 0.92

6 9 0.0084 0.51 10.5 3.6 2 23 874 896 873 896 0.96

7 9 0.082 5 7.4 4.2 2 23 910 932 909 932 0.92

8 9 0.0017 0.1 12.7 0.7 2 23 993 1015 993 1015 0.95

9 9 0.033 2 8.7 0.6 1 23 1109 1131 1109 1131 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00068	0.042	14.0	0.6	2	23	241	263	240	263	0.94
2	9	0.011	0.67	10.2	4.6	2	23	377	399	377	399	0.91
3	9	0.0053	0.33	11.1	2.3	3	23	474	495	472	495	0.94
4	9	0.012	0.72	10.1	0.4	2	23	729	751	728	751	0.96
5	9	0.0011	0.069	13.3	0.5	2	23	801	823	800	823	0.92
6	9	0.0084	0.51	10.5	3.6	2	23	874	896	873	896	0.96
7	9	0.082	5	7.4	4.2	2	23	910	932	909	932	0.92
8	9	0.0017	0.1	12.7	0.7	2	23	993	1015	993	1015	0.95
9	9	0.033	2	8.7	0.6	1	23	1109	1131	1109	1131	0.99

Sequence Information

Coding Sequence: ATGGCTGCATCCATATATGCCACCCCACCGCCAGATCTGAGCAGCGAGGACACTGCTCTCTCCGACGTCTCCAACTCATCGACACTCAACACGAACAGGAACAACCacaccagcggcagcaacagcaacaatccACATGAAGCCGCAGGAGCAACACCCACAGCCACGTCAGCCACAACCAGAGGAGCaacaggagctggaggagtgGAAAGCACTTCACCCGCCGACCATTTGGTGCCGGCAATGGAGCTGGAACTGGAGCCGAAGCCAGCGGGAAGCGGAACCAATGAGGCGGACCAATTGGAGGAGGCAGAGGATGGACGCaaggatgtggatgcggaggaggaggtgggcGATGCCAACATGGCCACCATGGCGGCAGCCATGCAGCTGCAGATCCTGGAGGCCCTAAGTGATGCGGCCAAGAAGCGACGCAAGCAGCACAATCCCAGCCGCTTGGAGGCGCTCAATTTGAGTGGGGAACCCACTGGTGAAGTGGGTCAAAAGAAAGCAGACTCCTCCACCGTGGACTACGAGGAGAAGTTGTCGAAGATGTTCCTTCCCAAGTCGATTGAGCAGCTAAAGGAGACCTTCGaaatgctgcagcagcaaaagcaagaGGAGGAGCAACCGGAAGCGGGAGAGGAAAtggaagcggaaacggaagccaTGGCAGACATATCAGAATCCAGCAAGCACCGCGAGAATCCATACCACACTTACTGCAAGCAGTGCGGCGAGAGTTTCGAGACCGAGTTCAAGTTGAGCCTGCACATGTTGCAGGATCACGGCGAGGAAAGGTCCGGTGATCAGGATCCCGCTGACTTTCTGGCCTCCATCAAGGTGAAGCTGGAGCGTGCCGACATTCCCAGTCCGCAACAGGAGCAGAATATGCAGCACGACCTTACCAATGGTCATGGCAAGGACTTGGaacgggagcaggagcactgGTTCCAGGCCATGCAGGCGCAGCACCATCCACATGGTCCACAAATGCCACCTGCTTTTCCCTTTCCACCGGAGGCAGCCTTGGGACCAGCTGGCTACCTGCCTCTGCTCGGTATGTCCGGGTTTCCAGGAGTGGATGGTCTCAACCGCCCTCCATTGAGGATCTTCAATCCCGAGGCCTACTGTGAGCTGTGCAACAAGGAGTTCTGCAACAAGTACTTCCTCAAGACGCACAAGGCCAACAAGCACGGCATCTTTGATCCCGTTGGCGAATCGAGCTCCAACAACACCTCCAGTCaccacaataacaacaacaataacatcaCCAGTAGTAACAACAATACCAGTGGTCACCCCAATCCCAGTATGAGTTCCATGAGTCAAATGTTCCAGCTACAAAGGGAGGCTCAGGTGCCGAAACAGGATCCCACACCAGCCGGCGGAGCTTCGAATCCCGTGGCCTCGGTGCACTGCGACATCTGTTCCAAGCGTTTCACTAACATATTCGCCATGCGTCGCCATCGGGCCAAGCAGCACGAGACACAACCAGCTGCCCAAGTTTCACCCAACTCCCAGACACCCatgcaatcgcaatcgcatcGGGGAAGTCCCAACGAGCCATCGCATCCAACTATAAAGCAGGAAATGTCACAGGATGCGGAGATCAAGCCCTATCAGTTGCCCGAAGGTTTCCGCGAGGACTTCACaatggagcaggaggagctgagCTTTGTGCCACCACCCCGGAAGTTGCCCTCCCATCTGCAGCAACAGGCGAAGGATTCCAACTTCAATCCTGACAAGCTACGTCGCCTGGGCGTTCAGTTTCCCGACTTTTTCTGCGAGCTGTGCTGCCGGGAGTACGCCAATCGATACTTCCTACGCACTCACAAGTGGAAGCGCCACGGTCTGTTTGTGCCACCCGAAGACGTGGCACCACAGCCAGGCAGCAAGGATGAAGCCCAGATGGCCAGTGCTTGGCCCTTCATGCCACTCAATCTGATGCTGGccaaggcagcagcagccaccatggatcagcaggagcaggagcgcgagcaggaagcggaaacggatTCAGAGCAGCCCAGTAAGAGGATCAAGTTGGAACAGGGACAGACACCGCCGGAGGGATACGATGAGGATAAGCTGAATGGTTCGGTGGTGGGCTTGCAGAATCTTCAGAAGCTGCAGTCCATGTTGCAGCAACTGAACGACATCAATGGCAAGCGCCCGCTACCCTGTCATCTTtgtggccaggagcaggagaatCAGTATACTTTGAGGGCTCACTTGATGACCGAACATGCTGGCCAGATGCAACTGCCCATGCCCATACCGATTCCACTGCCCGACCAGCAGGCCCCACATCCCATGGCAAGTTTATATCATGCCCAGGGAAATCCGCAAACTCCGCCGGCGCCAGGAGCCAGATCCCCGCCAGGTTGTGATCTGCGGTGCCAGCAGTGCGATCGTGATTTCTCCACAACCCAGGAATTCAAGCAACATATCGCCGAGGTGCACTTGGGCAGAAACGGAGGCCTGAGCGGAAGTCCCCTGCGCGAGGGTTTCTTCACACCCGAACGCCCAGTGGCGCCGTCAGCGGGCGGACCCGGAACCCCAGCCGCTCCGGCTGCAAATCGTCCACCTTATACCCTAACACCCACGAGCAGCTACTGTGAGATTTGCAACAAGGAGCTGTGCAACAAATACTTCATGAAGACGCACATGCAGCGGATGCACGGCATCGAGATCGAGAATGGCGCCCAGATTGGTGGCGTGGTGTGCAACATATGCAACAAGGAGCTGTGCAGCAAGTACTTCCTGCGGGTGCACAAACACAACACCCATGGCATCATCGAGGAGGGCTCCCCACTGCCACAGCCGAGGGGTCAGAATGGAGTCAAAGCCGATGCAGCCGCCGCCGTAGCAGCATCACAGCCATCGCAAGCACAGCAGGATCAGGACCTCAATGTCTCACCAACCACTGTGGAGGGGAGTGGCGGCAGCTCATCCAACTCGGCCCATGAGGTGTGCCCACTCTGCTCTCGCCAATTCCGCAGCTTCAAGTGGCTGCGATCCCATCTGATGAACGAACACGGAACCGCCGGAGTGGAACGCCTCCGGGAAATGGACACCACCCAGTCCTCGACGCGCAGCAAGCCGAACAGTCCCACGCTCAAGATTCCCAACGGAAGTGGCAGTAACCCAGGAGCAGCGGGTGCCGGAGCCGGAAATACCGCTCCCAATCTCGCCCAGGCCCTGCAAAATCTCAATGCCCAGCATCtctttggccaaatgcaacagcagcagatgccCAAGATGCCACCACTTCCCTTGCCCGGAATGTTTGGCGAGCAGGCGGCCAGGTTCAAGGAGTACCAGTGCTCACTGTGTCCCTTCAGCACGCCCTACTACGCCTTCTTGTTCATCCATGAGCGATCGCATGCTCTGCTCAACAACGGAGGTGAGGGCATGGAGTTGCCCATGGAGACGCCACCACCACAACCCTCCAGAAGTTCGGGTAAATCACGCAGTAAATCCAGCAAATCGTTGGTGGCACCTCCTCCTAATAAATCCGAAGAAACAGAGCCTCCACTGGAGCCCACCAATCTCAGCACCTCAGCGCCCAAGGTGGCATCTCGTTCCCCCTCAACTGGGGCTGGATCTCCTCCCGCCTCCTCCCCCAAGGCAACCAGCTCAACTTCACCCAAGATTCAACGTCGTCGATCCACTTCCAAGCCCCCAACGACGCCAAATGGATTGGGCAGTGCAACTGGTGGCCACCGATCGGCGGCCACCTCGCCCTTCGAGGGCTGCGGGGAATTGGCCAACGGCATTGGCAAGCCGGCCAGCTATGCCCAACCCGATGGGGCAGAGGAAGCATATCAGATGCAGGCCTTCCACCTGCAGCCCGCCGACCAGGACTCCAAAATGCAGTTCGCACCTGCCCTGGTCTACCTGCCCGTCCGCGTCCGGGCCTCGGAGTCGGCCACGCTCAGCTTCCGGCTCACACCGGCCTAA
Protein Sequence: MAASIYATPPPDLSSEDTALSDVSNSSTLNTNRNNHTSGSNSNNPHEAAGATPTATSATTRGATGAGGVESTSPADHLVPAMELELEPKPAGSGTNEADQLEEAEDGRKDVDAEEEVGDANMATMAAAMQLQILEALSDAAKKRRKQHNPSRLEALNLSGEPTGEVGQKKADSSTVDYEEKLSKMFLPKSIEQLKETFEMLQQQKQEEEQPEAGEEMEAETEAMADISESSKHRENPYHTYCKQCGESFETEFKLSLHMLQDHGEERSGDQDPADFLASIKVKLERADIPSPQQEQNMQHDLTNGHGKDLEREQEHWFQAMQAQHHPHGPQMPPAFPFPPEAALGPAGYLPLLGMSGFPGVDGLNRPPLRIFNPEAYCELCNKEFCNKYFLKTHKANKHGIFDPVGESSSNNTSSHHNNNNNNITSSNNNTSGHPNPSMSSMSQMFQLQREAQVPKQDPTPAGGASNPVASVHCDICSKRFTNIFAMRRHRAKQHETQPAAQVSPNSQTPMQSQSHRGSPNEPSHPTIKQEMSQDAEIKPYQLPEGFREDFTMEQEELSFVPPPRKLPSHLQQQAKDSNFNPDKLRRLGVQFPDFFCELCCREYANRYFLRTHKWKRHGLFVPPEDVAPQPGSKDEAQMASAWPFMPLNLMLAKAAAATMDQQEQEREQEAETDSEQPSKRIKLEQGQTPPEGYDEDKLNGSVVGLQNLQKLQSMLQQLNDINGKRPLPCHLCGQEQENQYTLRAHLMTEHAGQMQLPMPIPIPLPDQQAPHPMASLYHAQGNPQTPPAPGARSPPGCDLRCQQCDRDFSTTQEFKQHIAEVHLGRNGGLSGSPLREGFFTPERPVAPSAGGPGTPAAPAANRPPYTLTPTSSYCEICNKELCNKYFMKTHMQRMHGIEIENGAQIGGVVCNICNKELCSKYFLRVHKHNTHGIIEEGSPLPQPRGQNGVKADAAAAVAASQPSQAQQDQDLNVSPTTVEGSGGSSSNSAHEVCPLCSRQFRSFKWLRSHLMNEHGTAGVERLREMDTTQSSTRSKPNSPTLKIPNGSGSNPGAAGAGAGNTAPNLAQALQNLNAQHLFGQMQQQQMPKMPPLPLPGMFGEQAARFKEYQCSLCPFSTPYYAFLFIHERSHALLNNGGEGMELPMETPPPQPSRSSGKSRSKSSKSLVAPPPNKSEETEPPLEPTNLSTSAPKVASRSPSTGAGSPPASSPKATSSTSPKIQRRRSTSKPPTTPNGLGSATGGHRSAATSPFEGCGELANGIGKPASYAQPDGAEEAYQMQAFHLQPADQDSKMQFAPALVYLPVRVRASESATLSFRLTPA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00512293;
90% Identity: iTF_00504958;
80% Identity: -