Basic Information

Insect: Drosophila simulans
Gene Symbol: zfh1
Assembly: GCA_016746395.1
Location: NC:17664108-17668347[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0011 0.066 13.3 0.2 5 23 132 151 131 151 0.96

2 8 0.67 41 4.5 4.1 3 23 159 179 157 179 0.95

3 8 2.8e-05 0.0017 18.3 2.0 1 23 187 209 187 209 0.98

4 8 0.051 3.2 8.1 1.8 8 23 220 235 215 235 0.85

5 8 3.5e-07 2.2e-05 24.3 1.3 1 23 241 264 241 264 0.91

6 8 3.7e-05 0.0023 17.9 3.0 3 23 272 292 270 292 0.96

7 8 0.66 41 4.6 0.1 7 23 297 313 297 313 0.95

8 8 1.3e-06 7.7e-05 22.6 2.2 1 23 319 341 319 341 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0011	0.066	13.3	0.2	5	23	132	151	131	151	0.96
2	8	0.67	41	4.5	4.1	3	23	159	179	157	179	0.95
3	8	2.8e-05	0.0017	18.3	2.0	1	23	187	209	187	209	0.98
4	8	0.051	3.2	8.1	1.8	8	23	220	235	215	235	0.85
5	8	3.5e-07	2.2e-05	24.3	1.3	1	23	241	264	241	264	0.91
6	8	3.7e-05	0.0023	17.9	3.0	3	23	272	292	270	292	0.96
7	8	0.66	41	4.6	0.1	7	23	297	313	297	313	0.95
8	8	1.3e-06	7.7e-05	22.6	2.2	1	23	319	341	319	341	0.97

Sequence Information

Coding Sequence: ATGTCGCAACCATCTGGTGAATTCCGTTGCCGAGTTTGCCTTAAACAGGATGAACTCCTGGTGGATATTTATGAGATCGTAGAAGAGATGCAGGTAGACCTGTGCACCTTGTTGGAAACGTGTGGCGGCATAAAGGTAGACCGCAGAGATGTGCAGCCAATGTATTTATGCCAGGAGTGCACCAACGAGCTTCTCATCGCCGCAAAGTTTCGCAAAAAGTGCGAGGAGTCGGAGAAGTTGCGCGATATGGCTCGCGAGATGAGCATGGACACGGCAGAACGCCTAGCTTCGGaggaaataattattattgatcCCAGCGACTATATTGAACAGCTCTCCGCTGTGGAGGATCCCGAAAATGAACCTATTGGAGTTTCACGCTGGAACTGGCAGCATTGTGGCGCTGGTTTCCAGCAATCGGAAGCACTGCGTCGGCACATCCAAAAAGTCCATGCTTCAATAACTATTATTGACTGTAGGGATTGCAGGCGGATCTTTACGAAAGTGGGTTGCTACCAGGTCCACAATTGCTCTCATGCCAAGTCACTCAAACGTAAGCACAAGTGCCTGGAGTGCGGTAAGTGCCTTCAATCCGCCTCTAGTCTGGCAAGCCACATTCGCCTGCACACCGACGAAACGGCCTTCACCTGCGATCAGTGCGCCTTCAGGACCAATGGAGCATTGGAGACTCATCTGAGGCGCCACAAGCAGGTCATGCAGCACAAGTGTCCGCACTGCGGACGTGGATTTGTAGAATCCAGCAACTTGCGACGCCATATAGTTGCCAGGCACCCGGAGGAACGTCCGCATCTTTGCAACTTCTGTCAGCGCAGTTTCTCCAGGGTCTACATGCTGGAGCTGCATCTTCGTACACACACTGGCGAACAAGACAAACGTTTTGCCCAGCTGGGAGTCCTCAAGAGTCACGAGCGGATCCATACCGGTGAACGCCTGCACCGCTGCCAAGTGTGCGAAAAAACTTTTACGCGGGCGGGACAGCTCCGAAAGCACGCGTTGCGTCATGAAACCGAGCAGTGA
Protein Sequence: MSQPSGEFRCRVCLKQDELLVDIYEIVEEMQVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAKFRKKCEESEKLRDMAREMSMDTAERLASEEIIIIDPSDYIEQLSAVEDPENEPIGVSRWNWQHCGAGFQQSEALRRHIQKVHASITIIDCRDCRRIFTKVGCYQVHNCSHAKSLKRKHKCLECGKCLQSASSLASHIRLHTDETAFTCDQCAFRTNGALETHLRRHKQVMQHKCPHCGRGFVESSNLRRHIVARHPEERPHLCNFCQRSFSRVYMLELHLRTHTGEQDKRFAQLGVLKSHERIHTGERLHRCQVCEKTFTRAGQLRKHALRHETEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00619310; iTF_00607912; iTF_00591856; iTF_00592560; iTF_00504858; iTF_00539898;
90% Identity: iTF_00539898;
80% Identity: -