Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:8217786-8224116[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0012 0.074 13.2 0.4 1 23 140 162 140 162 0.97

2 14 5.2e-05 0.0032 17.5 3.0 1 23 367 389 367 389 0.98

3 14 1.5 91 3.5 1.7 1 23 395 418 395 419 0.91

4 14 0.049 3 8.1 0.8 1 23 440 463 440 463 0.96

5 14 0.00099 0.061 13.5 1.9 3 23 729 749 728 749 0.92

6 14 0.04 2.4 8.4 1.4 1 23 755 778 755 778 0.98

7 14 0.53 32 4.9 2.1 2 23 815 836 814 837 0.93

8 14 0.0083 0.51 10.5 0.7 1 23 858 881 858 881 0.97

9 14 0.019 1.1 9.4 0.8 1 23 1086 1109 1086 1109 0.92

10 14 0.0013 0.082 13.0 4.1 1 23 1121 1143 1121 1143 0.98

11 14 0.0016 0.098 12.8 1.4 2 23 1149 1171 1148 1171 0.94

12 14 0.0015 0.093 12.9 3.9 2 23 1178 1202 1177 1202 0.93

13 14 0.00068 0.042 14.0 0.7 1 23 1207 1229 1207 1229 0.98

14 14 0.008 0.49 10.6 0.3 1 23 1235 1258 1235 1258 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0012	0.074	13.2	0.4	1	23	140	162	140	162	0.97
2	14	5.2e-05	0.0032	17.5	3.0	1	23	367	389	367	389	0.98
3	14	1.5	91	3.5	1.7	1	23	395	418	395	419	0.91
4	14	0.049	3	8.1	0.8	1	23	440	463	440	463	0.96
5	14	0.00099	0.061	13.5	1.9	3	23	729	749	728	749	0.92
6	14	0.04	2.4	8.4	1.4	1	23	755	778	755	778	0.98
7	14	0.53	32	4.9	2.1	2	23	815	836	814	837	0.93
8	14	0.0083	0.51	10.5	0.7	1	23	858	881	858	881	0.97
9	14	0.019	1.1	9.4	0.8	1	23	1086	1109	1086	1109	0.92
10	14	0.0013	0.082	13.0	4.1	1	23	1121	1143	1121	1143	0.98
11	14	0.0016	0.098	12.8	1.4	2	23	1149	1171	1148	1171	0.94
12	14	0.0015	0.093	12.9	3.9	2	23	1178	1202	1177	1202	0.93
13	14	0.00068	0.042	14.0	0.7	1	23	1207	1229	1207	1229	0.98
14	14	0.008	0.49	10.6	0.3	1	23	1235	1258	1235	1258	0.92

Sequence Information

Coding Sequence: ATGGCGCTGAACAAAAGGAAGAGCCCGTACTCGGACCCAATTTCGGGCGCCGAAGTGGACTACAAGTTGTCTTGTCGCTGTTGCTTGAAGACGAACGTGGAGTACGTCAAACTGGACTCGGTGTCGGTGGCGCGTAGTCTGGACCCGGCGGACGCCACTGAGAAGATACCGCTCCTTCGCTGCCTGCTCTTCTGCGTGAGCGCCGATAATGCGCCGGAGCTGCCGCAGCACATCTGCATCGAGTGCAGCAAGAGCCTGCAGATTGCTTACTACTTCCTTCAGAATGCGCTGCGTGCCCACGAGATCCTGTGCCGGAAACTGTGTCCCAAGGTCACAAGGAGACTGAATGGCACTATCGCTCACGAACTGGAAAAGCCAGCGTCTGCAGAGCCGGCACAGCCCCTAAAGACCATGCGGCACGAGTGTCAGGTCTGCGGAGTAGTGGTCTACAATCGCCTGGAGCTCAAGCAGCACATACGCCAGCATGCAGAGGGTCTTTCGTACAACTGCAAGTTGTGCAGCTTCACGTCGTTGAAGCAACGCGTTTTGTTTGAGCACTATGTGACCATGCACAACATGCCCCTCAGTCAGGCAGAGGAGCACGTAAAATCGAAGCATTTTCCAGCGCCAAAAGAAGAAGAGGTCAAGGCAGTGTGCACGCTTGAGGATATGGAGTTGCTGATACCCACCGTACTTAGGCCGGAAGATTACGTACAGCCGCATCCGAATATTGATAACGACCAACTGCGAGACATTGATCACCAGCTGGCCGTCAGCATGGGTGAACCCTTACCGGCAGTGGACAGCCTCACTTCCACGCTGCCGCCGATGGATACGCCCAATGTTAGCATCGGCACCGAGTACCTTGTCCTTCCCGATGGTTCGCTGCAGCAGGTTAACGGAAGCGGCGTGGTCATCGAGTATATTGACGATAGCAAACCGAATAGTTCCGGCAACGTCAATATAAGTCTACAAAATCTCCTGTCCAGCCATAATGATCCGATGGAAATCGATGTCAACGAATTGATCGTGGAGGAAACGATGCCACAGATAAGAATCAAGCCAAAACCAGCCGTTATCGGAACATCCATTCACAAGCACAAGTGCAAATTGTGtccgaaaacattttccactgtAGCGCGTCTAAAATCTCATCAGTTGACTCACAACACTCTTCCTAAATTCTTCTGCGACCAATGCGACTTTTACTCGTTGCGCAGCGCCGATCTAATACAGCATTACAAGATGGTCCACCATCGGTTCAATGAAAATGGCAAGGCCGGCAAGGAACAGGCGAAAGTTGCAGAGTCTCGTGTCTACTCGTGCGACATGTGCCTGTTCGAGACGTCCACCGTTAGCCAGCTGCGAATCCACTACAAGGAGCGGCACACGGTCCAGCCCACGGAGGTGCAACTGCGTCCCAGTTGGACGGGCGAGTCAACGACAACGAGAGGCGTTGCCGCCAAGCAGCAGACTCCGGCCAAGATATCAAATCACACCGACATCCCGTTGGGCATTAAATATCCGCCTGGTGTTTTGGAAACGCAAGCGTCAGTGCAGCAACCGGTGGTAGATCAACCAATGCCTGACCCAGTGCAGCAAACGGAGCCGATGGCCACTACATCGACGACCATCACCGAATCGGGCGACATCAACGTAGTGGTGGATGCGACGCCGCTCTTCTATGCGGCAACCTCCAACTCCCTGTTAGTGACGAACCCGGCGCCAGTGACAACAGTGGAGGAAACCACCGGCGCGGCGAGCAATCATGCATTTGGAATCTTTCCCGAAATCTCAGAGAGCAATCTGCCCGTGAACGAAGCCGTACCTCAGGCACCAGCCAATACATCTAACATTTCGATGTTTGGCGACATGCAGGACTTCATTGACAACACCGATGTGGCTGCCATATGCACAATTCCCGCGGATGACATGCCCGTTGTGGATGGTGACGACATTGTGATTGATAATAACAATATCAGTCTGGACTTTGATGCCGAGAATTTGTTCGAAGacttcgaggaggaggaggatacTGTGGCCGACGAAGAAGACGAGGCCGACAATGAAGACGAGAATGACAACAATGATGCTGCCACGGATCAGAATCTGCTGCTGACCagcgacgatgatgatgtggACGACTTTGATGATGAGCAATCGAAGCATCTGCAGAAGCCCTACTGCATTTACTGCAATAAGAAGTTTACCAGTCAGTATAAATTCGAGAACCACATGTTCGTTCATCGGGGTCTGGCTCCCTATCGCTGCGAGCTGTGCACCAACCTCTACAACATGAAGCGATTGCTGATCAGGCACTATAAAACTGTGCACAAGCGAATGCCCACGAGGGACATGGTCCAGGCGAAGGGCGATAAGGTTTCCGTAGCCCGCACCAACATCGAAAAACTGTATCCTGGCAGGATAAAGAATCCAATGCTCATGTGCGCAAAGTGTCCGTTTGAATGCGAATCAGATTCGGAGATGCGCAAACATCTGAATGCCCACCATGGAATCAATGACGGAGTGTCCGAGCATGCAAACGAAGTGTTTATTATACGCAAATTACCATTTGAATGCCCGCGCTGCATTCGATCGTTTGCGGCCAAGACCACCCTTAGCCGCCACCTGCAGCGCAGTCATTTGGTAGACACAATTATAGAGATGCAAACGTCGCATTGCGGGGAAGCCAACACGACCACGATGGCCACATCCTCATCGACGATTCCTGGGCCCGTAAACTCGGTCACAGTGGATGGCCAACATAATGAGATGATGCAGACGGATGTTGGGGCGGAAAAGATGACGGAAGCTTTAggcaatggcgatggcaatGAAGAAGCCGGCACAGATGATGGATCAGGAGAAATCGCAGAACCGGCGGTGCCAGAGGAAGAACTAGATCCCGTAACATTGGACGCAGCCACAGCGGTGACTacaacagcaatagcagcagcaatatcagcggcagcagcagcggcagctacTTCGTTAGAATCACCCGTAGCAACCACAGCTTCATCGTCCACCACTCTCTttcccacgcccacacccTTTGATTTTGAATATGACATAATGAGGGACGAAGCCCAGCAATCGTCGCCCAATATCCATGACGTATCCAAAGACCTCAGCGACAATGCCTCATTCAGCAGCCCAATTAATGAAAGCGATAAGCTGCTGTCCACCACTGCCCTGGAAACTTCACCAGCGAAGGGTTTACGCTCCAACAGCCGTCTGCATCGTTCTTCCCTTCACATGTGCAAGCTTTGTAACCAGACATTTGACGAGCTGGGCAAGTTGGTCAAGCATGAAATGGAGCTGCACTCCAATACGGAACGTTCGCGATGGGGCTATCAGCACAAGTGTCCCATCTGCAATACAACCTACCGCACGCTCACGTTGCTCAAGTTCCATATGAAGCGACACAGTAATAGAAAAACACAGTGCAAGCTGTGCCCCAAGACCTGTGTAACCATTGCAGAGCTCGAGCGGCACACGAAGGCCAAGCACAGCAAGGATAAGACGCTTCGGTGCTCTATGGATGGCTGCCGAAAGACTTTTGCCTTCAAACACCATTTGATACGCCATCAGAAGGCCTCTCATCTGAGCACGCGGTATATATGTCCCGTTTGCAATAAGGAGGAAAAGTCCAATGTGCATCTGAAAAATCATATGAGCGTGCACAAAGGTGAGATAACCTACAAGTGTCCCAAGTGTGATCGCTCCTATTTGCGGCGTGGCAGACTCGTAACCCATGTACTCCTAATCCATAACATGCAACTTACCACCGAAGAGTTGGAAAACGTCTCATCCCTGGCTAAGAACAAAGCCAAACCTAACGATCTTAAAGACGCGACGCCCGTGGAGCTCCTGGATGGCCGTAAGGATGCGAGCGGTGCAAGCGAAGAAAATGGGCAGCCCTGA
Protein Sequence: MALNKRKSPYSDPISGAEVDYKLSCRCCLKTNVEYVKLDSVSVARSLDPADATEKIPLLRCLLFCVSADNAPELPQHICIECSKSLQIAYYFLQNALRAHEILCRKLCPKVTRRLNGTIAHELEKPASAEPAQPLKTMRHECQVCGVVVYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRVLFEHYVTMHNMPLSQAEEHVKSKHFPAPKEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPNIDNDQLRDIDHQLAVSMGEPLPAVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVNGSGVVIEYIDDSKPNSSGNVNISLQNLLSSHNDPMEIDVNELIVEETMPQIRIKPKPAVIGTSIHKHKCKLCPKTFSTVARLKSHQLTHNTLPKFFCDQCDFYSLRSADLIQHYKMVHHRFNENGKAGKEQAKVAESRVYSCDMCLFETSTVSQLRIHYKERHTVQPTEVQLRPSWTGESTTTRGVAAKQQTPAKISNHTDIPLGIKYPPGVLETQASVQQPVVDQPMPDPVQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGAASNHAFGIFPEISESNLPVNEAVPQAPANTSNISMFGDMQDFIDNTDVAAICTIPADDMPVVDGDDIVIDNNNISLDFDAENLFEDFEEEEDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPYCIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIRHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTSHCGEANTTTMATSSSTIPGPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEAGTDDGSGEIAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAAAATSLESPVATTASSSTTLFPTPTPFDFEYDIMRDEAQQSSPNIHDVSKDLSDNASFSSPINESDKLLSTTALETSPAKGLRSNSRLHRSSLHMCKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCPICNTTYRTLTLLKFHMKRHSNRKTQCKLCPKTCVTIAELERHTKAKHSKDKTLRCSMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHVLLIHNMQLTTEELENVSSLAKNKAKPNDLKDATPVELLDGRKDASGASEENGQP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00592627;
90% Identity: iTF_00539895;
80% Identity: -