Basic Information

Insect: Drosophila simulans
Gene Symbol: HIVEP2
Assembly: GCA_016746395.1
Location: NC:8486064-8533067[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.00093 0.057 13.5 0.4 1 23 430 452 430 452 0.98

2 8 0.00026 0.016 15.3 2.8 1 21 458 478 458 482 0.89

3 8 0.033 2 8.7 0.1 1 19 1074 1092 1074 1095 0.93

4 8 2.4e-06 0.00015 21.7 2.0 1 23 1783 1805 1783 1805 0.99

5 8 1e-05 0.00063 19.7 5.3 1 23 1811 1835 1811 1835 0.92

6 8 4.7e-05 0.0029 17.6 3.7 2 23 2274 2295 2274 2295 0.97

7 8 0.0007 0.043 13.9 1.2 1 23 2301 2325 2301 2325 0.91

8 8 0.0022 0.14 12.3 2.7 1 23 2346 2370 2346 2370 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.00093	0.057	13.5	0.4	1	23	430	452	430	452	0.98
2	8	0.00026	0.016	15.3	2.8	1	21	458	478	458	482	0.89
3	8	0.033	2	8.7	0.1	1	19	1074	1092	1074	1095	0.93
4	8	2.4e-06	0.00015	21.7	2.0	1	23	1783	1805	1783	1805	0.99
5	8	1e-05	0.00063	19.7	5.3	1	23	1811	1835	1811	1835	0.92
6	8	4.7e-05	0.0029	17.6	3.7	2	23	2274	2295	2274	2295	0.97
7	8	0.0007	0.043	13.9	1.2	1	23	2301	2325	2301	2325	0.91
8	8	0.0022	0.14	12.3	2.7	1	23	2346	2370	2346	2370	0.92

Sequence Information

Coding Sequence: ATGGAAAATGCAACCACCACAACGGCCAAGCATTACAAAACCGCAGGCAAACAGTACAAGACCAATAAAGTGAACAATACGCGACgtgccacagcagcagcggcagcagcagcagcagcagcagcaaccacaacagtaacaacagcagcaacgccAACCAAGAAGCGGACATATCGGgaaactgcaacagcaaccacagtCACTCAGAGATCAACCAACAAGGCCAACATCGCTGCAGCAATTGcattggcagcagcaacagaggcaacagcaccagcatcagcaactgcagcagcaacagatgcaACATTAACAGCCTCtaaagcggcagcaacagcagcagcaacagatgctgctagtggcaacagcaacagcagcagcaaacccAGCACGAGCACACGAGATAAGCTAGGCGAGGTGCCGCTGCCGACTGTTGACAGCAACCAcatcatcagcaacaacaataataataataacaataacaacacaaataataataacaacaacaaccaccacaGTGATAATAGTATTAGTGAGAATAGTTATGAATTTAAGAGTAGAGATAAAGCAAGTCTAAGTGATAGCAAAATGACGCTACAACAGATGGCAGCAGTCAGCAGCAACCAGGAGCCAGTGGCTCCCAATGTGGCCAACACGATGAGCAACTCGagcatcatcagcagccaGCAGACCACCGCAAATGCCACACCCGCCACCGATGAGGCTCCGTTGGGGGATCGGTCAAATATTTCACGCTATCTGCACAAGAAGTTCAAACGTTTGGCCAGCACCACCGAGGTGGACAGCTGGAGTGCGACGAATGGCGGCGGAGCACTGCAAGCAGGTGGCGATGCCGTTCGCACCACATCGCTGTCCTCAAACAGTTCGCTTTCACCGCCACCAACAACGCCGCTGGCCAACGGTCACCATCTGATGACCCAACAGCAAAGCCAccagcaagtgcagcagcaacagtcgcCGCCGCCTTCAGTAGCAATACATGAATTCAGTGCCAATTTTGTAAATAGCAATCATGTCAATGCCATTGGTCATGAGGAGAGCATCATCAGCAATAGTGGCTACAAAGCGGCGGGAAGAACGCGAACGCCTCtagccaacagcaacagcaacacgaacagcaccagcaacagcaaccatgCAGCAAATGCCACACTGTCACCGGCCTCATTTGCCCAGCATCAGCAATTGACGCAGCCAACAACAGTGAGTCCTGGAATTccaggcggagcagcagcgccaAATCCTGCATGCGAGAAGTCCGGACGATACGTTTGTCAGTACTGTAACTTGATCTGTGCCAAGCCCTCGGTGCTGGAGAAGCACATACGGGCCCACACGAACGAACGGCCGTATCCGTGCGAAACGTGCGGCATTGCGTTTAAGACGAAGAGTAATTTGTACAAACATTGCCGCTCGAGATCGCATGCGGCCAGAGCGCGGGGCCTGGAAGTGCCAGCCGACGCCGACGATGGTTTGTCCGATCAGGATGCAGAGCTGAGCAACAGTAGTTCAGAGTTGCCGAGTCGCGCTGGTTCGCCTTACGACGAGCCAATCAATTCGCCCACACCCTCACCTTCCACACTGTCTGCGGCCAAGAGCGCATACATCCAACAGCCTCCGCTACCCACTTACATGCAGCAACTGCCTCTGGGCTCGCCGGCAGCGGGAACATTGCCACCCACCACAGCGGACAATCACCACTCGGCCACTGCCCAGCATCGCCAGTCGATCGACTACAAGCCATATAAGCCCAAGTTCCACAATGCCTCGTTGTACTCATGTAGCAGTAAggagctgcaacagcagcagatacagcagcagcagctgcagatacAGCAGCAGAAACACCAATTGGCGCAGCAAAAGCTGTCCATTCAGCTTCCTCTGGCGCAGCAGCCGTCACTGGCGCATCCCACACTTTCGCCAAGCACGCAGATGAAGATGAAGCACCACATTAACTCGCATCAGATCCAgttgcaaatgcagcagcagcaatcccTGTTGGCCCAGCAATCACTGTTGGCTGCCATGCCACCTGGCGGGGTGTATTACCTGGGGCAACCTCCATACTACAACCAAGATGCAGCGGCTGCCATTCACCAGCATGCGTTAGCCATTCAGCAATTCCAAATCCACctggcacagcagcagcaacaacaacagcagcagcaacagcagcagcaacacccacCGTTGGTCAAGCCGCCACCACCAATGCAACAAGCTCCGAGTCTCCCGCCGCAACAGCTGGTGCGTGCCAATAGCCAGATTTCCAGTGTAGCAACAGCACcagccactcccactcccgcCGCCAATCTCAGCACTTTTGCCAGCTCAAGTGGTGGCAAGCAAGTAAATGTGGCCAAAGTGCAGGAGCACATTTCCAAGTTGATCTCTCAAAATGAAGCCATAGTTGAAAACAAGGAGATATTGCTGCAGAAGAAGTACCCCAAACAGCTTAGTCGTTCCCGCAGTTTCAACAATGCCAACAGCAATAATGCTTCGCAGCACGGGAGCAACGCGTCGGCATTGCATGCAAACAATAGTCACAACAACACCAACGCCCAGATGCCGGAGCGCGAGACTAAAGTGAATTTGGCACAGGCCATCTtccagaaacagcaacagcagcttcagcagcagcagcagataacccagcagcagcagcagcagataacacagcagcagcagcagcagataacccagcagcagcagcagatgcagctcGAGCAACAGAACTACTATACGTACatccaacagcaacaggaatgccaacagcaacagatcGAACCACCAAATGGGGTGGTTAAAAGGAATGCCTATAAGCCCGGAATAGTGATGACTACGCCggtgaagcagcagcagcaacttccgCCACCGCCGTCCCCGTTGCCCATGCAAACATTGCAATATCGCCAGGATCCTGCAACACCAGTGGCAAAAATTGAGCAGCCGACGACGGCAGTGCCTGTTATGCCTCTGAATTTATCAGCGAAGCCTAAACCAACTCTGGTCACTGTGCCCGTCAGTTCCTTGTCCACCAGCTCTCTGGCACCGACTCCAACGACTTCTACCAATTCGACTAGTAGCTCCAAAACTGCTCCACCACCTGCTCAGGTTAATAATTCGATAATTAAGAACCTACTTCTTAATGCTCGAGGATTGGCCGTGCCGATTGGCGAAGGCGATGATGCTGTTTATTCGTGTCCCATCTGTGCAAGCGAATTCCGCAGTGCGGACGATCTGAAGCTGCACAACAGCACTTACTGTCAGGATGCGAGCTCAAGTGCACCAATGAGTCCAGCATCTTCGCCCTTCCGCTCCAACTCGATCTCGTTGAGTCTGCCAGAGCTAAAGAGCCACATGGCCAACTCGAAGAATCCCTTATCTCTGGCCAAGTTGGCCTGGTCGCAACTGAAAACCAAAAGGAGTAGTTTGGTATTAAGTCGCCTAAGTGCAGCACAGACGCCAGCAAGGACATCAACTGTAACAGCTCCCACTGTAACAGCTTCTGCCCCAGCTCCTGCTGTAGCTACGGTCACTGCTCCATCATCAGCACCTGCCCCCCAGATTGAAGCACTGCGCTTTGTGGATGCGCCTCTACCATCGCCTGGGCCATTGTTGGGAAAAACTCCCTTAGTGGACTATGCTCAGCAAAGTGCACCACGCAAGGCCCAGGATTCTGTGGTCATAACCAAAATGCACGAGGATCGGCAATTTGTGATTGAAGCTCAGCCCGCCAAACGCATCAAGACTAGCGATTTGGTTGTGGCATCCTCCTCTCAGCAACCGACAAGTTTCaacttttcttttaataatcaGAATAGCAGTAATAGTGTGCCGGAGTTGCAGTCCTCCAAGGAGGAGCGACTGCGCAGATTCACCTCTTCGGGGGGCAGCATGATACCCATTTCGGAGTGTCCAGACTTGGACAACAGCCCGAAGATGATTAGAACACCGTTGCTGTCCGGCGGAAGCTTCCAGGATGTTTCAGTCAAAGTCAACAACGAAACAGGATCATCCAGTAAGGAGCGCAAGCTGATGGCACTGGTCAGTGGCAGTGGACTTCTCGGCGTTAGCTCAGGTCCGCAGCACTTTCAATTTCCGCCCATTAACTCAATAACTGCCTTCAATCCGCTAACGCTGCCACCGATGAGCGGTGGAGATAAATCCACTCCAGCAACACCAATACCTCATGTGCCTGGAATGCCGGGACCCGGTAGTCTGACACCACAAATGCCGCTACTGCCGCCTCCGCCACAACAGCTGCAGCTACCCATTCCCTCTAGTCGAGGTCGCAGTCCAAATCGAAAGCAACCCAGCCCGCTGCTGTTGGGAGGAGGATCCGGTGAACTGAAGGCCCTGTCGCCATTCGGTGGAGTTCAGAATGTGCCAAGCGAGTTCAGTCGACAGCCACCAACTCCTGCCCAGCGCCAAGCGCTGCAGTGGAACAGCAAGGAGACACCGAAGAAAGCACCATTTAACTTTCTACGCATGGCGGATAATGTGAAGACCACTGAACCTGAAGTACGACACTTTAATCTGGAAAATGTGATTGCTGGGAAACAGCAAGAGTTGCCCCTAACACCACTACATGTTGATACTCCCAACGGAAACGCTCCAGAAGAGACCAGTCCCGTAGCCAGTTCCTCAGCATCGGCGAAGTCCAAGTTTCTGCGCCCTACTAGTTTGCCACTGAAACCCGGTACATTTACTCCTAAACGCCATCATGGCATTACACCGACAGCTAATACATTGCCGCTGATCTCGCCGGAGACACCCAGGCCGTCCAAATCCTGTGTGCAACTGTATCTCAATGGACACGCCTACACATATCTGGGCCTCAAATGCAGCACAAAGATGTTTTACTGTACGGTGAACTGTCCACAGCCTTCGTATGTGGCAGGAATGCACAAACTATCGATGTATAGTGTGTGGCAGGTTTGCGAGGAGAACCAGCCACATCCACTTGGATTCAAACTTAAGCAAGTTATGGCACTCTACGACTCCCGTCAAAGGATGTTAGGAAATGGCAGCTCCACCGCCATGGCTGGATCGGGAAAACTTAGTTACAACTTAGTCGCTTCCCAGCAAATCGTTTCCTCCCCCTCGACATCCTCCACCAGCAGTGCTTTCTATCAAGGACCCCTAAAGACCCCACCCACTGTCACGATTGCCGCTCTCAGTGAGGCAAATGTGGCGGCCAAGGCGAATGAGGAGGCACAGGCCAAAAAGTTGGAGACAAGTCCATCCGGGCAGCCCCTGGTGGGTGGCTACGAGTCTCATGAGGATTACACGTACATCCGTGGCCGAGGAAGGGGAAGATATGTTTGCTCCGAGTGCGGAATTCGTTGCAAGAAGCCGTCGATGCTCAAGAAGCACATTCGCACTCATACGGACGTGAGGCCATTCACTTGCAGCCATTGCAACTTCAGTTTTAAGACCAAGGGAAATCTGACCAAGCATATGCAATCGAAAACTCACTTTAAGAAGTGCATTGAACTGGGAATAAATCCGGGACCAATGCCGCCAGACAGCGAGTTCTTGGATGTAGATATGGACTTTGACCAGCAGTCATCCACTTCGGCAGGTGGACGCACATCGTCGATGGCTGGGGAATCGGATTCCGATGACTACAGTGATAATGAATCTGAAAGCAGTGATACGGATGAGTCCAAGTCGCGACTGAAAGAGCACGAAGCAGCCAGAGGCCTACTCTCGTTATCAATGACGCCGCCCATTCCGCAGAGCGTATCGCCCTATCCGCAGTTGCAGGATACACCCCTACCAGCGGCCAGTCCTGCAAACAGCATTGGCTCTTCGGGCTCGCAACCTAAGAGATTAGTGTGCTCCTTTACATCGCCGAAGCCACCTTTCGACTACCAGAAGCAGGAACAGTATTACTCCAATCCGGAGGAGTCCAAACCGAAAAGGGGTGTGGCCAGCGAGGAGAGTGCTCCCATGGATCTCACTAAGCCGCGCGGCTCCATCTTATCAATTTCCCCCTCGCCTGTTTCGCTGCCCGTCCACGATCTTCCCAAATCGCAGGCCCAACAGATGCACGATGTTATCTTCGGAACCTCCGGCAACGAAAGCGGTTTCATGAAGACTCTGATCTCGGTTTCGGACAAAGTGCGAATATCTGCCGAAATGGAAGAGCAGGCCAAGCACGAGGCAGAGGGCGAGGATGTTCAACTACAGACCTACATTAAGGAGCATGCGCTGCATCAAGCCAAGATAAAGCAGAGTCAGTTTAGCCGCAGCTATCTGATCAACACATTATACACAGCGGCGTCTCCTGTAATGAGCAGTACTAGCACTCTCTTTACCGCCAACAGCAGGCCCGTTATGAGCGTAAATGAGGTACCTAGCATCGAAGTGCACGAAGTAAAGACTCCCGAAGCCATTGAGGCACCTCGTAGTGCACCTGAACTGGCTCCGGTTATTCTTGCTCAGATTGCCCAGGAAGAAAACGAGGAGCCTAATATCGCAGAGCCACACAATGCCAATCTGCctgctgcagtgcagcaacCGGATGTCAATGATTTTACTGGAGTACTTGGAAATCCGACTGCACCACCAACAGCGTCTGTGGCTGCTACTTCAgtaaccacaacaacagctgcaTCTGTGGCACCCTCATCCACTGCCAACTCAACTCAGCCCGCCCAGCGTACTGTGATTGTGGGCGAAGATGGCTTCAAAAGCTCTACTCCCACTAGCAAGAGCGGCGATCTCCAGCATGTATCGTATGGCAGAGGAGTGCCGCCAGCTCCCATTGCAGGTGATGCACGTCCCACTTGCACAATCTGCACCAAGACGTTTCAGCGGCAACATCAGCTGACCCTGCACATGAATATTCATTACATGGAGCGAAAGTTCAAGTGCGAGCCATGCAGCATATCCTTCCGCACGCAGGGACATCTGCAGAAGCACGAGCGATCGGAAGCGCACAAAAACAAGGTTATGATGACGTCGACTTTTGGTGTTCCAACCACCTCGAATCCACGACCCTTCGAGTGCACCGACTGCAAGATCGCCTTCCGCATCCATGGGCATTTGGCCAAGCATTTGCGCTCCAAGACGCATGTTCAGAAGCTGGAGTGCCTGCAGAAGTTGCCCTTCGGGACCTATGCTGAAATTGAACGTGCAGGAATTAGTCTTACTGAAATCGATACAAGCGACTGTGAAAACTCGCTGATATCACTGAAGTTGCTGGCCCAGAAACTGGTGGAGAAGGATCCTAGTAAGCTCAGTAGCTATACCACACCTTCTGGCATGATGCAGCTGGCCCAGGATGCAACAGGTCCCGTCTCGCAGGATAGTGCGTCCGAGGATGGCTTTAGTGCCGCAATTGCCTCGGCTATAGCTTCGCTGGACAACGACAGTGCTGGCAACACACCCAAGCGAGCCAGCTCGATGTCCGAGGATGAAACGGTGGCTAATGGCCTAAACCATAGCCTGAAGCGTCGTTTGCCGGGCAGTTTCAGCAGTACGGGCGAGGAGAGCGATAATCCACCGGAAAGCAGTGGCGAGAAGCGGGCTCGTTCTGGCCAGGAGCTGCCTGTTCCCGTGGCCGTTCCCGTGGCTGCTTCAGCAGCGGCAAGCAACTGA
Protein Sequence: MENATTTTAKHYKTAGKQYKTNKVNNTRRATAAAAAAAAAAATTTVTTAATPTKKRTYRETATATTVTQRSTNKANIAAAIALAAATEATAPASATAAATDATLTASKAAATAAATDAASGNSNSSSKPSTSTRDKLGEVPLPTVDSNHIISNNNNNNNNNNTNNNNNNNHHSDNSISENSYEFKSRDKASLSDSKMTLQQMAAVSSNQEPVAPNVANTMSNSSIISSQQTTANATPATDEAPLGDRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQAGGDAVRTTSLSSNSSLSPPPTTPLANGHHLMTQQQSHQQVQQQQSPPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNHAANATLSPASFAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHIRAHTNERPYPCETCGIAFKTKSNLYKHCRSRSHAARARGLEVPADADDGLSDQDAELSNSSSELPSRAGSPYDEPINSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSPAAGTLPPTTADNHHSATAQHRQSIDYKPYKPKFHNASLYSCSSKELQQQQIQQQQLQIQQQKHQLAQQKLSIQLPLAQQPSLAHPTLSPSTQMKMKHHINSHQIQLQMQQQQSLLAQQSLLAAMPPGGVYYLGQPPYYNQDAAAAIHQHALAIQQFQIHLAQQQQQQQQQQQQQQHPPLVKPPPPMQQAPSLPPQQLVRANSQISSVATAPATPTPAANLSTFASSSGGKQVNVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANSNNASQHGSNASALHANNSHNNTNAQMPERETKVNLAQAIFQKQQQQLQQQQQITQQQQQQITQQQQQQITQQQQQMQLEQQNYYTYIQQQQECQQQQIEPPNGVVKRNAYKPGIVMTTPVKQQQQLPPPPSPLPMQTLQYRQDPATPVAKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTSSLAPTPTTSTNSTSSSKTAPPPAQVNNSIIKNLLLNARGLAVPIGEGDDAVYSCPICASEFRSADDLKLHNSTYCQDASSSAPMSPASSPFRSNSISLSLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPLVDYAQQSAPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPTSFNFSFNNQNSSNSVPELQSSKEERLRRFTSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGLLGVSSGPQHFQFPPINSITAFNPLTLPPMSGGDKSTPATPIPHVPGMPGPGSLTPQMPLLPPPPQQLQLPIPSSRGRSPNRKQPSPLLLGGGSGELKALSPFGGVQNVPSEFSRQPPTPAQRQALQWNSKETPKKAPFNFLRMADNVKTTEPEVRHFNLENVIAGKQQELPLTPLHVDTPNGNAPEETSPVASSSASAKSKFLRPTSLPLKPGTFTPKRHHGITPTANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCSTKMFYCTVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTIAALSEANVAAKANEEAQAKKLETSPSGQPLVGGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPMPPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRLKEHEAARGLLSLSMTPPIPQSVSPYPQLQDTPLPAASPANSIGSSGSQPKRLVCSFTSPKPPFDYQKQEQYYSNPEESKPKRGVASEESAPMDLTKPRGSILSISPSPVSLPVHDLPKSQAQQMHDVIFGTSGNESGFMKTLISVSDKVRISAEMEEQAKHEAEGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSTSTLFTANSRPVMSVNEVPSIEVHEVKTPEAIEAPRSAPELAPVILAQIAQEENEEPNIAEPHNANLPAAVQQPDVNDFTGVLGNPTAPPTASVAATSVTTTTAASVAPSSTANSTQPAQRTVIVGEDGFKSSTPTSKSGDLQHVSYGRGVPPAPIAGDARPTCTICTKTFQRQHQLTLHMNIHYMERKFKCEPCSISFRTQGHLQKHERSEAHKNKVMMTSTFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLRSKTHVQKLECLQKLPFGTYAEIERAGISLTEIDTSDCENSLISLKLLAQKLVEKDPSKLSSYTTPSGMMQLAQDATGPVSQDSASEDGFSAAIASAIASLDNDSAGNTPKRASSMSEDETVANGLNHSLKRRLPGSFSSTGEESDNPPESSGEKRARSGQELPVPVAVPVAASAAASN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00592606;
90% Identity: iTF_00619363;
80% Identity: -