Dsim000180.1
Basic Information
- Insect
- Drosophila simulans
- Gene Symbol
- -
- Assembly
- GCA_016746395.1
- Location
- NC:2497770-2501179[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 8 0.12 7.5 6.9 1.8 5 23 234 252 233 252 0.95 2 8 7.1e-05 0.0044 17.1 1.4 2 23 316 337 315 337 0.97 3 8 0.003 0.19 11.9 0.2 1 13 343 355 343 365 0.90 4 8 2.2e-06 0.00014 21.8 0.7 2 23 372 393 372 393 0.97 5 8 2.9e-06 0.00018 21.4 1.0 1 23 399 421 399 421 0.98 6 8 9.6e-05 0.0059 16.6 2.2 3 21 429 447 428 449 0.95 7 8 5.9e-05 0.0036 17.3 0.4 1 23 455 478 455 478 0.97 8 8 3.4e-05 0.0021 18.0 0.7 3 23 486 506 484 506 0.97
Sequence Information
- Coding Sequence
- ATGTCGCCGCCGTCCAGCCCCGCTCCACGCCGGCCGTTCCCCATGGATGCCTTGTGCCGCGTGTGCCACAAGGCATCGCCGCTCTGCCTGTCGCTCTTCAAACAGCTCGACAATCCAATTTCCGGCAAACTTGCGACGCTGGCCAGCGTTTTAAGCTACTGCAGCGGTCTGGAGATCCAAGAGGAGGAGCTCTTCCTCCCCCACCACATCTGCCCGGGCTGCGTGGCCAAGTTGCAACTCTCGCTGGAGTTCAAGCGGAGTGTCCACCGCATGGACAGAATTCTGCGGCAGAGTCATGCGGACTTTTGCCGCAGCAAAAGGATCAGCGCGGTGAATACTAGGCCCAGGCTGTCACCCGAGATTCCGGAGGACATTGTACTTGTGCTCGATGACCAGGAGGTGACTGAGCATCCAGCAGAAACGGTACGAAATGAGGAGGAACTCGTGGTCGTAGAATCAGATGAGGAGGAAAGCCGGGTGGAAGGGCCAATTATACAGGAGGAGAGGCTGGATAATGCACTGGAACAGCAAGCAGACTTTCCAGGTAGGGAGAACAACGAGGAACAACAGAGTCACACATTTGAAGAGATCTACTTGGTTGACAAAGCAGATGACGATATCTGCGAGATTGTCGACGATTCGGATACGGAGCAACGTAGGAGCAGGTTAGGAAGATCCAAGCCGTCGCTGCAAAGTTCCATTTGCGGCAAACAACTGCACAGCAAGCGGACCTTTCAGAACCACATGACGCTACATAGCCCGCATCCCGTTCGCCAAGATGGCAACGTCGACTGCATTGAAGAATCCCTCCAAGTAGAGCCCGTATTGCAGGCCAATGCTGGCGAAGATCTCTACGAGATTGTGGAGAAAACAGCGCAGCCTTCTGCGGCGCAGAGAACTTTTCCGAGTAGGAGCCGGCTGTGGAAACCACTCAATCCCTGCCTAAAGTGCCAAATCTGCGGCAAGCAACTAAGCACCAACAACTCCTTCAAGTACCACATGCAGCTACATGGCACGGCCAGGCCCTACGTTTGCACGATCTGCGGAGAGTCCTTCAAGACGCGAAACGCCCACGACGGCCATGTCACGCTGCACGATCGAAACAATCCGAATCGGTGCCCCACCTGCTTCAAGGTCTTCCGGCAGGCATCCTCGCTGCGCACACACCTTCTAATCCACAGCGGAATCAAGCCATTCCCGTGCACCATCTGCGGCAAGAGGCTGACCCAGAAGTCGGGCCAAAAGAAGCACATGCTCACCCACACGGGCGAGATGCCGCACGGCTGCGACATCTGCGGCCGCCGCTTCCGCTTCTCGAGCAACCTGGCTGCCCACAAGCGCTGCCACAGCCAGGAGAAGCCCCACCCGTGCCCGGTGTGCCAGGAGCGCAGCTTCGGCAGCAGGTCCGAGCTCAACCGCCACATGCTCGTCCACAGCAGCGAGCGACCATTCGGCTGTGAGCAGTGCGGCAAGTCCTTCAAGCGCCGCATCTCACTCGGCATCCACCGCCAGTCGCACAAGGCGGGCAGGCAGCGGTCAAGTGGTGGTCcaactggaggagcaggacgagCATGA
- Protein Sequence
- MSPPSSPAPRRPFPMDALCRVCHKASPLCLSLFKQLDNPISGKLATLASVLSYCSGLEIQEEELFLPHHICPGCVAKLQLSLEFKRSVHRMDRILRQSHADFCRSKRISAVNTRPRLSPEIPEDIVLVLDDQEVTEHPAETVRNEEELVVVESDEEESRVEGPIIQEERLDNALEQQADFPGRENNEEQQSHTFEEIYLVDKADDDICEIVDDSDTEQRRSRLGRSKPSLQSSICGKQLHSKRTFQNHMTLHSPHPVRQDGNVDCIEESLQVEPVLQANAGEDLYEIVEKTAQPSAAQRTFPSRSRLWKPLNPCLKCQICGKQLSTNNSFKYHMQLHGTARPYVCTICGESFKTRNAHDGHVTLHDRNNPNRCPTCFKVFRQASSLRTHLLIHSGIKPFPCTICGKRLTQKSGQKKHMLTHTGEMPHGCDICGRRFRFSSNLAAHKRCHSQEKPHPCPVCQERSFGSRSELNRHMLVHSSERPFGCEQCGKSFKRRISLGIHRQSHKAGRQRSSGGPTGGAGRA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00539850; iTF_00592576;
- 90% Identity
- iTF_00592576;
- 80% Identity
- -