Basic Information

Insect: Drosophila simulans
Gene Symbol: topi
Assembly: GCA_016746395.1
Location: NC:16322082-16324808[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 8.6e-06 0.00053 19.9 1.1 2 23 231 252 231 252 0.97

2 10 2.3 1.4e+02 2.9 0.1 2 23 278 299 277 299 0.83

3 10 0.068 4.2 7.7 0.0 2 23 363 384 362 384 0.90

4 10 0.0017 0.11 12.7 1.7 1 23 431 455 431 455 0.92

5 10 0.51 31 4.9 0.4 2 21 470 489 469 492 0.87

6 10 4.3e-07 2.7e-05 24.0 1.9 1 23 513 535 513 535 0.95

7 10 0.00099 0.061 13.4 1.3 1 23 541 566 541 566 0.96

8 10 0.48 30 5.0 0.5 1 23 572 594 572 594 0.86

9 10 3.3e-08 2e-06 27.5 0.4 1 23 600 622 600 622 0.99

10 10 0.0015 0.09 12.9 2.0 1 23 628 651 628 651 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	8.6e-06	0.00053	19.9	1.1	2	23	231	252	231	252	0.97
2	10	2.3	1.4e+02	2.9	0.1	2	23	278	299	277	299	0.83
3	10	0.068	4.2	7.7	0.0	2	23	363	384	362	384	0.90
4	10	0.0017	0.11	12.7	1.7	1	23	431	455	431	455	0.92
5	10	0.51	31	4.9	0.4	2	21	470	489	469	492	0.87
6	10	4.3e-07	2.7e-05	24.0	1.9	1	23	513	535	513	535	0.95
7	10	0.00099	0.061	13.4	1.3	1	23	541	566	541	566	0.96
8	10	0.48	30	5.0	0.5	1	23	572	594	572	594	0.86
9	10	3.3e-08	2e-06	27.5	0.4	1	23	600	622	600	622	0.99
10	10	0.0015	0.09	12.9	2.0	1	23	628	651	628	651	0.96

Sequence Information

Coding Sequence: ATGAAAATCAAACTTTCGGGTGAGTATACGCTGGCCGAGATCGAAGTCGATTTGGACCAGCAGTTGACCCCGAACGAACTGCAACCCGGAGCCACAGTGCTGGCCACCAACGAGAGTACTGGCGGCTTAGAGCGGATTGTCAGCCATGAGGAGCTGTCCAGGTTCTTCGCCGTGGGTCCACCGGTCGCCTTACCAATGCCCACGGATGTGGTAGTGGAGCGCACACTGGCGGATCCGGCTTTCAAGCAAATCCTGCAGGAGGCCGACGGCAAGAAAGGCTTCGATCCCGAGGCGGAGCAAATGAAGATTCGCGACTTTTTGGCCGGCGTCACCAGCAGCAAGATGACCACTGAGCAATCGGTCTTTCATGGATCTCGTTCCAATACCTCTGCGCCCACTGTCAACCGTATAAAGTGTCCGACATGTTTGGTCCAGTTCGATGCTGTGGCCTTTCAAAATCATGCCTGTGAAGCGAAGCCGGCCGAGTTGATGGTGCCTCAGCAGGAGAAGCCACATCTTGTGCCTACTGTAtctgctcctccggctccgATAAGCAAACCGGCTTGCGAGCGGGTAATCAGGGAGAACCAAGTGCGTTTGCGACGTTACTTCAAAGATGAGATGAAGTACGATCTGGCCACAGGCATCGAAAGCTCGCGCATCCAAAAAAACACATCCAAGGGTCCCAACGAGTGCACCATGTGCGACCGCAAGTTTGTCCACGCCTCTGGGCTGGTGCGCCACATGGAGAAGCACGCCCTGGACTTGATCCCTTCGCAGACCAGCGAGCAACCACATACGATACCGGCTGCCGGACTGCATGTGGTGGTTAAGTGCAACCCTTGTGGCCGAATCTTCTATGATCCGCAGGTGGCCTTTAGACACGGCTTTATTCACGATTCGGAGCATTCAACGATGCGTCAAGGTCGAATGCCCCAAGTACCCTCCAGTAGAGCAGATTTCaatgagctgctgctggatggCGAGTCGCTGATAGACAACGATGCCTCTTTTGCAGCGAGCAATCCAAACACCAACCCACCGGAGAAGGAAATGTTCACCAGCCTGATCCTGGGAAGCGTTTTGCAGTGCGAGTTCTGCGAGTACATGTTCGCTGACATAGCCGAGCTGCTAGTCCATTCCGCTGCTCATGTGGCGGAGCGGCGCTTTGAGTGCACCGCCTGCGACATTCAGATGAGCACGGCGAAGGAAGCCAGCATCCACTTCCAGACGGACTGCATCTTCATGCGCGAGGCAGTCAGGTCGCTAAATGTCACGATCAGTCGCTACTTTGTGTGCAATGTGTGCGAGCTGAAGTTCGCCAACACGGACCTGCTCCAGGAGCATCGGTGTACCTCCTTTCACTACTTTCCTCGCCTCAGCGAGAATGGCAAGAAGCTGGTGCTGCCGTGTGAGTTTTGCGACGTCAACTTTGAGTTCGCCCACGAGTTTCTGGCGCACAACGAGGAGAAGCATCTCAACAAAAAGAAGCGAGAGAAGGAAGCGCGCAACACGGGCGCCGGCCGAATACGTCAGTATCTCTGCGATATCTGCGGCAAATCGTACACCCAGTCAAGCCATCTGTGGCAGCATCTACGCTTTCACCAGGGTGTGAAGCCCTTCGTTTGCCAGGAGGAAAACTGCGATCGGAAGTTCACCATTCGCCCAGATCTGAACGACCACATTCGCAAGTGCCACACGGGCGAACGTCCATATCTTTGTCTGGTGTGTGGAAAGCGCTTTCTCACCGGATCCGTCTTCTATCAGCACCGTCTGATCCATCGCGGCGAGCGGCGCTATGAGTGCGATGAGTGTGGTAAACGTTTCTATCGCGCGGACGCGCTCAAGAACCATCAACGCATCCACACCGGAGAGAAGCCGTACAGCTGCCTCTTCTGCACGAAGACCTTTCGCCAGCGCGGCGACCGTGACAAGCACATCCGAGCTCGACACTCTCACCTGGATGCCAACTCGCGTCTCATGATGCAGATGCAGAAATTCCAACTGGAGACGGCGGCTGCGCAGAAGGCTCAGGGTCATAATCCCGAGCAGCAGGATAACGATGGTGGTGCCAGCACCTTAGACGTGCCCTCGGGCTCTGGATTCGTGTCGACTGAGCCAGGCGTCGCGGAGATACAGTACTCCATTGCgccggagcagcaggacgaaATGGTGTGTGTGCCCATTGACCAGGTCAACAACAGTTTCTTTATGTCGCACTACATGCAAGCTGTTCCTATGGAGGAGGATGGTTCGGGGCAGCATATAATTGTCTTCGAGCAGCCAGGCCAGGATATGGATATGATGTCCATTTACGATCAGCAACAGGTTGGGGAACCAATGCATGAGGGCGGCGTGCCCCAGCGGGCGCCTGAGGAAAACGCTAGGGTGGTGGTTGTCAAGAACAATCCAACTAAGCCGATCTTTTCGGATACCTATATGTAA
Protein Sequence: MKIKLSGEYTLAEIEVDLDQQLTPNELQPGATVLATNESTGGLERIVSHEELSRFFAVGPPVALPMPTDVVVERTLADPAFKQILQEADGKKGFDPEAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNTSAPTVNRIKCPTCLVQFDAVAFQNHACEAKPAELMVPQQEKPHLVPTVSAPPAPISKPACERVIRENQVRLRRYFKDEMKYDLATGIESSRIQKNTSKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNPCGRIFYDPQVAFRHGFIHDSEHSTMRQGRMPQVPSSRADFNELLLDGESLIDNDASFAASNPNTNPPEKEMFTSLILGSVLQCEFCEYMFADIAELLVHSAAHVAERRFECTACDIQMSTAKEASIHFQTDCIFMREAVRSLNVTISRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLSENGKKLVLPCEFCDVNFEFAHEFLAHNEEKHLNKKKREKEARNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQGHNPEQQDNDGGASTLDVPSGSGFVSTEPGVAEIQYSIAPEQQDEMVCVPIDQVNNSFFMSHYMQAVPMEEDGSGQHIIVFEQPGQDMDMMSIYDQQQVGEPMHEGGVPQRAPEENARVVVVKNNPTKPIFSDTYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00504897;
90% Identity: iTF_00592584; iTF_00539853;
80% Identity: -