Basic Information

Insect: Drosophila siamana
Gene Symbol: zfh2
Assembly: GCA_035047445.1
Location: JAWNPP010000032.1:1081750-1098257[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 1.4 82 3.8 0.2 2 23 133 155 132 155 0.90

2 10 0.00012 0.0073 16.5 1.4 2 23 605 627 604 627 0.96

3 10 3e-05 0.0018 18.4 0.7 1 23 659 683 659 683 0.92

4 10 0.0053 0.32 11.4 0.4 1 22 775 796 775 799 0.91

5 10 0.51 31 5.1 0.7 1 23 995 1018 995 1018 0.97

6 10 4.4 2.7e+02 2.2 0.1 3 23 1135 1157 1134 1157 0.84

7 10 0.007 0.42 11.0 2.3 2 21 1230 1249 1229 1253 0.89

8 10 5.7e-05 0.0035 17.6 2.3 1 23 1304 1326 1304 1326 0.98

9 10 0.001 0.062 13.6 1.0 2 23 1333 1355 1332 1355 0.94

10 10 0.00011 0.0067 16.6 1.8 1 23 1973 1995 1973 1995 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	1.4	82	3.8	0.2	2	23	133	155	132	155	0.90
2	10	0.00012	0.0073	16.5	1.4	2	23	605	627	604	627	0.96
3	10	3e-05	0.0018	18.4	0.7	1	23	659	683	659	683	0.92
4	10	0.0053	0.32	11.4	0.4	1	22	775	796	775	799	0.91
5	10	0.51	31	5.1	0.7	1	23	995	1018	995	1018	0.97
6	10	4.4	2.7e+02	2.2	0.1	3	23	1135	1157	1134	1157	0.84
7	10	0.007	0.42	11.0	2.3	2	21	1230	1249	1229	1253	0.89
8	10	5.7e-05	0.0035	17.6	2.3	1	23	1304	1326	1304	1326	0.98
9	10	0.001	0.062	13.6	1.0	2	23	1333	1355	1332	1355	0.94
10	10	0.00011	0.0067	16.6	1.8	1	23	1973	1995	1973	1995	0.97

Sequence Information

Coding Sequence: ATGTCCAGTACTGATGTTGAAACTTTTAATGGCAAAATAGTATACAATCTTGATGGCAGTGCATTTATTATCGATGCAGGCAGTGTGAATGCCTCTTCGAGCACAAGTTTAACATCCGCAACGCTTACCAGCAAACCATCGTCTAAAGCTGCCGCACAGTTAGATATACTACCATCAACGACTAAAACGGGCGGAAATATCGCCGAGGGGAAATCTTTTCCGAATAAAGTGCGACATTTTCAGGATCAAATCGTAACGGATCACGGAATTTTAAAAGATTATTATCAGTTAAGCCCGAAAATTCACTCGTTTCGTGTGATCTCAGCTCAAGATGTCAACACCCACTGTCAGGATGGtgcaaatgtatttcaaaCGCCTTCGCACAAGCCCATATTGATGTGCTTCATCTGTAAATTGTCTTTTGGCAACGTTAATTCATTTAGTTTACATGCGAAAGCAGAGCACGGGCTCAATTTGGTGGagcttgagcagcagctgctaaaacgcgaattttccaGTGCCATCATTCAGAGAAATATGGATGAAAAGCCGCAAATATCATTCCTTCAGCCACTTGATCCAGACAACGAGGACGCGGCCAATTCCGAAAGTAGCTGCAATTTGGTGGAGGCGTTAGCAGATCCAGTCTCGAACCGTTGCCCTCGTAATGATGGTAATTGCAATGATGATAATCGAAAAGATATCGATGGTAATAGCAGTGATAGTCATGGCGATAATGGTAATAATAACGATAGTGATCGGGAAGATGTTTTGGTGAAGACAATGGTGGCATCCAAAGTAGCAGTCAAAAGCACTGTGAAACTTAGTTCCTTAAATACAGCAACCATAAAGACTAATAACATCGCTCCAAAATCAACAGCATGCGTCAATACACATGCAATTAAAGCAACGTCAAAAACAACGACACCTTCATCATTGACATTATCAAACTCAATGTGCATCTCATCTGTGTCCATTGTTACACCAGCTTTAACGCAAGCTTCGTTACTAAATGACTTGGAAGTACTGCAGCAGCCAAGTGATATTTTGGGAACTCGAACTGATAACCTAAGTAGCGATAAGTCGATACCAAATGAATCCCCTACTGTCATGGGTTCAACATCTCCTACATCACGTCCAGAGCCAGAAGAAGGTGGTAATCCGAATCATGCAACAGCAGACGCAGATGCAGCAGAAGCCATTGGAACAAACACGGAGGACATGTTGCAACAGCATCTAATAACTttgcaagagcaacaacagcaaccagagCCTCCAACGGGCGCTATCTTCCCATCGATAGAAGCTCAAGCTCATTCACATCTTAGTTCCTTTCATGCATCCCTTGCAGCATTAGCCAACGAGCAAAACGCAAGAGGTGTCAAACTACTTTCGGACTTTTtccaacagcaactacaacatcaacagcaacaactcatATTTCCGAGCAAATGCCCAGATCATGTAGATTTTAAGGGTGTCGACTGCAAATCATGCGAATTGTTAGATATTCAACCTCCCATGAAGTCGCCAGTCACTCCACAACCCTCAATACAATTTCCACCACAGAGATCTCCTAATACCAACAATAGTGGGGGATTGACAACACCCATGCCCATCTCGCCCAATGCTTCATCTGTTGTCAATATGAGCAGCACGACAACAGCCTCCAGTTTTACAATTGGTGCCTGTTCTGACCATATCAATGGACGTCCTCAAGGTATCGACTGTGCTCGTTGTGAAATGCTTTTGAATTCGGCACGCTTAAATAGCGGAGTCCAGATGTCAACACGCAACTCATGTAAGACCCTTAAATGTCCGCAATGTAATTGGCATTATAAATACCAGGAGACGTTAGAGATTCATATGCGTGAAAAACACCCGGATGGGGAAAGTGCCTGTGGTTATTGCTTAGCAGGTCAACAGCATCCACGGTTGGCACGAGGCGAGTCCTACTCATGTGGCTATAAGCCATATCGGTGCGAGATCTGCAATTATTCGACAACGACCAAGGGTAACTTATCAATACACATGCAGTCCGATAAGCACCTGAACAACATGCAGGAGTTAAACAGCTCCCAGAATATGGTTGCCAAATTATTGCTACCAAGTCCCAGTTCTTCCCAGTCCCAAGGAGTCGGTCTGTCAACAAcacctcagcagcagcagcatccacagCAGGTTTCATTGGGATCAACAGGCTCCACGTCCAGTGGAAGCGTTAGTGTTaatgtcagcagcagcaatgtaAACAATACTGCAGGCTCACCCACATTAGTGTCATCATCTTCAACAGGAAATTCAATCAAACCCAAGCCGTCATTTAGATGTGACATCTGTAGCTATGAGACGTCTGTAGCGCGTAATCTACGCATTCATATGACCAGTGAAAAGCATACGCACAATATGGCCGTGCTCCAGAATAATATCAAGCACATTCAGGCTTTTAATttactgcaacaacagcaattgggATCCACACCAGGAGTTGGAGGAAATACCAATAACTTTCTGCCTGTTTCGGAGGTAGCCTTTGCCGACTTGGCATATAACCAGGCCCTGATGATTCAACTGATTCAACAGAATGCAgtagtgcaacaacaacagcagcaacaaacagcgaaCAGTAGCAAAGTGTCGCCCACATCGCCATCGACAGTCTGCAGTACTCCCGATCAATTCACATACTCCCCAAAGGCGCTGAAGATGGGGTTGAATATGGCTATGGGCATGGGCATGACCATGGGACAATCGAATGGTTCTTTTGATGTTGGATTAAACTTGACAGCAACAGTGGGATTACCTGATGGATCTGCAGTAGATACGGGATCATCCGGTTTGGCATTAACAGATAATAACATATTTTCACCAGCCTCAGTATCAAGTTGCTCTACAATCGGCAGCAAGAATCCAAATCTGAATCCCAATCCGAATCTGAACATGACCACATCGGATGTAAATTCAAGTGGAGAAACAACGGTCTTTAAATGCAATCTCTGTGAATATTTTGTGCAAtcgaaaaaagaaataattctGCACTTGGAGACAAGGCACCCAGCAGCTGAAAGTGATGATTTCATAAGTATACCAACAAACGCGGCGGCTTTACAGGCATTTCAGACAGCTGTAGCAGCTGCGGCACTTGCGGCTGTTCACCGTTGCAGTATTACGCccacaacagctacaacagaAGGAGAGACTGTTGAAGCTTCTAATGCAGATGCACCTGCCATTGTTCTCGAGTCTGGTCCTGGTCTCGACCATTTTAATATTAAGCAGGAGCAACTCGAAGGTAGAGACGATGAGCATGACAATACGGAAACcaactgcaataaattaaaatctcAAGAGAATATGAATGAATCGCACCCAATTTTGGCAGCAGCATCTTCTGGGGTGTCATGCCCGTTGTGCTTGGAACAGGGCTATAGTGAAAAATCCTTGCTAGAAGCACATCTAATGAATGTGCATAATGTGACGCGTGATGGATTGGACCGACTACTGCAGCTTGTTGATAACAAAGCCTGGCAGCGATCGCCATCATCGTTGTCATCCATAACAACAGTTGAGGAGGATGTAGGCAAATCCAATATCGACAATCATACAACTGCATCAATATCCACATCATCTAAAGTCACAAGAGGACCATGTTCCATTGGAGGAATCACCGGCGTTATACGAAGTCTTTCTTGTCAAGAATGCGACACCACTTTTAAGCATGAAGAGCAGTTGCTACAACATGCCCAGCACTCGCAGCACTATCCAATGCAAAGCAATGATTACCTTTGCCTTTCAGCGTCCCATACGCAACGTCCATGTTTCATGAAATTCTCAAGTCTCCCGCTAATGGTGGCGCACTTCAAGGATGTGCATATGAGCGTTGTCTTCTCGGAGCGCCATGTTTACAAGTATCGCTGCAAGCAATGCTCATTGGCATTTAAAACGCAGGAGAAGCTAACCACCCACATGCTGTACCACACCATGCGAGACGCAACCAAATGTTCGCAATGTCAGCGCAACTTCCGCAGCACTCAGGCCTTGCAGAAGCACATAGAGCTTGCACATGGAGCTGTCgatgatgattcccgagatgTTATCTCACCTGTCTCCAATGTCAATAATGACGTGGACAAGCTGGCAAACGACACAAACGTATTTGATGTTACCTCCGTAACACCTAGTGACCTAGctgCAAAAATTAATGAGACCGTAAATAACATTTCGGATCGATCGGGATCACCAATCCCACGAGATTCATCTGCGACTGAATCGCATCAAACTTCCTCACCCCCGCTACCAactgagcagcaacagcaattagCTGCATTTACAGCCTCATTGATAAAGCGGCAGCACGATGCTGGTCTTCTTGAAACAGCAGATGGACAATTAGCCCACCAATTACAAGGTCTACAAGGTCTTCAGAATTTgcaacaagtgcaacagcaactaagCAATGCATCTGCCGTATCGGGAATGCCGATCAATCCAGTGGACATGCTAAACCTAATGCAGTTCCATCATTTGATGTCACTAAATTTTATGAATCTAGCACCTCCATTGATATTTGGAGCTAACTCTGCGTCTTCCGGTGgtaataaaacaacaatatcGGGAGGTGTTCAAAATAATGGAATTTCTGCCATATCTTCAACGGGCTCTGGAGAAATTTCAGCAACTGTTACAGGTGATGCCCTCCCAAACATGAGTAGTATTCTTGGACAGTCGACTTCTAGCAACAACCAGCAACAAttatcaaacaatcaaaaaagaGCACGAACCCGAATCACAGATGAACAACTCAAGATTCTCCGTGCCCATTTTGATATCAATAACTCACCAAGCGAAGAAAGTATTATGGAAATGTCACAAAAAGCTAATCTGCCAATGAAAGTGGTGAAACATTGGTTTCGCAATACATTGTTTAAGGAGCGCCAACGCAATAAGGATTCACCctacaattttaataatccACCATCAACTACGCTTAATCTCGAAGAGTATGAGCGCACAGATTCAGCTGGAATAGGTGCAGAAATAGCGACCATCACAGCAACCGCTCCCGTATCGGAGACTCCATTAATAATTGCACCTGCCTCACGTTCAATGGCAAATGAAGCTAACAATATATCTAATTGCTTTCAAGTGCAAGAGCCCGAAACGGCTCTAACAAAGTCCGAGCAGCTAGACAATTCGAAGagtttgccattgccactcGATGTCCAAATAAAGACTGAGCCTCAAGATGACAACTTAACTACTCCTTCGGAaaatcaacatcagcatcagcattcaTTTCTGTATCTTAAGCAGCAAAAAGGAGACACAACGGTAGAATCATTGGATGATCAATCACCAGGGACATCatcccagcaacagcagcagcagcaacagcaacatcagcaacaagtTAATTGCTTTGAGACGAAATCGGAAAGCGGCAGTTCTGATGTACTTTCTCGCCCACAAACTCCAAATCTGTATAATAGCATGAATGATTTGCTTAGCCAACAGTTAGAACACATCGGAAGTAACATGGGACCaccaaaattgcaaataaccggtaaatcatttgaaaaattaacGGGTTCAATCGCAACGGGAACAGCAACGTGTTCCCAACTCGACAACAATTCATCAAACTCATCGAATTCATCATCTTCCACATCGGGTGGCAAACGAGCAAATCGCACTCGTTTCACAGATTATCAGATCAAAGTCCTTCAGGAATTTTTCGAAAACAATTCTTATCCAAAGGATAGTGATTTGGAGTATTTGAGCAAACTACTGTTGCTTTCACCACGGGTTATTGTCGTCTGGTTCCAGAATGCTCGtcaaaagcagcgcaaaatttatgaaaatcaaCCAAACAATTCTTTATACGAGACCGAAGagaccaaaaagcaaaatatcaACTACGCGTGCAAAAAGTGCAACTTGGTTTTTCAACGTTATTACGAGTTGATCAGGCATCAGAAAAACCATTGCTTCAAGGAAGAGAATAACAAGAAGTCAGCTAAAGCGCAAATAGCTGCGGCACAAATCGCACAAAATCTGAGCTCAGAGGATTCCAATTCATCCATGGATATACACCATAATCAAGTAACAGTTGGAGCAGGAGGTACGGGACTGccgcaaaatgttgctgctgcagctgtagctgcggctgctgccgcagctgtGGCTCATTCGCAATTCGgttcatcgccatcgccacaGCATTTATTCAGCAAATCCTCATCACTCACAGATTTTAGTCCATCGACTACACCAACACCTCCACAACGAGAACGTAGTAACAGTTTAGaccagcaacaccaacaacagcccCAGCGTGTGCTCAAACTTGAGGCTTTTTTCCTCATCAGAACAGGCATCATACGGTCCATTTGGTAG
Protein Sequence: MSSTDVETFNGKIVYNLDGSAFIIDAGSVNASSSTSLTSATLTSKPSSKAAAQLDILPSTTKTGGNIAEGKSFPNKVRHFQDQIVTDHGILKDYYQLSPKIHSFRVISAQDVNTHCQDGANVFQTPSHKPILMCFICKLSFGNVNSFSLHAKAEHGLNLVELEQQLLKREFSSAIIQRNMDEKPQISFLQPLDPDNEDAANSESSCNLVEALADPVSNRCPRNDGNCNDDNRKDIDGNSSDSHGDNGNNNDSDREDVLVKTMVASKVAVKSTVKLSSLNTATIKTNNIAPKSTACVNTHAIKATSKTTTPSSLTLSNSMCISSVSIVTPALTQASLLNDLEVLQQPSDILGTRTDNLSSDKSIPNESPTVMGSTSPTSRPEPEEGGNPNHATADADAAEAIGTNTEDMLQQHLITLQEQQQQPEPPTGAIFPSIEAQAHSHLSSFHASLAALANEQNARGVKLLSDFFQQQLQHQQQQLIFPSKCPDHVDFKGVDCKSCELLDIQPPMKSPVTPQPSIQFPPQRSPNTNNSGGLTTPMPISPNASSVVNMSSTTTASSFTIGACSDHINGRPQGIDCARCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAKLLLPSPSSSQSQGVGLSTTPQQQQHPQQVSLGSTGSTSSGSVSVNVSSSNVNNTAGSPTLVSSSSTGNSIKPKPSFRCDICSYETSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNLLQQQQLGSTPGVGGNTNNFLPVSEVAFADLAYNQALMIQLIQQNAVVQQQQQQQTANSSKVSPTSPSTVCSTPDQFTYSPKALKMGLNMAMGMGMTMGQSNGSFDVGLNLTATVGLPDGSAVDTGSSGLALTDNNIFSPASVSSCSTIGSKNPNLNPNPNLNMTTSDVNSSGETTVFKCNLCEYFVQSKKEIILHLETRHPAAESDDFISIPTNAAALQAFQTAVAAAALAAVHRCSITPTTATTEGETVEASNADAPAIVLESGPGLDHFNIKQEQLEGRDDEHDNTETNCNKLKSQENMNESHPILAAASSGVSCPLCLEQGYSEKSLLEAHLMNVHNVTRDGLDRLLQLVDNKAWQRSPSSLSSITTVEEDVGKSNIDNHTTASISTSSKVTRGPCSIGGITGVIRSLSCQECDTTFKHEEQLLQHAQHSQHYPMQSNDYLCLSASHTQRPCFMKFSSLPLMVAHFKDVHMSVVFSERHVYKYRCKQCSLAFKTQEKLTTHMLYHTMRDATKCSQCQRNFRSTQALQKHIELAHGAVDDDSRDVISPVSNVNNDVDKLANDTNVFDVTSVTPSDLAAKINETVNNISDRSGSPIPRDSSATESHQTSSPPLPTEQQQQLAAFTASLIKRQHDAGLLETADGQLAHQLQGLQGLQNLQQVQQQLSNASAVSGMPINPVDMLNLMQFHHLMSLNFMNLAPPLIFGANSASSGGNKTTISGGVQNNGISAISSTGSGEISATVTGDALPNMSSILGQSTSSNNQQQLSNNQKRARTRITDEQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTDSAGIGAEIATITATAPVSETPLIIAPASRSMANEANNISNCFQVQEPETALTKSEQLDNSKSLPLPLDVQIKTEPQDDNLTTPSENQHQHQHSFLYLKQQKGDTTVESLDDQSPGTSSQQQQQQQQQHQQQVNCFETKSESGSSDVLSRPQTPNLYNSMNDLLSQQLEHIGSNMGPPKLQITGKSFEKLTGSIATGTATCSQLDNNSSNSSNSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNSLYETEETKKQNINYACKKCNLVFQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHNQVTVGAGGTGLPQNVAAAAVAAAAAAAVAHSQFGSSPSPQHLFSKSSSLTDFSPSTTPTPPQRERSNSLDQQHQQQPQRVLKLEAFFLIRTGIIRSIW

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00595064;
90% Identity: iTF_00595064;
80% Identity: iTF_00595064;