Basic Information

Insect: Drosophila siamana
Gene Symbol: zfh1
Assembly: GCA_035047445.1
Location: JAWNPP010000004.1:12142855-12147252[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0017 18.5 1.0 1 23 146 168 146 168 0.97

2 15 0.00087 0.052 13.8 1.2 3 23 176 196 174 196 0.94

3 15 9.4e-05 0.0057 16.9 0.1 1 23 361 383 361 383 0.98

4 15 0.0038 0.23 11.8 2.3 1 23 389 411 389 411 0.98

5 15 3.3e-05 0.002 18.3 2.3 1 23 442 465 442 465 0.95

6 15 0.00016 0.0097 16.1 1.0 1 23 493 515 493 515 0.94

7 15 0.011 0.68 10.3 1.3 1 23 521 544 521 544 0.97

8 15 0.028 1.7 9.1 0.4 3 19 553 569 552 570 0.95

9 15 0.00016 0.0099 16.1 5.6 1 23 579 601 579 601 0.97

10 15 0.043 2.6 8.5 1.2 2 23 607 628 606 628 0.96

11 15 9.6e-06 0.00058 20.0 1.0 1 23 637 659 637 659 0.98

12 15 0.0011 0.066 13.5 0.1 3 23 667 687 665 687 0.97

13 15 5.8e-05 0.0035 17.5 0.5 1 23 693 715 693 716 0.95

14 15 0.095 5.7 7.4 0.8 1 23 726 748 726 748 0.96

15 15 0.0094 0.57 10.6 0.2 1 23 1292 1314 1292 1314 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0017	18.5	1.0	1	23	146	168	146	168	0.97
2	15	0.00087	0.052	13.8	1.2	3	23	176	196	174	196	0.94
3	15	9.4e-05	0.0057	16.9	0.1	1	23	361	383	361	383	0.98
4	15	0.0038	0.23	11.8	2.3	1	23	389	411	389	411	0.98
5	15	3.3e-05	0.002	18.3	2.3	1	23	442	465	442	465	0.95
6	15	0.00016	0.0097	16.1	1.0	1	23	493	515	493	515	0.94
7	15	0.011	0.68	10.3	1.3	1	23	521	544	521	544	0.97
8	15	0.028	1.7	9.1	0.4	3	19	553	569	552	570	0.95
9	15	0.00016	0.0099	16.1	5.6	1	23	579	601	579	601	0.97
10	15	0.043	2.6	8.5	1.2	2	23	607	628	606	628	0.96
11	15	9.6e-06	0.00058	20.0	1.0	1	23	637	659	637	659	0.98
12	15	0.0011	0.066	13.5	0.1	3	23	667	687	665	687	0.97
13	15	5.8e-05	0.0035	17.5	0.5	1	23	693	715	693	716	0.95
14	15	0.095	5.7	7.4	0.8	1	23	726	748	726	748	0.96
15	15	0.0094	0.57	10.6	0.2	1	23	1292	1314	1292	1314	0.97

Sequence Information

Coding Sequence: ATGAACAGTCAGGATTATGGCGGCATCCAATGGATACAGCAGCACTCCGAATCCTCGGATATGCTGGAAAACGGCGCCAACGAAAATGAGGTGACTGCAGCCGCCTATTTGGTCAATGGCAACGCTACCGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATCTTTATGGCACGCGACGGACAGCTAAGCGAGATCATCGCTGCCAATGAATCCGGAGGCGGCACTGTGCTAATCACAGACAGCGGCGTCGCCTATGCGGAGTCCTTCGACGACGAGGCGCAAGTGGTCACCGAGGAGATCATCACAGATGATTGGGTGCAGGATCAGGGCGCCGAGCGCGTGGAAATCGCCGCTGAGCAAATTGCAGGCAATGCCAATGCGCTGGAACTGCTGGACATGGAGCAGGACGAGTATACGGCACTGCGTCCCTATCCCTGCGACTTCTGCAGCCGGCGTTTTCGCAAAAAGGCCAGCCTGAACAATCACATGCTCGCCCATCAAACGGACCGACCGCATCTTTGCAAGCTGTGCGGCGCACGCTTCTCCCGCCGCGCCGAGCTTATCAGCCACTTCAAGGCGCACGCAGAGGCGCAGGATGCAGCCGACGCAGAggctgcggcggcagctgctatTAAATTTGAGCCAGCGCAGTCGCGGCAAATGGTGGATCATTTCTACGAGCAGGAATGGCCCATGTATcaggaacaggaacaggagcacgaacaaatgcagcaggagcagcagcagcaacagctggaCGCCGAGCAACAACTGACGGTCGCCAGCCAAGTGGTACAGCAGGCCAGCTATGCGGCAGTCAGTGCTGtggcagcgccaacagcgACGCGTGGTCGCATCAGTCGTCTCAAGCCCAAGGAGGAGAGCACACAGTACATTGTGCTGGCCGAGAAGCAGGCAACGGATGAACTGCAGGAGTTCATGGCTGAGTTGCCGGTACATGCCACAGCAGCGTTACCGACAGAAGCCGTCGTTGGCGCCGCCAACGTCGTGACGGCGGACAGTCAACAGGCTGCTGAGGCGTCACGTTTCCCAGTGCTGGACGACAGCAAACCCTTCGTTTGTCAGCAGTGCGGCTTGGCATTTGCGCGCGAAAAAGCGCTCGTCTCACACATCAAGAATCATCGCGTCGACTCTCCCTTCGAGTGCAATCAGTGCCAGGAGATGTTCTGGGACACGCACAGCCTGCAGGAGCATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAGTACGATCCCGCCTCGGCGGGCGATGACAGCGCCACCGAATCGGAACCCGAGCAGCTCTACGGTGAATTCTATTGCACCGAATGCGGCATTTCGTTTCATCGCCAGGATCTGTTGCGGCGCCATGCCAAGCAACAGCACAAGCTGAGCGCCAACGATGTGGCCGAGGGCAGTGCAGACGCTGagggcgatggcgatgccgagAATACCAAAGATGCGACGCATTGTTGTGACACGTGCGGCAAATCATTTGCCCGTGCATTGGAGCTGCGCGCTCATGCCGACATTCATGCCCGTTTCCCGCCATTCAAATGCGTCTTGTGTGGCATCAGCTTTTACGAAGAACAGGCGATCAAGCGCCACTTGCACACACGCCATCCGCACGACCTCAAGCCGAATTCGTGTGTGCTGTGCGGCAAGGAGTGTCGCGATCGCAAGGCACTGATCAAGCATGCCTGGGATCATTCGCGTGAAAAATGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGCGACAAATCGGTTGTTTGTGAGGTCTGCCACGAAGAGTTTCCCGACGGACGCACACTTTCCAATCACCGGCACTCGCACAGCACCACGTCGCCGGGCAAACTGTTTCCCTGCCATGAGTGCGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATCCATGTGCGCATCCACACCGGCGAACGGCCGTACGGCTGTCGCTATTGCTGGAAGGCCTTCGCCGATGGCGGCACACTGCGCAAACACGAGCGCATTCACACCGGCGAGAAGCCCTACGCGTGCTCGGTGTGTCCGCGTGCATTCAACCAGCGTGTCGTGCTGCGTGAGCACATACGGTCGCATCATTCGGGCCTGGATGCAGTGCGGGGCACGTATCATTGCACTGTGTGCACTGCGGATCTGTCCTCATCCAATGCGCTGATACACCATCTCATTGAGCACAGCGACACAAACACCGCCAAGCAACGACAGCCAATTACTGGTCCCCGCAAATACAAGCGACGAAGGAAACTGCAGCCGCATGAGATTGCGCACATGCGAGCAGAGAACAAGGATGGCGACGAATACGCCAGCGACATCGATCTCGGCGAACTGGACGTGGAAAATGTGGACGATTTCTTTGATGGCGCCGACGCAGCGCCCGCCAAAAAGGAGAAGCGCAAACGCAATGCGGCCGCACAAGCGAAGCCAGTGGCGAATGGCGTTAATAACAacgcgacaacagcagcgacaaaagCCGCCGCCAATGGCAGTCAGGAGCGCACGTGGGACGATAAATTCCAGCAGgccaacagcaatggcaatgatGATGCCTTCAAGAGTATCTTTCCCATCGATTCGATGGTGATGGTCAATGACACCACATTGCAGCCCATCAGCCCAGCGAGGAGTGCTGCAGTTGCGTCCAAAACGCGGCGCAGCGCCAAGCACACGACACCACAGGCACAACAGCAgacgccgagcagcagcagcaaaccaggagcaacagcagcaggagctgctgcgCTTGCCGATGAGGGCAGCAAGTCGAGTGTGTCGGCGTCCTcgagcagtcgcagcagccgcaagaAGACGGCCAAGTCCGCCAAGAGCAcgagcacaacagcagccgcagccgcaaccGCAGCGAGCAGTTCGGGTCCTCGCATGATACACACGGAAAAGTCACGTGTGCCGCCAGAGAATGCAACGAAGAGGACGCGCGGTCGTTCGTATGTGACGCGCACAAATGCCAGCGAGACGAGCAGTCAGCAGCTGGGCGGTCTGGTGAAGTCCAGCGGCGTGGCCAGTTCGCGCATTGTGGATGACTATGAGATTATTTCGCCCGCCACGCAGCCACCGAACCAGATCAGCTCCAGTCCGCTGCACATTAAGcaggaacaggagcagcatcaccaccaccagcaccagcaccagcagcagcgcggaTCGCTCATGTACGATGACACACATCTGCTGCTCGATACGGCGCTGTCGCGCGAGAAAACCTACGAGAAGTTCAATCCCAGCATTGTCAATGATCTCGAGGAGATACTGCGCAGTCCGCTCAAGCATGATCACAATGCTCGGCTGCGTTTCACCAGCGAATCCTCGACCACGCCCCAATTTCTGCCCGAAGAGGAGCAGAATCTAATCAAAATCGAACCGACGTCCCCAGACTTGCGTGAAATGGTCGAGAGTCAGCAGCGCGTCAGCTCCGCGGGACATGGCAACACACCcacgtcatcatcgtcgtcgtcggcggcgCGAACTTCGCGCCATCTGCGGCAGCTGACTGGCAACTCGAGCTCACGAGCTGGCTCCAAacgtggcagcagcagtaaatcTGCGTCTGCGTCCAACGCCAAGAAGTCGGCATTGTCGTCGTCACCATCGGTGGCCGTCAGCAAAGGCAGCTCGTACCTCAGCTATGGCGTCGACTCCTATCATGTGAGTGTGGCTGGCAATGCGAGCTCTTCGGACGTCAGCTCGGGTTTCTTTTCCATCTCGGAGGTGGTGTCGGCTGCCGATGCCGCCGATGCGGCTGCcaaagcggcagcggcaaataAACCGGAGCGACGCACGCGTTGCTTTGAGTGTGAAATGTGTTCGGCGTACTTTCCGGATCGAGCTCAGCTGCTGGAGCATGTGCATATACACATCTGA
Protein Sequence: MNSQDYGGIQWIQQHSESSDMLENGANENEVTAAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGVAYAESFDDEAQVVTEEIITDDWVQDQGAERVEIAAEQIAGNANALELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQTDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAAIKFEPAQSRQMVDHFYEQEWPMYQEQEQEHEQMQQEQQQQQLDAEQQLTVASQVVQQASYAAVSAVAAPTATRGRISRLKPKEESTQYIVLAEKQATDELQEFMAELPVHATAALPTEAVVGAANVVTADSQQAAEASRFPVLDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDTHSLQEHQKTHQFEESNSEYDPASAGDDSATESEPEQLYGEFYCTECGISFHRQDLLRRHAKQQHKLSANDVAEGSADAEGDGDAENTKDATHCCDTCGKSFARALELRAHADIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPHDLKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNALIHHLIEHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDGDEYASDIDLGELDVENVDDFFDGADAAPAKKEKRKRNAAAQAKPVANGVNNNATTAATKAAANGSQERTWDDKFQQANSNGNDDAFKSIFPIDSMVMVNDTTLQPISPARSAAVASKTRRSAKHTTPQAQQQTPSSSSKPGATAAGAAALADEGSKSSVSASSSSRSSRKKTAKSAKSTSTTAAAAATAASSSGPRMIHTEKSRVPPENATKRTRGRSYVTRTNASETSSQQLGGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQHHHHQHQHQQQRGSLMYDDTHLLLDTALSREKTYEKFNPSIVNDLEEILRSPLKHDHNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSAGHGNTPTSSSSSSAARTSRHLRQLTGNSSSRAGSKRGSSSKSASASNAKKSALSSSPSVAVSKGSSYLSYGVDSYHVSVAGNASSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRTRCFECEMCSAYFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: -
80% Identity: -