Basic Information

Insect: Drosophila serrata
Gene Symbol: topi
Assembly: GCA_002093755.1
Location: NW:3623713-3628466[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 2.3 1.5e+02 2.8 0.4 2 19 147 163 146 163 0.90

2 10 9.4e-06 0.00061 19.8 1.4 2 23 251 272 251 272 0.97

3 10 0.051 3.3 8.0 0.2 2 23 298 319 297 319 0.85

4 10 0.01 0.65 10.3 0.1 2 23 379 400 378 400 0.96

5 10 0.00043 0.028 14.6 3.1 1 23 447 470 447 471 0.97

6 10 4.5e-07 2.9e-05 24.0 1.9 1 23 530 552 530 552 0.95

7 10 0.00018 0.012 15.8 1.0 1 23 558 583 558 583 0.97

8 10 0.55 35 4.8 1.8 1 23 589 611 589 611 0.88

9 10 3.3e-08 2.2e-06 27.5 0.4 1 23 617 639 617 639 0.99

10 10 0.0012 0.078 13.2 2.5 1 23 645 668 645 668 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	2.3	1.5e+02	2.8	0.4	2	19	147	163	146	163	0.90
2	10	9.4e-06	0.00061	19.8	1.4	2	23	251	272	251	272	0.97
3	10	0.051	3.3	8.0	0.2	2	23	298	319	297	319	0.85
4	10	0.01	0.65	10.3	0.1	2	23	379	400	378	400	0.96
5	10	0.00043	0.028	14.6	3.1	1	23	447	470	447	471	0.97
6	10	4.5e-07	2.9e-05	24.0	1.9	1	23	530	552	530	552	0.95
7	10	0.00018	0.012	15.8	1.0	1	23	558	583	558	583	0.97
8	10	0.55	35	4.8	1.8	1	23	589	611	589	611	0.88
9	10	3.3e-08	2.2e-06	27.5	0.4	1	23	617	639	617	639	0.99
10	10	0.0012	0.078	13.2	2.5	1	23	645	668	645	668	0.96

Sequence Information

Coding Sequence: ATGGACCCAGAAAATTTGGGGAACCTTCAGGAAGTTGAGCAGCAGGCGGGGGAATATACACTGGCCGAGATCGAGGTTGATATGGAGTCGCAGCTGACGCCCAATGACCTCGATCCAGGTGCTACGGTGTTGCTCTCCATTGAGGGGGAGGGAGATGGTGAGCGCATTATGAGCCACGAGGAGCTATCCAGATGGTTTTTGGTAGAGCCGTCAAGTCCGGCACCAATGCCAACAGATGTGGTGGTGCAACGCACCCTGGAAGACCCCGCTCTCAAGCAGATCCTCCAGGAGGCCGACGGCAAGCCGGACTTTGATCCCGAGGCAGAGCAAATGAAGATTCGCAGCTTTCTGGCAGGCTTTACACACAACAGGCTGACCACGGAGCAGTCGGTATTTCAAGGATGCCGCGCGAATGCCAATGCCTTTAGCAGCCGGATTAAGTGCCCGGATTGCCTTGGCAGTTTCGATCCGTCTTCGTACCACAATCACCCCTGTGCCGTTGAGGTCGAAGGCAAGTCGAATACCAATCAGAAGTCTGTCGACGAAGCTGGGAAAcgggcagcaacagcaggagtAGCCAGTGCTGTACCTGagcctcctgctcctccttcccCATGCAAACCGAACAGCTTGCGTTTGATCGCGGAGAACCAGATTCGCTTGCGTCGCTTCATGAATGATGAGTTGAAGTACGACGTAAACAGTGGCGTGGAGCAGCCGCGCAGCCGTAAGTCCGGCAAGGGGCTCAACGAGTGCAGCAAATGTGATCGCAAGTTCGTTCACGCCTCCGGATTGGTGCGCCACATGGAGAAACACGCTCTGGATCTAATACCCTCGCAGAGTAACCCACAACCGGCCGCATCGCTGGCGCCTGGATTCACTGCCGCTGTGAAGTGCAACGTCTGTGGGCGCATCTTTTACGATCCACAGGTGGCGTTGAAGCATGGCCACATTCACTTCAATGTTCAGAAAGGTAGTCAATCGGAAACTGCGGACAAGTATGCCACCAATATAGATTTCAAACAGTTTCTGAAGGATAGCGAGTCGCTGCTGGGTGAAAATGGCTTGGAAACGGAGAAGCCAAATAGTCTGGAGAACGATTTGTTCAGCACTGTCGTTCTGGGCAGCGTCCTGCAATGCGAATTCTGCGATTACCTGTTCTCTGACATTACGGAGCTGCTCGCCCATTCGGCCACTCACCCGGTAAAGCGGCGTTTTGAGTGCACCGCCTGTGACATTAAGATGGATACTGCCAAGGAGGCCAGACTCCATTTCGAGGCGGACTGCATCTTTATGCGCGAGGCGGTGAAGTCGCTGAGTGTTTCGGTCAGCCGCTTCTTTGTGTGCAATGTATGCGAGCTGAAATTTGCCAACTCGGAGCTGCTGCAGGACCATCGCTGCACCTACCATCACTATTTTCCGCGGCTGAGTCTGCATGGGACGCGCCTGCTGCTTCCCTGCGATTTTTGCGAGGTAATGTTCGAATGCGCCAGTGAGGTCCAGCCGCACAACGAAGAGAAACACTCCAGCAAGAAGAAGCGAGAAAAGGATTCGCGTGGCAGCGCGGCCAGCGGCCGCCAGCGTCAGTATCTGTGCGACATCTGCGGCAAATCCTACACCCAGTCGAGTCACCTGTGGCAGCACCTTCGTTTCCATCAGGGCGTGAAGCCGTTCGTCTGCCCGGAGGAGAAATGCGACCGCAAGTTTACCATCCGACCGGACCTCAACGACCACATCCGTAAGTGCCACACGGGGGAGCGGCCGTTTCACTGTCTGGTGTGCGGCAAACGTTTCCTCACTGGCTCCGTGTTTTATCAGCATCGCCTGATTCATCGTGGCGAGAGGCGCTACGAGTGCGAGGAGTGCGGTAAGCGATTTTATCGCGCCGATGCTCTTAAGAACCATCAGCGCATTCACACTGGGGAGAAGCCGTTTAGCTGTCTCTTCTGCACCAAGACATTCCGCCAGCGTGGCGATCGCGACAAGCACATGAGGGCCCGTCACTCGCACCTTGATGCCAACTCGCGCCTTATGATGCAGATGCAGAAATTCCAGCTGGAGTCGGCCGCAGCCGCCAAGGCCAAGGGCAAGAAGGCTACGACCGGAGTGGCTCTGTCTGCTTGTGATAGTCCCCCCACTGCGGAGGGTTTGGAACCTGGAGAAGTCGATTTAGAAGATCACATTCACAATGCAGAACAGGACGAGGACGTGCCAAACTATTTTATAGTGAAACAATACGTGCAGCCTAGGGAAAATGACCAGGATGGTTTCAATATGCGGGAGGGGACCTGCGCCATGGAGGACGGTTGCACCATGGACGAGGACGACCAGCAGATAATTCTCTACGAGGCACAGCCGGCTCAGGGTATTATGGAAATGGGAGACGATCAGCGATCGAGTCAGAATTTGATAACTTTTGACTATAAGGAGCCGAATGAGCAACCAATGCGGGATGAGGACTACGTTCAACTGCTTCAGAGCGACGAGAACGCCAGAGTTGTGGTTGTTCAAAACAATCCAGCACAGCCTATGTTTTCCAATTCGTACATGTAA
Protein Sequence: MDPENLGNLQEVEQQAGEYTLAEIEVDMESQLTPNDLDPGATVLLSIEGEGDGERIMSHEELSRWFLVEPSSPAPMPTDVVVQRTLEDPALKQILQEADGKPDFDPEAEQMKIRSFLAGFTHNRLTTEQSVFQGCRANANAFSSRIKCPDCLGSFDPSSYHNHPCAVEVEGKSNTNQKSVDEAGKRAATAGVASAVPEPPAPPSPCKPNSLRLIAENQIRLRRFMNDELKYDVNSGVEQPRSRKSGKGLNECSKCDRKFVHASGLVRHMEKHALDLIPSQSNPQPAASLAPGFTAAVKCNVCGRIFYDPQVALKHGHIHFNVQKGSQSETADKYATNIDFKQFLKDSESLLGENGLETEKPNSLENDLFSTVVLGSVLQCEFCDYLFSDITELLAHSATHPVKRRFECTACDIKMDTAKEARLHFEADCIFMREAVKSLSVSVSRFFVCNVCELKFANSELLQDHRCTYHHYFPRLSLHGTRLLLPCDFCEVMFECASEVQPHNEEKHSSKKKREKDSRGSAASGRQRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEEKCDRKFTIRPDLNDHIRKCHTGERPFHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHMRARHSHLDANSRLMMQMQKFQLESAAAAKAKGKKATTGVALSACDSPPTAEGLEPGEVDLEDHIHNAEQDEDVPNYFIVKQYVQPRENDQDGFNMREGTCAMEDGCTMDEDDQQIILYEAQPAQGIMEMGDDQRSSQNLITFDYKEPNEQPMRDEDYVQLLQSDENARVVVVQNNPAQPMFSNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00491692;
90% Identity: -
80% Identity: -