Basic Information

Insect: Drosophila seguyi
Gene Symbol: zfh1
Assembly: GCA_008042675.1
Location: VNJU01005257.1:45673-67752[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0067 0.49 10.9 1.2 3 23 74 95 72 95 0.95

2 9 0.0006 0.043 14.2 0.1 1 23 289 311 289 311 0.97

3 9 8.7e-05 0.0063 16.8 0.6 2 23 325 346 324 346 0.97

4 9 4.6e-06 0.00034 20.8 6.3 1 23 355 377 355 377 0.99

5 9 0.00027 0.02 15.2 1.2 3 21 385 403 383 404 0.94

6 9 0.0063 0.46 11.0 0.7 2 21 637 656 636 657 0.92

7 9 1.2e-05 0.00089 19.5 0.5 1 23 980 1002 980 1002 0.94

8 9 4.6e-05 0.0033 17.7 7.4 1 23 1008 1030 1008 1030 0.98

9 9 0.0023 0.17 12.3 4.3 1 21 1036 1056 1036 1057 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0067	0.49	10.9	1.2	3	23	74	95	72	95	0.95
2	9	0.0006	0.043	14.2	0.1	1	23	289	311	289	311	0.97
3	9	8.7e-05	0.0063	16.8	0.6	2	23	325	346	324	346	0.97
4	9	4.6e-06	0.00034	20.8	6.3	1	23	355	377	355	377	0.99
5	9	0.00027	0.02	15.2	1.2	3	21	385	403	383	404	0.94
6	9	0.0063	0.46	11.0	0.7	2	21	637	656	636	657	0.92
7	9	1.2e-05	0.00089	19.5	0.5	1	23	980	1002	980	1002	0.94
8	9	4.6e-05	0.0033	17.7	7.4	1	23	1008	1030	1008	1030	0.98
9	9	0.0023	0.17	12.3	4.3	1	21	1036	1056	1036	1057	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCGTCGTCTTCACGTTTCGGCCAAGAGGATACCATCATACAGCAGAGCATGCCATCCACCGCCTTCACCATGCAGTTTCCCTCGCTGGCCTCCAGTCTGCTTCACCACAACCAGTCGCCGAAGCACAGCAATCCAGGCAATGCGGTGCAGGATGCCCAGATTGCACAGCCAGGTCCGGCTGCAGATGCCTTCATGGTCAATTGCACCCAGTGCCATAAGCGCTTCATAGGGTTTCAGAGCCTCAGCGAGCACATGGCCAGCGAGCATCCCCACCACAAGCTGAACTGTGGAGCTGCCCAGCCCGAGAGCGATGCCGAGGATGAGCAGAGCAATctcagtggcagcagcagtcggCGGTACATCAAGTCACCGGCACAGGCCACTGGCAACAccccaaacaacaacagcatcagTGCCCATCCCAGTAGCAACTCcagtaacaataacaataataacaacaatagcgAGCTGACTaaaaaccacaacaacaatagcacaACACCAAAGATGTCGCCCATGTGCTCACCTGGCTCCATGCCACCGAGCGACTTGTTCGCTCACCTGCCCCATGGAACGCCACAGTTGCAATTGCAGGCCCAGTTTATGGCCGCCGCTTTGGCCATGCAATCCGCCCGAACCGCCAGCTCCAGTtcgccacagcaacagcaccagcagcagcaacatcaccagcaacagcagatgGCATTGCAGCAACTGCTGCCACCTCAGCTTCCTGGCAGCAATAGCAGCGTGGGCAGCAATTCCGCCTACGATCTGGATCTGAGTGCTCCCCGATCCACGTCCAGTCCCGGCTCCACCACCGGAGATCGGGAGCTGGGCGGTGCCTATCCCTGCATGCAATGCACGGCCGCCTTTGCCACACGGGAGCAGCTCGAGCAGCATCAGCTGTTGCACTCGCCCTGCGGCCAGCCAGCGGCACAGAATGTCTCTCAGACCTGCCGCATCTGCCAAAAGGCATTCGCGAATGTGTATCGCCTCCAGCGTCACATGATCAGCCACGATGAGAGCGCTCTGCTGCGAAAGTTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTCAAGCATCATCTCAAGGAACATGTCCGGATCCATTCCGGGGAAAAGCCCTTTGGCTGCGACAACTGCGGCAAGCGCTTCTCCCACTCGGGCAGCTTCTCCTCCCACATGACGTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGCGCTCTGCTCAAGCGACTGGAGAAGAGTCCCGGCTCCGGAGGCGCAGCTCGTCGCTCGCCCTCAGATCAGGGTCTTAAGCAGGATCAGCAATCGGGGCTGCCGGGACTGCCAAATCCGATGATCTACTTTGCCAGCGATGCTCAGGGGCAGGCGGGCAATGCAGCTGCCACGCCCTTCCCGCCTTTCCATCCCACGAACTACATGAATGCGGCTCTGTTTTCCTTCCCCAATCCCTTCATGGCTGCCGCCGCTCTGGATCCTCGCGTTCATCCGTACAGCATCCAGCGGCTGCTGCAACTCACTGCTGCAGGTCAGCAGCAaagggaggagcaggagcagcaacagcaacagcagcagctggagcaggaggagcgcGAGCCCGAGGAGGAGACGCCCGATGAGCCTAAGTTGATCATGGACATTGATGAGCCGGAAACCAAAGATCTTAGGGCTTCCACACCCGAAGTACGAGAGGAGGCAGCGGCTCCTATTAAGCAGGAGCCCAGCAGGGAACCCTCTCCAGTTCCCGAGAGTGATCCCGCTACGCCGCAGGAGATCAAGCAAGAACAGGTACAGGAACCGCTGTCGGTAGAGGAGGCAGAGCCACAGTCCTCGGTTGAAGAGCCCATCCCAATAGAGCAACCCGCCGATTTGCGCTGCAGTCGCTGCTCCAAGCAGTTCAACCACCCAACAGAGCTGGTGCAGCACGAGAAGGTGTTGTGTGGCCTTATCAAGGAGGAGCTAGAGCAACATTTccatcaacaacagcagcagcagcaactccagcACCAGACCACGTCCTTTGTGATGCCCTCCGCCAGTGAAGAAgacgacgaggatgaggagatggaggaggagccgcGACAGGAGAGCGGTGAGCGCAAGGTCCGAGTGCGGACGGCCATCAAcgaggaacagcagcagcaattaaaGCAGCATTACTCCCTGAACTCGCGACCCAGCAGAGATGAGTTTCGGATGATAGCCGCTCGCCTGCAGCTCGACCCTCGCGTGGTCCAGGTCTGGTTCCAGAACAATCGATCTCGCGAGCGAAAGATGCAAAGTTTCCAGAGTAATCAAACCACGCCGGTGGCCAACAATGAAGCTCAGACCTCGCAGACTTCACGCGAGGATCAACCCTTGGATCTGTCCATCAAGCGAGATCTGCTGACGCCAAAAAGCGAGAGCTCGCCACCTTACATACCGCCTCAGAGCACTGAGGCCCTGAATCCCGAGGCCGCCATCAATCTTAGCAGGAAATTCTCCAGCTCCGCTTCAATGTCGCCAGCCTCGATTTCACCGTCGTCCGCGGCAGCCATCTACTTCGGCGCTGgaccgccgccgtcgccgcccAACAGCCAACTGGAGGCCACTCCTCGAACGGCCGGCCAGGCCTTTCCGGGTCTGCCCTACATGCTGCCCATGCCCCGACTCCCCATGGAGGCCCTGTTCCAAATGCGTCCCGGTGGCGAGTATGCCCCCAATCATCCCCTGATAAACAGTATTAAGCTGCCCGATTATCGTGGCACAAGTCTGAGTCCCGGCGGATCAGAGAAGCGGTCGTGGCGCGACGATGACTCGCGCATCTCCCACGAGGATGACTTTAGCGGCGGACTGCTGCCGCCGAAGCCGAAGCGAAGCAAGCAGGAGACCCATGGCCATGCCGGTGATCCCGATCTGCCCTTTGTGTGCGATCAGTGTGACAAGGCCTTCGCCAAGCAGAGCTCATTGGCGCGCCACAAGTACGAGCATTCCGGTCAAAGACCCTACCAGTGCATGGACTGCCCAAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAACGTCTGCATAGCGGCGAGAAGCCCTTCCAATGCTCCAAGTGCCTGAAACGCTTCTCCCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTATTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDTIIQQSMPSTAFTMQFPSLASSLLHHNQSPKHSNPGNAVQDAQIAQPGPAADAFMVNCTQCHKRFIGFQSLSEHMASEHPHHKLNCGAAQPESDAEDEQSNLSGSSSRRYIKSPAQATGNTPNNNSISAHPSSNSSNNNNNNNNSELTKNHNNNSTTPKMSPMCSPGSMPPSDLFAHLPHGTPQLQLQAQFMAAALAMQSARTASSSSPQQQHQQQQHHQQQQMALQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDRELGGAYPCMQCTAAFATREQLEQHQLLHSPCGQPAAQNVSQTCRICQKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSGGAARRSPSDQGLKQDQQSGLPGLPNPMIYFASDAQGQAGNAAATPFPPFHPTNYMNAALFSFPNPFMAAAALDPRVHPYSIQRLLQLTAAGQQQREEQEQQQQQQQLEQEEREPEEETPDEPKLIMDIDEPETKDLRASTPEVREEAAAPIKQEPSREPSPVPESDPATPQEIKQEQVQEPLSVEEAEPQSSVEEPIPIEQPADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFHQQQQQQQLQHQTTSFVMPSASEEDDEDEEMEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNSRPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQSNQTTPVANNEAQTSQTSREDQPLDLSIKRDLLTPKSESSPPYIPPQSTEALNPEAAINLSRKFSSSASMSPASISPSSAAAIYFGAGPPPSPPNSQLEATPRTAGQAFPGLPYMLPMPRLPMEALFQMRPGGEYAPNHPLINSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDFSGGLLPPKPKRSKQETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00480071;
90% Identity: iTF_00485024;
80% Identity: iTF_00593732;