Basic Information

Insect: Drosophila santomea
Gene Symbol: zfh1
Assembly: GCA_016746245.1
Location: NC:27562572-27586600[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.0011 0.068 13.3 1.7 2 23 75 97 74 97 0.95

2 10 3.1 2e+02 2.4 1.0 11 23 221 233 218 233 0.87

3 10 0.0017 0.11 12.7 0.2 1 23 301 323 301 323 0.96

4 10 8.8e-05 0.0056 16.7 1.7 2 23 337 358 336 358 0.97

5 10 4.3e-06 0.00027 20.8 6.3 1 23 367 389 367 389 0.99

6 10 0.00026 0.016 15.2 1.2 3 21 397 415 395 416 0.94

7 10 0.0059 0.38 11.0 0.7 2 21 642 661 641 662 0.92

8 10 8.4e-06 0.00053 19.9 0.5 1 23 979 1001 979 1001 0.95

9 10 4.3e-05 0.0027 17.7 7.4 1 23 1007 1029 1007 1029 0.98

10 10 0.0021 0.14 12.3 4.3 1 21 1035 1055 1035 1056 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.0011	0.068	13.3	1.7	2	23	75	97	74	97	0.95
2	10	3.1	2e+02	2.4	1.0	11	23	221	233	218	233	0.87
3	10	0.0017	0.11	12.7	0.2	1	23	301	323	301	323	0.96
4	10	8.8e-05	0.0056	16.7	1.7	2	23	337	358	336	358	0.97
5	10	4.3e-06	0.00027	20.8	6.3	1	23	367	389	367	389	0.99
6	10	0.00026	0.016	15.2	1.2	3	21	397	415	395	416	0.94
7	10	0.0059	0.38	11.0	0.7	2	21	642	661	641	662	0.92
8	10	8.4e-06	0.00053	19.9	0.5	1	23	979	1001	979	1001	0.95
9	10	4.3e-05	0.0027	17.7	7.4	1	23	1007	1029	1007	1029	0.98
10	10	0.0021	0.14	12.3	4.3	1	21	1035	1055	1035	1056	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTCTGGCGCCGTCGTCTTCACGTTTCGGCCAAGAGGATACCATCATTCAGCAGAGCATGCCCTCCACCTCCCCCTTCGCCATGCAGTTTCCCTCGCTGGCATCCACCTTGCTGCACCACAACCAGTCGCCGAAGCACAGCAATCCGGGCTCCAGTGGGATCCAGAATGCCCATCCCAACCAGCCAGGTGCCGCCGCCGATGCCTTCCTGGTCAAGTGCACCCAGTGCCACAAGCGATTCACCGAGTATCAGTCCCTCAGCGAGCACATCGCCAGCGAGCATCCCCACGACAAGCTGAACTGCGGAGCTGCCCAGCCGGAAAGCGATGCCGAGGACGAGCAGAGCAACAtgagcggcggcagcagcaggcggTACGCCAAGTCGCCGCtggccagcaacagcaacaacaacagcagcaccgCCAACGCCAATGCCAATAGCAGCAGTAACCAGTCCatgaacaacaacagcgagctggccaagaaccacaacaacaacgccaACAAAATGTCGCCCATGTGCTCACCCGGCTCCCTCACACCCGGCGACCTCTTCGCCCAGCTCCAGCACCCGCCGCCCCAGCTGCCGCCCCACCTGCACGCCCAGTTcatggccgccgccgccatGGCCATGCAGTCCGCCCGCACCGCCAGCTCGCCCagccaactgcagcagcatcagcatcagcatcagcagcagcaactgcagcagcagcagcagcagcatcaacagcaacagcagcagcatcagatGGCCATGCAGCAACTGCTGCCGCCGCAACTGCcgggcagcaacagcagcgtgGGCAGCAACTCCGCCTACGACCTGGACCTCAGCGCCCCCCGCTCCACCTCCAGTCCGGGCTCCACCACCGGCGACCTGAGCGGCGCCTACCCCTGCATGCAGTGCACCGCTTCCTTCGGCACCCGCGACCAACTGGAGCAGCACGAGCAGCTCCACTCGCCCTGCGGCCCGGCGGCGGTCAGCAATGTCTCTCAGACCTGCCGCATCTGCCACAAGGCCTTCGCGAACGTGTACCGCCTGCAGAGGCACATGATCAGCCACGACGAGAGCGCCCTGCTGCGGAAGTTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTTAAGCACCACCTCAAGGAGCACGTGAGGATCCATTCCGGCGAGAAGCCCTTCGGATGCGACAACTGCGGCAAGCGCTTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTGAAGCTGAACAACAACCGCGCTCTGCTGAAGCGCCTGGAGAAGAGCCCCGGATCCGCATCCTCCGCATCGCGGCGATCGCCATCTGAGCACGGCAAGGGCAAGCTGCCGGAGCAGCCGTCGCTGCCGGGACTGCCACATCCCATGAGCTACTTCGCCAGCGATGCCCAGGTGCAGGGTGGAAGTGCGGCACCCACGCCCTTCCAGCCATTCCATCCCAACTACATGAACGCCGCCCTGCTGGCCTTTCCCCACAACTTCATGGCCGCCGCGGCTGGCCTGGATCCTCGGGTGCATCCCTACAGCATCCAGAGGCTGCTGCAACTCTCGGCCGCCGGTCAGCAGCAGCGCGAGGAGGAGCGagaggagcagcagaagcagcagcagcagcaggaggaggaggagactCCCGATGAGCCCAAGCTGGTCATGGATATCGAGGAGTCGGAGGCCAAGGAAAGAGCACCCACGCCAGAGGCCGCCGAAGAAGCCACTCCCATCAAGCGGGAGCAGAGCAGGGAAGCCTCTCCCGCTCCAGACAGCTACCTCTCCTCCTCGCAAGCGAtcaagcaggagcaggagcccCTGAACGCAGCAGAGGAACGGCAAACTCCTGTGGAAGAGCACGCGCCCGTGGAGCAAGCCGCCGATCTGCGCTGCAGTCGCTGCTCCAAACAGTTCAACCATCCCACTGAGTTGGTGCAGCACGAGAAGGTGCTTTGCGGCCTGATcaaggaggagctggagcagcacttccagcagcaacaggccACGTCCTTCGTCTTGGCCTCCGCCAGCGAAgaggatgaggaggacgaggagatGGACGTGGAGGAGGAGCCCCGCCAGGAGAGTGGCGAACGGAAAGTGCGAGTGCGAACGGCCATCAatgaggagcagcagcagcagctaaagCAGCACTACTCCCTGAACTCCCGACCCAGCAGGGATGAGTTCCGCATGATTGCAGCCCGCCTGCAGCTGGATCCTCGAGTGGTTCAGGTGTGGTTCCAGAACAATCGCTCCCGTGAGCGCAAAATGCAGAGTTTCCAGAACAATCAGGCCACAGTCCCGTCGGCGGCGGCCAATGACTCACAGACATCGCTAACCCGAGAGGATCAACCGCTGGACTTGTCCGTGAAGCGAGATCCCCTCACGCCCAAGAGTGAGAGCTCGCCGCCCTACATAGCTCCACAGTCGGCAGATGCCCTGAATCCCGAGGCCATCAATCTCAGCAGGAAGTTCTCCACATCCGCATCGATGTCGCCGGCCTCAATTTCACCGTCATCCGCGGCAGCGCTCTACTTTGGCGCTGCCCCGCCGCCTTCGCCACCAAATAGCCAACTGGATTCCACTCCGCGAAGTGGCCAGGCCTTTCCGGGACTACCGCCATACATGCTGCCCATGCCGCTGCCCATGGAGGCGCTGTTCAAGATGCGCCCGGGCGGCGACTTCGCCTCCAACCATCCCCTGATGAACAGTATTAAGCTGCCCGACTACCGCGGCACCAGCCTGAGTCCCGGCGGTTCGGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCCCACGAGGATGAGTTCGGCGCCGGCGTCCTGATGCCACCGAAACCCCGCAGGAGCAAGGCCGAGACCCACGGCCACGCTGGCGATCCCGATCTGCCCTACGTGTGCGATCAGTGCGACAAGGCCTTCGCCAAGCAGAGTTCCCTGGCGCGCCACAAATACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTCACGGAGCACAAGCGTCTGCACAGCGGCGAGAAGCCCTTTCAGTGCTCCAAGTGCCTGAAGCGCTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGGTATTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDTIIQQSMPSTSPFAMQFPSLASTLLHHNQSPKHSNPGSSGIQNAHPNQPGAAADAFLVKCTQCHKRFTEYQSLSEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGGSSRRYAKSPLASNSNNNSSTANANANSSSNQSMNNNSELAKNHNNNANKMSPMCSPGSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAAMAMQSARTASSPSQLQQHQHQHQQQQLQQQQQQHQQQQQQHQMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFGTRDQLEQHEQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSASSASRRSPSEHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPTPFQPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPYSIQRLLQLSAAGQQQREEEREEQQKQQQQQEEEETPDEPKLVMDIEESEAKERAPTPEAAEEATPIKREQSREASPAPDSYLSSSQAIKQEQEPLNAAEERQTPVEEHAPVEQAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQATSFVLASASEEDEEDEEMDVEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNSRPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQNNQATVPSAAANDSQTSLTREDQPLDLSVKRDPLTPKSESSPPYIAPQSADALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPRSGQAFPGLPPYMLPMPLPMEALFKMRPGGDFASNHPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGAGVLMPPKPRRSKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00588330;
90% Identity: iTF_00596880;
80% Identity: iTF_00591606;