Drub000925.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila rubida
Gene Symbol
zfh1
Assembly
GCA_035046165.1
Location
JAWNOF010000012.1:6038515-6043064[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.8e-05 0.0017 18.5 1.0 1 23 146 168 146 168 0.97
2 15 0.00086 0.051 13.8 1.2 3 23 176 196 174 196 0.94
3 15 9.4e-05 0.0055 16.9 0.1 1 23 355 377 355 377 0.98
4 15 0.0038 0.22 11.8 2.3 1 23 383 405 383 405 0.98
5 15 3.3e-05 0.0019 18.3 2.3 1 23 436 459 436 459 0.95
6 15 0.00018 0.01 16.0 2.9 1 23 487 509 487 509 0.95
7 15 0.011 0.66 10.3 1.3 1 23 515 538 515 538 0.97
8 15 0.027 1.6 9.1 0.4 3 19 547 563 546 564 0.95
9 15 0.00016 0.0096 16.1 5.6 1 23 573 595 573 595 0.97
10 15 0.042 2.5 8.5 1.2 2 23 601 622 600 622 0.96
11 15 9.5e-06 0.00056 20.0 1.0 1 23 631 653 631 653 0.98
12 15 0.0011 0.064 13.5 0.1 3 23 661 681 659 681 0.97
13 15 5.8e-05 0.0034 17.5 0.5 1 23 687 709 687 710 0.95
14 15 0.075 4.4 7.8 1.4 1 23 720 742 720 742 0.97
15 15 0.00041 0.024 14.9 0.2 1 23 1284 1306 1284 1306 0.98

Sequence Information

Coding Sequence
ATGAACAGTCAGGATTATGGCGGCATCCAATGGATACAGCAGCATTCCGAATCCTCGGATATGCTGGAAAACGGCGCCAACGAAAATGAGGTGACTGCAGCCGCCTATTTGGTCAACGGCAACGCCACCGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATCTTTATGGCACGCGACGGGCAACTAAGCGAGATCATCGCTGCCAATGAAGCCGGAGGCGGCACTGTGTTAATCACGGACAGTGGCGTCGCCTATGCGGAGTCCTTCGACGATGATGCGCAAGTGGTCACGGAGGAGATCATTACAGATGACTGGGTGCAGCATCAGGGCGCCGAGCGCGTGGAAATCGCTGCCGAGCAAATTGCGGGCAATGGCAATGCGCTGGAATTGCTGGACATGGAGCAGGACGAGTATACCGCACTGCGTCCCTATCCCTGCGACTTCTGTAGCCGGCGCTTTCGCAAAAAGGCCAGCCTCAACAATCACATGCTCGCGCATCAAACAGATCGACCGCATCTCTGCAAGCTGTGCGGCGCACGCTTCTCCCGCCGTGCCGAGCTCATCAGCCACTTCAAGGCGCACGCAGAGGCGCAGGATGCAGCCGATGCAGAGGCTGAGGCGGCAGCTGCTATTAAATTTGAGCCAGCGCAATCCCGCCAAATGGTCGATCATTTCTACGAGCAGGAATGGCCCATGAATGGCCCATACGAGCCAAtgcagcaggaacagcaacagcaacagttggacGCCGATCAGCAGCTGACGGTGGCCAACCAGGTGGTGCAGCAGGCCAGCTATTCAGCAGTCAGTGCTgtggcagcgccaacagcggCGCGTGGTCGCATCAGTCGCCTCAAGCCGAAGGAAGAGAGCACACAGTACATTGTGCTAGCCGAGAAGCACGCAGCGgatgagctgcagcagttcaTGGCTGAGTTGCCCGAACATGCCACGGCAGCGTCGCCTGCAGAAGCCGTCGCTGCAGCCAACGTGACGACGGAAAATCAACAGGTTACTGAAGCGTCACGCTTTCCAGTACTGGACGACAGCAAACCCTTTGTTTGCCAGCAGTGCGGCTTGGCGTTTGCGCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGACTCTCCTTTCGAGTGCAATCAGTGCCAGGAGATGTTCTGGGACACGCACAGCCTGCAGGAGCATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAGTACGATCCCGCCTCGGCGGGCGAAGACAGCGCCACCGAATCGGAGCCCGAGCAGCTCTATGGTGAGTTCTACTGCACCGAATgtggcatttcatttcatcgTCAGGATCTGTTGCGGCGTCACGccaagcaacagcacaaattgAGTGCCAACGATGCGGCAGAGGGCAGTGCAGATGCCGagggcgatggcgatgccgagAATACCAAAGATGCGACGCATTGTTGTCACACATGCGGCAAATCGTTTGCCCGTGCATTGGAGCTGCGCGCCCATGCCGAGATTCACGACCGTTTCCCGCCATTCAAATGCGTGTTGTGTGGCATCAGTTTTTACGAGGAACAGGCCATTAAGCGGCACTTGCACACACGCCATCCGCAAGACCTCAAGCCCAATTCCTGTGTGCTGTGCGGCAAGGAGTGTCGCGATCGCAAGGCACTCATCAAGCACGCCTGGGATCATTCGCGTGAAAAATGCCACTCGTGCTCCAAGTGCGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGACACATGGCCTCGCATCGCGACAAATCGGTGGTCTGTGAGGTGTGCCACGAAGAGTTCCCCGACGGACGCACTCTCTCCAATCACCGGCATTCGCACAGCACCACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGCGGCAAGACCTTCGGCTCGCGCAGCTCCCAGCAGATTCATGTGCGCATCCACACGGGCGAACGTCCGTATGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTGCGCAAGCACGAACGCATTCACACCGGCGAGAAGCCCTACGCCTGCTCGGTGTGTCCGCGGGCGTTCAATCAGCGTGTGGTGCTGCGCGAGCACATTCGCTCCCACCACTCGGGCCTGGATGCAGTGCGTGGCACGTATCACTGCACGGTGTGCACTGCGGATCTGTCCTCATCCAATGAGCTGATACACCACCTCATTCAACACAGCGACACAAACACCGCCAAGCAACGACAGCCAATTACTGGTCCCCGCAAATACAAGCGCCGAAGGAAACTGCAACCGCATGAGATTGCGCATATGCGAGCGGAGAACAAAGACGGCGATGAGTACGCGAGCGATATGGATCTCGGCGAACTGGACGTGGAGAATGTGGACGATTTCTTCGATGGCGCCGATGCAGCGCCAGCCAAAAAGGagaaacgcaaacgcaatgCTGCCGGACAAGCGAAGCCAGTGGCAAACGGCgttaacaacaacacgacaccAGCCAAATCCGCCTATGGAAATGTGGAGCGTGCGTGGGACGATAAATTCCAGCAGGCCaatagcaatggcaatgcTATCAACCAGCTAGCAAGCGATTATGCCTTTAAGAGTATCTTTCAAATCGATTCGATGGTGGTGGTTAATGACACCACATTGCAGCCCATCAGCTCAGCCAGcggtgctgcagttgcatcgAAGACGCGGCGCGGCGCCAAGCACACGCCACAAACAACTCAGCAGCCGACGccgagcaacggcagcagcaaatctggagcagcagcagccggagcagtTGCGCTCGCTGATGAGGGCAGCAAGTCGAGTGCGTCGGCGTCCTCGaacagtcgcagcagccgcaaaaagTCGACCAAGTCCGCCAAGAATGcgagcacaacagcagccgcagcgagtAGTACGCGGCCGCGCATGATCCACACGGAAAAGTCGCGTGTGCCACAAGAGAATACGACAAAGAGGACGCGGGGTCGTACGTATGTGACGCGCACAAATGCCAGCGAgacaagcagccagcagctgggcggTCTGGTGAAGTCCAGCGGCGTGGCCAGTTCGCGTATTGTGGATGACTATGAGATTATTTCGCCCGCCACGCAGCCACCGAACCAGATCAGCTCGAGTCCGCTGCACATTAAGcaggaacaggagcagcatcagcaccagcaacagcgcGGGTCGCTCATGTACGATGACACACATCTGCTGATCGATACGGCGTTGTCGCGCGAGAAAACTTACGAGAAGTTTAACCCCAGCATTGTCAATGATCTCGAGGAGATACTGCGCAGTCCGCTCAAGCACGATCGCAATGCCCGCTTGCGTTTCACCAGCGAATCCTCGACAACGCCACAATTTCTGCCCGAGGAGGAGCAGAATCTAATCAAAATCGAACCAACGTCGCCGGACTTGCGGGAAATGGTCGAGAGTCAGCAGCGCATCAGTTCCACGGGGCATGGCGGCGGCACACCCacatcatcgtcgtcagcGGCGCGTACTTCGCGCCATCTGCGACAGCTGACCGGGAACTCGAGTTCACGAGCTGCCACCAaacgcggcagcagcagtaaagcAGCGGCGTCTGTGTCGAGTGCCAAGAAATCCGGattatcgtcatcatcatcatcgtctgTAGCCGTCAGCAAAGCCAACTCCTACCTCAGCTATGGCGTCGACTCGTACAATGTGAGTGTGGCTGGCAACGCCAGCTCTTCGGATGTCAGTTCGGGATTCTTTTCCATCTCGGAGGTGGTGTCCGCTGCCGATGCCGCTGATGCAGCTGCGAAAGCGGCAGCCGCCAACAAACTGGAGCGGCGCACTCGTTGCTATGAGTGTGAAATGTGTTCGGCCAACTTTCCGGATCGAGCTCAGCTGCTAgagcatatgcatatacacatCTGA
Protein Sequence
MNSQDYGGIQWIQQHSESSDMLENGANENEVTAAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANEAGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGNALELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQTDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAEAAAAIKFEPAQSRQMVDHFYEQEWPMNGPYEPMQQEQQQQQLDADQQLTVANQVVQQASYSAVSAVAAPTAARGRISRLKPKEESTQYIVLAEKHAADELQQFMAELPEHATAASPAEAVAAANVTTENQQVTEASRFPVLDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDTHSLQEHQKTHQFEESNSEYDPASAGEDSATESEPEQLYGEFYCTECGISFHRQDLLRRHAKQQHKLSANDAAEGSADAEGDGDAENTKDATHCCHTCGKSFARALELRAHAEIHDRFPPFKCVLCGISFYEEQAIKRHLHTRHPQDLKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIHHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDGDEYASDMDLGELDVENVDDFFDGADAAPAKKEKRKRNAAGQAKPVANGVNNNTTPAKSAYGNVERAWDDKFQQANSNGNAINQLASDYAFKSIFQIDSMVVVNDTTLQPISSASGAAVASKTRRGAKHTPQTTQQPTPSNGSSKSGAAAAGAVALADEGSKSSASASSNSRSSRKKSTKSAKNASTTAAAASSTRPRMIHTEKSRVPQENTTKRTRGRTYVTRTNASETSSQQLGGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQHQHQQQRGSLMYDDTHLLIDTALSREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRISSTGHGGGTPTSSSSAARTSRHLRQLTGNSSSRAATKRGSSSKAAASVSSAKKSGLSSSSSSSVAVSKANSYLSYGVDSYNVSVAGNASSSDVSSGFFSISEVVSAADAADAAAKAAAANKLERRTRCYECEMCSANFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00579414;
90% Identity
-
80% Identity
-