Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 6.7e-06 0.00084 20.2 0.6 2 22 171 191 170 191 0.95

2 6 0.0088 1.1 10.4 0.1 2 23 201 222 201 222 0.97

3 6 1.7e-05 0.0021 19.0 3.2 2 23 229 250 228 250 0.96

4 6 4.9e-05 0.0061 17.5 0.7 1 23 256 278 256 278 0.98

5 6 0.00018 0.023 15.7 6.3 2 23 286 307 285 307 0.96

6 6 5.1e-08 6.4e-06 26.9 0.9 1 23 314 336 314 336 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	6.7e-06	0.00084	20.2	0.6	2	22	171	191	170	191	0.95
2	6	0.0088	1.1	10.4	0.1	2	23	201	222	201	222	0.97
3	6	1.7e-05	0.0021	19.0	3.2	2	23	229	250	228	250	0.96
4	6	4.9e-05	0.0061	17.5	0.7	1	23	256	278	256	278	0.98
5	6	0.00018	0.023	15.7	6.3	2	23	286	307	285	307	0.96
6	6	5.1e-08	6.4e-06	26.9	0.9	1	23	314	336	314	336	0.98

Coding Sequence: ATGAGCACAACGCGTCCGTTCTGTTTCGTTTGTGGCAAAGTGAAGTCTGTTGGTGTCTTTCAGCTCATCGAAGGCTGCATCGTACCTGGCACATTCAAGCCCATCAAAGACATACTCAAGTACTTTGAAAAAGTTATCAATCAGCGCCTGGATCTGACGCCGACCTCTACGGCTTGTCGGGATTGTCTGGAGTACCTGTTCAATTACGACCGGCTTGTTAGGAATCTGAGCCAAGTTCAGCGTCAGATTGCGAATTCCCTGTTGAGTTGTCGCAAAAGGAAGTCGGCCTGTGTGCAGCCTAAAAAAGATGCCATAAAACCAAAGCTGCAGGAAGTTCCAGTCCGTTCAAGAACATCAGAAAATGTATCGCCGCCATTGTCAGCTCAAAAAGTGTTTAAGGACGAGCCACAAGAAGTCGAGTTTGCagaggagcaacaacaagattTTGATGAATTGAGCGATAGTCCTCCGCCCATTGACGATTCGGATGGAGACGATAATCTAGATATTCCTTGTCACATATGTGGCgaattgttttcaaatcaGGATTGCCTAGAGAGACATATTAAAACGGACAATTGTCAAAAGAACGAATTTGCCACCTGCAACATTTGCGGCATTAAGGTTAAGGACGAAGAGGTCCTTGATTTGCACATGAACCTTCACGAGGGCAAAACCGAGTTGGAATGCCGCTATTGCTCGAAGAGGTTTTCGCACAAACGCAACGTTTTGCGCCACATGGAGGTGCATTGggacaaaaagaaatatcaatGTGAAAAATGTGGCGAACGTTTCTCGCTCTCGTGGCTAATGTACAATCACCTGATGCGCCACGACGCCGAGGAGCACGCCCTCATCTGCGAGGTGTGCCATCAGCAATTTAAAACGAAGCGCACCTACAAACATCATCTGCGCACCCATCAGACGGATCGGCCGCGCTTCCCGTGCACAGACTGCGATAAGTCCTTTGTGGACAAGTACACGTTGAAGGTGCACAAGCGTGTCCATTTGCCAGCTGAGCCTGCAGTTGCCACAGCAGAAAGTCACACAGCCAACCAATAA
Protein Sequence: MSTTRPFCFVCGKVKSVGVFQLIEGCIVPGTFKPIKDILKYFEKVINQRLDLTPTSTACRDCLEYLFNYDRLVRNLSQVQRQIANSLLSCRKRKSACVQPKKDAIKPKLQEVPVRSRTSENVSPPLSAQKVFKDEPQEVEFAEEQQQDFDELSDSPPPIDDSDGDDNLDIPCHICGELFSNQDCLERHIKTDNCQKNEFATCNICGIKVKDEEVLDLHMNLHEGKTELECRYCSKRFSHKRNVLRHMEVHWDKKKYQCEKCGERFSLSWLMYNHLMRHDAEEHALICEVCHQQFKTKRTYKHHLRTHQTDRPRFPCTDCDKSFVDKYTLKVHKRVHLPAEPAVATAESHTANQ

Sequence clustering based on sequence similarity using MMseqs2