Basic Information

Gene Symbol
zfh2
Assembly
GCA_018903745.1
Location
JAEIGN010000622.1:919583-939095[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00011 0.007 16.6 1.4 2 23 24 46 23 46 0.96
2 12 2.7e-05 0.0017 18.5 0.7 1 23 78 102 78 102 0.92
3 12 0.0047 0.3 11.4 0.4 1 22 186 207 186 210 0.91
4 12 6.7 4.3e+02 1.5 0.3 1 20 351 371 351 373 0.90
5 12 1.1 68 4.0 1.9 1 23 394 418 394 418 0.91
6 12 0.42 27 5.3 0.1 1 23 666 689 666 689 0.91
7 12 6.2 4e+02 1.6 0.1 10 23 801 815 792 815 0.79
8 12 0.59 38 4.8 1.4 2 21 872 891 871 895 0.89
9 12 2.2e-05 0.0014 18.7 1.4 1 23 946 968 946 968 0.98
10 12 0.00063 0.04 14.2 1.3 2 23 975 997 974 997 0.94
11 12 0.00075 0.048 13.9 1.7 1 23 1300 1322 1300 1322 0.97
12 12 0.0032 0.21 11.9 0.3 3 23 1441 1461 1439 1461 0.96

Sequence Information

Coding Sequence
ATGCTACTGAACTCGGCTCGTCTTAATAGTGGCGTTCAAATGTCCACGCGTAACTCCTGCAAAACTCTCAAATGCCCGCAATGCAATTGGCACTACAAATACCAGGAAACATTGGAAATCCATATGCGGGAAAAACATCCAGACGGAGAAAGTGCCTGTGGATACTGTTTAGCAGGCCAACAGCATCCACGGTTGGCGCGTGGCGAATCATACTCATGCGGCTATAAGCCATATCGATGCGAGATATGCAATTATTCGACGACTACAAAGGGCAACCTATCGATACATATGCAGTCGGACAAGCACTTGAACAACATGCAGGAATTAAACAGTTCGCAGAATATGGTTGCTGTGGCAGCAGCTGCTGCTGCAGCTAGCGCCAAACTAATGCTGCCCAGTCCAACGCCGACACAAGCAGTACCGACACAAACAGCAGGAGCAGCGAGTGTTAGTGCTTCGGCTTGTGCAAATGCGGTGCCAAGTAATGCAACAATAACTGCAAAGGAGATAGCAACGACAACAACAGCATTGTCCTCGAATAAGCCAAAACCAACCTTTCGCTGCGATATTTGCAGCTATGAAACATCGGTGGCACGGAATCTACGCATTCACATGACCAGCGAGAAGCATACGCACAACATGGCAGTCCTACAAAATAATATTAAGCATATACAGGCATTGAATTATCTGCAGCAGCAACAGCAACCAGCAGTAGCTGCAGGAAATGCAAACAGCTTTATGACAGCTGGGCCAGAGGTGGCCTTAGCCGATTTGGCTTATAATCAAGCGCTGATGATACAGCTGCTGCAGCAGAATGCTCAAGCTCAGCAGCAACAGCTGCTGCCTTCCACTGCTAGTAAGTTGTCGCCAACAAACACAAGCTCGCCAGTTAGCACGCCCGAGCAGATGCATGCAACATTTGCCACATACTCGCCAAAGCCCATGAAAATGCCAACTGGTATTATGAATCTAGCGACCACGAGCAGCATTGAGCCAGAGGCGTGCGATGCGTACTCGGAGAGCCAGCCAGAACTTTGGCCCACGGCCCTATATAGCTGCCTAATATGCGATTGCTATAGCACCAACGATATGGAGGAGTTGAACCAGCACTTGCTGCTGGATCGATCGAGACAATTGTCTACCACATCCACTGACATCATGGTGATACACAATAATAACTATATATGTCGCTTGTGCAACTACAAGACCAATCTGAAAGCCAACTTCCAGCTCCACAGCAAGACGGACAAGCACTTGCAGAAGCTCAACTTTATTAATCATATACGTGAGGGCGGACCGCGCAATGAATACAAACTGCAGTATCAAACCCAGCTGGCAGCGAATGTGGTGCAGTTGAAGTGCAACTGTTGCGATTTTCATACAAACTCCATACAGAAGATGTCGCTGCACACGCAGCAGATGCGGCACGACACAATGCGCATGATCTTTCAACACTTGCTGCATATTATACAGAAGAGTCGCATGCATCGTTGTTACAGGGAGTCGCCGATGCCGCATGATGAACAACAAGAGCTTCAACAGCAGCCATCGCCATCTCAATCACAATCAACATCATCCACGAAGAAATCTCTTTGCTGTCAACTGTGTAACTTTGTTGCCAAAAATCTGCATGATATGGTGCTTCACGTGAAAGGCTTGCGTCATATACAGGTTGAGCAATTCATTTGCCTACAGCGGCGCAGCGAGAATATCGAAATGCTTGGACTCAACGAAATATTCAAGGTCACCGAACAGATGCCACTAGCCAGCACTGAAGACTCAAGCCTCGATTGTGGTCTTAATTTGGCAACGACAGCTTCTGTCAGTGCAGCGACAGAAATGGGCTTCGGATCATCGACGGATGGCAATATATTCTCACCTGCCTCTGTCTCCAGCTGTTCAACATCATGTGGTAAAGCACAGGCGCGCATCGCTTCCCCATTGTCATCGAGCACGCCACACGAACTGGGTGCCAGCAGTGCAGCGACTACTATTTTCAAATGTAATATCTGCGAATATTTTGTGCAATCGAAAAAGGATGTGGAAGGACACATCGAAGCTGTTCACCCCAGTGCTGAGATAGATGATTATATTAGTATACCGACAAATACGGCAGCTCTTCAAGCTTTTCAAACAGCCGTCGCAGCTGCTGCTCTCGCTGCCGTCCAGCGTTGTAATGCCACGCCCACTTCGACACCGACGCCGACGCCGACGCCCACGCCTACAACTCCAGATGGACGTGGTATTGGCATAGACTTGGATGATTGCCCGATTGAAATAAAGCGAGAACGGTTGGACGACAACGACAGAACGCTTAGAGTTGCGGCTAAAGATAACAAGAGCGCAAATGAAAAGCTGCCCCAATCGGGTGTTTCATGTCCACTTTGCTTGGAGAGCGGATATAGCGAGAAATCGTCTCTGGAAGCGCATCTAATGAATGTTCACAGTGTGATGCGAGATGGGCTTGCTCGACTCTTACAGCTCGTCAATCACAAGTCATGGCGTCCTGCCAAGAACACCGATGCGACAACGACAGACGATGGCAAAAGTGCGATGAACGATGCCACGCCCACAGCTAGCACAGGTACAACAACGGGCGTTATACAGGCCATGTCGTGCCAGCAGTGCGAGTCGAACTTTAAGCACGAAGAACAATTACTACAACATGCGCAACAAACACAACATTATCCAATGCAAAACGGTGAATACCTTTGCCTACTTGTAAACCATGTTGGTCGTCCATGTTATATGACTTTTACCACCTTGTCCTTAATGATTGGACACTTCAAGGACTCGCACATGAGTCTGGTCATCTCAGAGCGGCACGTCTACAAATATCGATGCAAGCAATGCTCTCTAGCATTTAAGACACAGGAGAAGCTTACCGCCCACATGCTCTACCACAGCATGCGTGACGCTACCAAATGTTCACTCTGCCAACGCAATTTCCGTAGCACTCAGGCACTGCAGAAGCATATGGAGCAAGCACATTCAACCGAATGTACGGCTATCACGAGCAGCAGTCCCAGGGATATGTCGCCCAGTCCTTTGTATGGGGCCATCGAAATGGATAAGCCTCCATCAGAATCGAATGTTTTTGACTTTACTACAGCACGAGCCAGTGAAACCATTGCCAGAACGAATGAGGCTGGAGTAAAGCAGTCGCCACAGCGCACTAGACTTCAGAGTATACAGAGCTTGCAGCAAATACAGCAACAATTGAATGCTGCAGCAACGGGTTCGGGCATGCCCATTAATCCGGTGGACATGCTTAATTTGATGCAGTTCCATCATTTGATGTCACTCAATTTTATGAACCTGGCCCCACCATTGATATTTGGTAGCAATGCTACAGCTGGAGTTGGTGGAGCTTCAGTAGCAACTGGAGCAGGAATAGCTAGTGCAGTGAGTGGAGTCCAGAACAATGGCATTGGTCCAGTCTCTGCAGCTTGTGGCTCTGAGCGGCAGCCAAAGTGCTCAGGTGGTACAACAAGCGGCAGCCTGACAAGTGATGCCCCCAACATGAACATAATCTCGACCAACAACAATCAGATAGCGGGTACGAGCTCATCGTCGAGCGACCGACCTTCAACAACAGTTTGCTTAGAGAGCAACTCGTCGAATTCATCGAATTCATCATCCTCAACATCCGGTGGAAAGCGTGCGAATCGCACACGTTTCACAGACTATCAAATTAAGGTGTTGCAGGAGTTTTTTGAAAACAATTCATATCCTAAAGACAGTGATTTGGAGTATCTAAGCAAATTGCTGCTTCTATCGCCAAGGGTAATTGTTGTCTGGTTTCAAAATGCTCGACAAAAGCAACGCAAAATTTACGAGAATCAACCAAACAATTCTCTGTACGAAAGTGAGGAGACTAAGAAGCAAAACATTAACTATGCCTGCAAGAAGTGTAGTCTAATATTTCAGCGCTACTATGAGCTGATTCGACATCAGAAGAATCACTGCTTCAAGGAGGAGAACAATAAGAAGTCTGCCAAGGCTCAAATTGCAGCTGCACAAATCGCTCATAATCTTAGTTCAGAGGATTCGAATTCGTCCATGGATATACATAACCATCAGGCAACGGGAAGCTTGGGTCAAAATGTGGCAGCTGTTGTCGTTGCTGCTGCCGCTGCAGCAGCACATTCGGCACACTCAACACACTCGAGCTCGCAGCCATTCGGCTCATCGCCATCGCCGCAACATCTATTTAGCAAGGCGTCATCGCTAACCGACTTTAGTCCATCGACAACGCCAACACCTCCGCAGAGGGAGCGTAGCAATAGTTTAGATCAGCAGCGGTTACCAAAATTAGATTGTGAGAAGTGTGAAATGCAATTCAATCAATTGGAATTATTGCGTGAGCACCAGCTTATGCATTTGATGAGCCCGGCTCTATTTCCTGCTAGCGGCCATCAGTCATCAAGTCAGTCTGAAGCAGCTTATGGTCCCTTTGGCAGTATATTGCAGGGATTGCAGCAAGCTGCACAGCAGCAACAGCAACAACAGCCACCAGCAAAGAAAAGAAAATGCTCTGAAAGCTCGTCAAATGCTGAGGAAGTATCAATGGGAGAGTTTGAGACTACACAAAAGAAATACGAGTTCCTATATCAATATTTTATGCAGAATGAAGCCAATGCTGAGCTTAAACAGCAATTTCTACTTCAGCAGCAGCAGGGAAATGAAACAGATTTGGAGTTACAGTTCTTAAGCAATTTCTATCAGCAAAGTGAACTAAAAAAGGTTAATAGCTACGATTTTTTATTGGAATATTATCGCAAAAATGAGGACACTTTGAAACAACACAATCAGCAATTGTCGTTTAGCTCCAGCAAGAAACCAACAATTGAATTTTTACTACAATACTATCAGTTAAATGAGTCAAAGAAGTTTTTTCAGTTAGCTGCCTCGCCCCAAATAAAGTCTCGACCGTCGTCGCAGCAGCCGAACGCGACGGCGGATGAACCAAACAAAATGATCGGCATACAGCATCAGCTAAAAGAGAACAAGGTTAAACTTGAGCAAATTGAGCATCTGGAGGAGGAACAGGAGAATAGAATTGAACCAGCAACCACTCAAGGTTGTATAATTAATTCGAATGATCTGATGTCGCCTGATGAGAAGCTCAATAATAATCATATCAACATTAATATTAATGTAGCTCAAGAGCAACTAAACAAGTCGAATGAGGCAATCAATAGTGACGAACAGAAACTGCCCAACGATAAGCCGCAGTATTTTCAAAATCTTGAAGACTTTCTCGACGCCACAATGATTGAGAATAATTCACAAATGCTAACATTCAATGACGACGATAATCCAAGTCCTAAAGTTGAGAGTGTCAAAGTTAATGACTGTTTGCCTTTAGACACTGCTTCAGTACAGCTCAACGCTCCATCGAAGCAAAACAAACGGCTGAGAACAACAATACTTCCAGATCAATTGAACTTCCTGTATGAGTGCTACCAAACCGAGTCCAATCCCAGCCGTAAAATGCTTGAGGAGATTTCTAAAAAAGTCAATCTTAAGAAACGTGTCGTACAAGTTTGGTTTCAAAACTCACGAGCTAAAGATAAGAAATCGAGGAATCAACGACAATATGCGCACATTTCGGATGACAACAACAGTTTTGATGGATCCAGTAGCAAGGAGGCTGGCAACAGCAACAACAGCAACAATGGATGTGGTGGTGGCACTGCCGGTGGTGGCATCAAGTCAAGCAAATCTCTAGCTTCTAACCTAGAAGCAAACGATCAACAGCTGCAAGATTGCCAATTATGCCAAATACCACAGGTAAATATGCATAAGCATGCATTCAGCGTCGAGCACATCTGCAAGATGAAGGAGCTGCTTGAGCACACCAGCGAGTTCTATGCCCACAGCAATGCCAGTGGTAGTGACAACGATAACGAATGCGACAAAGATAGAGAGAAACGGTTCTACAGTCTCTCGAAGGCATTTCTACTGCAGCATGTTGTATCTAATGCGAGCAGTAACATTGCACCCACCTCCTCAAATGGGAAACTGGATGATGAAAACTACGATCCAAGTGCATCGGTGATGGCTGCCAACGATTTGAGAGACGGGCGATCGGTGACAACGGCAGCGGGCCATCGTCATTTGGCAGGAGACATTGCCGTATCCGTAAAAGACAACGACATCGGTATGCTAGAGGCTGGCAGAAAGAATTTGTCAGCCAATCGAGATCTAATGGAACAACTATTCAATCGCAATCACATCACTGTTATAGGTGGTAAATAA
Protein Sequence
MLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAVAAAAAAASAKLMLPSPTPTQAVPTQTAGAASVSASACANAVPSNATITAKEIATTTTALSSNKPKPTFRCDICSYETSVARNLRIHMTSEKHTHNMAVLQNNIKHIQALNYLQQQQQPAVAAGNANSFMTAGPEVALADLAYNQALMIQLLQQNAQAQQQQLLPSTASKLSPTNTSSPVSTPEQMHATFATYSPKPMKMPTGIMNLATTSSIEPEACDAYSESQPELWPTALYSCLICDCYSTNDMEELNQHLLLDRSRQLSTTSTDIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGPRNEYKLQYQTQLAANVVQLKCNCCDFHTNSIQKMSLHTQQMRHDTMRMIFQHLLHIIQKSRMHRCYRESPMPHDEQQELQQQPSPSQSQSTSSTKKSLCCQLCNFVAKNLHDMVLHVKGLRHIQVEQFICLQRRSENIEMLGLNEIFKVTEQMPLASTEDSSLDCGLNLATTASVSAATEMGFGSSTDGNIFSPASVSSCSTSCGKAQARIASPLSSSTPHELGASSAATTIFKCNICEYFVQSKKDVEGHIEAVHPSAEIDDYISIPTNTAALQAFQTAVAAAALAAVQRCNATPTSTPTPTPTPTPTTPDGRGIGIDLDDCPIEIKRERLDDNDRTLRVAAKDNKSANEKLPQSGVSCPLCLESGYSEKSSLEAHLMNVHSVMRDGLARLLQLVNHKSWRPAKNTDATTTDDGKSAMNDATPTASTGTTTGVIQAMSCQQCESNFKHEEQLLQHAQQTQHYPMQNGEYLCLLVNHVGRPCYMTFTTLSLMIGHFKDSHMSLVISERHVYKYRCKQCSLAFKTQEKLTAHMLYHSMRDATKCSLCQRNFRSTQALQKHMEQAHSTECTAITSSSPRDMSPSPLYGAIEMDKPPSESNVFDFTTARASETIARTNEAGVKQSPQRTRLQSIQSLQQIQQQLNAAATGSGMPINPVDMLNLMQFHHLMSLNFMNLAPPLIFGSNATAGVGGASVATGAGIASAVSGVQNNGIGPVSAACGSERQPKCSGGTTSGSLTSDAPNMNIISTNNNQIAGTSSSSSDRPSTTVCLESNSSNSSNSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNSLYESEETKKQNINYACKKCSLIFQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAHNLSSEDSNSSMDIHNHQATGSLGQNVAAVVVAAAAAAAHSAHSTHSSSQPFGSSPSPQHLFSKASSLTDFSPSTTPTPPQRERSNSLDQQRLPKLDCEKCEMQFNQLELLREHQLMHLMSPALFPASGHQSSSQSEAAYGPFGSILQGLQQAAQQQQQQQPPAKKRKCSESSSNAEEVSMGEFETTQKKYEFLYQYFMQNEANAELKQQFLLQQQQGNETDLELQFLSNFYQQSELKKVNSYDFLLEYYRKNEDTLKQHNQQLSFSSSKKPTIEFLLQYYQLNESKKFFQLAASPQIKSRPSSQQPNATADEPNKMIGIQHQLKENKVKLEQIEHLEEEQENRIEPATTQGCIINSNDLMSPDEKLNNNHINININVAQEQLNKSNEAINSDEQKLPNDKPQYFQNLEDFLDATMIENNSQMLTFNDDDNPSPKVESVKVNDCLPLDTASVQLNAPSKQNKRLRTTILPDQLNFLYECYQTESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRQYAHISDDNNSFDGSSSKEAGNSNNSNNGCGGGTAGGGIKSSKSLASNLEANDQQLQDCQLCQIPQVNMHKHAFSVEHICKMKELLEHTSEFYAHSNASGSDNDNECDKDREKRFYSLSKAFLLQHVVSNASSNIAPTSSNGKLDDENYDPSASVMAANDLRDGRSVTTAAGHRHLAGDIAVSVKDNDIGMLEAGRKNLSANRDLMEQLFNRNHITVIGGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00586494;
90% Identity
iTF_00586494;
80% Identity
iTF_00586494;