Basic Information

Insect: Drosophila repleta
Gene Symbol: zfh1_4
Assembly: GCA_018903745.1
Location: JAEIGN010000727.1:1985376-2014903[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0011 0.069 13.4 1.1 2 23 73 95 72 95 0.94

2 8 0.00099 0.064 13.5 0.1 1 23 224 246 224 246 0.97

3 8 2.4e-05 0.0015 18.6 1.8 2 23 260 281 259 281 0.97

4 8 8.3e-06 0.00054 20.1 6.4 1 23 290 312 290 312 0.99

5 8 0.00024 0.016 15.5 1.2 3 21 320 338 318 339 0.94

6 8 1.1e-05 0.0007 19.7 0.5 1 23 845 867 845 867 0.94

7 8 4.1e-05 0.0026 17.9 7.4 1 23 873 895 873 895 0.98

8 8 0.002 0.13 12.6 4.3 1 21 901 921 901 922 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0011	0.069	13.4	1.1	2	23	73	95	72	95	0.94
2	8	0.00099	0.064	13.5	0.1	1	23	224	246	224	246	0.97
3	8	2.4e-05	0.0015	18.6	1.8	2	23	260	281	259	281	0.97
4	8	8.3e-06	0.00054	20.1	6.4	1	23	290	312	290	312	0.99
5	8	0.00024	0.016	15.5	1.2	3	21	320	338	318	339	0.94
6	8	1.1e-05	0.0007	19.7	0.5	1	23	845	867	845	867	0.94
7	8	4.1e-05	0.0026	17.9	7.4	1	23	873	895	873	895	0.98
8	8	0.002	0.13	12.6	4.3	1	21	901	921	901	922	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTTCCTCTTTGGCCTCCAGTTTGCACCACCACCAAGCCCACAACAAGCCGAGCAATGCGGCTGCCAACCCAGAGCTGGCCGCCAGCGCCACAGCCAGCGCGGCTGAGGACTGCCTGGTCAAGTGCACGCAGTGCAACAAGCGCTTCACCGACTTTCAGTCCTTCAGCGAGCACATTGCCAACGAGCATCCGCATGACAAGCTCAACTATGAGTCGCATCGTGCGGCCGCTGAGGCTTCGCAGCCGGAGAGCGAGGCGGAGGAGGACGAGCAGAGCAACTTGAGCAGCAGCAGTCGTCGCTATGCCAAATCCCCAAACTCCAACAACAACAACAACAATAGCGAGACAGCAAAGAATCAGAATAACAACAACAACAACAGCAGCAGCAACAGCGGCAGCCATAGAAGCCAGCACTCACCACTGAGCTCACCTGTGGCAGCCACGATCAACGATCTGTTTGCCCACCTGCCGCACCAGCCGCCGCAGCTGCCCGCCCACTTGCACGCCCAATTCATGGCCGCCGCTGCTCTGGCCATGCACCCGGGCTCCACAACGGGCGACCTCGGCGCCGCCTTTCCCTGCATGCAGTGCACCGCCGCCTTCGCCAGCCGCGAGCAGCTCGAGCAGCACCAGCTGCTGCACTCGCCCACGGGCCCGCAGACCACACAGAACGTGACGCAGACCTGCAAAATATGCCACAAGGCCTTCGCGAACGTGTATCGCCTCCAGCGACACATGATCAGCCACGACGAGTCCGCACTGCTGCGCAAATTCAAGTGCAACCAGTGCGACAAGGCCTTCAAGTTCAAGCATCACCTGAAGGAGCACGTGCGCATCCATTCCGGCGAGAAGCCCTTTGGCTGCGACAACTGCGGCAAGCGCTTCTCGCACTCCGGCAGCTTCTCCTCGCACATGACCTCCAAGAAGTGCATTAGCATGGGCCTCAAGCTCAACAACAATCGACAAATGCTCAAGACTCTGGACAAGAACTCAAGCGCCAGACGCTCGCCCACAGACCAGCAGCAGCAGCAGCAGCAGCTGGCGGGCAAGCGGAAGCTGTCCGAGCAGGTGCTCCCGAACCCCATGAACTACTTTGCCGGCGAAGTGCAGAACCCACCAACCACAGTGAATGCTCCTGCGCCCTTCTATCCCAACTACAATGCGGCTTTGCTGGCATTCCCGAATGCCTTTATGGCGGCCGCGCTAGATCCGCGCATGCATCCCTATAGCATACAACGACTGCTGGAGCTGACTGCTGCCGGGCAGCAGCAACAACAGCAGCAGCAGCAGCGGGAGGAGCAGCTGGAGCAGGAGCACAGGGAGCAACAGAAGCTGTACGAGACCAGCAAAGATGATGATGAGACGCCAGATGAGCCCAAATTGGTTATGGACCTGGAGGAAGCGGAGCCCAAGCCTGCGGCCAGCCCAGAATCGCCCGTCGCTGAGACCGTAGCTATCGACGTGGGCGTCGTTAAGCAGGAGCCTAGTCGCGAGCCGACGCCTCCGGACACGCCCAACGATGCGGACGAGGATGAGGAGGACGAGGAGGAGCCACGCCAGGATTACCATGCTGGCAGCAGCGACAGCGGCGAGCGCAAGGTGCGCGTGCGCACCGCCATCAACGAGGAGCAGCAGCAGCAGCTCAAGCAACACTACGCCCACAATGCGCGTCCCAGTCGAGATGAGTTCCGCATGATCGCCGCCCGACTGCAGCTGGACGCGCGCGTCGTCCAGGTCTGGTTCCAGAACAATCGTTCGCGGGAACGCAAACTCCAGAGCTATGCGAGCAACGGCGAGGCCCCAGCTGCAGCAGCTCCAGCACCACCCCAGCCACGCGCTGGCGAGGATCAGCCTCTGGATTTGTCCGTGAAGCGTGATGCTTCGCCCTTGTACGGCTTGGCGTCCCAGCAGGCAGCCATGCTGCCCGCGCCCGCTGACTTTCAGGAGACCATGGCCATTAACCTGAGCCGCAAGTTGTCCGGGTCGGCGTCCATGTCGCCGGCTTCGCTGTCGCCCTGCTCGGGCGCCTCCTCACTGCAGCAGTCGGCAGCAGCTGCGGCTGCCGCTGCAGCGCTTTACTTTGCGCCCCCCTCGCCGCCCAGCCTGCACGAGTCGGCGCCCGCGCCCGCTCCGCGTGGCCAGGCATTCGCCGGGCTGCCGCCCTACATGTTGCCACGCCTACCCATGGAGGCACTTTTCCAGATGCGGCCCGGCGGCGACTATGCGCCCAATCCGCTCATGAACAGTATTAAGCTGCCCGACTATCGCGGCACCAGCCTCAGCCCCGGCGGCTCCGAGAAACGTTCGTGGCGCGACGATGATTCGCGCATCTCGCACGACGACGACTACGTCCTGGCGAGCGGTGGCCTGCTGCCGCCCAAGCCCAAGCGGGCCAAGGCCGAAACGCACGGACACGCAGGTGATCCGGACTTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAACAGAGCTCCCTGGCGCGCCACAAGTACGAGCATTCCGGTCAGCGACCCTATCAGTGCATGGACTGCCCGAAGGCCTTCAAGCATAAGCATCATCTGACGGAGCACAAGCGTCTGCATTCCGGCGAGAAGCCATTTCAGTGCTCCAAGTGCTTGAAGCGGTTCTCCCACTCGGGCAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFSSLASSLHHHQAHNKPSNAAANPELAASATASAAEDCLVKCTQCNKRFTDFQSFSEHIANEHPHDKLNYESHRAAAEASQPESEAEEDEQSNLSSSSRRYAKSPNSNNNNNNSETAKNQNNNNNNSSSNSGSHRSQHSPLSSPVAATINDLFAHLPHQPPQLPAHLHAQFMAAAALAMHPGSTTGDLGAAFPCMQCTAAFASREQLEQHQLLHSPTGPQTTQNVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCNQCDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRQMLKTLDKNSSARRSPTDQQQQQQQLAGKRKLSEQVLPNPMNYFAGEVQNPPTTVNAPAPFYPNYNAALLAFPNAFMAAALDPRMHPYSIQRLLELTAAGQQQQQQQQQREEQLEQEHREQQKLYETSKDDDETPDEPKLVMDLEEAEPKPAASPESPVAETVAIDVGVVKQEPSREPTPPDTPNDADEDEEDEEEPRQDYHAGSSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRMIAARLQLDARVVQVWFQNNRSRERKLQSYASNGEAPAAAAPAPPQPRAGEDQPLDLSVKRDASPLYGLASQQAAMLPAPADFQETMAINLSRKLSGSASMSPASLSPCSGASSLQQSAAAAAAAAALYFAPPSPPSLHESAPAPAPRGQAFAGLPPYMLPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHDDDYVLASGGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00586575;
90% Identity: iTF_00586575;
80% Identity: iTF_00586575;