Basic Information

Insect: Drosophila quinaria
Gene Symbol: ewg
Assembly: GCA_035047525.1
Location: JAWNPO010000455.1:32088964-32096120[+]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.2e-108 3e-104 347.7 0.0 1 212 47 257 47 258 0.98

2 3 0.99 5.8e+03 -2.9 3.2 91 114 369 392 353 427 0.53

3 3 0.3 1.7e+03 -1.2 6.0 92 135 451 494 434 507 0.67

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.2e-108	3e-104	347.7	0.0	1	212	47	257	47	258	0.98
2	3	0.99	5.8e+03	-2.9	3.2	91	114	369	392	353	427	0.53
3	3	0.3	1.7e+03	-1.2	6.0	92	135	451	494	434	507	0.67

Sequence Information

Coding Sequence: ATGCTCGACGATGATATCCAAAGTCTGGCCACggatgatgaggatgatgagTTGATTAGCAGCGATGGCAGCTTATATGATGGTGATCTCAATACAATAGCCGTCAACGATGATGTCGCCCATCAATTGGCCGCCGCTGGgccagtgggcgtggcagcggcTGCCGCCATTGCCAGCTCAAAGAAACGGAAACGTCCGCATTGCTTTGAAACGAATCCATCGGTGCGAAAGCGACAACAGAATCGCTTGCTGCGCAAACTGCGCGGAATCATCTATGAGTTCACCGGTCGGGTGGGCAAACAGGCGGTGGTGCTGGTGGCGACGCCGGGCAAACCGAATACCAGCTACAAAGTGTTTGGCGCCAAGCCGTTGGAGGATGTCCTGCGGAATCTCAAGAATATTGTGATGGATGAGCTGGACAATGCGTTGGCACAACAGGCGCCGCCGCCACCGCAGGAGGATCCATCGCTGTTCGAATTGCCCGGCCTGGTGATCGATGGTATTCCCACGCCCGTCGAGAAAATGACACAGGCCCAGCTGCGTGCGTTCATACCGCTCATGTTGAAGTATTCAACGGGACGGGGCAAACCCGGCTGGGGCCGAGAGTCGACGCGACCGCCATGGTGGCCCAAGGAATTGCCGTGGGCAAATGTCCGCATGGATGCCCGCTCCGAGGATGACAAGCAGAAGATCAGCTGGACACACGCACTGCGCAAGATTGTGAtcaattgttataaatatCATGGACGGGAGGATTTGTTGCCCACGTTTGCGGATGATGAGGACAAGGTGAATGCGTTAATCTCACAGTCGGGCGATGAGGACGAGGATATGGAGCAGCTATCGAATACGCCCACCATTCAGACGGTGCAGACGGTGACGCCCGCGGTTAGCACCACCAACAGTCAACCACAACAGGTGAATGTGGTGAAGATCAACAGCGCTGGTACAGTGATCACCACGCACACGGCCCAAACAAACACGCCGGCACCAACAATAATCCAGAGCACGAACAATCAACATGtgacaaccacagcaacattGCCGGCATCCACAAAGATTGAGATTTGTCAGGCGCCGGCgccgcaacaacagcaacagcagcaacatcaccatcaacagcagcagcagcaacaccatcatcatcaacagcagcagcagcaacatcatcatcatcatcatcagacaACAAGTGGCAGCAACACGGTGCACATACAGGCTGTGAGTCAGGGACAACCGCAGACCATTCAGCTGACAACGGCGAGCggaacggcaacggcaacggcggtgccaacgacagcagcagctgtaagtgcatcagcagcagctgccgcagtcgcacaacaacaacagcagcagcaacaacaacaacaacagcagcagcaacagcaacaacaacaatcgaatGCTGCACAAACTGTGACCGCGCAACAAATTGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTCAGCGACGTTGATTACACCACACAGACCGTGTTATCGCAGAATGCTGATGGCACTGTCTCCCTCATCCAAGTGGATCCCAATAATCCCATCATCACACTGCCAGACGGCACAACCGCCCAAGTCCAGGGCGTGGCAACGCTGCATCAAGGCGAAGGTGGCGCCACCATTCAAACGGTGCAAAGTCTCACTGATGTGAATGGACACGAGAATATGACGGTTGATCTAACCGAAGCACAAGATGGTCAAATCTTTATAACCACCGAGGATGGACAAGGCTATCCCGTGTCCGTGAGCAACGTCATTTCGGTGCCCGTTTCCATGTATCAATCCGTGATGGCGAACATGCAGCAGCTTCATAGCGGCGATGGCACCGTGTGCTTGACGCCAATGCAGGTAGATAGCAACAACCACAGTGCAACacgcggcaacaacaacagcaatagcaacaccaacaacagcaacaatagtaGTAGTAATAGTTGTATTAGTGGCAACACATCGTCGCTTGGCATTTCTGTTATCAATGCCAGTACCATAATGGGCAGACGCACTgtagcggcagcggcagctgcaacagcgacagcaacaacaacaacaacagttgctgctgctgcggctgctgctgcaacaacagcaactcaaCTCACGTTGCAAGCGCCGCTGGGCACACGCCTCTTTTGGGCGCCAAGTGGCAACAATGCCAGCTCAAGCTTTAATCTCgctaacaacagcaacaacaacaacaatagcatgcttactaacaacaataacaataataacattaacaacaacaacaacaacaacattaaaatgCCGCTGCCTATTGTGCAgacagcgacgtcgacgtcacaGCAGCGTCGCAGTCGCTCGGCAACAGCGCAAAAGCGACGCAGGCAAACAagtggcaactgcaacagcagcaacaacaacaacaacaagttgtcgTGCGGCAAAAGCAATGATGCTGCAAGCAGctctgcctctgccgctgccgctgccattCGCTGCGTCGACAGCGCGAGTTTAACAAATGCGCAGCTTCAGTTGCcggcaaaaacaattaaattggaGCATTTGGAGTAG
Protein Sequence: MLDDDIQSLATDDEDDELISSDGSLYDGDLNTIAVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVTPAVSTTNSQPQQVNVVKINSAGTVITTHTAQTNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQQQQQHHHQQQQQQHHHHQQQQQQHHHHHHQTTSGSNTVHIQAVSQGQPQTIQLTTASGTATATAVPTTAAAVSASAAAAAVAQQQQQQQQQQQQQQQQQQQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLHSGDGTVCLTPMQVDSNNHSATRGNNNSNSNTNNSNNSSSNSCISGNTSSLGISVINASTIMGRRTVAAAAAATATATTTTTVAAAAAAAATTATQLTLQAPLGTRLFWAPSGNNASSSFNLANNSNNNNNSMLTNNNNNNNINNNNNNNIKMPLPIVQTATSTSQQRRSRSATAQKRRRQTSGNCNSSNNNNNKLSCGKSNDAASSSASAAAAAIRCVDSASLTNAQLQLPAKTIKLEHLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00594986;
90% Identity: iTF_00533540; iTF_00585703; iTF_00601499;
80% Identity: -