Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0022 0.15 12.6 0.2 1 21 122 142 122 143 0.96

2 6 2.3e-05 0.0016 18.8 0.7 2 23 157 178 157 178 0.98

3 6 0.00071 0.049 14.1 2.1 1 23 184 206 184 206 0.98

4 6 3 2e+02 2.7 1.0 1 11 233 243 233 245 0.92

5 6 0.55 38 5.0 0.1 1 21 255 275 255 276 0.92

6 6 0.0014 0.093 13.2 0.7 1 20 283 302 283 302 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0022	0.15	12.6	0.2	1	21	122	142	122	143	0.96
2	6	2.3e-05	0.0016	18.8	0.7	2	23	157	178	157	178	0.98
3	6	0.00071	0.049	14.1	2.1	1	23	184	206	184	206	0.98
4	6	3	2e+02	2.7	1.0	1	11	233	243	233	245	0.92
5	6	0.55	38	5.0	0.1	1	21	255	275	255	276	0.92
6	6	0.0014	0.093	13.2	0.7	1	20	283	302	283	302	0.96

Coding Sequence: ATGAACTCTAAGCGCATCAAGTACACGACAGAGGACGTGGATGGTGGGGAACCACAACAGTATACCTATGCCTATACCACCGAGGATGATGATACCGAAACGGCTGTCGTAACGCTCAGCGATCGTGATCATGAGGCCTTGGCCAATGCCCAGGAGGTGATTATCGATGAGAATGGGCATGCGGTGACATTGCAACAATTGGTGGAGAATAGTACAGTTGAGGAGGTGGAAACGATTGAACAGGGGGATGGGCACGAGGAAGGCGAAGAAGGTGAAGAAGAGGACGATGATCTTGGCTCGATTGTCTGTGAGGGCACCATCGATCATAGTCCCGATTCGGATTCGCAATCGCGTAACAAAACCTTCTATTGCCCCAATTGTGGCAATTGCTATAGTGCTGCTGGATCCGTAAAACTCCATATGCGTGCCTGTCTCCGGCAAAGGAATGAAATCTCTGCCGAGGATCGCAAGTGCACAGTTTGCagtaaaattttcaattcggTCGCCTACCTCAAGGAGCACATGATGCGTCATGCTGGAGAGCAACCATTCCGTTGCACACGCTGTTATCGCAAATTTGTGGACGAAGCCAAATACAATACGCACATGGATTCCCACAAGCATCAGGATAAACTGGAGGCCGAGGCCGAAGCTCTCGCTGCCCAGCATGGTGGCAAAAAGGTTGTAGTCAAGGAGTTCACCTGCTCTTTTTGTAGCCAAAATTTCACAGTCGTCTTCGATGTTGGCCAAGTGAAACGTCGCTATGCCTGCGATGCCTGTCGCGATAAATACTCGAATGCGGAGGCACTGCGTCAGCATAAACAACAGGTCGAGGAGAAACGGGAGTTCAGCTGTCAACGCTGTGGACGCAAATTTGTCTTCGAAGGATTCCTGCAACGTCATCTGCCCACATGCGATGGCAGCATTAAGCATCGTCGTGACATGAAGTAG
Protein Sequence: MNSKRIKYTTEDVDGGEPQQYTYAYTTEDDDTETAVVTLSDRDHEALANAQEVIIDENGHAVTLQQLVENSTVEEVETIEQGDGHEEGEEGEEEDDDLGSIVCEGTIDHSPDSDSQSRNKTFYCPNCGNCYSAAGSVKLHMRACLRQRNEISAEDRKCTVCSKIFNSVAYLKEHMMRHAGEQPFRCTRCYRKFVDEAKYNTHMDSHKHQDKLEAEAEALAAQHGGKKVVVKEFTCSFCSQNFTVVFDVGQVKRRYACDACRDKYSNAEALRQHKQQVEEKREFSCQRCGRKFVFEGFLQRHLPTCDGSIKHRRDMK

Sequence clustering based on sequence similarity using MMseqs2