Dput012422.1
Basic Information
- Insect
- Drosophila putrida
- Gene Symbol
- topi
- Assembly
- GCA_037043535.1
- Location
- JBAMBI010000494.1:175171-177867[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 1.7 1.1e+02 3.5 2.0 2 20 136 153 135 155 0.92 2 11 2.1e-06 0.00015 22.1 1.9 2 23 228 249 228 249 0.97 3 11 0.092 6.3 7.5 0.1 2 23 275 296 274 296 0.87 4 11 0.006 0.41 11.2 0.3 2 23 359 380 358 380 0.96 5 11 0.012 0.85 10.2 0.2 1 21 427 447 427 451 0.90 6 11 3.4 2.3e+02 2.5 0.2 2 20 466 484 465 488 0.78 7 11 4.8e-07 3.3e-05 24.1 1.9 1 23 513 535 513 535 0.95 8 11 0.00049 0.034 14.6 1.1 1 23 541 566 541 566 0.96 9 11 0.42 29 5.4 1.7 1 23 572 594 572 594 0.88 10 11 3.6e-08 2.5e-06 27.7 0.4 1 23 600 622 600 622 0.99 11 11 0.00068 0.047 14.2 1.2 1 23 628 651 628 651 0.95
Sequence Information
- Coding Sequence
- ATGGATGAGAATTTGCAAGTTTATACGGATGGTGAGTTCGTTATGGCGGAGTTTGAGTTCGATTCGGAGCTGGTGTATCCCAGTGGAGAATTGCAGCAGGGTGCCACTGTGCTGGCGGTCAATGAGTCTGATGGCATTGTAAGCTTCGACGGATTGGACAACCTCTTTGATCTTTCGAATGTGATTGAGATTAATGCAGTAGAACCCTTTGAGCACACGTTGGAGGATCCATCTATACAGCAAATACTGCAGCAAGCTGATGATAAGGTTGACTTTGATCCAGAAGAAGAGCAAGAAAAATTACGGGACTTCCTTGCAGTAGCAAACAATAATATTCCTACTAAAAACACTTTGCCTCAAGTGGGATCCTTATTCTCTCAGTCTTCCGAAACTATTCGGGCTATTAAATGCTCAAATTGCAATGCTCTCTTCGACAAGTCATCTTTCCAGACTCACAAGTGTGAACTCGAGGGAAAGCAGACACCAATTGTTACTCCTCAAAAGATGACACTATCTCATGATAAAGTGGCAGCTGTGCCGCCCAAGAAATACCCTAGCGAACGTATTATCACCGAGAATCAAGTGCGCATACGTCGCTATATGAAGGAAGAGCTAAAGTATGACCTGGAAACGGGTGTCGACAGTTCCAAGATTAAGAAATCATCGTCCAAGGGTCCCAACGAGTGTCACATTTGTGATCGCAAGTTTGTGCATCCCTCGGGACTAGCACGACATATGGAGAAACATACGCTGGACTTGATTCCCACCCAAACCAATGTACAACAGACAGCAGTGGGTACTCTGGGTCTTCTGGTTGTGCTCAAATGTAATCTCTGCGGTCGCATATTTTATGATATCAAACTGGCACTGGAACATGTCTATGTACATTATGAACCGTTGGATAAGATCAAAGTGTCCACAATTGTTGAAGAAAATCCAACGGATTTGAAGCAACAGCTGGATATACTCATGGAGGAGGGAGAGCAGCTATTGACGGTTGCTGTCCAACTGGAAAAGTTATCACAAGATTTGGGCACGGAATACTTTTCCCCACTCATTGTGAACAACGTGCTCCAGTGCGAGTTTTGTGACTACATCTTTGCCGATGTCTCCTGTTTGTTGGTACATTCGGCCACTCATGTTCCCGAGCGACGTTTTGAGTGCACTGCTTGTGATCTGCGCATGACCACCGCCAAGGAGGCCAGTGTACACTTTCAGACCGACTGTGTCTATATGCGTGAAGGATTAAAACAGTTGCCGATATGTCCCAGTCGTTACTTTGTCTGCAACGTGTGTGAAGTGAAGTTTGCCAATGTGGAGCTTCTCCAGGAGCATCGCTATAGCTTGTATCATTACTTTCCACGTCTCAGCGAGTCTGGCAGCCGTCTTCTACTTCCTTGTGAGTTTTGTGGCGTTAACTTTGACTATGCCCATGAGATTCAGCCCCATTATGAGGAGAAGCATCTGAATAAGAAGAAACGTGAGAAGGAGTTGCGTAATAACACGAATCCCTCAAATGAGGGACGATTGCGTCAATATCTATGCGACATTTGTGGCAAATCATACACACAGTCAAGTCACTTGTGGCAACACTTGCGTTTCCATCAGGGTGTGAAGCCGTTCGTTTGTCAGGAGGAGAACTGTGGGCGCAAATTCACTATCCGTCCGGATCTCAACGATCACATTCGAAAGTGCCACACGGGAGAGCGTCCTTACCACTGTCTGGTGTGTGGCAAGCGTTTCCTCACCGGTTCCGTTTTCTATCAGCATCGTCTCATCCATCGTGGCGAGCGGCGTTACGAGTGCGAGGAGTGTGGCAAGAGATTCTATCGTGCGGATGCCTTAAAGAACCATCAACGTATTCACACTGGTGAAAAACCATACGATTGTCCGTTTTGCACAAAGACATTCCGTCAGCGTGGTGATCGGGATAAACATGTGCGAGCACGTCACTCTCACTTGGATGAGCATACCCGCTTGATGATGCAAATGCAGAAGTTTGAACTGGAAACTGCGGCTGTGTTGAAGGCTAAGCAAATGCAGGAGAACAGTGATTATGAGTTTGTTTCTGAAACTTCATCTGCATCATTCATGCCACCATCGGAACAACAATATGAGATGGTTGAGATAGATCAAAACTATATTTGTGAAGCACCAGAAGGTGAAGAAATGGCCACAATGTTAATTGATAATACAGATTATGACGAGGTAATTACCTGTGGCGATATGGAGGGAATCGAAACTGTTGAGGTGCCACAGTTTTCTTCGGAAAACGCTAAGGTTGTGGTCGTTGAAAATAATTCTTCACAGCCGTTTTATTTCTAA
- Protein Sequence
- MDENLQVYTDGEFVMAEFEFDSELVYPSGELQQGATVLAVNESDGIVSFDGLDNLFDLSNVIEINAVEPFEHTLEDPSIQQILQQADDKVDFDPEEEQEKLRDFLAVANNNIPTKNTLPQVGSLFSQSSETIRAIKCSNCNALFDKSSFQTHKCELEGKQTPIVTPQKMTLSHDKVAAVPPKKYPSERIITENQVRIRRYMKEELKYDLETGVDSSKIKKSSSKGPNECHICDRKFVHPSGLARHMEKHTLDLIPTQTNVQQTAVGTLGLLVVLKCNLCGRIFYDIKLALEHVYVHYEPLDKIKVSTIVEENPTDLKQQLDILMEEGEQLLTVAVQLEKLSQDLGTEYFSPLIVNNVLQCEFCDYIFADVSCLLVHSATHVPERRFECTACDLRMTTAKEASVHFQTDCVYMREGLKQLPICPSRYFVCNVCEVKFANVELLQEHRYSLYHYFPRLSESGSRLLLPCEFCGVNFDYAHEIQPHYEEKHLNKKKREKELRNNTNPSNEGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSHLDEHTRLMMQMQKFELETAAVLKAKQMQENSDYEFVSETSSASFMPPSEQQYEMVEIDQNYICEAPEGEEMATMLIDNTDYDEVITCGDMEGIETVEVPQFSSENAKVVVVENNSSQPFYF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00558128; iTF_00608644;
- 90% Identity
- -
- 80% Identity
- -