Basic Information

Insect: Drosophila pseudotalamancana
Gene Symbol: topi
Assembly: GCA_037075185.1
Location: JBAMCK010000385.1:287933-290492[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 6.3e-05 0.0044 17.4 1.3 2 23 246 267 246 267 0.97

2 9 0.011 0.75 10.4 0.5 2 23 295 316 294 316 0.92

3 9 0.009 0.63 10.6 0.1 2 23 378 399 377 399 0.96

4 9 0.018 1.3 9.7 1.2 1 21 446 466 446 470 0.90

5 9 4.8e-07 3.4e-05 24.1 1.9 1 23 532 554 532 554 0.95

6 9 0.00049 0.034 14.6 1.1 1 23 560 585 560 585 0.96

7 9 0.42 29 5.4 1.7 1 23 591 613 591 613 0.88

8 9 3.7e-08 2.6e-06 27.6 0.4 1 23 619 641 619 641 0.99

9 9 0.00068 0.048 14.1 1.2 1 23 647 670 647 670 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	6.3e-05	0.0044	17.4	1.3	2	23	246	267	246	267	0.97
2	9	0.011	0.75	10.4	0.5	2	23	295	316	294	316	0.92
3	9	0.009	0.63	10.6	0.1	2	23	378	399	377	399	0.96
4	9	0.018	1.3	9.7	1.2	1	21	446	466	446	470	0.90
5	9	4.8e-07	3.4e-05	24.1	1.9	1	23	532	554	532	554	0.95
6	9	0.00049	0.034	14.6	1.1	1	23	560	585	560	585	0.96
7	9	0.42	29	5.4	1.7	1	23	591	613	591	613	0.88
8	9	3.7e-08	2.6e-06	27.6	0.4	1	23	619	641	619	641	0.99
9	9	0.00068	0.048	14.1	1.2	1	23	647	670	647	670	0.95

Sequence Information

Coding Sequence: atggaTCCGAATTTGGAGTTGTACGGGGATGGCGAGTTCCTAATGGCCGAATTCGAGTTCGTTGGGGATTTGGTTGTGAACAGCGATGAGCTGCAGCCGGGGGCCACTGTGCTGGTATCCAATGAGACCGATGGCATTGTTAGCCACGAGGACTTGGCCAAGTTCTTCGAGCTACAGGCGGCCATGCCCATGCCCCCGGAGGAGGCTGTCGAACGCACGCTGGCCGATCCGACATTGAAGCAAATCCTGGAGGAGTCCGACGGAAAGGTGGATTTCGATCCCGAGGCAGAGCAGGAAAAGTTGCGTGAGTTTCTGTCGGGAGTCAACAATAAAATGACGGTCTCGGAGAAGAGTGCCGCACCCAGTGCAGCCGAGGTGGCACAaaagccgcagccgcagccgcaaccGCCGGTGACCCAGCCACGCCCTGGGATGCCGCAATCGACAGTCTTTCGCTTCATCAAGTGCTCCAATTGCAACGGCCTCTTCGACACACCCTCGTTCCAGGACCACAGCTGTGAATACGAGTCGGATCAGAAACCGATGTCCGTAAATCGCGTGCCATCAGCCCAGGAGAAGAAGGCGCCGACGCCGCCTCGGAAAACGCCTAGCGAACGCATCATCGTTGAAAACCAGGTGCGCATTCGGCGCTATATGAAGGACGAGCTTAAGTATGATCTGGAGACGGGCTTCGACAACTCGAAGGCCAAAAAGACCTCCACCAAGGGGCCCAACGAGTGCAGCATCTGCGAGCGAAAGTTCGTGCACACCTCCGGCTTGGTGCGTCACATGGAGAAGCATGCGCTTGACCTAATCCCGACACAAACCAACAtccagcagcaacatgcgGCTCCCTCGGCACTCGGGCTGCTGGTGGTACTCAAATGCAATCACTGTGGCCGCATCTTCTACGATGTGAAACTTGCGCTGGAGCACATCTTTGTGCACCAGTCGACAACGGAGGTGGCCGAGCTGGAGCCCGTTGTCGAGGATAAAACGGTTTTGAAGCGGCAGCTAGAGCAGCTTCTGCAGGAGGGCGAGCAACTGCTGACCATAGCCGCCGAGCTGGAGAGGATGTCGCTCAAGAACGACGACGAATACTTCACCACCCACGTGCTGGGAAACGTGCTTCAGTGCGAGTTCTGCGACTACATTTTCGCGGACGTCTCCTTCTTGCTGGTGCACTCGGCCACACACGTGCCGGAGCGCCGCTTCGAGTGCACCGCCTGCGATCTGCGCATGACCACGGCCAAGGAGGCCAGTGTCCACTACCAGACCGACTGCGTCTATATGCGCGAAGGACTCAAGCAGTTGCAGGCGCAGCCGAATCgattttttgtatgcaatgTGTGCGAGTTGAAGTTTGCCAATGTCGAGCTGCTCCAGGAGCATCGCTACAGCTGCTATCACTACTTTCCTCGGCTCTGCGAGAGCGGCAAGCGCCTGATGCTGCCGTGCGAGTTCTGTGCCACAAACTTTGAGTACGCGCACGAGATACAGCCGCACTACGAGGAGAAGCATctgaataagaagaagcgtGAAAAGGAGTTgcgcaacagcggcaacacgGCCACCATGGGACGACTGCGTCAGTACTTATGCGACATTTGCGGCAAATCGTACACCCAGTCCAGCCATCTGTGGCAGCACCTACGCTTTCACCAGGGTGTAAAGCCGTTCGTGTGTCAGGAGGAGAACTGCGGCCGTAAGTTTACCATACGCCCAGATCTCAACGATCACATACGTAAGTGCCACACAGGTGAACGGCCGTACCACTGTCTGGTTTGTGGCAAACGCTTTCTCACCGGCTCGGTTTTTTATCAGCATCGACTCATACATCGCGGCGAGCGGCGATACGAGTGCGATGAGTGTGGCAAGCGGTTCTATCGCGCCGATGCATTAAAAAACCATCAGCGCATACACACCGGGGAGAAGCCCTACGATTGTCCATTTTGCACCAAGACGTTCCGCCAGCGCGGCGATCGGGATAAGCATGTGCGAGCCCGTCACTCGCACTTGGACGCGAATGCACGACTGATGATGCAGATGCAAAAATTCGAATTGGAAACGGCAGCAGCGCTAAAGGCCAAGCAAATGCAGGAGGGCGGagttgaatttgttgttgattcaGCGGCAGCCACGTCTATCCATTCGCCAACGTCACCCATGGGCCATGAGCACCAGTTTGATATGGTCGAATTGGATCCCAGTGATTTTGGTGAGGGATCCGAGTTTATTCAAAGTATCCCAATGCCCATTAACAACGAGGAGCAGGAGATTATGTCGTTCGTAGACCTCGAAGGGACAGAACCAATTGAGCAACAACCATTCCAGTTGGAGAACAATGAAAACGTTAAGGTGGTAGTAGTTGAAAATAATACATCGCAGCCGTTTTATTTCTAA
Protein Sequence: MDPNLELYGDGEFLMAEFEFVGDLVVNSDELQPGATVLVSNETDGIVSHEDLAKFFELQAAMPMPPEEAVERTLADPTLKQILEESDGKVDFDPEAEQEKLREFLSGVNNKMTVSEKSAAPSAAEVAQKPQPQPQPPVTQPRPGMPQSTVFRFIKCSNCNGLFDTPSFQDHSCEYESDQKPMSVNRVPSAQEKKAPTPPRKTPSERIIVENQVRIRRYMKDELKYDLETGFDNSKAKKTSTKGPNECSICERKFVHTSGLVRHMEKHALDLIPTQTNIQQQHAAPSALGLLVVLKCNHCGRIFYDVKLALEHIFVHQSTTEVAELEPVVEDKTVLKRQLEQLLQEGEQLLTIAAELERMSLKNDDEYFTTHVLGNVLQCEFCDYIFADVSFLLVHSATHVPERRFECTACDLRMTTAKEASVHYQTDCVYMREGLKQLQAQPNRFFVCNVCELKFANVELLQEHRYSCYHYFPRLCESGKRLMLPCEFCATNFEYAHEIQPHYEEKHLNKKKREKELRNSGNTATMGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSHLDANARLMMQMQKFELETAAALKAKQMQEGGVEFVVDSAAATSIHSPTSPMGHEHQFDMVELDPSDFGEGSEFIQSIPMPINNEEQEIMSFVDLEGTEPIEQQPFQLENNENVKVVVVENNTSQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00475441;
90% Identity: -
80% Identity: -