Basic Information

Insect: Drosophila pseudotalamancana
Gene Symbol: ewg
Assembly: GCA_037075185.1
Location: JBAMCK010000693.1:735325-740235[+]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.8e-108 2.5e-104 347.6 0.0 1 212 46 256 46 257 0.98

2 3 2 1.8e+04 -9.2 15.4 85 135 378 428 338 441 0.62

3 3 2 1.8e+04 -8.1 5.2 7 29 458 480 454 490 0.51

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.8e-108	2.5e-104	347.6	0.0	1	212	46	256	46	257	0.98
2	3	2	1.8e+04	-9.2	15.4	85	135	378	428	338	441	0.62
3	3	2	1.8e+04	-8.1	5.2	7	29	458	480	454	490	0.51

Sequence Information

Coding Sequence: ATGCTCGACGATGATATGCAGAGTTTGGCCACCGATGACGAGGATGACGATTTGATCAGCAGCGAGGGCAGCCTATACGATGGCGATCTCAATACGCTGGTCAACGACGATGTCGCCCATCAGCTGGCCGCTGCTGGtccggtgggcgtggctgcggcCGCTGCCATCGCTAGCTCAAAGAAGCGAAAGCGTCCGCATTGCTTCGAAACGAATCCGTCGGTGCGGAAGCGTCAACAGAATCGCCTGCTACGAAAGCTGCGCGGCATCATTTACGAGTTCACCGGACGGGTGGGCAAGCAggcggtggtgctggtggcTACGCCGGGTAAGCCGAATACCAGCTACAAGGTGTTCGGTGCCAAGCCGCTGGAGGATGTGCTGCGCAATCTGAAGAACATTGTGATGGATGAGCTGGACAATGCGCTGGCCCAAcaggcgccgccgccgccccaGGAGGATCCGTCGCTGTTCGAGCTGCCCGGCTTGGTGATCGATGGCATACCGACGCCCGTCGAGAAGATGACGCAGGCACAGCTTCGCGCCTTTATACCGCTAATGCTGAAATATTCGACCGGACGAGGCAAACCCGGCTGGGGCAGAGAGTCGACACGTCCGCCATGGTGGCCCAAGGAGCTGCCGTGGGCGAATGTCCGCATGGACGCCCGATCCGAGGATGACAAGCAGAAGATCAGCTGGACACATGCGCTCCGCAAGATCGTCATCAATTGCTACAAATATCATGGACGCGAAGATCTGCTGCCCACCTTTGCCGACGACGAGGACAAGGTGAACGCATTGATCTCCCAGTCGGGCGATGAGGACGAGGACATGGAGCAGCTGTCCAACACGCCCACCATTCAAACGGTACAAACGGTGACGCCGGCTAACAGTAATCCAGTCGCCAGCCAAcctCAGCAGGTGAATGTGGTGAAAATCAACAGCGCCGGCACCGTTATAACCACACACACGGCCCAATCGAATACGCCGGCGCCAACGATCATCCAAAGCACGAACAATCAGCACGTGACAACGACGGCCACCTTGCCGGCCTCGACGAAGATTGAGATCTGTCAGGcgccagcagcgcagcagcagcacctccaacagcagcagcagcagcaacagcaacagcagcagcaacaacagcagcagcagcagcagcagcaccttatccaccaacagcagcaacaacaacaacaacaacagcagcagcagcaacaacatcatttGCAGACAAGCAACAATACAACGGTGCACATACAAACCGTTAGTCAGGCACAGCCGCAGACAATACAATTGACAACGGCCAGCGGTacagcgacggcaacggcagtGCCAACAACAGCGGCCGCTGTAAGTGCctcagcggcggcggcggcggcggcggctgctgctgcccaacAAGCTGCACAAGCGGCGCAAGCAGCGCAGCCCACAATCGCAGCGCAGCAGACAGTCACCGCCCAGCAAATCGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACCACACAAACGGTTTTGTCGCAAAACGCCGATGGCACCGTCTCTCTCATACAGGTGGATCCTAACAATCCTATAATCACGCTACCCGATGGCACAACCGCTCAAGTACAGGGTGTGGCAACGCTGCATCAAGGCGAAGGCGGCGCCACCATACAAACGGTACAAAGTCTGGCGGACGTGAATGGACATGATAACATGACCGTCGATCTTACCGAGGCGCAGGACGGTCAAATCTTTATCACCACCGAAGATGGGCAAGgTTATCCGGTGTCCGTGAGCAACGTTATATCGGTGCCCGTTTCCATGTATCAGTCGGTGATGGCCaacatgcagcagctgcagacgAACAGCGACGGCACCGTGTGCCTGGCCCCCATGCAGGTagataacagcaacagctcctCCAACACTAGCGCCTCGCGCATCAACAAcaccaataccaacaacaacaacaacaacagcagcaacagcaacttgaATAACAGTAATAGTAGCGGCAGCGCAGCAACTGCGCCAGCCTCGCTGCTAGGCATCTCTGTAATTAACGCTGGCGCCGTGCTCAGTCGGCGTCTCGCTGGCAGCGGCGCTGGCGCCGCAGCGACAGCGCCGAATGCTGGACAACAGCAGGCGTTAACATTGCAGGCGCCGCCGGGCACTCGATTTTATTGGGCCGCTAGTCCGGCCAGCGGCagcgccgccagcagcagcactttgAATGCTGCCGCTAGCTTAAATCTcgccaataacaataataatagcatgctaactaacaacaataacaacaacaataataataataataacagcagcagcagcaacagcggcgtcggcagcagcagcagtaacagcattAAAATGCCGCAGCCCATAGTTTTAACAGAGCCAGCAACGTCGACTGCGCAGCGACGCTATGAAGCTTGCGCGTCGCGACGCTCAACAGCGCAAAAGCGACGCaagctgaacaacaacaacagcagcaacaacagtaaattAACACTGCGCAAAAGGACAAGCGATGTAacggttgttgctgctgctgctgctgctgaaacTTCGAGcagcgccgctgctgctgcggccatACGCTGCGTCGACAGCGCCAGCCTGACAAACGCAAGCGGcgcgtcgctgctgttgcagctgccagctAAGACCATTAAATTAGAGCATTTGGAGTAG
Protein Sequence: MLDDDMQSLATDDEDDDLISSEGSLYDGDLNTLVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVTPANSNPVASQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAAQQQHLQQQQQQQQQQQQQQQQQQQQQHLIHQQQQQQQQQQQQQQQHHLQTSNNTTVHIQTVSQAQPQTIQLTTASGTATATAVPTTAAAVSASAAAAAAAAAAAQQAAQAAQAAQPTIAAQQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLADVNGHDNMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDNSNSSSNTSASRINNTNTNNNNNNSSNSNLNNSNSSGSAATAPASLLGISVINAGAVLSRRLAGSGAGAAATAPNAGQQQALTLQAPPGTRFYWAASPASGSAASSSTLNAAASLNLANNNNNSMLTNNNNNNNNNNNNSSSSNSGVGSSSSNSIKMPQPIVLTEPATSTAQRRYEACASRRSTAQKRRKLNNNNSSNNSKLTLRKRTSDVTVVAAAAAAETSSSAAAAAAIRCVDSASLTNASGASLLLQLPAKTIKLEHLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00573056;
90% Identity: -
80% Identity: -