Basic Information

Insect: Drosophila pseudoobscura
Gene Symbol: ush
Assembly: GCA_009870125.2
Location: CM020870.1:18887050-18902239[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0074 0.56 10.9 0.0 1 20 263 282 263 284 0.90

2 9 0.00032 0.024 15.2 0.8 1 23 340 362 340 362 0.98

3 9 0.056 4.3 8.2 1.0 2 21 418 437 418 438 0.92

4 9 0.055 4.1 8.2 2.9 2 21 829 848 828 849 0.93

5 9 0.01 0.77 10.5 0.0 3 21 898 916 896 917 0.91

6 9 0.0073 0.55 11.0 0.0 2 23 984 1005 983 1005 0.98

7 9 0.0043 0.32 11.7 1.3 1 23 1011 1033 1011 1033 0.99

8 9 0.00078 0.059 14.0 0.8 1 23 1088 1111 1088 1111 0.96

9 9 0.21 16 6.3 0.4 2 20 1220 1238 1219 1240 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0074	0.56	10.9	0.0	1	20	263	282	263	284	0.90
2	9	0.00032	0.024	15.2	0.8	1	23	340	362	340	362	0.98
3	9	0.056	4.3	8.2	1.0	2	21	418	437	418	438	0.92
4	9	0.055	4.1	8.2	2.9	2	21	829	848	828	849	0.93
5	9	0.01	0.77	10.5	0.0	3	21	898	916	896	917	0.91
6	9	0.0073	0.55	11.0	0.0	2	23	984	1005	983	1005	0.98
7	9	0.0043	0.32	11.7	1.3	1	23	1011	1033	1011	1033	0.99
8	9	0.00078	0.059	14.0	0.8	1	23	1088	1111	1088	1111	0.96
9	9	0.21	16	6.3	0.4	2	20	1220	1238	1219	1240	0.91

Sequence Information

Coding Sequence: ATGCCTGAACATTTTATGACCAAAAAGGCCCgtccgccgccgccccccAAGTCGaactcatcatcatcatcagcgccCAGTGCCCATCGTCAGCTGGCGGGGAAGTGGGGCGGAGTCCAGGGcgagggccagggccaggtccAGGGTCAGGACTTAGGCCAGAGCGAAGGAGGAAGGAGCACCAGCTATTCCAAAGATTTAACCGCTCAGGAGCTGGGCGaagagaaacagcaacagctacagcagcagcagcagcaggaggatcCAATGGATCTTcaggacaacaacaacaacagcgatgcagatgcagatgcagaggATGCTGTGTCCGAACAGCCGGAAGAGACTCAGGATTTAGGGGAAACAGAAATGGATGGAAACAGAATggaccaccaccaccaggcggaggagcaggagcaggtggAGGCAGACgcagaggcggaggaggcACCGATCAGTCCTAGTACGCCGCCACGGAGTCCTACGCCGCCTCTAGTTCTGGTGCCAAAGCTGGAGCAGCCAGCGACTCCGCCATCGGAATCGCCATCGCCCAGTCCttcgcccacgcccacgcccaccgCAACGCCCACTCCGAGGCTACCAAAGCTCCGCCTCAATGCGCTGCTCGCCTCGGATCCCGCCCTCAAGCCGGACGCCAAGGAGCTGCACCTGTCGGACAAGCGTCTGCTGGCACCGCCGCCGCACATCAAGCCCGAGCCGCAGCCCCCGCAGGCACAGCCCCCCCTACAGCCCGATCTCGTGGAGCCGCTGCTGAAGCCGGCGCGATTCATGTGCCTGCCATGCGGCATAGCCTTTAGCTCCCCCTCGACCCTGGAGGCGCATCAGGCGTACTATTGCTCGCATCGGAACAAGGACACGGAGGATGCGGATGGATCCAATGCGGACAAGTCCGGCGGCGGGGAGAAGTCCGCCGCGGGCGGAGTctctggcggcggcgggggcagTGGGAGCAGTGGCTCCGAGCCGCCGGCTAAGGTGGCGCGCATCGGGAAGCAGTACGCGTGCACCCAGTGCTCCTACAGTGCCGACAAGAAGGTGTCCCTCAACAGGCACATGCGCATGCACCAGACCTCGCCGGCCCCCAGTCTGGGCAGCCTCGGATCCCTCGGCAGCCTGCCCAGCCTCACGGCGAACGGGGTGCCAGGATCTGCAGGAGTAGttggcggaggcggaggcggaggcagcagcagcgccctCGAGGAGGGCTCTAGTCAACAGCAAACCGACCGCTACTGCAGCGACTGTGATATCCGATTCAACAACATCAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGCTCCCGTCGCTCCGACGGCCGTGTGACCCCCAAGGGTGGCTccgaaggagcagcagccgccgccgccgccgccgccgcccgaGAAGCAGGAGGATCGGTTTCAGCAGGCAGCGCTTCTGCGGCAGCCGCTGCCCCTGGAAAGCTCAGTCCGCAGACGCGCAACAAGACGCCCACCCCGGCCatggtggcggcagcggcggcggctgcagcagcagcagcagctgctgcctcgTTGCAGGCCCCCACCCCACAGCCCTTTTTGGCGCTACCCACGCACCCGATCATCATAGTGCCCTGCAGCCTGATCCGAGCGGCAAGCATCATTCCAGGACCACTGCCCACACCCGCTTCGGGGATCGTAAATCTGGAGTCCACCTGCTTCACCGTGGACAATGGGGCCATCAAGCCGCTGGCCACCGCTCTGATCAGCAATGCGCTCGCCGGGAATATGAATCACTTTGTCAATTCCCTGCACATACCCGCCCTGGAGCCGGATCGTCCCACAGCAGGCACAGGCTCAgccgaaggaggaggaggaggagtcctGGAGCCAAAAAGTAGCAGTCCACCAGAACCCAAGAGGAAGGAGGCTGGAGGCAGTCGTGAATCTGCGCCTCTCGACCTTTCGTTTCGACGATCTCCCATCTCCATCCTGCAGCATCGACAGCGGCATATCCGatccgctgccgcagccgcagccgctgcccTGCTGGATGTGGAGGAAGTGCTCCTCGGAGCGGGCAAGGAAAACGTGGAAACTGTCGGCGGAAGAGCTGGAGGCAGTGTGACGCCCGAGCAGATCGTCTGCGCACCCTCTCTGCCCAGCAGCCCCTCAATGAGTCCCTCGCCCAAGCGACGGGCGAGTCCCAGGAGTTCGGGGGCGGGCAGTGCCTCTTCCATGTCGCCGCCTGGCTTGAATCACCATCTGCTGGACATCCGCTCCATGCTGCCAGCCGACTTTGGCCTGTCGGAGTCGCTCCTGGCGAAGACCAATCCAGAGCTGGCCCTCAAGCTggcggctgccgctgcggccgcTGTTGCGGCTGGAGGCAGTGCCCCCTCTTCCCTGGCGGCTGCTCAGGTTGCCTCCAATACAGGTGGCAATTCTGGCAgtcagcatcaacagcagcagccgcagatcTACGTGAAGCAGGGCGTCTCCAAGTGCAAGGAGTGCAACATCGTGTTCTGCAAATACGAGAACTATCTGGCCCACAAGCAGCACTACTGCTCGGCACGCAACCAGGAGCCAGCCGGCGAGGGCTCCGACTCCAAGTCCGCCGTTTCGCCATCGAATGCCACGGCCGGcaatggtggtggtggcgccTCTGCCGTGGAGACCACGCCCGTGGCCTACCAGCAGCTCATCTGTGCCGCCTGCGGCATCAAGTACACCTCGCTGGACAACCTGCGCGCCCACCAGAACTACTACTGCCCCAAGGGAGGAGCCACGGCCGCCACTGCGTCCTCCGAGGCGCCGCTGGTGGCCAAGGAGAAGTGCGGCAAGTGCAAGACCCTGCACGACCACGGACACCCGTGCCCGGCGCCCCCCGCTGCCACGCCCCTGACGGCGCCCTCCAGCCTCCAGTCTTCGGCGGGAGCCCCCTCCGGGGTGAACAGCGTCAACAAGTGCCCCGTGTGTGGGGTCGTCAGTCCGACGGCGGCCCTGGCCCGCAAGCACATGGAGATGCATGGGACGGTGAAGGCCTTCCGCTGCAGCATCTGCCAGTACAAGGGGAACACTCTGCGCGGCATGCGCACCCACATCCGCACGCACTTTGACAAGAAGACGAGCGACGTCAACGAGGAGCACTACATGACCTGCATCTTCGAGGAGGATAACTCCGCCCACTCCGCTGTGGCCCAGGAAATGCCACCCACAgtagcagccgcagcagcagtaccGCAGGAGCCACCGATGGAGCATCCGCCGCAGTTGTTCAACTGCGATTACTGCAACTATGCCTCCACCTACAAAGGCAATGTGCTGCGACACATGAAATTGCTGCATCCGCATGTTGCCATCAATTCGCCCTCGATTTCCCCCGAGTCGCGTGAACAGGAGACGCTCCTTTCAAGCTCCACTCCGAATGCGCACGAAGCGTCCAATGGCGAGGCAGTCATCTTCCACATCAAATCAGAGCCTGGACTGGACAATCCACCGACGCTGGGACTCGTTCACGAGAACAACAACTCGCCCATTGGCACGCCACTGCCGCATATCAAGGCCGAGCCGATGGACATAGGCCTCGATGCCATGTCACCCACATCGCTGGCCCTGCCACCGCCCGTCGCCTCGCCCTTGGCAGCCGCTGCAGCCGAGGCCATGAAAAAGTACTGCTCCGTGTGCGACATATCCTTCAACTACGTGAAGACCTTCCTGGCCCACAAGCAGTTCTACTGCAAGAGCAAGCCCCCACGGCCCGAAGTCAAcgacagccccagccccaatgCCAATCATGTGGCcggagtgggtgtgggagtgggggtgggcatgggaatgggggGCCAGCCGCTGCAGTCGCCCAGCGAATTGATGCTGATGCAGAAGAACAAGGAGAACCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MPEHFMTKKARPPPPPKSNSSSSSAPSAHRQLAGKWGGVQGEGQGQVQGQDLGQSEGGRSTSYSKDLTAQELGEEKQQQLQQQQQQEDPMDLQDNNNNSDADADAEDAVSEQPEETQDLGETEMDGNRMDHHHQAEEQEQVEADAEAEEAPISPSTPPRSPTPPLVLVPKLEQPATPPSESPSPSPSPTPTPTATPTPRLPKLRLNALLASDPALKPDAKELHLSDKRLLAPPPHIKPEPQPPQAQPPLQPDLVEPLLKPARFMCLPCGIAFSSPSTLEAHQAYYCSHRNKDTEDADGSNADKSGGGEKSAAGGVSGGGGGSGSSGSEPPAKVARIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAPSLGSLGSLGSLPSLTANGVPGSAGVVGGGGGGGSSSALEEGSSQQQTDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGRVTPKGGSEGAAAAAAAAAAREAGGSVSAGSASAAAAAPGKLSPQTRNKTPTPAMVAAAAAAAAAAAAAASLQAPTPQPFLALPTHPIIIVPCSLIRAASIIPGPLPTPASGIVNLESTCFTVDNGAIKPLATALISNALAGNMNHFVNSLHIPALEPDRPTAGTGSAEGGGGGVLEPKSSSPPEPKRKEAGGSRESAPLDLSFRRSPISILQHRQRHIRSAAAAAAAALLDVEEVLLGAGKENVETVGGRAGGSVTPEQIVCAPSLPSSPSMSPSPKRRASPRSSGAGSASSMSPPGLNHHLLDIRSMLPADFGLSESLLAKTNPELALKLAAAAAAAVAAGGSAPSSLAAAQVASNTGGNSGSQHQQQQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQEPAGEGSDSKSAVSPSNATAGNGGGGASAVETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGATAATASSEAPLVAKEKCGKCKTLHDHGHPCPAPPAATPLTAPSSLQSSAGAPSGVNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDNSAHSAVAQEMPPTVAAAAAVPQEPPMEHPPQLFNCDYCNYASTYKGNVLRHMKLLHPHVAINSPSISPESREQETLLSSSTPNAHEASNGEAVIFHIKSEPGLDNPPTLGLVHENNNSPIGTPLPHIKAEPMDIGLDAMSPTSLALPPPVASPLAAAAAEAMKKYCSVCDISFNYVKTFLAHKQFYCKSKPPRPEVNDSPSPNANHVAGVGVGVGVGMGMGGQPLQSPSELMLMQKNKENLQEAAI*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00484660;
90% Identity: iTF_00474059;
80% Identity: -