g10211.t2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pseudoobscura
Gene Symbol
zfh2
Assembly
GCA_009870125.2
Location
CM020871.1:1297532-1316134[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.4 30 5.5 0.5 3 23 2 23 1 23 0.96
2 13 0.00014 0.01 16.4 1.4 2 23 266 288 265 288 0.96
3 13 3.4e-05 0.0026 18.3 0.7 1 23 320 344 320 344 0.92
4 13 0.006 0.45 11.2 0.4 1 22 431 452 431 455 0.91
5 13 2.8 2.1e+02 2.8 0.1 1 21 596 617 596 618 0.92
6 13 1.3 1e+02 3.8 1.9 1 23 639 663 639 663 0.91
7 13 0.065 4.9 8.0 0.5 1 23 910 933 910 933 0.98
8 13 4.7 3.5e+02 2.1 0.1 3 23 1035 1057 1033 1057 0.81
9 13 0.049 3.7 8.4 0.9 2 21 1138 1157 1137 1161 0.89
10 13 6.5e-05 0.0049 17.4 2.3 1 23 1212 1234 1212 1234 0.98
11 13 0.0013 0.099 13.3 2.0 2 23 1241 1263 1240 1263 0.94
12 13 0.00033 0.025 15.2 1.7 1 23 1631 1653 1631 1653 0.97
13 13 0.0012 0.087 13.5 1.4 1 23 1768 1790 1768 1790 0.97

Sequence Information

Coding Sequence
ATGTGCTTTATATGCAAACTATCCTTTGGCAACGTGAAGTCATTTAGCCTGCATGCGAACACAGAGCACAGACTCAACCTGGAAGAGCTCGAGCAGCAGCTACTGAATCGCGAATACTCCAGTGCCATTATTCAGCGTAATATGGATGAGAAACCGCAGATATCCTTCCTGCAGCCCCTGGACATAAATGCCACTTGTGCTGTCGAGAAGCTTATACTGGCTCCTGATGAAATTTGTACTCCACTGTCTTCTGAGCCAGAGCTCGAACATGATAATTATGAGGACGAAGAAGATCGGGCGCTGGCCGCCAACGAACCAAATGCCAATAGGGTCAAGCTTCTCACGGAGTTTcttcaacagcagctgcagcagcagcagcagcaacagagtTCCTTGTTCCCCAGCTTATGTTCCGAGCATCCCGACTTCAAAGGGGTCGATTGCAAAACTTGTGAGCTCATTGATATCCAACAACGGTCTAAATCACCGCCTCCATTGCACCAGCACCTTGGTCTGgctcaatctcaatctcagGCCATGCCTTTGTCGCAGCCTCAGCCACATCGCTCTCCTAACAGCAGTAGTGGGGGTCTGGCAATATCGCCCAGCTCCTCATCGGTGACCAGCGTAGGAAATGCGTCTGGTACGGCTTCCAGCTTTACAATCGGCGCGTGCTCCGAACACATCAATGGCCGACCCCAAGGAATAGACTGTGCCCGCTGCGAAATGCTGCTGAACTCGGCTCGACTCAATAGCGGCGTCCAGATGTCAACCCGCAACTCATGCAAGACTCTTAAATGTCCCCAATGCAATTGGCACTACAAATATCAGGAGACGCTGGAGATCCATATGCGTGAAAAGCATCCTGATGGGGAAAGCGCCTGTGGCTATTGCCTAGCAGGACAACAGCATCCGCGGCTGGCCCGTGGCGAGTCGTACTCATGCGGCTATAAGCCATACAGATGCGAGATATGCAACTACTCCACGACCACAAAAGGTAACCTTTCCATACATATGCAGTCTGACAAACACTTGAACAACATGCAGGAGCTAAATAGCTCACAAAATATGGTTgccgctgcggcggcagcagctgcaagtGGGAAATTGTTGCTGTCCAGCCCATCGCCACAAGGTGCCGGCCAACCAACTGTGGCCCAACTGGGCtcgagcgggagcgggagcacCGCTGTCGTCTCTAGCAGCGTTGGGAGCAATGCCGCTATGGGTGTACCGCCAACGTCTGGTGGCACGGGGGTAGTAGTAGCCAGCATCAAACCGAAGCCCTCGTTTCGGTGCGACATCTGCAGCTACGAGACTTCCGTTGCTCGCAATCTGCGAATTCACATGACCAGTGAGAAGCATACGCATAACATGGCTGTGCTACAAAACAATATAAAGCACATTCAGGCGCTAAATTTcttacaacagcaacagcaaggcGCTAGTGGCAGTACTTCAGGCTCCAGTGCTAGTAGCTTCATGCCGGAGGTGGCATTGGCTGATCTGGCCTACAACCAGGCGCTCATGATTCAACTTctgcaccaacagcagcagcagcagcagcagcagcagtcatcTAATACCAAAATGTCGCCCACATCATCCTCGCCAGTAAGTGCAACGGATCAGTTTTCATTTTCCCCAAAGCCCATGAAGCTTGGCcatggaatgggaatgggtttGGGGATGCCAATGGGAATTGGCCATTCAAATGAAGCATCCGGCGAATCGGGGAGCGATGCTCATCCACTGGCGAAGCCTGATATGTGGCCCACGGCGCTCTACAGTTGCCTAATCTGCGACTCCTTCAGCACAAACAATTTGGACGATCTTAACCAGCATCTGTTGGTAGATCGATCCCGACAATCCTCAAGCGCATCCGCCGATATAATGGTCatacacaacaacaactacataTGCCGGCTCTGCAACTACAAGACGAACCTAAAGGCCAACTTCCAACTGCACAGTAAGACGGACAAGCATTTGCAGAAACTAAACTTTATAAATCACATCAGGGAGGGCGGAGCCCGTAATGAGTATAAACTCCAGTATCAGCCTCAGCTCACTGCCAATGTGGTGCAACTAACTTGCAACTGTTGCGACTTTCACACCAATTCCATACAGAAGCTTTCCATGCACACTCAGCAAATGCGACATGACACGATGCGTATGATTTTCCAGCATTTGTTATACATTACGCAGCAGAGTCGTATGCACAAGGAGTCGCCTTGCACGGCAGCAGACGATGCTCAATGTCCTTGTCCGGACGATGATCAACAATCGATTGCAACGATCGAAAAGGTTCTCATTTGCCAGCTGTGCAGCTTTGCCGCCAAAAATCTGTATGAAATGGTTCAGCATGTGAAGGGCATAAGACACTTGCAAGTCGAGCAATTCATTTGTCTACAGCGTCGTAGTGAAAACCAGGAGATGCCCGGATTAAATGAGGTATACAAAGTGACTGAACGGATCCGTGGTAGCGAAGATATCATTTTTGAAGCTGGCTTCAATATGGCAACAAACACACCAGTTGGTGGATCGTCGGAGGTCGGCTTtgccgcagcaacagcgggATCCTCCGCCGCTGCAGATGGCAATATATTATCTCCAAAGTCGACCTCTAGTTGCTCGACATCTTGTGGCAAGAGTGTAGGTCGCATCGCGTCTCCAAGCATGAATGATTTTAGTTTGAGTGCTTCAAACAGCATACCCACCACAGTTTTCAAGTGCAATTTGTGCGAGTACTTTGTGCAATCGAAGAAGGACATGGCCAGCCACATTGAAACCGTGCACCCAGGGGCAGAGAGTGACGACTTCATGAGTATACCAACAAACACGGCGGCTCTGCAAGCCTTCCAAACTGCGGTTGCAGCCGCAGCCATAGCAGCGGTCCAACAACGCTGTAGTGCCATCAACATGCCTAGAGAAGCAGATACGGAAATCGGTCCTTGCATTAGCGACTGCCCTATAGATATTAAGCGTGAGCGTCTCGAAGAGGAGGACGGTCCAATGACGGGTATAGAGGAAAGAAAACCAACAGCTAATCTAGATGCGGAGATGTCAGACGCGAAGGCTACAAAACCATCGGGTGTGCAGTGTCCCCTATGTCTAGAAAATGGCTTCCGAGAGAAGTCATTGCTTGAGACCCATTTGACGAGCGTGCACAGCGTCACCAAAGATGGCCTAGCTAGGCTATTGCAACTGGTCGATAGTAAGGCCTGGAGTTCACCCGGAACTGATTCACCATCCGTAACCGCAACTACGAGTACAGCATCCAATTGCAATTCCAATGCAGAGGACTGTGCGATAACCATAGGGAGTGTAATTACCGAAGACTGTGTGTCGAGCTTCCCCGTTGTTGCAGCAGCCAGTTCCACCGCAAGCTCAGCAGGATTGCAAGGACTCTCTTGCCAGCAGTGTGAGGCGAGCTTCAAGCACGAGGAACAGCTGTTACAGCATGCACAGCAGACGCAACACTTTCCAGAGCAAAATGGAGAGTACATTTGCCTCGCGACAAGTCACATCAGCCGTCCCTGCTCTATGAGCTTCAGCTCACTCCCGTCAATGATCAGCCACTTCAAAGACTCGCACATGAGTTTGGTTATCTCAGAGCGCCACGTCTACAAATATCGTTGCAAGCAGTGCTCACTGGCATTCAAAACACAGGAGAAACTTACCACACATATGCTCTATCATACAATGCGCGATGCTACCAAGTGTTCTTTATGTCAGCGGAACTTTCGTAGCACACAGGCCCTGCAGAAGCACATGGAACAGACGCACTCCAATGAGGCAGCTGGAGCTGCGGCTGGCAGTGCAATGACCAATAGTCCCCGACCGCCGACACCAAACTACGGCGAGATAGAAAAATTGCCATCGGGCGAACGAGAACCCCCGATTGGCAGTGACGCAGGGCCCAAGTCGAATAACACCTCAAGACGTTCACTATCACCGCTGCGATCAGAGTTGCAATATACTAAGGAGGCGGCGCAACTGTCGCCCAGCCCGCACGCTCTTGATACAAACCAaactcagcagcagcaacagcacttGGCCACACTGACGGCTGCGTtgctcaagcagcagcagtgtcACCCAGATGCAAATGTCCTGTCGGCAGATCCTTTATCGTTGTCCGCTGCCGACTTTTCTCAACAGCTGCACGGCCTACAGAATCTCCAAAATCTGCAGCATATGCAGCAGCAATTTAGTGCAGTTGCTGCATCTTCGGGAATGCCCATTAACCCGGTGGATATGCTCAACCTAATGCAATTCCATCATTTGATGTCTCTTAACTTTATGAATCTGGCCCCACCACTGATATTTGGGGGAAATACTGCCACCGGCAATGCAGCTTCAACAGCCGCTGCCCAAAATAACGGCATGCCCCCCTCTTCCTTATCAGCACCAGCTTCCCAAACAACGGACATGCAGATTGTGAGCGGAGCAAGTAACTTTACGGGAGAATCTACCAACGCGAACAATCCCACGGCACAGCACAGTATCAATAGTAACTCTCAGATGAACAACAACCAAAAGCGAGCTCGCACGCGCATCACGGACGATCAGTTGAAAATATTGCGTGCACATTTCGACATAAATAACTCGCCCAGCGAGGAGAGCATTATGgagatgtcacaaaaggcgaATTTGCCAATGAAGGTGGTTAAGCACTGGTTCCGAAACACGCTGTTTAAAGAACGACAACGAAACAAGGATTCACCCTACAACTTTAATAACCCACCGTCAACTACCCTAAACTTGGAGGAGTACGAGCGCACAGGTCAGACCAAGAATGCCAGACAAAAGCAACGCAAAATCTACGAAAATCAACCAAATAATTCACTCTTCGAGAACGAAGAGACCAAGAAGCAAAACATTAACTACGCTTGCAAGAAGTGCAGTCTAGTGTTCCAGCGCTATTACGAGCTAATACGTCACCAGAAGAATCACTGTTTCAAGGAggagaacaacaaaaagtcAGCCAAAGCTCAAATTGCTGCTGCGCAAATTGCCCAAAATCTTAGTTCGGAAGACTCGAACTCTTCAATGGATATACATCACTCTGGCATCTGTCCTCCTGGTCCTCTGGTTGCACAGACTATTTCAGCCCCTGTGTCTATCGTAACATCATCCGGACACGCGGCGTCCCAGCCATTTGGCGCTTCGCCCTCGCCACAGCATATATTTAGCAAGTCGTCTTCACTCACTGACTTCAGCCCATCCACGACTCCAACGCCTCCACAGCGGGAACGTAGCAACAGTTTGGACCAGCCGAATCGAAGCGCATCGAAGTTTGACTGCGATAAATGTGAACTGCAGTTTAGCCACCTGGAGTTATTGCGTGAACATCAAATGATGCATTTGATGAATCCAGCAGCACTCTTGGCCGCCGCCGGTCAACACTCCAATCCAGATGCCAGCTATGGTCCTTTCGGTAGCATATTGCAGAGTCTGCAACATGCAGCGgctcaacagcagcagcatcaacagcctCCAACAAAAAAGCGGAAATATTCGGATAGCTCTTCCAACGCAGATGATTTAACGTCTGTGGGGGAAATGGAGACCCCCCAGAAGAAATATGAATTTCTATATCAATACTTTTTGCAGCATGAGACGAACTCCGAGCTGAAACAGCAGTTCCtgatgcagcaacagcagcagcatcagcaaggAAATGAAACGGATTTTGAGTTGGAGTTCTTAACTAATTTCTATCAACAGAGCGAGCTGAAGAAAGTCAGCAACTACGACTTTTTATTACAATATTATCGCAAAAGTGAAGCAATATCCTTGAACACAAAGCCGCTTCAGCAAACTTTCAGCTCAAGCAAGAAGCCTACGATTGAGTTCCTCTTGCAGTACTATCAGCTTAATGAGTCAAAAAAGTTTTTTCAGTTAGTTGCCTCGCCCCAAACGATGCCTGATGGTCAAGGGTACCAACCGTCGTCGCAGTTGCCGAACGCGACGGCGGATGAAACCATGAACGTTATCGGCGAACCAGAAGAGGGGCAGCAATTGCCAGACCAATTACAGAATCATCCGGACTCCAACGTCGACAAGAAGGAACAGGAAAGGCTGAATAACAACAGTATTAACGTCAACTCGAGTTCATCTGAATCACCTCAGTTTAATTCAGCTAGAACTCTTACTTTTAACGATGACGACACTGCTAGCCAGAAAGATGAAGTCAAAGTTTCCTCAACGCTCAAGGTCCATGAAGTGGAAAATGTAACATCAGTGTCTCCGGTCAATGCCCCATCGAAGCAGAACAAGCGCCTACGCACGACAATACTTCCAGagcaattgaattttttgtaCGAATGCTATCAATCCGAGTCGAATCCAAGCCGAAAAATGCTTGAAGAGATATCAAAGAAAGTAAACCTCAAGAAACGTGTAGTACAGGTTTGGTTTCAAAATTCACGTGCCAAAGACAAAAAATCTCGAAATCAGCGGCATTACTCGCATATTTCGGATGACAACAGCTACGACGGCTCTAGCGGCAAAGAGGTTGGCAATGAGCTGAAAGTGAAGTGCGTTTCTGTCGCTCAGGACCACGATATGGATCTGCAGGACTGTCAGCTTTGCCAAGTCACACAGGTCAACATGCAAAAGCACGCTTTTAGCGTAGAGCATATATGCAAAATGAAGGAGCTTCTTGAACAAACCACCGAGCTATACGCTAACAGCAATGGCAGCGGTAGTGATGATAACGATTCCGACAGAGAAAAGCGCTTCTACAGCCTGTCAAAGGCTTTTCTATTACAGCACGTTGTTTCTAATTCTGCTAACATATCTACACAACtgcatacgcatacgccgaGTGCTGGCCCAGACACAGATGTTCTCCCAGAAGAGAACTGTCTGCTTAAGTTTGACGCTACTACTTGCGAGGACAAAGGGCATAAGCGTCATTCGGCTGCCGACGTTGGAAATAAGGATGTGAAAAATGTCGGTGGCAATCAGGATCTCATGCATCAGTTATTCAATCGAAATCATATCACCGTTATAGGTGGAAAATGA
Protein Sequence
MCFICKLSFGNVKSFSLHANTEHRLNLEELEQQLLNREYSSAIIQRNMDEKPQISFLQPLDINATCAVEKLILAPDEICTPLSSEPELEHDNYEDEEDRALAANEPNANRVKLLTEFLQQQLQQQQQQQSSLFPSLCSEHPDFKGVDCKTCELIDIQQRSKSPPPLHQHLGLAQSQSQAMPLSQPQPHRSPNSSSGGLAISPSSSSVTSVGNASGTASSFTIGACSEHINGRPQGIDCARCEMLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAASGKLLLSSPSPQGAGQPTVAQLGSSGSGSTAVVSSSVGSNAAMGVPPTSGGTGVVVASIKPKPSFRCDICSYETSVARNLRIHMTSEKHTHNMAVLQNNIKHIQALNFLQQQQQGASGSTSGSSASSFMPEVALADLAYNQALMIQLLHQQQQQQQQQQSSNTKMSPTSSSPVSATDQFSFSPKPMKLGHGMGMGLGMPMGIGHSNEASGESGSDAHPLAKPDMWPTALYSCLICDSFSTNNLDDLNQHLLVDRSRQSSSASADIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGARNEYKLQYQPQLTANVVQLTCNCCDFHTNSIQKLSMHTQQMRHDTMRMIFQHLLYITQQSRMHKESPCTAADDAQCPCPDDDQQSIATIEKVLICQLCSFAAKNLYEMVQHVKGIRHLQVEQFICLQRRSENQEMPGLNEVYKVTERIRGSEDIIFEAGFNMATNTPVGGSSEVGFAAATAGSSAAADGNILSPKSTSSCSTSCGKSVGRIASPSMNDFSLSASNSIPTTVFKCNLCEYFVQSKKDMASHIETVHPGAESDDFMSIPTNTAALQAFQTAVAAAAIAAVQQRCSAINMPREADTEIGPCISDCPIDIKRERLEEEDGPMTGIEERKPTANLDAEMSDAKATKPSGVQCPLCLENGFREKSLLETHLTSVHSVTKDGLARLLQLVDSKAWSSPGTDSPSVTATTSTASNCNSNAEDCAITIGSVITEDCVSSFPVVAAASSTASSAGLQGLSCQQCEASFKHEEQLLQHAQQTQHFPEQNGEYICLATSHISRPCSMSFSSLPSMISHFKDSHMSLVISERHVYKYRCKQCSLAFKTQEKLTTHMLYHTMRDATKCSLCQRNFRSTQALQKHMEQTHSNEAAGAAAGSAMTNSPRPPTPNYGEIEKLPSGEREPPIGSDAGPKSNNTSRRSLSPLRSELQYTKEAAQLSPSPHALDTNQTQQQQQHLATLTAALLKQQQCHPDANVLSADPLSLSAADFSQQLHGLQNLQNLQHMQQQFSAVAASSGMPINPVDMLNLMQFHHLMSLNFMNLAPPLIFGGNTATGNAASTAAAQNNGMPPSSLSAPASQTTDMQIVSGASNFTGESTNANNPTAQHSINSNSQMNNNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQTKNARQKQRKIYENQPNNSLFENEETKKQNINYACKKCSLVFQRYYELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHSGICPPGPLVAQTISAPVSIVTSSGHAASQPFGASPSPQHIFSKSSSLTDFSPSTTPTPPQRERSNSLDQPNRSASKFDCDKCELQFSHLELLREHQMMHLMNPAALLAAAGQHSNPDASYGPFGSILQSLQHAAAQQQQHQQPPTKKRKYSDSSSNADDLTSVGEMETPQKKYEFLYQYFLQHETNSELKQQFLMQQQQQHQQGNETDFELEFLTNFYQQSELKKVSNYDFLLQYYRKSEAISLNTKPLQQTFSSSKKPTIEFLLQYYQLNESKKFFQLVASPQTMPDGQGYQPSSQLPNATADETMNVIGEPEEGQQLPDQLQNHPDSNVDKKEQERLNNNSINVNSSSSESPQFNSARTLTFNDDDTASQKDEVKVSSTLKVHEVENVTSVSPVNAPSKQNKRLRTTILPEQLNFLYECYQSESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYSHISDDNSYDGSSGKEVGNELKVKCVSVAQDHDMDLQDCQLCQVTQVNMQKHAFSVEHICKMKELLEQTTELYANSNGSGSDDNDSDREKRFYSLSKAFLLQHVVSNSANISTQLHTHTPSAGPDTDVLPEENCLLKFDATTCEDKGHKRHSAADVGNKDVKNVGGNQDLMHQLFNRNHITVIGGK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00580525;
90% Identity
iTF_00581046;
80% Identity
iTF_00580526;