Basic Information

Insect: Drosophila pseudoobscura
Gene Symbol: zfh1
Assembly: GCA_009870125.2
Location: CM020868.1:1182649-1206885[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00084 0.064 13.9 1.2 2 23 75 97 74 97 0.95

2 9 0.019 1.4 9.7 0.1 1 23 301 323 301 323 0.96

3 9 0.00012 0.0088 16.6 1.7 2 23 338 359 337 359 0.97

4 9 5.7e-06 0.00043 20.7 6.3 1 23 368 390 368 390 0.99

5 9 0.00034 0.026 15.2 1.2 3 21 398 416 396 417 0.94

6 9 0.0095 0.72 10.6 1.8 2 21 664 683 663 684 0.92

7 9 1.5e-05 0.0011 19.4 0.5 1 23 1046 1068 1046 1068 0.94

8 9 5.6e-05 0.0043 17.6 7.4 1 23 1074 1096 1074 1096 0.98

9 9 0.0028 0.21 12.3 4.3 1 21 1102 1122 1102 1123 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00084	0.064	13.9	1.2	2	23	75	97	74	97	0.95
2	9	0.019	1.4	9.7	0.1	1	23	301	323	301	323	0.96
3	9	0.00012	0.0088	16.6	1.7	2	23	338	359	337	359	0.97
4	9	5.7e-06	0.00043	20.7	6.3	1	23	368	390	368	390	0.99
5	9	0.00034	0.026	15.2	1.2	3	21	398	416	396	417	0.94
6	9	0.0095	0.72	10.6	1.8	2	21	664	683	663	684	0.92
7	9	1.5e-05	0.0011	19.4	0.5	1	23	1046	1068	1046	1068	0.94
8	9	5.6e-05	0.0043	17.6	7.4	1	23	1074	1096	1074	1096	0.98
9	9	0.0028	0.21	12.3	4.3	1	21	1102	1122	1102	1123	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTTCACGTTTTGGCCAAGAGGATAACAGCATCATACAGCAGAGCATGCCATCGTCCACAGCCTTCACCATGCAGTTTCCCTCCCTGGCCTCCAGtctgcaccaccaccaggcACCGCACAGCAAGGCGAGCAACGGCTCCGGTGGCAGCCAGGAGCAGCACGCCCAGCCAGGTGTCTCCGTGAATGACTTCCTGGTCAAGTGCCCGCAGTGCCACAAGCGCTTCACAGAGTTTCAGTCCCTCAGCGAACACATCGCCAGCGAGCACCCGCACGATAAGCTGAACTTTGAGGCCAGTCGCGGCTCCAGCGGCGCCGTGCAGCCCGAGAGCGATGCCGAGGACGAGCAGAGCAATCTGAGTGGCAGCCGGTACGCCAAGTCccccgccaccaccgccgccacccaCGCCACGCccagtaacaacaacaacagcgatcTGGCCAagaaccacaacaacaacaacagcagcaacagcagtaagaTCTCTCCCATGTGCTCGCCGGGATCGGGGGGtcccgccaccaccgccgcagCAGATCTCTTCGCCCACCTCTCGCACGGAGCCCCGCCCCAGCTGCCCTCCCACCTGCACGCCCAGTTcatggccgccgccgccctggCCATGCAGTCGGCCCGCTCCGTCAGCTCCTCCGCCAGTTCGCCcaacagccaccaccaccaccagcagcagcaccagcagcagtcgcacCACCATctccaacaacagcagctccaccagcaggcgcagcagctgctgccgccccAGCTGCcgggcagcaacagcagcgtgGGCAGCAATTCCGCCTACGATCTGGACCTCAGCGCCCCGCGGTCCACCTCCAGTCCGGGCTCCACCACGGGCGACCTGAGCGGCGCCTACCCCTGCATGCAATGCACTGCCGCCTTCGGCAGCCGCGAACAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCACCGGGGGCCAGCCCACGGCACAGAATGTCTCTCAGACTTGCCGAATCTGCCACAAAGCCTTCGCGAATGTGTACCGCCTGCAGCGGCACATGATCAGCCACGACGAGTCGGCGCTGCTGCGCAAATTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGGTTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGCCTGGAGAAGAGTCCTGGCGCCGGGCCCCGACGCTCGCCCACGAACCTGCAGGGCCCCAAGAACGGTGCTGGAAAGATGTCCGAGCAACAGTCCCTGCCTCCGCTGCCCAATCCCATGATCTACTTTGCCGGCGAGGCACAGGCGCAGGCCGCGGCCCCGAATGGAGCTCCTCCGCCGTTCTATCCCAACTACATGAATGCGGCCCTGCTGGCCTTCCCCAATCCCTTCATGGCAGCGGCCCTGGATCCCCGCGTCCACCCCTACAGCATACAGCGGCTCCTGGAGCTGACGGCCgccggacagcagcagcagcagcaacaacagcagcagcaacgcgaGGAGCGcgaagagcaggagcagcacgaAGAGCCTGAGACGCCGGAGGAGCCCAAGCTGGTGATGGACATCGACGAGGCTGAGGCCAAGGAGCGTATGGTGCCACAGGCCAGCCCCCAGACCATGCCAGAGGAGATCGAACCCGTCGTCGATATGGCCACTGCTCCCATCAAGCAGGAGCCCAGCCGCGAGCCCACCCCACTCCCGGAGAGTGCACCGCCCTCGCCCAAGTCCTtcaagcaggagcaggaggagcccCGTTCCGTGGAGGAGGATCAGGCCATGGCATCGGCTCAGCCCGAAGCCTCTGTCTCCTCCCCCAGGGGAGACACACCCGCCGAGCTGCGGTGCAGCCGCTGCGACAAGCAGTTCAACCACCACACGGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATcaaggaggagctggagcagcactaccaccagcagcagcagcagcaacagcaccaccaacagctccagcagcagcagcaccaccagcaggcGTCCTTTGCCCTGCCCTCTGCCAGCGAGgatgacgacgaggaggaggagcgcgaGAACGACAACGACACGGAGCCGCGTCCGGACAGCAACGAGCGCAAGGTGCGCGTGCGCACGGCCATcaacgaggagcagcagcagcagctgaagcagCACTACGCCCTCAATGCGCGGCCAAGTCGCGACGAGTTCCGGATGATTGCGGCCCGCCTCCAGCTGGACCCGCGCGTGGTCCAGGTCTGGTTCCAGAACAATCGGTCCCGCGAGCGCAAGATGCAGAGCTATGCCAGTGTCCACTCGGCAGCTCCTGCCGCCAATGAAGTGCCCACCACTCCAGTGGCCAGCCGTCCCACAACCGAGGATCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCCTGACGCCCAAGAGCGACCACTCTGCCGCGTACGGCTTGCCCCAGCAGCAGGCTGCCGGACAGCCAGGCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGCCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCCTCGTCGGGCGCCTCTCTGCAGCAGTCCTCGGCAgctgcggccgccgctgcggcAGCCCTCTGGCCCTTTGGTGGTCCGCCTCCATCGCCGCCCAGTCAGCTCGAGGTCACGCCCGCGCAGCACTGCTCGACGCCGCGAGGCGGCCAGGCCTTCCCCGGACTCCAGTACATGCTCCCCATGCAGCGGCTCCCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTCCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCCTGATGCCCCCCAAGCCCCGTCGCGGCAAGGCCGAGACCCACGGACATGCCGGCGATCCGGATCTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAGCGGCTGCACAGCGGGGAGAAGCCCTTCCAGTGCTCCAAGTGTCTGAAGCGCTTCTCTCATTCGGGGAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKASNGSGGSQEQHAQPGVSVNDFLVKCPQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPATTAATHATPSNNNNSDLAKNHNNNNSSNSSKISPMCSPGSGGPATTAAADLFAHLSHGAPPQLPSHLHAQFMAAAALAMQSARSVSSSASSPNSHHHHQQQHQQQSHHHLQQQQLHQQAQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFGSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGAGPRRSPTNLQGPKNGAGKMSEQQSLPPLPNPMIYFAGEAQAQAAAPNGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQQQQQQQQREEREEQEQHEEPETPEEPKLVMDIDEAEAKERMVPQASPQTMPEEIEPVVDMATAPIKQEPSREPTPLPESAPPSPKSFKQEQEEPRSVEEDQAMASAQPEASVSSPRGDTPAELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHHQQLQQQQHHQQASFALPSASEDDDEEEERENDNDTEPRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYASVHSAAPAANEVPTTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAAYGLPQQQAAGQPGPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQLEVTPAQHCSTPRGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKPRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00580613;