Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00014 0.0097 16.1 1.6 1 23 147 169 147 169 0.98

2 5 4.5e-08 3.2e-06 27.1 1.8 1 23 175 199 175 199 0.98

3 5 8.5e-05 0.0061 16.8 2.5 1 23 205 227 205 227 0.98

4 5 3e-06 0.00021 21.4 1.8 1 23 233 255 233 255 0.99

5 5 2.1e-06 0.00015 21.8 0.9 1 23 263 287 263 287 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00014	0.0097	16.1	1.6	1	23	147	169	147	169	0.98
2	5	4.5e-08	3.2e-06	27.1	1.8	1	23	175	199	175	199	0.98
3	5	8.5e-05	0.0061	16.8	2.5	1	23	205	227	205	227	0.98
4	5	3e-06	0.00021	21.4	1.8	1	23	233	255	233	255	0.99
5	5	2.1e-06	0.00015	21.8	0.9	1	23	263	287	263	287	0.92

Coding Sequence: ATGCCGAATATGATGTGCCGTATTTGTTCCAAGCAGGGGGCCACAACAAACATTTTCCTGCCAAAAAACCGGCATCTTTACAGACAAATTCATTCCATTACTGGAGTCCAGTTGAGCGATAGAAACGACCTGCCCAGCCACATGTGCCAGGTGTGCGTGGGTGATTTGGAGGGCGCCATCAAATTCCGCCAACGCTGCATTATATCCGAGAAGCAACACTTGAGCCGACTAAACTCCTCGGAATCTGCCAATGATGACCACCCGCTCAAAGAGATAGATAAAATCCGAAAAGAAATGTTTTTCACGGACTCAGATGAGCCACAAAATAAATGTGATACAGTTTTAAGCTCGGATATCGACACGGAGTCTTGCAATTCGGAGGAAGCCCAGGCGGTAGCTTCCTTTAAAGCTCCAAGACCAGTTTCTAGGGCTGGCCCTTATACATGTGATGAATGCGGAAAGTTGATTAATCACTGGACCAACTTTCAGGAGCATAGGCTCAGGCATACGGGTATCAAGGACTTCAAGTGCCAGTTTAGCGGCTGTGGTAAGTCCTTTGCAACCCGAAAGGAGCTTACCCGCCATATCCGACGTCACACTGGTGAGCAGCCCTATCCCTGCAGTTACTGCCCACGTCGGTTCTCGGATGTGGGCTCCCGACAACAGCATCATCGACGACATCGAAACGAGCTATACTACCAGTGCGATGTGTGCGAAAAAGGCTTCGTTAGCTCGGGCTGTCTCAATAAGCACAAAATGACACATTCGTCGAACAAGATCCGGCAACACTATTGTGAAATTTGCGACAAAAGTTTTATGCGAGCGGGCCTCCTGAAGCAACATTTGAACACAAGCGTTCACCTAGAAAGGGTACTCCTGGCAGATATGGATTCCATATGTGATTAA
Protein Sequence: MPNMMCRICSKQGATTNIFLPKNRHLYRQIHSITGVQLSDRNDLPSHMCQVCVGDLEGAIKFRQRCIISEKQHLSRLNSSESANDDHPLKEIDKIRKEMFFTDSDEPQNKCDTVLSSDIDTESCNSEEAQAVASFKAPRPVSRAGPYTCDECGKLINHWTNFQEHRLRHTGIKDFKCQFSGCGKSFATRKELTRHIRRHTGEQPYPCSYCPRRFSDVGSRQQHHRRHRNELYYQCDVCEKGFVSSGCLNKHKMTHSSNKIRQHYCEICDKSFMRAGLLKQHLNTSVHLERVLLADMDSICD

Sequence clustering based on sequence similarity using MMseqs2