Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.5e-05 0.0018 18.5 0.1 1 22 182 203 182 203 0.97

2 6 0.0022 0.16 12.3 0.1 2 23 213 234 213 234 0.97

3 6 4e-06 0.00028 21.0 2.8 2 23 241 262 240 262 0.96

4 6 5.1e-05 0.0036 17.5 0.7 1 23 268 290 268 290 0.98

5 6 0.0001 0.0074 16.5 6.4 2 23 298 319 297 319 0.96

6 6 1.9e-07 1.4e-05 25.1 0.8 1 23 326 348 326 348 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.5e-05	0.0018	18.5	0.1	1	22	182	203	182	203	0.97
2	6	0.0022	0.16	12.3	0.1	2	23	213	234	213	234	0.97
3	6	4e-06	0.00028	21.0	2.8	2	23	241	262	240	262	0.96
4	6	5.1e-05	0.0036	17.5	0.7	1	23	268	290	268	290	0.98
5	6	0.0001	0.0074	16.5	6.4	2	23	298	319	297	319	0.96
6	6	1.9e-07	1.4e-05	25.1	0.8	1	23	326	348	326	348	0.98

Coding Sequence: ATGAGCTCCACACGTCCGTTTTGCTTCGTTTGCGGCAAAGTAAAATCAGTCGGAGTCTGTCAGCTCATCGAAGGATGCATTGTGCCAGGGACTTTCAAGCCCATCAAAGATATATTGAAATATTTTGAAAAGATCATCAATCAGAGGTTGGAACTGCAACCCAACTCCGCCGCGTGCAGGGATTGCCTGGAGTACTTGTTCAATTATGATCGACTTGTTAGGAATCTTGTGCAGGTACAGCGCCAGATTGCTGATGCCCTTCTAGGATGCCGTCAGGGAAAAGGTGGAAAGGCCACGGGAAAGCCGGTGGAAAAGACAGACGTTACAAAGGCACGAGTACAGGTTCCAGCCTTTAAGATCATTCATCCGACAACAAAGAATCTGAATAGCCCCAACACTTCGTCTTTTTTATTAGAAAATGACCAAAACGAAGAAATCAAGGAAGAGGAGTTTATTACGGAGGAAGTGATGGATGACTTCCAATTTAGTGAAGTCGAGGAAAGCATGTCGTCTTCTGAGGATGACTACTTGGAAACCATTGATTATCCTTGTCACATATGTGGCGAAATGTTTTCCAGCCAAGAAATTCTAGACCGACACATCAGGACGGACAACTGTCAGAAAAGCGACGACGCAACTTGCAACGTATGCGGCCTCAAGTTTAAAGATGACGAAGTTTTGGACCTCCACATGAATCTTCATGAAGGAAAGACCGAGCTGGAATGCCGTTACTGCGATAAGAAGTTCTCACACAAAAGGAACGTTCTGCGGCACATGGAGGTGCACTGGGATAAGAAGAAGTACCAGTGTGATAAGTGTGGTGAGCGATTCTCGCTGTCTTGGCTTATGTACAACCACCTAATGCGTCACGATGCCGAAGAGAACGCCCTTATTTGCGAGATTTGCCATCAGCAATTCAAAACCAAGCGCACCTATAAGCACCACCTGCGTACGCATCAAACAGATAGGCCGAGATATCCCTGCACTGAATGCGAGAAGTCCTTTGTAGACAAATACACGCTAAAAGTTCATAAGCGAGTTCATGAGCAGGTTAAAGAGTAG
Protein Sequence: MSSTRPFCFVCGKVKSVGVCQLIEGCIVPGTFKPIKDILKYFEKIINQRLELQPNSAACRDCLEYLFNYDRLVRNLVQVQRQIADALLGCRQGKGGKATGKPVEKTDVTKARVQVPAFKIIHPTTKNLNSPNTSSFLLENDQNEEIKEEEFITEEVMDDFQFSEVEESMSSSEDDYLETIDYPCHICGEMFSSQEILDRHIRTDNCQKSDDATCNVCGLKFKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEICHQQFKTKRTYKHHLRTHQTDRPRYPCTECEKSFVDKYTLKVHKRVHEQVKE

Sequence clustering based on sequence similarity using MMseqs2