Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 6.3e-06 0.00052 20.4 0.6 2 22 166 186 165 186 0.95

2 6 0.0098 0.8 10.3 0.1 2 23 196 217 196 217 0.97

3 6 2.1e-05 0.0017 18.7 3.4 2 23 224 245 223 245 0.96

4 6 4.9e-05 0.004 17.6 0.7 1 23 251 273 251 273 0.98

5 6 0.00019 0.015 15.7 6.4 2 23 281 302 280 302 0.96

6 6 1.1e-07 8.7e-06 26.0 1.6 1 23 309 331 309 331 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	6.3e-06	0.00052	20.4	0.6	2	22	166	186	165	186	0.95
2	6	0.0098	0.8	10.3	0.1	2	23	196	217	196	217	0.97
3	6	2.1e-05	0.0017	18.7	3.4	2	23	224	245	223	245	0.96
4	6	4.9e-05	0.004	17.6	0.7	1	23	251	273	251	273	0.98
5	6	0.00019	0.015	15.7	6.4	2	23	281	302	280	302	0.96
6	6	1.1e-07	8.7e-06	26.0	1.6	1	23	309	331	309	331	0.99

Coding Sequence: ATGAGCACAGCACGACAGTTCTGTTTCGTTTGTGGTAAAATTAAATCTGTTGGCGTCTTTCAGCTTATTGAAGGATGCATCGTGCCTGGCACTTTCAAACCAATTAAAGATATTATCAAATATTTTGAAAAAGTAATTAATCAACGTTTGGAATTAACGCCAACCTCCGCTGCCTGCCGGGATTGCCTTGAATATCTTTTCAACTACGACAGGCTTGTTAGAAATCTCAGCCAGGTTCAACGTCAAATTGCCAACTCGTTGCTAAGTTGCCGAAAAAAAAAGGGTGTCTCTTTGAAACCCAAAAAGGAGGTTACAAAACCCAAATCACAGGATGTAAAATCCAATCAGTTACCACTACAAAAGTCGATTAAGCAGGAAGCTTTCGCTGCTACCATTAAGCAGGAAGCATTCGCTGACGAACAGCAACAGGATTTTGTGTTTAGCGAAAGCGAGAGCACCACAGAGTCGTCGGAAGAAGAAATAAACCTTGACATTCCTTGTCATATATGTGGTGAATTGTTTTCCACCCAGGACTGCCTAGAGAGGCACATTAAAACTGACAATTGCCAAAAGAACGAATATGCCACCTGCAACATTTGCGGCCTTAAAGTAAAGGATGAGGAAGTGCTTGACTTGCACATGAACCTTCATGAGGGAAAGACTGAATTGGAATGCCGATACTGTACAAAAAAGTTCTCACACAAACGCAACGTGTTGCGACACATGGAGGTGCATTGGGACAAAAAGAAATATCAATGTGAAAAATGTGGAGAGCGTTTCTCTTTATCGTGGTTAATGTACAATCACCTAATGCGACACGATGCCGAGGAGCATGCACTTATTTGTGATGTCTGTCATCAACAATTCAAAACGAAACGCACCTACAAGCATCATCTACGCACCCACCAAACAGATCGACCGCGATTCCAATGTACAGATTGCGAGAAGTCGTTCGTGGACAAATATACATTAAAGGTACATAAGCGTGTGCATTTACCTGTCGAAGCCACACAAGCTACATAA
Protein Sequence: MSTARQFCFVCGKIKSVGVFQLIEGCIVPGTFKPIKDIIKYFEKVINQRLELTPTSAACRDCLEYLFNYDRLVRNLSQVQRQIANSLLSCRKKKGVSLKPKKEVTKPKSQDVKSNQLPLQKSIKQEAFAATIKQEAFADEQQQDFVFSESESTTESSEEEINLDIPCHICGELFSTQDCLERHIKTDNCQKNEYATCNICGLKVKDEEVLDLHMNLHEGKTELECRYCTKKFSHKRNVLRHMEVHWDKKKYQCEKCGERFSLSWLMYNHLMRHDAEEHALICDVCHQQFKTKRTYKHHLRTHQTDRPRFQCTDCEKSFVDKYTLKVHKRVHLPVEATQAT

Sequence clustering based on sequence similarity using MMseqs2