Basic Information

Insect: Drosophila pruinosa
Gene Symbol: topi
Assembly: GCA_018150935.1
Location: JAECWR010000094.1:11516770-11519257[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 9.5e-06 0.00078 19.8 0.8 2 23 222 243 222 243 0.97

2 9 0.026 2.1 9.0 0.1 2 23 269 290 268 290 0.85

3 9 0.0011 0.091 13.3 0.2 2 23 352 373 351 373 0.96

4 9 0.029 2.4 8.8 1.6 1 21 420 440 420 444 0.90

5 9 7.9e-06 0.00065 20.1 1.7 1 23 507 529 507 529 0.95

6 9 0.00053 0.044 14.3 0.7 1 23 535 560 535 560 0.96

7 9 0.36 29 5.4 1.7 1 23 566 588 566 588 0.88

8 9 3.1e-08 2.5e-06 27.6 0.4 1 23 594 616 594 616 0.99

9 9 0.00057 0.047 14.2 1.8 1 23 622 645 622 645 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	9.5e-06	0.00078	19.8	0.8	2	23	222	243	222	243	0.97
2	9	0.026	2.1	9.0	0.1	2	23	269	290	268	290	0.85
3	9	0.0011	0.091	13.3	0.2	2	23	352	373	351	373	0.96
4	9	0.029	2.4	8.8	1.6	1	21	420	440	420	444	0.90
5	9	7.9e-06	0.00065	20.1	1.7	1	23	507	529	507	529	0.95
6	9	0.00053	0.044	14.3	0.7	1	23	535	560	535	560	0.96
7	9	0.36	29	5.4	1.7	1	23	566	588	566	588	0.88
8	9	3.1e-08	2.5e-06	27.6	0.4	1	23	594	616	594	616	0.99
9	9	0.00057	0.047	14.2	1.8	1	23	622	645	622	645	0.95

Sequence Information

Coding Sequence: ATGGATGAGAATTTGAATCAATATGAAGATGGTGAGTTCGTCATGGCCGAGTTTGAATGCGATACTGGAATGTTGGTGGATCGTAACAGTGAATTGCAGGAGGGTGCCACTGTGCTGGTGGCCAACGAGAGCGATGGCGTAATTAATTTTGATGATCTAAGCAAGTTTTTCGATATCTCGAATGTCATGCAGATTGAAACGGAAGATGCCGTTGAGCGCACACTTGCGGATCCAGACCTCAAGCAAGTACTGCAGGAAGTCGATGATAAGGCTGACTTCGACCCGGAAGCGGAGCAAGAAAAGTTGCGCGACTTTCTTGTGGAAGCAAACAACAAAATGGTCATACAGGAGAGCATGCCTATGGTGCCAGGTGGATCCTTAAAGCAGCCAGTGGACGTCATCAAGTGCTCCAATTGTAATTGTCTCTTCCATTCGTCAGCTTTTCAAACGCACCGTTGTGAACCGTCGAAACCAACGGAAACTTCTCCAAAGATGCCACCACCTGTAGACAGGTCTGTACCACCCAAGAAACCTCCAAGCGAACGCATTCTCATCGAGAATCAGGTACGCATTCGTCGCTATGTAAAGGAAGAGCTTAAGTATGATCTGGAGACGGGAGTGGACAGTTCCAAGGTCAAAAAGTCTGCTTCCAAGGGACCCAACGAGTGCAACATTTGTGAGCGCAAGTTTGTGCACGCCTCGGGTTTGGTGCGTCACATGGAGAAGCATGCGCTTGACCTCATACCCACACAATCGACTGTCCCGCATTCGGCACTGTCGGCCCTTGGTTTACTTGTCGTAGTCAAGTGCAACAATTGTGGACGTGTCTTTTATGATGCCAAGATTGCGCTAGATCATATCAATGTACACTATCAACTGGTTCCCGAGGCAAAGAAAGTCACGGCAGTTAAAGAGAGTGAAGCGGATTTGAAGCGACAGCTGGATGCACTTCTGGTGGAAGGACATCAGCTTCTTGCGGTCAGTACGCAGCTAGAAAAGGTGGAGCGTTATGAGAATGAATACTTTTCCTCACTTATTCTGAGCAATGTGCTCCAGTGCGAATTTTGCGATTACGTCTTTGCTGACATAACCTACCTGCTGAAACATTCGGCTACCCATGTCCCAGAGCGTCGGTTTGAGTGTTCCGCTTGCAATTTACTTATTACCACCACCAAGGAGGCCAGTGTGCATTATCAAACCGACTGTGTCTACATGCGCGAAGGACTCAAGCAACTCCACACATCGCCCAATCGCTACTTTGTGTGCAATGTGTGTGAGCAAAAGTTCGGTAATGTTGAGCTGCTGCAGGATCATCGATACAGCTGCTACCACTACTTTCCACGTCTCAGCGAGACCGGTAAGCGTCTGCTGTTGCCCTGTGAATTCTGTGCTATCAACTTTGAGTACGCCCATGAGATTCTGCCGCATTATGAGGAGAAGCATCTAAATAAGAAGAAACGTGAGAAGGAATTGCGCAGTAATAATAGTAATACTGCGGCTGTGGGTAGACTGCGTCAATATCTGTGCGATATTTGTGGTAAATTATACACACAGTCCAGTCACTTGTGGCAACACTTGCGTTTCCATCAGGGTGTCAAGCCCTTTGTTTGCGATGAGCCGGGTTGTGGTCGCAAGTTTACTATTCGGCCGGATCTCAACGATCATACACGAAAGTGTCACACTGGGGAGCGACCATATCATTGCTTGGTATGCGGCAAGCGCTTTCTTACAGGATCCGTTTTTTATCAGCATCGTCTCATACATCGCGGCGAGCGGCGATACGAGTGCGATGAGTGCGGCAAGCGTTTCTATCGTGCTGATGCATTGAAAAACCATCAGCGTATTCATACTGGCGAGAAACCCTACGATTGCCAATACTGTACGAAGACTTTTCGTCAGCGCGGTGATCGTGACAAGCATGTACGAGCGCGTCATTCACACTTGGATGAAAATGCACGCGCGATGATGCGAATGCAAAAGCTTCAATTGGAATCGGCCGCTGCGTTAAAGGCTAAGCAAATGCAGGAAAGTACTGAATTTCTAACAGACCCCGCCTCCTTGGTTCATTTGCCATCATCTGCTATGATGTCGGAGCAGCAGTATGATATGGTTGAGCTAGATCCCAATGATTTTTGTGAGGCATCTGAATTCGAACAAGTGTCAATTGAAAATCCTGAATATGGAATAATTGCGTATGGGGAACCAGGAGCAATGGAACCAGTTGAAGTATCGCAGTTTAAGAGGGATACAGCTAGAGTCGTGGTTGTTGAAAATAACTCTTCGCAGCCGTTTTATTTTTAA
Protein Sequence: MDENLNQYEDGEFVMAEFECDTGMLVDRNSELQEGATVLVANESDGVINFDDLSKFFDISNVMQIETEDAVERTLADPDLKQVLQEVDDKADFDPEAEQEKLRDFLVEANNKMVIQESMPMVPGGSLKQPVDVIKCSNCNCLFHSSAFQTHRCEPSKPTETSPKMPPPVDRSVPPKKPPSERILIENQVRIRRYVKEELKYDLETGVDSSKVKKSASKGPNECNICERKFVHASGLVRHMEKHALDLIPTQSTVPHSALSALGLLVVVKCNNCGRVFYDAKIALDHINVHYQLVPEAKKVTAVKESEADLKRQLDALLVEGHQLLAVSTQLEKVERYENEYFSSLILSNVLQCEFCDYVFADITYLLKHSATHVPERRFECSACNLLITTTKEASVHYQTDCVYMREGLKQLHTSPNRYFVCNVCEQKFGNVELLQDHRYSCYHYFPRLSETGKRLLLPCEFCAINFEYAHEILPHYEEKHLNKKKREKELRSNNSNTAAVGRLRQYLCDICGKLYTQSSHLWQHLRFHQGVKPFVCDEPGCGRKFTIRPDLNDHTRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYDCQYCTKTFRQRGDRDKHVRARHSHLDENARAMMRMQKLQLESAAALKAKQMQESTEFLTDPASLVHLPSSAMMSEQQYDMVELDPNDFCEASEFEQVSIENPEYGIIAYGEPGAMEPVEVSQFKRDTARVVVVENNSSQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00595450;
90% Identity: -
80% Identity: -