Dpru003517.1
Basic Information
- Insect
- Drosophila pruinosa
- Gene Symbol
- ZFX
- Assembly
- GCA_018150935.1
- Location
- JAECWR010000199.1:6075688-6080463[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 12 0.022 1.8 9.2 4.3 1 23 225 250 225 250 0.91 2 12 2.7e-05 0.0022 18.4 0.1 2 23 258 282 257 282 0.93 3 12 2e-06 0.00016 21.9 0.3 1 23 289 311 289 311 0.96 4 12 5.9e-05 0.0048 17.3 0.2 1 23 318 340 318 340 0.98 5 12 0.0002 0.016 15.7 0.4 1 23 346 368 346 368 0.98 6 12 1.9 1.6e+02 3.1 2.0 1 21 374 394 374 397 0.79 7 12 0.11 9.2 7.0 1.9 1 23 403 425 403 425 0.95 8 12 0.0051 0.42 11.2 4.8 2 23 432 453 431 453 0.96 9 12 2.2e-05 0.0018 18.7 1.3 2 23 468 489 467 489 0.98 10 12 0.00036 0.029 14.9 0.4 1 23 578 601 578 601 0.95 11 12 0.00059 0.048 14.2 0.8 1 23 607 629 607 629 0.97 12 12 0.00071 0.058 13.9 6.3 3 23 636 656 636 656 0.99
Sequence Information
- Coding Sequence
- ATGAATGAGGCATCGTCGGGGTTAGAACAAAAACTTTGCCGTACCTGTTTAACAAATTTGCAATCGGATGACGCCTTTGACCTATTCATTGTTCCAGGCCTTGCCAAAAAATTGTGTGTTTGCACTTCTCTGTCTGTGGAGAACCAAGATGGATTCCCTTCAAACATCTGCTCAACCTGTTACATCCGTCTCAATGAGCTGCATGACTTTCAAACACAGTGCGTAGACTCTGCCCTAAAATTCAAGGAGATGCTGGTCAACACTTTCGGGATTCGTTTAATTTCTGATGATAAATTTTGCGTGGTAAATGCAGCAGACAAGGAGCAAACATCTGAAGATGACCAAACGCATTTTGACACCATGCTGAATACCAAAATCGAAATTGAGGACAACATTATTTTGCACAATGATGCAAAAGCAGTGGAGGACGAGATGGAATGTAATGTGTTGGATGATTTTGCAAATGACGATAAAGATGTGGATTTCACGGTGGAGAGTAGCGATTCCGAATATAAGCAGCTGTCGAAACTTCAACCCCAGAACACTGACACGAACCATACACAAAAAAGTGATAAAGATGAAGGTAAATCGAAACCAAAGCAGGTGTTGCTGAAGTTCAAAAAGACAATTAACTACGATCAGCATATGAAAGGGCACAGCGATCTGTTCACCCACCAGTGTTTAGTGCAGTCTTGCAATAAAGGGTTTATGACATCCAAAAAACTGCAAATTCACATGAAGCACTCGCACCCAGAACTCTGCGAAATGTTACCATGCACTGCAGAAGGATGTGACAAGAAGTTCGCTCAGAAACGCATGCTCACGCAGCATATGCTAGTGGTACACAGCATTCCTAGAAACCATTATCCGTGCTTAGAGTGCGGGAAGAAATTCCGTTCTCCAATTGGACTTAAGAAGCACATGTACGAACATACAGGTGAGGATAAGCCATTTGTATGTAGTTTGTGCCCCAGACGCTTTGCCGTAAGCACCGAGTTGCGGGATCACTTGCTTCGCCATGCTGGAATCAGGATATTTGTCTGTCCGCACTGCGGGGTGGGCAGGACAACCAAAAAGGAGTTAGATAATCACATATTGATGCATACCAAGGAGAAAAAGTTCAAATGCGATCAGTGTGATTATGCCACACATAGTAAGCGTTCGATGTCCTTCCACGTCAAGCTGGTGCACATGAATATTAAGGAGTTTCCCTGTCAATTCTGTGGAAGGCCTTGTAGCACAGCCTATATCCGCAAGCTTCACGAGCGGACTCACTCTGTGGAGAAGTACTGTGAATGCAAGATCTGTGGCAGGATCTTGCATTCCAAAAAGCGCTTAGCGAAACACTTAAGGAGGCATGAGAAAGACAAATGGTTGCCAGTGGATATCGGGGATCGTTCCAAGTGCAACATCTGTGGCAAAATTTTCCAATACGAGAAGAGCTTTGCGAAGCACTTGAAGACACATGAGAAAAGTGATCTGCCGCCAGTAGATATCCCTCGTCATAAGACAGACCACATGAAGGGGGACGCAGAGCTGAAAGCTCCGCATGTGGCTGACGATCTACAGAAGACGTGTAGCGACAAGCCCGCAACAAACGTTCCAGAAGTAGCAGGCGCAGAAGCCAAACCAAAAAGGTCAAGGCTGGCGGTCACGTCGATCAATCGCATACCCTTAGTCTCTGTCGCGTCAAAGTCACCGAAAGTGAAATTCACCAAGAAAAAGGGTCAGTACATTTGTCAGATCTGCGGGCAAGGCTTTAGCAAAATTTACAATGCAAAACGCCATTATAGTATCACACACGAAAAGGTAAAAGATTTCGCCTGCCGCTTTTGTCCCAAACGCTTTTCCATCAAACAAAATTGGCGGGTTCACGAACGCATTCACACAGGCAAGAAGGCCTGGTGCAAGATATGCGACAAGCATTTCCGCCATGAGACGGCGCTGAAGAATCACAGCAAGACGCACTGCAAACCCAACAAAAGTAAACAGATTCCCGCATCCGAACAGCTTGAGAAAGAGCAAGAGATTGAGAAGGCGATCACATGA
- Protein Sequence
- MNEASSGLEQKLCRTCLTNLQSDDAFDLFIVPGLAKKLCVCTSLSVENQDGFPSNICSTCYIRLNELHDFQTQCVDSALKFKEMLVNTFGIRLISDDKFCVVNAADKEQTSEDDQTHFDTMLNTKIEIEDNIILHNDAKAVEDEMECNVLDDFANDDKDVDFTVESSDSEYKQLSKLQPQNTDTNHTQKSDKDEGKSKPKQVLLKFKKTINYDQHMKGHSDLFTHQCLVQSCNKGFMTSKKLQIHMKHSHPELCEMLPCTAEGCDKKFAQKRMLTQHMLVVHSIPRNHYPCLECGKKFRSPIGLKKHMYEHTGEDKPFVCSLCPRRFAVSTELRDHLLRHAGIRIFVCPHCGVGRTTKKELDNHILMHTKEKKFKCDQCDYATHSKRSMSFHVKLVHMNIKEFPCQFCGRPCSTAYIRKLHERTHSVEKYCECKICGRILHSKKRLAKHLRRHEKDKWLPVDIGDRSKCNICGKIFQYEKSFAKHLKTHEKSDLPPVDIPRHKTDHMKGDAELKAPHVADDLQKTCSDKPATNVPEVAGAEAKPKRSRLAVTSINRIPLVSVASKSPKVKFTKKKGQYICQICGQGFSKIYNAKRHYSITHEKVKDFACRFCPKRFSIKQNWRVHERIHTGKKAWCKICDKHFRHETALKNHSKTHCKPNKSKQIPASEQLEKEQEIEKAIT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -