Dpru017271.1
Basic Information
- Insect
- Drosophila pruinosa
- Gene Symbol
- lz
- Assembly
- GCA_018150935.1
- Location
- JAECWR010000438.1:276171-277722[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.16 7.2e+02 -0.2 0.6 48 71 55 78 18 101 0.57 2 2 3.9e-49 1.8e-45 153.7 0.0 5 93 101 189 97 190 0.97
Sequence Information
- Coding Sequence
- ATGGTGACATCCTCGGCATCGCCAACAGGAACGGGCTGGTCGGCACCTGCAGATTACAAGAGCGCCAGTACAGCTGTTACAGCAGCCGCGACTGAGATCATGTGTGAGGTGCTGCCATCGAGCAGCGCCAGCGTTGGCAGCAGTTCGCCAACGGGTGGAGCTAGCAATGGTACCGTCAATAGTGCACATAGTGGTAGCCATAAAAAGAACAACAACAGTGTTAATAATAACAACAACAACAACAATAACAATGCAGTTCATCAGGATCTTCTATGGATGGAAAGATTTGTGCTCGAAAGGCAACAAGAATATCCGGGGGAGTTGGTGCGAACGAGTAACCCATACTTTCTTTGCTCCGCCCTGCCCTCCCACTGGCGCTCGAATAAAACTCTGCCGCTGGCATTTAAAGTTGTTGCCTTGGCGGAAGTCGGCGATGGAACGTATGTGACCATCCGAGCGGGAAATGATGAAAACTGCTGCGCAGAGTTACGCAACTACACCGCCCAGATGAAGAATGGTGTAGCCAAGTTTAACGATCTGCGTTTTGTGGGACGAAGTGGAAGAGGTGAGTAG
- Protein Sequence
- MVTSSASPTGTGWSAPADYKSASTAVTAAATEIMCEVLPSSSASVGSSSPTGGASNGTVNSAHSGSHKKNNNSVNNNNNNNNNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALAEVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00338918; iTF_00582040; iTF_00556991;
- 90% Identity
- -
- 80% Identity
- -