Basic Information

Insect: Drosophila planitibia
Gene Symbol: topi
Assembly: GCA_035043785.1
Location: JAWNMS010000025.1:6235671-6238387[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 3.9e-05 0.0024 18.1 1.0 2 23 227 248 227 248 0.97

2 10 0.031 1.9 9.0 2.2 2 23 274 295 273 295 0.94

3 10 0.0019 0.11 12.8 0.1 2 23 354 375 353 375 0.96

4 10 1.8 1.1e+02 3.4 0.1 1 22 381 402 381 402 0.92

5 10 0.052 3.2 8.3 1.3 1 21 422 442 422 446 0.90

6 10 4.8e-07 3e-05 24.1 1.9 1 23 510 532 510 532 0.95

7 10 0.00012 0.0071 16.6 0.5 1 23 538 563 538 563 0.97

8 10 0.42 26 5.4 1.7 1 23 569 591 569 591 0.88

9 10 3.6e-08 2.2e-06 27.7 0.4 1 23 597 619 597 619 0.99

10 10 0.00067 0.042 14.2 1.2 1 23 625 648 625 648 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	3.9e-05	0.0024	18.1	1.0	2	23	227	248	227	248	0.97
2	10	0.031	1.9	9.0	2.2	2	23	274	295	273	295	0.94
3	10	0.0019	0.11	12.8	0.1	2	23	354	375	353	375	0.96
4	10	1.8	1.1e+02	3.4	0.1	1	22	381	402	381	402	0.92
5	10	0.052	3.2	8.3	1.3	1	21	422	442	422	446	0.90
6	10	4.8e-07	3e-05	24.1	1.9	1	23	510	532	510	532	0.95
7	10	0.00012	0.0071	16.6	0.5	1	23	538	563	538	563	0.97
8	10	0.42	26	5.4	1.7	1	23	569	591	569	591	0.88
9	10	3.6e-08	2.2e-06	27.7	0.4	1	23	597	619	597	619	0.99
10	10	0.00067	0.042	14.2	1.2	1	23	625	648	625	648	0.95

Sequence Information

Coding Sequence: ATGGATTCAAGATCAGGTCAGCTTTACGATGATGGTGAATTCGTGATGGCCGAGTTCGAGCTCGATGACGATTTGATGGTGGACAGCAATGGCATGCAGTCAGGTTCCACTCTACTGGTGTCCAATGAGAGCAATGGTCTCCTCGGTCACGAGGATTTGGCCAAGTTCTTTGAGCTGCAGGGCGGCTTTCAGATACCCGCCGAGGAGGTTGTGGAACGCACGTTGACAGATCCGGCGCTAATGGGAATCCTGCATGAAGCCAACGGACAGATGGATTTTGATCCGGAAGCAGAACAACTCAAATTACGCGAGTTCTTATCGGGCGTTAACAATTGCATGGAGCTGAATGCGTTGCCAGGTGTGGTGGTCGACGAGAATAAAAGTCCAGCCCTCCGTTTCATCCTGTGCTCCAATTGCAACGGAATCTTCGATACGCCCGCATTCCAAAATCACATCTGTGAATACGATGCGAACCAGAAACAAATCGTAGCTCAGCAATTACCACCACAGCCGGAGAAGAAGGCATTTTCGTCACCAAGGATAACGGGCAGCGAGCGCATCATCGTTGAAAATCAGGTGCGCATGCGTCGCTATATGAAGGATGAGCTCAAGTATGACCTGGAGACGGGTCTGGACGACAGTTCCAAGGTGAAGGAGTCGACGGTCAAGGGCACCAACGAGTGCAGCATCTGTGAGCGCAAGTTTGTTCACTCCTCCGGCTTGGCGCGTCACTTGGAAAAGCATGCTCTGGACCTAATCCCCGCACAGGTAACGCTGCAACAGCATCACGCATCAAGGCTTGGCGTTCTTGTTGTCCTCAAATGCAAACACTGTGGACGCATTTTCTTCAACGTCAAGCTGGCGCTGGAACACATCCATGTGCATTGCTCGAACAGTGACGTGATCAAATCCAGAAATGTGgataaagtgaaattaaagCATCATCTCGAATTGCTACTGATGGAGGAgaagcaactgcaattgaTCACCAAGCTGGAGAAGATACCGCTGGATCGGCAGGAGGAAATGTTCAAAAACCATGTGGTGGCTAATGTCCTCCAGTGCGAGTTTTGTGACTATATCTTTGCCGATGTTGCGTCGCTGTTGCGCCACTCGGCCACCCATATGCCGGAACAGCGGTTCGAGTGCACCGCCTGTGATCTGCGCCTCACCACCGCCAAGGAGGCTAGTGTTCACTACCAGACCGACTGCGTCTATATGCGCGAGGAACTcaagcaactgcaaattgcGCTGAATCGTCTATTTGTGTGCAATGTGTGCAAGCTGAAGTATGCCAATGTGGAGCTGCTTCAGGAGCATCGCTACAGTTGCCTTCACTTCTTTCCGCGGATCAGCGAGACTGGCGCTCGGCTGATGTTGCCCTGTGAGTTCTGTGCCGCCAATTTTCAGTGTGCCAACGAGATACAGGCCCACTACGAGGAGAAGCATCTGAATCGGAAGAAGCGGGAGAAGGAACAACTGCGCAACATCAGCAGTGCATCATCGTCCAAGGTCCGACTGCGACAATATCTATGCGACATCTGTGGGAAATCATACACACAGTCCAGTCATTTGTGGCAACACCTCCGCTTTCATCAGGGTGTGAAGCCATTTGTTTGTCCGGAAGCGAACTGCGGTCGCAAATTCACCATACGGCCGGATCTCAATGATCACATACGAAAGTGTCATACTGGGGAACGGCCGTATCATTGTCTGGTTTGTGGCAAGCGTTTTCTCACCGGCTCCGTGTTCTACCAGCATCGACTCATCCATCGTGGCGAGCGGCGATACGAGTGTGAAGAGTGTGGCAAGCGTTTCTATCGCGCCGACGCATTGAAAAACCATCAGCGCATTCATACGGGCGAGAAGCCCTACGACTGTCCATTCTGCACGAAAACGTTCCGGCAGCGTGGCGATCGGGATAAGCATGTGCGGGCGCGTCACTCCCACTTGGATGAGAATGCTCGCCTGATGATGCGAATGCAGAAGTTTGAACTGGAGAAGGCGGCTGCGTTGAAGGCCAAACAATTGCACGAGGTGGGAATTGAATATTTGGTGGAGTCAGGGGATGCCACGTCTATTCATTCGGTAGCATCTCCGTCATCACATGAGCCACAATTCGATTATAGTGAATACCCCGAAGAAACTGAAATTGTATCAATGCCAATTAGAAATGAGGAGCCAGATATAATGTCGTATATGGAATTCGAGGGAGTAGAATCAATCGAAACACCACCGTTCAAGTTAGAAAATAATGGAAACGTCAAGGTTGTCGTGGTTGAAAATAATTCTTTACAGCCATTCTATTTCTAA
Protein Sequence: MDSRSGQLYDDGEFVMAEFELDDDLMVDSNGMQSGSTLLVSNESNGLLGHEDLAKFFELQGGFQIPAEEVVERTLTDPALMGILHEANGQMDFDPEAEQLKLREFLSGVNNCMELNALPGVVVDENKSPALRFILCSNCNGIFDTPAFQNHICEYDANQKQIVAQQLPPQPEKKAFSSPRITGSERIIVENQVRMRRYMKDELKYDLETGLDDSSKVKESTVKGTNECSICERKFVHSSGLARHLEKHALDLIPAQVTLQQHHASRLGVLVVLKCKHCGRIFFNVKLALEHIHVHCSNSDVIKSRNVDKVKLKHHLELLLMEEKQLQLITKLEKIPLDRQEEMFKNHVVANVLQCEFCDYIFADVASLLRHSATHMPEQRFECTACDLRLTTAKEASVHYQTDCVYMREELKQLQIALNRLFVCNVCKLKYANVELLQEHRYSCLHFFPRISETGARLMLPCEFCAANFQCANEIQAHYEEKHLNRKKREKEQLRNISSASSSKVRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEANCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSHLDENARLMMRMQKFELEKAAALKAKQLHEVGIEYLVESGDATSIHSVASPSSHEPQFDYSEYPEETEIVSMPIRNEEPDIMSYMEFEGVESIETPPFKLENNGNVKVVVVENNSLQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00557382;
90% Identity: iTF_00498343;
80% Identity: -